SG11201601193TA - Mutant calreticulin for the diagnosis of myeloid malignancies - Google Patents

Mutant calreticulin for the diagnosis of myeloid malignancies

Info

Publication number
SG11201601193TA
SG11201601193TA SG11201601193TA SG11201601193TA SG11201601193TA SG 11201601193T A SG11201601193T A SG 11201601193TA SG 11201601193T A SG11201601193T A SG 11201601193TA SG 11201601193T A SG11201601193T A SG 11201601193TA SG 11201601193T A SG11201601193T A SG 11201601193TA
Authority
SG
Singapore
Prior art keywords
diagnosis
mutant calreticulin
myeloid malignancies
malignancies
myeloid
Prior art date
Application number
SG11201601193TA
Other languages
English (en)
Inventor
Robert Kralovics
Thorsten Klampfl
Heinz Gisslinger
Original Assignee
Cemm Forschungszentrum Für Molekulare Medizin Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=51795161&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=SG11201601193T(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Cemm Forschungszentrum Für Molekulare Medizin Gmbh filed Critical Cemm Forschungszentrum Für Molekulare Medizin Gmbh
Publication of SG11201601193TA publication Critical patent/SG11201601193TA/en

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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • C12Q1/6886—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/0005—Vertebrate antigens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
    • C07K14/4728—Calcium binding proteins, e.g. calmodulin
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6869—Methods for sequencing
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/574—Immunoassay; Biospecific binding assay; Materials therefor for cancer
    • G01N33/57407—Specifically defined cancers
    • G01N33/57426—Specifically defined cancers leukemia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/10—Type of nucleic acid
    • C12N2310/14—Type of nucleic acid interfering N.A.
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/156—Polymorphic or mutational markers
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/158—Expression markers
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/172—Haplotypes
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
    • G01N2333/46—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans from vertebrates
    • G01N2333/47—Assays involving proteins of known structure or function as defined in the subgroups
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
    • G01N2333/46—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans from vertebrates
    • G01N2333/47—Assays involving proteins of known structure or function as defined in the subgroups
    • G01N2333/4701—Details
    • G01N2333/4727—Calcium binding proteins, e.g. calmodulin
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/50—Determining the risk of developing a disease

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • General Health & Medical Sciences (AREA)
  • Zoology (AREA)
  • Biochemistry (AREA)
  • Wood Science & Technology (AREA)
  • Biomedical Technology (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Analytical Chemistry (AREA)
  • Biophysics (AREA)
  • Pathology (AREA)
  • Medicinal Chemistry (AREA)
  • Hematology (AREA)
  • Physics & Mathematics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Oncology (AREA)
  • Hospice & Palliative Care (AREA)
  • Urology & Nephrology (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Cell Biology (AREA)
  • General Physics & Mathematics (AREA)
  • Food Science & Technology (AREA)
  • Toxicology (AREA)
  • Mycology (AREA)
  • Epidemiology (AREA)
  • Plant Pathology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
SG11201601193TA 2013-09-16 2014-09-15 Mutant calreticulin for the diagnosis of myeloid malignancies SG11201601193TA (en)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
EP13184632 2013-09-16
EP13186939 2013-10-01
US201361909313P 2013-11-26 2013-11-26
PCT/EP2014/069638 WO2015036599A1 (fr) 2013-09-16 2014-09-15 Calréticuline mutante pour le diagnostic de malignités myéloïdes

Publications (1)

Publication Number Publication Date
SG11201601193TA true SG11201601193TA (en) 2016-04-28

Family

ID=51795161

Family Applications (1)

Application Number Title Priority Date Filing Date
SG11201601193TA SG11201601193TA (en) 2013-09-16 2014-09-15 Mutant calreticulin for the diagnosis of myeloid malignancies

Country Status (16)

Country Link
US (5) US9371570B2 (fr)
EP (4) EP3494985B1 (fr)
JP (2) JP6745220B2 (fr)
KR (1) KR102433548B1 (fr)
CN (2) CN113564254A (fr)
AU (2) AU2014320262B2 (fr)
BR (1) BR112016005611B1 (fr)
CA (1) CA2924370C (fr)
DK (3) DK2808338T3 (fr)
ES (1) ES2577289T3 (fr)
MX (1) MX348980B (fr)
PL (2) PL3494985T3 (fr)
PT (1) PT2808338E (fr)
RU (1) RU2668808C2 (fr)
SG (1) SG11201601193TA (fr)
WO (1) WO2015036599A1 (fr)

Families Citing this family (26)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK2808338T3 (da) 2013-09-16 2016-06-06 Cemm - Forschungszentrum Für Molekulare Medizin Gmbh Mutant calreticulin til diagnose af myeloide maligniteter
US10550435B2 (en) 2014-11-12 2020-02-04 Neogenomics Laboratories, Inc. Determining tumor load and biallelic mutation in patients with CALR mutation using peripheral blood plasma
EP3227341A1 (fr) * 2014-12-02 2017-10-11 CeMM - Forschungszentrum für Molekulare Medizin GmbH Anticorps anticalréticuline mutante et leur utilisation dans le diagnostic et la thérapie de tumeurs malignes myéloïdes
WO2016160860A1 (fr) * 2015-03-30 2016-10-06 Loh Jeffrey Thomas Procédés pour la production in vitro de plaquettes et compositions et utilisations correspondantes
WO2016172505A2 (fr) * 2015-04-23 2016-10-27 Quest Diagnostics Investments Incorporated Procédés et compositions utilisables pour la détection de mutations affectant le gène calr dans les maladies myéloprolifératives
US11028428B2 (en) 2015-11-11 2021-06-08 The Catholic University Of Korea Industry-Academic Cooperation Foundation Peptide nucleic acid probe for multiplex detection of BCR/ABL negative myeloproliferative neoplasm-associated gene mutations
ITUA20162858A1 (it) * 2016-04-26 2017-10-26 Univ Degli Studi Di Torino Procedimento per la rivelazione di mutazioni di tipo 1 e 2 del gene calreticulina (calr) e relativo kit
CN109803674A (zh) * 2016-06-10 2019-05-24 Io生物技术公司 Calr和jak2疫苗组合物
CN106566875A (zh) * 2016-09-20 2017-04-19 上海荻硕贝肯医学检验所有限公司 用于检测骨髓异常增生综合征mds基因突变的引物、试剂盒及方法
CN107164473B (zh) * 2017-05-22 2020-08-25 复旦大学附属华山医院 一种检测calr基因1型突变的引物组合物及试剂盒
CN107164474B (zh) * 2017-05-22 2020-09-04 复旦大学附属华山医院 一种检测calr基因2型突变的引物组合物及试剂盒
CN108949971A (zh) * 2017-05-23 2018-12-07 曹国君 钙网蛋白基因1型突变检测用封闭pna探针
CN107462706A (zh) * 2017-08-01 2017-12-12 广西中医药大学附属瑞康医院（广西中西医结合医院） 一种肿瘤试剂盒
CN108434439B (zh) * 2018-01-23 2020-02-07 中国人民解放军总医院 钙网蛋白的医药用途
US11414698B2 (en) * 2018-03-22 2022-08-16 Chang Gung Medical Foundation Chang Gung Memorial Hospital At Chiayi Method of quantifying mutant allele burden of target gene
RU2679653C1 (ru) * 2018-08-01 2019-02-12 Общество с ограниченной ответственностью "Формула гена" Набор реактивов для выявления Ph-негативных миелопролиферативных новообразований и способ диагностики на его основе
WO2020084005A1 (fr) 2018-10-23 2020-04-30 Myelopro Diagnostics And Research Gmbh Composés ciblant la calréticuline mutante
GB2599229B (en) * 2019-02-21 2024-04-24 Marengo Therapeutics Inc Multifunctional molecules that bind to calreticulin and uses thereof
WO2020175689A1 (fr) * 2019-02-28 2020-09-03 学校法人順天堂 Anticorps capable de se lier à la calréticuline mutante tronquée, et médicament de diagnostic, prophylactique ou thérapeutique pour néoplasmes myéloprolifératifs
WO2021039958A1 (fr) * 2019-08-30 2021-03-04 東洋鋼鈑株式会社 Kit d'évaluation d'une mutation génétique liée à une tumeur myéloproliférative
IL270306A (en) 2019-10-30 2021-05-31 Yeda Res & Dev Prevention and treatment of pre-myeloid and myeloid malignancies
CN112795647B (zh) * 2019-11-14 2022-08-16 北京肿瘤医院(北京大学肿瘤医院) 一种肿瘤标志物及其应用
WO2021099906A1 (fr) 2019-11-18 2021-05-27 Janssen Biotech, Inc. Vaccins basés sur les mutants du gène calr et de la protéine jak2 et leurs utilisations
WO2021188619A1 (fr) * 2020-03-17 2021-09-23 Memorial Sloan Kettering Cancer Center Vaccins à peptide hétéroclitiques contre le cancer
JPWO2022045247A1 (fr) 2020-08-27 2022-03-03
WO2023245139A2 (fr) * 2022-06-17 2023-12-21 Icahn School Of Medicine At Mount Sinai Vaccin à base de peptide calr mutant

Family Cites Families (35)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20493A (en) * 1858-06-08 Bebtch-plaite
US3773919A (en) 1969-10-23 1973-11-20 Du Pont Polylactide-drug mixtures
US4263428A (en) 1978-03-24 1981-04-21 The Regents Of The University Of California Bis-anthracycline nucleic acid function inhibitors and improved method for administering the same
EP0052322B1 (fr) 1980-11-10 1985-03-27 Gersonde, Klaus, Prof. Dr. Méthode de préparation de vésicules lipidiques par traitement aux ultra-sons, utilisation de ce procédé et l'appareillage ainsi utilisé
IE52535B1 (en) 1981-02-16 1987-12-09 Ici Plc Continuous release pharmaceutical compositions
US4711955A (en) 1981-04-17 1987-12-08 Yale University Modified nucleotides and methods of preparing and using same
US4485045A (en) 1981-07-06 1984-11-27 Research Corporation Synthetic phosphatidyl cholines useful in forming liposomes
JPS58118008A (ja) 1982-01-06 1983-07-13 Nec Corp デ−タ処理装置
EP0088046B1 (fr) 1982-02-17 1987-12-09 Ciba-Geigy Ag Lipides en phase aqueuse
DE3218121A1 (de) 1982-05-14 1983-11-17 Leskovar, Peter, Dr.-Ing., 8000 München Arzneimittel zur tumorbehandlung
CA1223831A (fr) 1982-06-23 1987-07-07 Dean Engelhardt Nucleotides modifies, methodes de preparation et d'utilisation et composes les contenant
EP0102324A3 (fr) 1982-07-29 1984-11-07 Ciba-Geigy Ag Lipides et composés tensio-actifs en phase aqueuse
US4544545A (en) 1983-06-20 1985-10-01 Trustees University Of Massachusetts Liposomes containing modified cholesterol for organ targeting
HUT35524A (en) 1983-08-02 1985-07-29 Hoechst Ag Process for preparing pharmaceutical compositions containing regulatory /regulative/ peptides providing for the retarded release of the active substance
DE3486459D1 (de) 1983-09-26 1997-12-11 Udo Dr Med Ehrenfeld Mittel und Erzeugnis für die Diagnose und Therapie von Tumoren sowie zur Behandlung von Schwächen der zelligen und humoralen Immunabwehr
EP0143949B1 (fr) 1983-11-01 1988-10-12 TERUMO KABUSHIKI KAISHA trading as TERUMO CORPORATION Composition pharmaceutique contenant de l'urokinase
US5703055A (en) 1989-03-21 1997-12-30 Wisconsin Alumni Research Foundation Generation of antibodies through lipid mediated DNA delivery
GB9304200D0 (en) 1993-03-02 1993-04-21 Sandoz Ltd Improvements in or relating to organic compounds
US5792608A (en) 1991-12-12 1998-08-11 Gilead Sciences, Inc. Nuclease stable and binding competent oligomers and methods for their use
ATE301201T1 (de) 1993-06-07 2005-08-15 Vical Inc Für die gentherapie verwendbare plasmide
US5525711A (en) 1994-05-18 1996-06-11 The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services Pteridine nucleotide analogs as fluorescent DNA probes
CA2225460A1 (fr) 1995-06-23 1997-01-09 Winston Campbell Patterson Regulation de la transcription de genes codant des recepteurs du facteur de croissance endotheliale vasculaire
US5846727A (en) * 1996-06-06 1998-12-08 Board Of Supervisors Of Louisiana State University And Agricultural & Mechanical College Microsystem for rapid DNA sequencing
JP2002501380A (ja) 1997-04-23 2002-01-15 シュリナーズ ホスピタル フォー チルドレン カルレティキュリン欠損細胞
NZ521769A (en) * 2000-04-05 2004-12-24 Genome Therapeutics Corp The high bone mass gene of 11q13.3
US7205146B1 (en) 2000-06-14 2007-04-17 Oscient Pharmaceuticals Corporation Nucleotide and amino acid sequences relating to respiratory diseases and obesity
US6426220B1 (en) * 2000-10-30 2002-07-30 Isis Pharmaceuticals, Inc. Antisense modulation of calreticulin expression
GB0113266D0 (en) * 2001-05-31 2001-07-25 Bayer Ag Genes and proteins for prevention prediction diagnosis prognosis and treatment of chronic lung disease
EP1846026A4 (fr) 2005-01-26 2008-07-02 Univ Johns Hopkins Vaccin d'adn anticancereux utilisant des plasmides codant un antigene et une calreticuline tels que des oncoproteines mutantes
JP4616237B2 (ja) 2006-11-07 2011-01-19 日本電信電話株式会社 シリコン化合物薄膜の形成方法
CN101616029B (zh) † 2009-07-28 2011-10-26 中兴通讯股份有限公司 一种实现网络拓扑发现的方法及系统
US8841074B2 (en) * 2009-12-04 2014-09-23 Quest Diagnostics Investments Incorporated MPL mutations in JAK2 V617F negative patients with myeloproliferative disease
US20140271683A1 (en) * 2010-12-21 2014-09-18 The Board Of Trustees Of The Leland Stanford Junior University Therapeutic and Diagnostic Methods for Manipulating Phagocytosis Through Calreticulin and Low Density Lipoprotein-Related Receptor
CN103091499B (zh) * 2013-01-23 2015-07-08 三峡大学 一种肿瘤标志物钙网蛋白检测试剂盒的制备及应用
DK2808338T3 (da) 2013-09-16 2016-06-06 Cemm - Forschungszentrum Für Molekulare Medizin Gmbh Mutant calreticulin til diagnose af myeloide maligniteter

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US9371570B2 (en) 2016-06-21
EP3020727B1 (fr) 2018-04-04
AU2019229353A1 (en) 2019-10-03
CA2924370A1 (fr) 2015-03-19
BR112016005611A2 (pt) 2017-09-12
AU2019229353B2 (en) 2021-03-18
EP2808338B1 (fr) 2016-03-30
EP3494985A1 (fr) 2019-06-12
JP2023024989A (ja) 2023-02-21
JP6745220B2 (ja) 2020-08-26
EP3494985B1 (fr) 2021-02-24
AU2014320262A1 (en) 2016-03-10
PT2808338E (pt) 2016-06-15
JP2016537012A (ja) 2016-12-01
EP3020727A1 (fr) 2016-05-18
CA2924370C (fr) 2024-01-23
US20180251852A1 (en) 2018-09-06
AU2014320262B2 (en) 2019-06-13
RU2016114509A (ru) 2017-10-18
PL2808338T3 (pl) 2016-09-30
ES2577289T3 (es) 2016-07-14
RU2668808C2 (ru) 2018-10-02
DK3020727T4 (da) 2021-04-19
DK2808338T3 (da) 2016-06-06
US20220251666A1 (en) 2022-08-11
CN105916876A (zh) 2016-08-31
EP3339318A1 (fr) 2018-06-27
KR20160068754A (ko) 2016-06-15
MX2016003245A (es) 2016-09-13
RU2016114509A3 (fr) 2018-03-06
CN113564254A (zh) 2021-10-29
KR102433548B1 (ko) 2022-08-18
PL3494985T3 (pl) 2021-08-02
US20160251723A1 (en) 2016-09-01
WO2015036599A1 (fr) 2015-03-19
US10344335B2 (en) 2019-07-09
BR112016005611B1 (pt) 2024-01-16
US20150079091A1 (en) 2015-03-19
US11274350B2 (en) 2022-03-15
MX348980B (es) 2017-07-05
DK3020727T3 (en) 2018-07-02
US20200040399A1 (en) 2020-02-06
EP2808338A1 (fr) 2014-12-03
DK3494985T3 (da) 2021-04-19
EP3020727B2 (fr) 2021-02-24

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