SG11201510439PA - Microfluidic system with fluid pickups - Google Patents

Microfluidic system with fluid pickups

Info

Publication number
SG11201510439PA
SG11201510439PA SG11201510439PA SG11201510439PA SG11201510439PA SG 11201510439P A SG11201510439P A SG 11201510439PA SG 11201510439P A SG11201510439P A SG 11201510439PA SG 11201510439P A SG11201510439P A SG 11201510439PA SG 11201510439P A SG11201510439P A SG 11201510439PA
Authority
SG
Singapore
Prior art keywords
microfluidic system
pickups
fluid
fluid pickups
microfluidic
Prior art date
Application number
SG11201510439PA
Other languages
English (en)
Inventor
Anthony J Makarewicz Jr
Luc Bousse
Stefano Schiaffino
Original Assignee
Bio Rad Laboratories
Anthony J Makarewicz Jr
Luc Bousse
Stefano Schiaffino
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bio Rad Laboratories, Anthony J Makarewicz Jr, Luc Bousse, Stefano Schiaffino filed Critical Bio Rad Laboratories
Publication of SG11201510439PA publication Critical patent/SG11201510439PA/en

Links

Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B01L3/502769—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by multiphase flow arrangements
    • B01L3/502784—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by multiphase flow arrangements specially adapted for droplet or plug flow, e.g. digital microfluidics
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B01L3/502715—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by interfacing components, e.g. fluidic, electrical, optical or mechanical interfaces
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B01L3/50273—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by the means or forces applied to move the fluids
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B01L3/502746—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by the means for controlling flow resistance, e.g. flow controllers, baffles
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L7/00—Heating or cooling apparatus; Heat insulating devices
    • B01L7/52—Heating or cooling apparatus; Heat insulating devices with provision for submitting samples to a predetermined sequence of different temperatures, e.g. for treating nucleic acid samples
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
    • C12N15/1034—Isolating an individual clone by screening libraries
    • C12N15/1075—Isolating an individual clone by screening libraries by coupling phenotype to genotype, not provided for in other groups of this subclass
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6806—Preparing nucleic acids for analysis, e.g. for polymerase chain reaction [PCR] assay
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/02—Adapting objects or devices to another
    • B01L2200/026—Fluid interfacing between devices or objects, e.g. connectors, inlet details
    • B01L2200/027—Fluid interfacing between devices or objects, e.g. connectors, inlet details for microfluidic devices
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/04—Closures and closing means
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/04—Closures and closing means
    • B01L2300/041—Connecting closures to device or container
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/04—Closures and closing means
    • B01L2300/041—Connecting closures to device or container
    • B01L2300/044—Connecting closures to device or container pierceable, e.g. films, membranes
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/04—Closures and closing means
    • B01L2300/046—Function or devices integrated in the closure
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/06—Auxiliary integrated devices, integrated components
    • B01L2300/0672—Integrated piercing tool
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/0809—Geometry, shape and general structure rectangular shaped
    • B01L2300/0829—Multi-well plates; Microtitration plates
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/0861—Configuration of multiple channels and/or chambers in a single devices
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/0861—Configuration of multiple channels and/or chambers in a single devices
    • B01L2300/0864—Configuration of multiple channels and/or chambers in a single devices comprising only one inlet and multiple receiving wells, e.g. for separation, splitting
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00—Moving or stopping fluids
    • B01L2400/04—Moving fluids with specific forces or mechanical means
    • B01L2400/0403—Moving fluids with specific forces or mechanical means specific forces
    • B01L2400/0457—Moving fluids with specific forces or mechanical means specific forces passive flow or gravitation
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00—Moving or stopping fluids
    • B01L2400/04—Moving fluids with specific forces or mechanical means
    • B01L2400/0475—Moving fluids with specific forces or mechanical means specific mechanical means and fluid pressure
    • B01L2400/0487—Moving fluids with specific forces or mechanical means specific mechanical means and fluid pressure fluid pressure, pneumatics
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00—Moving or stopping fluids
    • B01L2400/04—Moving fluids with specific forces or mechanical means
    • B01L2400/0475—Moving fluids with specific forces or mechanical means specific mechanical means and fluid pressure
    • B01L2400/0487—Moving fluids with specific forces or mechanical means specific mechanical means and fluid pressure fluid pressure, pneumatics
    • B01L2400/049—Moving fluids with specific forces or mechanical means specific mechanical means and fluid pressure fluid pressure, pneumatics vacuum
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00—Moving or stopping fluids
    • B01L2400/06—Valves, specific forms thereof
    • B01L2400/0633—Valves, specific forms thereof with moving parts
    • B01L2400/0655—Valves, specific forms thereof with moving parts pinch valves
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00—Moving or stopping fluids
    • B01L2400/06—Valves, specific forms thereof
    • B01L2400/0677—Valves, specific forms thereof phase change valves; Meltable, freezing, dissolvable plugs; Destructible barriers
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00—Moving or stopping fluids
    • B01L2400/08—Regulating or influencing the flow resistance
    • B01L2400/084—Passive control of flow resistance
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/508—Containers for the purpose of retaining a material to be analysed, e.g. test tubes rigid containers not provided for above
    • B01L3/5085—Containers for the purpose of retaining a material to be analysed, e.g. test tubes rigid containers not provided for above for multiple samples, e.g. microtitration plates
    • B01L3/50853—Containers for the purpose of retaining a material to be analysed, e.g. test tubes rigid containers not provided for above for multiple samples, e.g. microtitration plates with covers or lids
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T436/00—Chemistry: analytical and immunological testing
    • Y10T436/25—Chemistry: analytical and immunological testing including sample preparation
    • Y10T436/2575—Volumetric liquid transfer

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Dispersion Chemistry (AREA)
  • Analytical Chemistry (AREA)
  • Clinical Laboratory Science (AREA)
  • Hematology (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Biophysics (AREA)
  • Physics & Mathematics (AREA)
  • Microbiology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Bioinformatics & Computational Biology (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Plant Pathology (AREA)
  • Immunology (AREA)
  • Physical Or Chemical Processes And Apparatus (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Automatic Analysis And Handling Materials Therefor (AREA)
  • Accessories For Mixers (AREA)
  • Sampling And Sample Adjustment (AREA)
  • Colloid Chemistry (AREA)
  • Micromachines (AREA)
SG11201510439PA 2013-06-21 2014-06-23 Microfluidic system with fluid pickups SG11201510439PA (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201361838063P 2013-06-21 2013-06-21
PCT/US2014/043715 WO2014205447A2 (en) 2013-06-21 2014-06-23 Microfluidic system with fluid pickups

Publications (1)

Publication Number Publication Date
SG11201510439PA true SG11201510439PA (en) 2016-01-28

Family

ID=52105551

Family Applications (1)

Application Number Title Priority Date Filing Date
SG11201510439PA SG11201510439PA (en) 2013-06-21 2014-06-23 Microfluidic system with fluid pickups

Country Status (7)

Country Link
US (3) US9409174B2 (zh)
EP (1) EP3011302B1 (zh)
JP (3) JP6449266B2 (zh)
CN (2) CN109738224B (zh)
AU (1) AU2014284148B2 (zh)
SG (1) SG11201510439PA (zh)
WO (1) WO2014205447A2 (zh)

Families Citing this family (70)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20040002147A1 (en) 1999-12-29 2004-01-01 Desantis Grace Nitrilases
CN100577809C (zh) 2001-02-21 2010-01-06 维莱尼姆公司 具有α淀粉酶活性的酶及其使用方法
EP2327765B1 (en) 2001-06-21 2015-04-01 BASF Enzymes LLC Nitrilases
US7226771B2 (en) 2002-04-19 2007-06-05 Diversa Corporation Phospholipases, nucleic acids encoding them and methods for making and using them
CA2481411C (en) 2002-04-19 2016-06-14 Diversa Corporation Phospholipases, nucleic acids encoding them and methods for making and using them
US7504120B2 (en) 2002-06-14 2009-03-17 Verenium Corporation Xylanases, nucleic acids encoding them and methods for making and using them
CA2920416A1 (en) 2003-03-06 2004-10-28 Basf Enzymes Llc Amylases, nucleic acids encoding them and methods for making and using them
ES2598037T3 (es) 2003-04-04 2017-01-24 Basf Enzymes Llc Pectato liasas, ácidos nucleicos que las codifican y métodos para su preparación y uso
ES2401795T3 (es) 2003-07-02 2013-04-24 Syngenta Participations Ag Glucanasas, ácidos nucleicos que las codifican y métodos para eleborarlas y utilizarlas
EP1668113B1 (en) 2003-08-11 2013-06-19 Verenium Corporation Laccases, nucleic acids encoding them and methods for making and using them
JP2008505619A (ja) 2004-06-16 2008-02-28 ヴェレニウム コーポレイション 葉緑素を酵素的に脱色するための組成物及び方法
CA2614769A1 (en) 2005-03-10 2006-09-21 Verenium Corporation Lyase enzymes, nucleic acids encoding them and methods for making and using them
US8426184B2 (en) 2005-03-15 2013-04-23 Bp Corporation North America Cellulases, nucleic acids encoding them and methods for making and using them
EP2420570B1 (en) 2006-02-10 2013-12-04 Verenium Corporation Arabinofuranosidase enzymes, nucleic acids encoding them and methods for making and using them
EP3406621A1 (en) 2006-02-14 2018-11-28 BP Corporation North America Inc. Xylanases, nucleic acids encoding them and methods for making and using them
JP5441417B2 (ja) 2006-03-07 2014-03-12 カーギル・インコーポレイテッド アルドース、それをコードする核酸、ならびにそれを生成および使用する方法
ES2383767T3 (es) 2006-03-07 2012-06-26 Verenium Corporation Aldolasas, ácidos nucleicos que las codifican y métodos para producir y usar las mismas
CN106222185B (zh) 2006-08-04 2021-12-03 维莱尼姆公司 葡聚糖酶、编码它们的核酸及制备和使用它们的方法
MX2009003034A (es) 2006-09-21 2009-11-18 Verenium Corp Fosfolipasas, acidos nucleicos que las codifican, y metodos de hacerlas y usarlas.
BRPI0719449A2 (pt) 2006-12-21 2017-06-20 Syngenta Participations Ag molécula de ácido nucléico isolada, sintética ou recombinante, polipeptídeo isolado, planta ou parte de planta, eículo de clonagem que compreende um ácido nucléico, cassete de expressão que compreende uma molécula de ácido nucléico e método para hidrolisar um polissacarídeo, oligossacarídeo ou amido
AR065544A1 (es) 2007-01-30 2009-06-17 Verenium Corp Enzimas para el tratamiento de lignocelulosicos acidos nucleicos que las codifican y metodos para prepararlas y usarlas
WO2008106662A2 (en) 2007-03-01 2008-09-04 Verenium Corporation Nitrilases, nucleic acids encoding them and methods for making and using them
EP2708602B1 (en) 2007-10-03 2019-02-27 BP Corporation North America Inc. Xylanases, nucleic acids encoding them and methods for making and using them
AU2008347234B2 (en) 2008-01-03 2015-05-28 Basf Enzymes Llc Transferases and oxidoreductases, nucleic acids encoding them and methods for making and using them
UA111708C2 (uk) 2009-10-16 2016-06-10 Бандж Ойлз, Інк. Спосіб рафінування олії
UA109884C2 (uk) 2009-10-16 2015-10-26 Поліпептид, що має активність ферменту фосфатидилінозитол-специфічної фосфоліпази с, нуклеїнова кислота, що його кодує, та спосіб його виробництва і застосування
SG11201510439PA (en) 2013-06-21 2016-01-28 Bio Rad Laboratories Microfluidic system with fluid pickups
US10632465B2 (en) * 2015-04-22 2020-04-28 Stilla Technologies Contact-less priming method for loading a solution in a microfluidic device and associated system
DK3302804T3 (da) 2015-05-29 2022-09-26 Illumina Inc Prøveholder og analysesystem til udførelse af specifikke reaktioner
WO2017078630A1 (en) * 2015-11-04 2017-05-11 Nitto Denko Corporation Apparatus and system for biofluid sample dispensing and/or assay
US20170189908A1 (en) * 2015-12-30 2017-07-06 Bio-Rad Laboratories, Inc. Droplet assay system with automatic calibration
EP3420107A4 (en) 2016-02-22 2019-07-31 BioFire Defense, LLC RAPID PCR DEVICES AND METHODS
JP6622147B2 (ja) * 2016-06-16 2019-12-18 株式会社エンプラス エマルション生成部材、およびこれを用いたサンプル採取管、ならびに採血管
KR102478013B1 (ko) * 2016-07-28 2022-12-15 바이오파이어 다이어그노스틱스, 엘엘씨 자체-구비형 핵산 처리
USD803173S1 (en) * 2016-09-07 2017-11-21 EMULATE, Inc. Perfusion module lid without pressure features
GB201617869D0 (en) * 2016-10-21 2016-12-07 Blacktrace Holdings Limited A microfluidic device
CN108148744A (zh) * 2016-12-06 2018-06-12 中山百慧生物科技有限公司 一种液滴数字pcr芯片及相应检测方法和检测系统
CN108148743A (zh) * 2016-12-06 2018-06-12 中山百慧生物科技有限公司 一种液滴数字pcr芯片及相应检测方法和检测系统
CN110505918B (zh) * 2017-02-13 2022-06-14 生物辐射实验室股份有限公司 用于形成乳状液阵列的系统、方法以及装置
CN106984370B (zh) * 2017-05-08 2019-09-20 北京旌准医疗科技有限公司 一种基于微流控芯片的自动进样系统
CN110945139B (zh) 2017-05-18 2023-09-05 10X基因组学有限公司 用于分选液滴和珠的方法和系统
US10544413B2 (en) 2017-05-18 2020-01-28 10X Genomics, Inc. Methods and systems for sorting droplets and beads
GB2562762B (en) * 2017-05-24 2022-07-13 Univ Heriot Watt Microfluidic mixing
CN113474084B (zh) * 2017-06-28 2024-02-09 生物辐射实验室股份有限公司 用于液滴检测的系统和方法
KR101951405B1 (ko) * 2017-06-28 2019-05-08 주식회사 파나진 시료 시약 반응 분석용 키트, 이를 이용한 표적 핵산 검출 장치 및 방법
US10610865B2 (en) 2017-08-22 2020-04-07 10X Genomics, Inc. Droplet forming devices and system with differential surface properties
WO2019083852A1 (en) 2017-10-26 2019-05-02 10X Genomics, Inc. MICROFLUIDIC CHANNEL NETWORKS FOR PARTITIONING
US11045805B2 (en) 2017-11-01 2021-06-29 Bio-Rad Laboratories, Inc. Microfluidic system and method for arranging objects
EP3703567A4 (en) * 2017-11-02 2021-08-11 Memed Diagnostics Ltd. CARTRIDGE AND SYSTEM FOR ANALYSIS OF A BODY LIQUID
JP6967427B2 (ja) * 2017-11-06 2021-11-17 Nok株式会社 ガスケットおよび密封構造
WO2019110591A1 (en) * 2017-12-06 2019-06-13 Samplix Aps A microfluidic device and a method for provision of emulsion droplets
KR101951670B1 (ko) 2017-12-13 2019-02-25 한국과학기술원 미세액적 내 유전자 검출을 위한 광학장치
EP3501651B1 (en) * 2017-12-22 2024-03-06 IMEC vzw Microfluidic routing
GB2572408B8 (en) * 2018-03-29 2022-06-22 Univ Heriot Watt Fluidic device
WO2019204187A1 (en) * 2018-04-15 2019-10-24 Optofluidic Bioassay, Llc Differential pressure assisted drainage system
KR101891968B1 (ko) * 2018-05-30 2018-08-27 티엔에스(주) 하이브리드 유전자칩
KR101891558B1 (ko) * 2018-06-15 2018-08-27 티엔에스(주) 하이브리드 유전자칩용 유전자 분석 장치
WO2020030090A1 (en) * 2018-08-09 2020-02-13 Versitech Limited Systems for automated handling of fluid samples into microfluidic droplets for in vitro diagnostic
CN108728347A (zh) * 2018-08-27 2018-11-02 中国农业科学院农业质量标准与检测技术研究所 一种基因检测装置
CN109351369B (zh) * 2018-10-23 2021-01-26 深圳市博瑞生物科技有限公司 微流控液滴生成芯片
CN109351368B (zh) * 2018-10-23 2021-04-30 深圳市博瑞生物科技有限公司 微流控芯片
US20220193678A1 (en) * 2019-04-08 2022-06-23 Technion Research And Development Foundation, Ltd. Multiplexed array of nanoliter droplet array device
US20220276277A1 (en) * 2019-08-01 2022-09-01 Nippon Chemiphar Co., Ltd. Reagent cartridge
EP4045294A1 (en) * 2019-10-18 2022-08-24 Morningbird Media Corporation Three-dimensional printer with multihead extruder and compositions for use therein
CN115335141A (zh) 2020-04-01 2022-11-11 默克专利股份有限公司 乳化装置
CN111826273B (zh) * 2020-07-22 2023-03-21 上海逢伙泰企业管理有限公司 一种用于核酸检测的自动化全封闭微流控芯片
WO2022060548A1 (en) * 2020-09-18 2022-03-24 Microgem International Plc Method and system for sample collection, storage, preparation and detection
DE102020211697A1 (de) * 2020-09-18 2022-03-24 Robert Bosch Gesellschaft mit beschränkter Haftung Mikrofluidische Vorrichtung
WO2023164124A1 (en) * 2022-02-25 2023-08-31 Redbud Labs, Inc. Sample tube connectors and methods for attaching a microfluidics device to a sample tube
CN114672412A (zh) * 2022-05-30 2022-06-28 季华实验室 一种微滴式数字聚合酶链反应芯片

Family Cites Families (28)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5942443A (en) 1996-06-28 1999-08-24 Caliper Technologies Corporation High throughput screening assay systems in microscale fluidic devices
US20020092767A1 (en) * 1997-09-19 2002-07-18 Aclara Biosciences, Inc. Multiple array microfluidic device units
US6902703B2 (en) * 1999-05-03 2005-06-07 Ljl Biosystems, Inc. Integrated sample-processing system
US20030215957A1 (en) 1998-02-20 2003-11-20 Tony Lemmo Multi-channel dispensing system
US6887431B1 (en) * 1999-02-16 2005-05-03 Applera Corporation Bead dispensing system
US8709153B2 (en) * 1999-06-28 2014-04-29 California Institute Of Technology Microfludic protein crystallography techniques
WO2001014865A1 (en) 1999-08-25 2001-03-01 Caliper Technologies, Corp. Dilutions in high throughput systems with a single vacuum source
NL1017374C2 (nl) * 2001-02-15 2002-08-16 Univ Delft Tech Inrichting voor het uitvoeren van een reactie, alsmede een werkwijze voor het uitvoeren van een reactie in de inrichting.
WO2002072423A1 (en) * 2001-03-09 2002-09-19 Biomicro Systems, Inc. Microplate lid
US20020187557A1 (en) * 2001-06-07 2002-12-12 Hobbs Steven E. Systems and methods for introducing samples into microfluidic devices
US6877528B2 (en) * 2002-04-17 2005-04-12 Cytonome, Inc. Microfluidic system including a bubble valve for regulating fluid flow through a microchannel
US20060073484A1 (en) 2002-12-30 2006-04-06 Mathies Richard A Methods and apparatus for pathogen detection and analysis
WO2006114596A1 (en) * 2005-04-26 2006-11-02 Aviza Technology Limited Microfluidic structures and how to make them
US8257964B2 (en) * 2006-01-04 2012-09-04 Cell ASIC Microwell cell-culture device and fabrication method
JP5170239B2 (ja) * 2007-05-15 2013-03-27 和光純薬工業株式会社 集積化ｐｃｒ−ｃｅマイクロ流体デバイスにおける圧力を均一化するための圧力マニホールド
WO2008154036A1 (en) 2007-06-11 2008-12-18 Wako Pure Chemical Industries, Ltd. Microchip large-volume pcr with integrated real-time ce detection
WO2010036352A1 (en) * 2008-09-23 2010-04-01 Quantalife, Inc Droplet-based assay system
US9157550B2 (en) 2009-01-05 2015-10-13 The Board Of Trustees Of The University Of Illinois Microfluidic systems and methods
NL2002862C2 (en) * 2009-05-08 2010-11-09 Friesland Brands Bv Microfluidic apparatus and method for generating a dispersion.
WO2011002957A2 (en) 2009-07-01 2011-01-06 Advanced Liquid Logic, Inc. Droplet actuator devices and methods
FR2951153A1 (fr) 2009-10-09 2011-04-15 Corning Inc Dispositif microfluidique
EP2550528B1 (en) 2010-03-25 2019-09-11 Bio-Rad Laboratories, Inc. Droplet generation for droplet-based assays
WO2012007787A1 (en) * 2010-07-15 2012-01-19 Indian Statistical Institute Architectural layout for dilution with reduced wastage in digital microfluidic based lab-on-a-chip
DE102010047384B4 (de) 2010-10-02 2012-06-28 Karlsruher Institut für Technologie Vorrichtung und Verfahren zur Erzeugung oder zur Ablage eines Fluidstroms aus Fluidsegmenten und ihre Verwendung
JP5922139B2 (ja) * 2010-11-01 2016-05-24 バイオ−ラッド・ラボラトリーズ・インコーポレーテッド エマルジョンを形成するためのシステム
CN102389730A (zh) * 2011-08-23 2012-03-28 东南大学 一种双重乳液制备芯片
CN106423314B (zh) 2011-09-28 2021-03-02 哈佛学院院长等 用于液滴产生和/或流体操纵的系统和方法
SG11201510439PA (en) 2013-06-21 2016-01-28 Bio Rad Laboratories Microfluidic system with fluid pickups

Also Published As

Publication number Publication date
JP6790044B2 (ja) 2020-11-25
JP7110300B2 (ja) 2022-08-01
EP3011302A2 (en) 2016-04-27
CN109738224A (zh) 2019-05-10
US20140378348A1 (en) 2014-12-25
US9687848B2 (en) 2017-06-27
WO2014205447A3 (en) 2015-03-12
WO2014205447A2 (en) 2014-12-24
JP2016528027A (ja) 2016-09-15
EP3011302B1 (en) 2019-11-27
US10682647B2 (en) 2020-06-16
CN105452839B (zh) 2019-01-15
US20160339436A1 (en) 2016-11-24
AU2014284148A1 (en) 2016-01-21
AU2014284148B2 (en) 2017-02-23
EP3011302A4 (en) 2017-01-18
US20170291174A1 (en) 2017-10-12
US9409174B2 (en) 2016-08-09
JP2019069439A (ja) 2019-05-09
JP2021040634A (ja) 2021-03-18
CN105452839A (zh) 2016-03-30
CN109738224B (zh) 2021-07-16
JP6449266B2 (ja) 2019-01-09

Similar Documents

Publication Publication Date Title
SG11201510439PA (en) Microfluidic system with fluid pickups
EP2968718A4 (en) LIQUID TREATMENT SYSTEM
PL3043718T3 (pl) Zespół do filtracji płynów biologicznych
GB201310452D0 (en) Fluid Manifolds
GB2537463B (en) Fluid injection system
EP2950429A4 (en) LIQUID DEVICE
ZA201600315B (en) Microfluidic device
PL2999959T3 (pl) Dwuczęściowy zespół płynowy
EP2972130A4 (en) MICROFLUIDIC FLOW SENSOR
GB2517985B (en) Sheaf-based fluid filter
GB201313725D0 (en) Fluid sensor
GB201311755D0 (en) Fluid sensor
SG11201602457RA (en) Microfluidic device
HK1223160A1 (zh) 電泳流體
PL2969215T3 (pl) Urządzenie mikroprzepływowe
GB201306815D0 (en) Functional fluid
ZA201507524B (en) Fluid valve
GB2519171B (en) Micro-Valve
IL240975B (en) liquid valve
GB2511126B (en) Fluid manifolds
GB201321116D0 (en) Fluid flow
DE112014003453A5 (de) Fluidsystem
GB201313726D0 (en) Fluid sensor
ZA201404166B (en) Fluid heater
GB201311382D0 (en) Fluid Sensor