SG11201507897SA - Salt of pyrazoloquinoline derivative, and crystal thereof - Google Patents
Salt of pyrazoloquinoline derivative, and crystal thereofInfo
- Publication number
- SG11201507897SA SG11201507897SA SG11201507897SA SG11201507897SA SG11201507897SA SG 11201507897S A SG11201507897S A SG 11201507897SA SG 11201507897S A SG11201507897S A SG 11201507897SA SG 11201507897S A SG11201507897S A SG 11201507897SA SG 11201507897S A SG11201507897S A SG 11201507897SA
- Authority
- SG
- Singapore
- Prior art keywords
- salt
- crystal
- pyrazoloquinoline derivative
- pyrazoloquinoline
- derivative
- Prior art date
Links
- UXYHZIYEDDINQH-UHFFFAOYSA-N C1=CNC2=C3C=NN=C3C=CC2=C1 Chemical class C1=CNC2=C3C=NN=C3C=CC2=C1 UXYHZIYEDDINQH-UHFFFAOYSA-N 0.000 title 1
- 239000013078 crystal Substances 0.000 title 1
- 150000003839 salts Chemical class 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/4738—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems
- A61K31/4745—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems condensed with ring systems having nitrogen as a ring hetero atom, e.g. phenantrolines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C309/00—Sulfonic acids; Halides, esters, or anhydrides thereof
- C07C309/01—Sulfonic acids
- C07C309/28—Sulfonic acids having sulfo groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
- C07C309/29—Sulfonic acids having sulfo groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton of non-condensed six-membered aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C57/00—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms
- C07C57/02—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms with only carbon-to-carbon double bonds as unsaturation
- C07C57/13—Dicarboxylic acids
- C07C57/145—Maleic acid
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/13—Crystalline forms, e.g. polymorphs
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Epidemiology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Hospice & Palliative Care (AREA)
- Psychiatry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP2013079639 | 2013-04-05 | ||
PCT/JP2014/059853 WO2014163147A1 (ja) | 2013-04-05 | 2014-04-03 | ピラゾロキノリン誘導体の塩およびその結晶 |
Publications (1)
Publication Number | Publication Date |
---|---|
SG11201507897SA true SG11201507897SA (en) | 2015-11-27 |
Family
ID=51658438
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
SG11201507897SA SG11201507897SA (en) | 2013-04-05 | 2014-04-03 | Salt of pyrazoloquinoline derivative, and crystal thereof |
Country Status (13)
Country | Link |
---|---|
US (1) | US9573947B2 (de) |
EP (1) | EP2982675B1 (de) |
JP (1) | JP5666755B1 (de) |
KR (1) | KR101997955B1 (de) |
CN (1) | CN105121440B (de) |
AU (1) | AU2014250392B2 (de) |
BR (1) | BR112015024393A2 (de) |
CA (1) | CA2907971C (de) |
ES (1) | ES2645149T3 (de) |
MX (1) | MX359843B (de) |
RU (1) | RU2655171C2 (de) |
SG (1) | SG11201507897SA (de) |
WO (1) | WO2014163147A1 (de) |
Families Citing this family (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2017090716A1 (ja) * | 2015-11-26 | 2017-06-01 | 持田製薬株式会社 | ピラゾール誘導体の結晶 |
CN110603039B (zh) * | 2017-06-01 | 2023-02-28 | 卫材R&D管理有限公司 | 组合吡唑并喹啉衍生物和美金刚的痴呆治疗剂 |
RU2019135261A (ru) * | 2017-06-01 | 2021-07-09 | Эйсай Ар Энд Ди Менеджмент Ко., Лтд. | Фармацевтическая композиция, содержащая ингибитор pde9 |
AU2018278422B2 (en) * | 2017-06-01 | 2022-03-17 | Eisai R&D Management Co., Ltd. | Lewy body disease therapeutic agent containing pyrazoloquinoline derivative |
JP7079777B2 (ja) * | 2017-06-01 | 2022-06-02 | エーザイ・アール・アンド・ディー・マネジメント株式会社 | ピラゾロキノリン誘導体とドネペジルの併用による認知症治療剤 |
US11530218B2 (en) | 2020-01-20 | 2022-12-20 | Incyte Corporation | Spiro compounds as inhibitors of KRAS |
WO2021231526A1 (en) | 2020-05-13 | 2021-11-18 | Incyte Corporation | Fused pyrimidine compounds as kras inhibitors |
US11999752B2 (en) | 2020-08-28 | 2024-06-04 | Incyte Corporation | Vinyl imidazole compounds as inhibitors of KRAS |
US11767320B2 (en) | 2020-10-02 | 2023-09-26 | Incyte Corporation | Bicyclic dione compounds as inhibitors of KRAS |
AU2022367432A1 (en) | 2021-10-14 | 2024-05-02 | Incyte Corporation | Quinoline compounds as inhibitors of kras |
Family Cites Families (16)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPH05132484A (ja) | 1991-04-26 | 1993-05-28 | Otsuka Pharmaceut Factory Inc | ピラゾロキノリン及びピラゾロナフチリジン誘導体 |
RU2145606C1 (ru) | 1994-05-24 | 2000-02-20 | Ф.Хоффманн-Ля Рош Аг | Трициклические дикарбонильные производные и лекарственный препарат на их основе |
EA200500322A1 (ru) * | 2002-08-07 | 2005-08-25 | Мицубиси Фарма Корпорейшн | Соединения дигидропиразолопиридина |
RU2426734C2 (ru) | 2003-10-03 | 2011-08-20 | Зм Инновейтив Пропертиз Компани | Пиразолопиридины и их аналоги |
WO2005118583A1 (en) | 2004-05-28 | 2005-12-15 | Millennium Pharmaceuticals, Inc. | 2, 5-dihydro-pyrazolo`4, 3-c!quinolin-4-ones as chk-1 inhibitors |
JP2006045118A (ja) | 2004-08-04 | 2006-02-16 | Mochida Pharmaceut Co Ltd | 新規ピラゾロキノロン誘導体 |
KR20080046728A (ko) | 2005-09-15 | 2008-05-27 | 아스카 세이야쿠 가부시키가이샤 | 복소환 화합물, 그의 제조 방법 및 용도 |
CN101553491B (zh) * | 2006-12-13 | 2013-05-29 | Aska制药株式会社 | 喹喔啉衍生物 |
AP2524A (en) | 2007-05-11 | 2012-12-04 | Pfizer | Amino-heterocyclic compounds |
UA105362C2 (en) | 2008-04-02 | 2014-05-12 | Бьорингер Ингельхайм Интернациональ Гмбх | 1-heterocyclyl-1, 5-dihydro-pyrazolo [3, 4-d] pyrimidin-4-one derivatives and their use as pde9a modulators |
RU2011140333A (ru) * | 2009-03-05 | 2013-04-10 | Астеллас Фарма Инк. | Хиноксалиновое соединение |
CA2757231A1 (en) | 2009-03-31 | 2010-10-07 | Boehringer Ingelheim International Gmbh | 1-heterocyclyl-1,5-dihydro-pyrazolo [3,4-d] pyrimidin-4-one derivatives and their use as pde9a modulators |
DK2615089T3 (en) | 2010-09-07 | 2016-06-06 | Astellas Pharma Inc | Pyrazoloquinolinforbindelser |
JP6042060B2 (ja) | 2011-09-26 | 2016-12-14 | サノフイ | ピラゾロキノリノン誘導体、その調製および治療上の使用 |
SI2573073T1 (sl) * | 2011-09-26 | 2015-02-27 | Sanofi | Pirazolokinolinonski derivati, njihova priprava in njihova terapevtska uporaba |
IN2014CN02463A (de) | 2011-10-07 | 2015-06-19 | Eisai R&D Man Co Ltd |
-
2014
- 2014-04-03 EP EP14780139.3A patent/EP2982675B1/de active Active
- 2014-04-03 US US14/778,695 patent/US9573947B2/en active Active
- 2014-04-03 WO PCT/JP2014/059853 patent/WO2014163147A1/ja active Application Filing
- 2014-04-03 BR BR112015024393A patent/BR112015024393A2/pt not_active Application Discontinuation
- 2014-04-03 AU AU2014250392A patent/AU2014250392B2/en active Active
- 2014-04-03 ES ES14780139.3T patent/ES2645149T3/es active Active
- 2014-04-03 JP JP2014538559A patent/JP5666755B1/ja active Active
- 2014-04-03 CA CA2907971A patent/CA2907971C/en active Active
- 2014-04-03 RU RU2015140619A patent/RU2655171C2/ru active
- 2014-04-03 KR KR1020157026005A patent/KR101997955B1/ko active IP Right Grant
- 2014-04-03 SG SG11201507897SA patent/SG11201507897SA/en unknown
- 2014-04-03 CN CN201480017423.2A patent/CN105121440B/zh active Active
- 2014-04-03 MX MX2015013620A patent/MX359843B/es active IP Right Grant
Also Published As
Publication number | Publication date |
---|---|
RU2015140619A (ru) | 2017-05-11 |
EP2982675B1 (de) | 2017-08-16 |
AU2014250392B2 (en) | 2018-03-01 |
KR101997955B1 (ko) | 2019-07-08 |
CN105121440A (zh) | 2015-12-02 |
ES2645149T3 (es) | 2017-12-04 |
RU2015140619A3 (de) | 2018-03-26 |
US9573947B2 (en) | 2017-02-21 |
AU2014250392A1 (en) | 2015-10-15 |
JPWO2014163147A1 (ja) | 2017-02-16 |
BR112015024393A2 (pt) | 2017-10-24 |
CA2907971A1 (en) | 2014-10-09 |
RU2655171C2 (ru) | 2018-05-24 |
EP2982675A4 (de) | 2016-08-10 |
CN105121440B (zh) | 2017-05-24 |
EP2982675A1 (de) | 2016-02-10 |
KR20150138203A (ko) | 2015-12-09 |
MX2015013620A (es) | 2016-02-25 |
MX359843B (es) | 2018-10-12 |
WO2014163147A1 (ja) | 2014-10-09 |
CA2907971C (en) | 2020-12-29 |
JP5666755B1 (ja) | 2015-02-12 |
US20160046623A1 (en) | 2016-02-18 |
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