SG11201507333XA - Biomarkers and methods of treating pd-1 and pd-l1 related conditions - Google Patents

Biomarkers and methods of treating pd-1 and pd-l1 related conditions

Info

Publication number
SG11201507333XA
SG11201507333XA SG11201507333XA SG11201507333XA SG11201507333XA SG 11201507333X A SG11201507333X A SG 11201507333XA SG 11201507333X A SG11201507333X A SG 11201507333XA SG 11201507333X A SG11201507333X A SG 11201507333XA SG 11201507333X A SG11201507333X A SG 11201507333XA
Authority
SG
Singapore
Prior art keywords
biomarkers
treating
methods
related conditions
conditions
Prior art date
Application number
SG11201507333XA
Inventor
Daniel Shin-Yu Chen
Priti Hegde
Hartmut Koeppen
Marcin Kowanetz
Original Assignee
Genentech Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Genentech Inc filed Critical Genentech Inc
Publication of SG11201507333XA publication Critical patent/SG11201507333XA/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • C12Q1/6886—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C07K16/2827—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against B7 molecules, e.g. CD80, CD86
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/18—Drugs for disorders of the alimentary tract or the digestive system for pancreatic disorders, e.g. pancreatic enzymes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/08—Drugs for disorders of the urinary system of the prostate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/10—Drugs for disorders of the urinary system of the bladder
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/574—Immunoassay; Biospecific binding assay; Materials therefor for cancer
    • G01N33/57484—Immunoassay; Biospecific binding assay; Materials therefor for cancer involving compounds serving as markers for tumor, cancer, neoplasia, e.g. cellular determinants, receptors, heat shock/stress proteins, A-protein, oligosaccharides, metabolites
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/574—Immunoassay; Biospecific binding assay; Materials therefor for cancer
    • G01N33/57484—Immunoassay; Biospecific binding assay; Materials therefor for cancer involving compounds serving as markers for tumor, cancer, neoplasia, e.g. cellular determinants, receptors, heat shock/stress proteins, A-protein, oligosaccharides, metabolites
    • G01N33/57492—Immunoassay; Biospecific binding assay; Materials therefor for cancer involving compounds serving as markers for tumor, cancer, neoplasia, e.g. cellular determinants, receptors, heat shock/stress proteins, A-protein, oligosaccharides, metabolites involving compounds localized on the membrane of tumor or cancer cells
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6854—Immunoglobulins
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6863—Cytokines, i.e. immune system proteins modifying a biological response such as cell growth proliferation or differentiation, e.g. TNF, CNF, GM-CSF, lymphotoxin, MIF or their receptors
    • G01N33/6869—Interleukin
    • G—PHYSICS
    • G06—COMPUTING; CALCULATING OR COUNTING
    • G06Q—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR ADMINISTRATIVE, COMMERCIAL, FINANCIAL, MANAGERIAL OR SUPERVISORY PURPOSES; SYSTEMS OR METHODS SPECIALLY ADAPTED FOR ADMINISTRATIVE, COMMERCIAL, FINANCIAL, MANAGERIAL OR SUPERVISORY PURPOSES, NOT OTHERWISE PROVIDED FOR
    • G06Q30/00—Commerce
    • G06Q30/02—Marketing; Price estimation or determination; Fundraising
    • G06Q30/0241—Advertisements
    • G06Q30/0251—Targeted advertisements
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/545—Medicinal preparations containing antigens or antibodies characterised by the dose, timing or administration schedule
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
    • G01N2333/52—Assays involving cytokines
    • G01N2333/54—Interleukins [IL]
    • G01N2333/5412—IL-6
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
    • G01N2333/705—Assays involving receptors, cell surface antigens or cell surface determinants
    • G01N2333/70503—Immunoglobulin superfamily, e.g. VCAMs, PECAM, LFA-3
    • G01N2333/70532—B7 molecules, e.g. CD80, CD86
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/52—Predicting or monitoring the response to treatment, e.g. for selection of therapy based on assay results in personalised medicine; Prognosis

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Urology & Nephrology (AREA)
  • Hematology (AREA)
  • Cell Biology (AREA)
  • Biomedical Technology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biochemistry (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Pathology (AREA)
  • Oncology (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • General Physics & Mathematics (AREA)
  • Genetics & Genomics (AREA)
  • Food Science & Technology (AREA)
  • Hospice & Palliative Care (AREA)
  • Business, Economics & Management (AREA)
  • Biophysics (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Strategic Management (AREA)
  • Finance (AREA)
  • Development Economics (AREA)
SG11201507333XA 2013-03-15 2014-03-12 Biomarkers and methods of treating pd-1 and pd-l1 related conditions SG11201507333XA (en)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201361802296P 2013-03-15 2013-03-15
US201361812678P 2013-04-16 2013-04-16
US201361829236P 2013-05-30 2013-05-30
US201361883186P 2013-09-26 2013-09-26
PCT/US2014/024746 WO2014151006A2 (en) 2013-03-15 2014-03-12 Biomarkers and methods of treating pd-1 and pd-l1 related conditions

Publications (1)

Publication Number Publication Date
SG11201507333XA true SG11201507333XA (en) 2015-10-29

Family

ID=50391526

Family Applications (2)

Application Number Title Priority Date Filing Date
SG10201701380TA SG10201701380TA (en) 2013-03-15 2014-03-12 Biomarkers and methods of treating pd-1 and pd-l1 related conditions
SG11201507333XA SG11201507333XA (en) 2013-03-15 2014-03-12 Biomarkers and methods of treating pd-1 and pd-l1 related conditions

Family Applications Before (1)

Application Number Title Priority Date Filing Date
SG10201701380TA SG10201701380TA (en) 2013-03-15 2014-03-12 Biomarkers and methods of treating pd-1 and pd-l1 related conditions

Country Status (18)

Country Link
US (2) US11299544B2 (en)
EP (3) EP2972373B1 (en)
JP (2) JP6483082B2 (en)
KR (6) KR20230070054A (en)
CN (2) CN110079599B (en)
AU (4) AU2014235453A1 (en)
BR (1) BR112015023120A2 (en)
CA (2) CA2905798C (en)
ES (1) ES2761260T3 (en)
HK (1) HK1212769A1 (en)
IL (2) IL241309B (en)
MX (2) MX2015011774A (en)
MY (2) MY197809A (en)
NZ (3) NZ751260A (en)
PL (1) PL2972373T3 (en)
RU (1) RU2701378C2 (en)
SG (2) SG10201701380TA (en)
WO (1) WO2014151006A2 (en)

Families Citing this family (138)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SG10201402815VA (en) 2008-04-09 2014-09-26 Genentech Inc Novel compositions and methods for the treatment of immune related diseases
PE20120341A1 (en) 2008-12-09 2012-04-24 Genentech Inc ANTI-PD-L1 ANTIBODIES AND ITS USE TO IMPROVE T-CELL FUNCTION
CN102782498A (en) 2009-10-21 2012-11-14 斯克里普斯研究所 Method of using non-rare cells to detect rare cells
US9945862B2 (en) 2011-06-03 2018-04-17 Eisai R&D Management Co., Ltd. Biomarkers for predicting and assessing responsiveness of thyroid and kidney cancer subjects to lenvatinib compounds
US9308236B2 (en) 2013-03-15 2016-04-12 Bristol-Myers Squibb Company Macrocyclic inhibitors of the PD-1/PD-L1 and CD80(B7-1)/PD-L1 protein/protein interactions
KR20230070054A (en) 2013-03-15 2023-05-19 제넨테크, 인크. Biomarkers and methods of treating pd-1 and pd-l1 related conditions
WO2015009856A2 (en) 2013-07-16 2015-01-22 Genentech, Inc. Methods of treating cancer using pd-1 axis binding antagonists and tigit inhibitors
CN112353943A (en) 2013-12-17 2021-02-12 豪夫迈·罗氏有限公司 Methods of treating cancer with PD-1 axis binding antagonists and taxanes
WO2015094995A2 (en) * 2013-12-17 2015-06-25 Merck Sharp & Dohme Corp. Gene signature biomarkers of tumor response to pd-1 antagonists
US20160312297A1 (en) * 2013-12-17 2016-10-27 Merck Sharp & Dohme Corp. Pd-l1 gene signature biomarkers of tumor response to pd-1 antagonists
TWI681969B (en) 2014-01-23 2020-01-11 美商再生元醫藥公司 Human antibodies to pd-1
TWI680138B (en) 2014-01-23 2019-12-21 美商再生元醫藥公司 Human antibodies to pd-l1
EA201691496A1 (en) 2014-01-27 2016-12-30 Эпик Сайенсиз, Инк. DIAGNOSTICS OF PROMOTIONAL CANCER BIOMARKERS BY CIRCULATING TUMOR CELLS
EA201691682A1 (en) 2014-02-21 2017-02-28 Эпик Сайенсиз, Инк. METHODS FOR ANALYZING RARE CIRCULATING CELLS IN THE BLOOD
US20160009805A1 (en) 2014-07-11 2016-01-14 Genentech, Inc. Anti-pd-l1 antibodies and diagnostic uses thereof
EP3189080A1 (en) * 2014-09-05 2017-07-12 Medimmune Limited Methods for identifying patients responsive to anti-pd-l1 antibody therapy using markers (cxcl9, krt8.trim29, and ifngamma)
JP6405457B2 (en) 2014-09-11 2018-10-17 ブリストル−マイヤーズ スクイブ カンパニーＢｒｉｓｔｏｌ−Ｍｙｅｒｓ Ｓｑｕｉｂｂ Ｃｏｍｐａｎｙ Macrocyclic inhibitors of PD-1 / PD-L1 and CD80 (B7-1) / PD-L1 protein / protein interaction
US9732119B2 (en) 2014-10-10 2017-08-15 Bristol-Myers Squibb Company Immunomodulators
WO2016061064A1 (en) * 2014-10-15 2016-04-21 Epic Sciences, Inc. Circulating tumor cell diagnostics for therapy targeting pd-l1
US9856292B2 (en) 2014-11-14 2018-01-02 Bristol-Myers Squibb Company Immunomodulators
JP2017538404A (en) * 2014-11-14 2017-12-28 リキッド ジェノミクス，インコーポレイティド Use of circulating cell-free RNA for diagnosing and / or observing cancer
JP6274542B2 (en) * 2014-12-02 2018-02-07 国立大学法人 東京大学 Method for determining therapeutic effect of anticancer agent comprising anti-CD4 antibody as active ingredient
CN107109700A (en) 2014-12-09 2017-08-29 默沙东公司 For the system and method for the gene expression characteristicses biomarker for deriving the reaction to the antagonists of PD 1
US9861680B2 (en) 2014-12-18 2018-01-09 Bristol-Myers Squibb Company Immunomodulators
US9944678B2 (en) 2014-12-19 2018-04-17 Bristol-Myers Squibb Company Immunomodulators
EP3252469A1 (en) * 2015-01-29 2017-12-06 Konica Minolta, Inc. Method for simultaneous detection of blood cells having interacting molecules
US20160222060A1 (en) 2015-02-04 2016-08-04 Bristol-Myers Squibb Company Immunomodulators
CN107405401B (en) 2015-02-26 2022-02-01 默克专利股份公司 PD-1/PD-L1 inhibitors for the treatment of cancer
KR102662228B1 (en) 2015-03-04 2024-05-02 머크 샤프 앤드 돔 코포레이션 Combination of PD-1 antagonists and VEGFR/FGFR/RET tyrosine kinase inhibitors to treat cancer
US10336824B2 (en) 2015-03-13 2019-07-02 Cytomx Therapeutics, Inc. Anti-PDL1 antibodies, activatable anti-PDL1 antibodies, and methods of thereof
US9809625B2 (en) 2015-03-18 2017-11-07 Bristol-Myers Squibb Company Immunomodulators
EA037621B1 (en) 2015-03-23 2021-04-22 Джаунс Терапьютикс, Инк. Antibodies to icos
ES2844799T3 (en) 2015-04-17 2021-07-22 Merck Sharp & Dohme Blood biomarkers of tumor sensitivity to PD-1 antagonists
HRP20201900T4 (en) * 2015-05-12 2024-06-07 F. Hoffmann - La Roche Ag Therapeutic and diagnostic methods for cancer
JP6884111B2 (en) * 2015-05-29 2021-06-09 ジェネンテック， インコーポレイテッド Methylation of PD-L1 promoter in cancer
WO2016196298A1 (en) 2015-05-29 2016-12-08 Genentech, Inc. Therapeutic and diagnolstic methods for cancer
WO2016200835A1 (en) * 2015-06-08 2016-12-15 Genentech, Inc. Methods of treating cancer using anti-ox40 antibodies and pd-1 axis binding antagonists
KR20180018762A (en) 2015-06-16 2018-02-21 메르크 파텐트 게엠베하 Pd-l1 antagonist combination treatments
JP6757959B2 (en) 2015-06-16 2020-09-23 株式会社 ＰＲＩＳＭ ＢｉｏＬａｂ Anti-cancer agent
CA2986263A1 (en) 2015-06-17 2016-12-22 Genentech, Inc. Methods of treating locally advanced or metastatic breast cancers using pd-1 axis binding antagonists and taxanes
WO2017024465A1 (en) * 2015-08-10 2017-02-16 Innovent Biologics (Suzhou) Co., Ltd. Pd-1 antibodies
WO2017053250A1 (en) * 2015-09-21 2017-03-30 Merck Sharp & Dohme Corp. Antibody that binds to human programmed death ligand 2 (pd-l2) and uses thereof
WO2017065000A1 (en) * 2015-10-15 2017-04-20 国立大学法人京都大学 Biomarker for predicting remarkable response of pd-1 pathway inhibitor
WO2017070423A1 (en) 2015-10-22 2017-04-27 Jounce Therapeutics, Inc. Gene signatures for determining icos expression
PT3368683T (en) * 2015-10-27 2020-04-06 Pharmassist Ltd Method for the quantification ofpd-l1
AU2016350701B2 (en) 2015-11-02 2021-08-19 Five Prime Therapeutics, Inc. CD80 extracellular domain polypeptides and their use in cancer treatment
RU2727914C2 (en) 2015-11-17 2020-07-24 Сучжоу Санкадия Биофармасьютикалз Ко., Лтд. Anti-ligand 1 antibody of programmed cell death (pd-l1), its antigen-binding fragment and their medical application
WO2017100541A1 (en) * 2015-12-10 2017-06-15 Gerd Binnig Methods for treatment and selection of patients responsive to immune mediated cancer therapy
CN106939047B (en) * 2016-01-04 2021-08-31 江苏怀瑜药业有限公司 PD-L1 antibody and preparation method thereof
AU2017205089B2 (en) 2016-01-08 2023-10-05 F. Hoffmann-La Roche Ag Methods of treating CEA-positive cancers using PD-1 axis binding antagonists and anti-CEA/anti-CD3 bispecific antibodies
CN105717298A (en) * 2016-01-29 2016-06-29 浙江数问生物技术有限公司 PD-L1 immunohistochemical kit
WO2017139755A1 (en) * 2016-02-12 2017-08-17 Rekoske Brian T Cancer therapy
MX2018010361A (en) * 2016-02-29 2019-07-08 Genentech Inc Therapeutic and diagnostic methods for cancer.
CN109476731A (en) 2016-02-29 2019-03-15 基础医药有限公司 The method for the treatment of cancer
US10143746B2 (en) 2016-03-04 2018-12-04 Bristol-Myers Squibb Company Immunomodulators
MX2017016851A (en) * 2016-03-04 2018-04-30 Sichuan Kelun Biotech Biopharmaceutical Co Ltd Pdl-1 antibody, pharmaceutical composition thereof, and uses thereof.
RU2744959C2 (en) 2016-03-23 2021-03-17 Мэбспейс Байосайнсиз (Сучжоу) Ко., Лтд New anti-pd-l1 antibodies
US10613092B2 (en) * 2016-04-01 2020-04-07 Agilent Technologies, Inc. Scoring methods for anti-PD therapy eligibility and compositions for performing same
US10358463B2 (en) 2016-04-05 2019-07-23 Bristol-Myers Squibb Company Immunomodulators
EP3443350B1 (en) * 2016-04-15 2020-12-09 H. Hoffnabb-La Roche Ag Methods for monitoring and treating cancer
TWI755395B (en) 2016-05-13 2022-02-21 美商再生元醫藥公司 Combination of anti-pd-1 antibodies and radiation to treat cancer
DE102016005947B3 (en) * 2016-05-16 2017-06-08 Dimo Dietrich A method for estimating the prognosis and predicting the response to immunotherapy of patients with malignant diseases
MX2018014047A (en) * 2016-05-17 2019-06-20 Genentech Inc Stromal gene signatures for diagnosis and use in immunotherapy.
JP6953444B2 (en) 2016-05-19 2021-10-27 ブリストル−マイヤーズ スクイブ カンパニーＢｒｉｓｔｏｌ−Ｍｙｅｒｓ Ｓｑｕｉｂｂ Ｃｏｍｐａｎｙ Immunomodulators for PET imaging
JP6781252B2 (en) * 2016-06-10 2020-11-04 公益財団法人がん研究会 Multiple staining method and staining kit
WO2018002924A1 (en) 2016-06-27 2018-01-04 Yeda Research And Development Co. Ltd. Veto cells generated from memory t cells
AU2016419048B2 (en) * 2016-08-11 2024-02-15 The Council Of The Queensland Institute Of Medical Research Immune-modulating compounds
CN106198984B (en) * 2016-08-22 2019-07-05 上海立闻生物科技有限公司 The detection method of Peripheral Blood of Patients with Non-small Cell Lung circulating tumor cell PDL1 gene
JP2019529437A (en) * 2016-09-20 2019-10-17 メディミューン，エルエルシー Compositions and methods for characterizing the efficacy of solid tumors against anti-PD-L1 antibody monotherapy
BR112019006504A2 (en) 2016-10-06 2019-06-25 Merck Patent Gmbh Avelumab Dosage Regimen For Cancer Treatment
AU2017339517B2 (en) 2016-10-06 2024-03-14 Foundation Medicine, Inc. Therapeutic and diagnostic methods for cancer
WO2018085358A1 (en) 2016-11-02 2018-05-11 Jounce Therapeutics, Inc. Antibodies to pd-1 and uses thereof
CN110267971B (en) 2016-11-07 2023-12-19 百时美施贵宝公司 Immunomodulators
TW201827076A (en) * 2016-12-12 2018-08-01 美商建南德克公司 Methods of treating cancer using anti-pd-l1 antibodies and antiandrogens
WO2018123999A1 (en) * 2016-12-28 2018-07-05 学校法人近畿大学 Method for selecting individuals to be administered immune checkpoint inhibitor
MX2019008348A (en) 2017-01-18 2019-10-21 Genentech Inc Idiotypic antibodies against anti-pd-l1 antibodies and uses thereof.
JP7162600B2 (en) * 2017-02-06 2022-10-28 ノヴァルティス アーゲー Methods of Predicting Response to Immunotherapy
KR20190134631A (en) 2017-03-01 2019-12-04 제넨테크, 인크. How to diagnose and treat cancer
KR20190133213A (en) * 2017-03-31 2019-12-02 브리스톨-마이어스 스큅 컴퍼니 How to treat a tumor
US11603407B2 (en) 2017-04-06 2023-03-14 Regeneron Pharmaceuticals, Inc. Stable antibody formulation
TW201839400A (en) * 2017-04-14 2018-11-01 美商建南德克公司 Diagnostic and therapeutic methods for cancer
AU2018258661A1 (en) 2017-04-28 2019-10-17 Five Prime Therapeutics, Inc. Methods of treatment with CD80 extracellular domain polypeptides
CN110914302A (en) 2017-06-01 2020-03-24 赛托姆克斯治疗学股份有限公司 Activatable anti-PDL 1 antibodies and methods of use thereof
CA3066054A1 (en) * 2017-06-04 2018-12-13 Rappaport Family Institute For Research In The Medical Sciences Method of predicting personalized response to cancer therapy and kit therefor
US12016900B2 (en) 2017-06-04 2024-06-25 Rappaport Family Institute For Research In The Medical Sciences Method of treating cancer with an immune checkpoint inhibitor in combination with another therapeutic agent
AU2018282865A1 (en) * 2017-06-13 2019-12-19 Bostongene Corporation Systems and methods for generating, visualizing and classifying molecular functional profiles
US11066445B2 (en) 2017-06-23 2021-07-20 Bristol-Myers Squibb Company Immunomodulators acting as antagonists of PD-1
US10636512B2 (en) 2017-07-14 2020-04-28 Cofactor Genomics, Inc. Immuno-oncology applications using next generation sequencing
AU2018304458B2 (en) 2017-07-21 2021-12-09 Foundation Medicine, Inc. Therapeutic and diagnostic methods for cancer
EP3692053A1 (en) 2017-10-03 2020-08-12 Bristol-Myers Squibb Company Immunomodulators
KR101982001B1 (en) * 2017-10-13 2019-05-27 한국과학기술원 Method for selecting of anti-pd-1 or anti-pd-l1 antibodies using alloimmunity or xenoimmunity
US20200239577A1 (en) 2017-10-15 2020-07-30 Bristol-Myers Squibb Company Methods of treating tumor
WO2019108135A1 (en) * 2017-11-30 2019-06-06 Singapore Health Services Pte. Ltd. A system and method for classifying cancer patients into appropriate cancer treatment groups and compounds for treating the patient
CN108179134B (en) * 2017-12-27 2020-11-24 武汉大学 EpCAM/PSMA-based double-antibody functionalized microfluidic chip and preparation method and application thereof
CA3087105A1 (en) * 2018-01-10 2019-07-18 Jiangsu Hengrui Medicine Co., Ltd. Pd-l1 antibody, antigen-binding fragment thereof, and pharmaceutical use thereof
WO2019143947A1 (en) * 2018-01-18 2019-07-25 Eutropics Pharmaceuticals, Inc. Methods for predicting cancer drug responsiveness
KR102089241B1 (en) * 2018-02-05 2020-03-16 한국과학기술원 A method for prediction of the immunotherapy effects to cancer patients
EP3754031A4 (en) * 2018-02-14 2021-11-10 National University Corporation Tokai National Higher Education and Research System Biomarker for predicting effects of anti-pd-1 antibody/anti-pd-l1 antibody therapy
CA3092108A1 (en) * 2018-02-26 2019-08-29 Genentech, Inc. Dosing for treatment with anti-tigit and anti-pd-l1 antagonist antibodies
WO2019169145A1 (en) * 2018-02-28 2019-09-06 Mayo Foundation For Medical Education And Research Methods and materials for treating cancer
JP2021519284A (en) * 2018-03-27 2021-08-10 ラボラトリー コーポレイション オブ アメリカ ホールディングス Sandwich ELISA to identify subjects who may benefit from therapeutic treatment
US20210123919A1 (en) * 2018-05-14 2021-04-29 Merck Sharp & Dohme Corp. Biomarkers for a combination therapy comprising lenvatinib and a pd-1 antagonist
KR102091637B1 (en) * 2018-07-10 2020-03-20 연세대학교 산학협력단 Methods for poviding information about responses to cancer immunotherapy and kits using the same
CN109116032B (en) * 2018-08-01 2021-09-03 广州市第一人民医院（广州消化疾病中心、广州医科大学附属市一人民医院、华南理工大学附属第二医院） Kit for detecting PD-L1 antibody immunotherapy and prognosis of prostate cancer patient
KR102084196B1 (en) * 2018-08-29 2020-03-03 연세대학교 산학협력단 Methods for providing information about responses to cancer immunotherapy and kits using the same
MX2021003214A (en) 2018-09-19 2021-05-12 Genentech Inc Therapeutic and diagnostic methods for bladder cancer.
CN113196061A (en) 2018-10-18 2021-07-30 豪夫迈·罗氏有限公司 Methods of diagnosis and treatment of sarcoma-like renal cancer
KR102195135B1 (en) * 2018-12-07 2020-12-24 한국과학기술원 A screening method of immunomodulators
AU2019403339A1 (en) * 2018-12-19 2021-07-08 Strata Oncology, Inc. Methods of detecting and treating subjects with checkpoint inhibitor-responsive cancer
KR102159538B1 (en) * 2019-01-11 2020-09-24 충남대학교 산학협력단 IL-6 marker for predicting treatment response of a patient with lung cancer to cancer immunotherapy and uses thereof
CN109596831B (en) * 2019-01-14 2020-05-29 臻悦生物科技江苏有限公司 Multiple immunohistochemical analysis kit for lung cancer and use method and application thereof
WO2020172591A1 (en) * 2019-02-22 2020-08-27 Mitra Rxdx, Inc. A method to predict a patient's response to an anti-cancer drug from an expression level of a set of genes
WO2020168541A1 (en) * 2019-02-22 2020-08-27 深圳华大生命科学研究院 Use of intestinal metagenome in screening therapeutic effect of pd-1 antibody blockers
WO2020195432A1 (en) 2019-03-27 2020-10-01 住友金属鉱山株式会社 Positive-electrode active material for lithium-ion secondary cell, method for manufacturing positive-electrode active material, and lithium-ion secondary cell
CN109884303B (en) * 2019-03-29 2020-05-29 臻悦生物科技江苏有限公司 Multiple immunohistochemical analysis kit for liver cancer and use method and application thereof
TWI750660B (en) * 2019-05-15 2021-12-21 上準微流體股份有限公司 Methods for predicting immunotherapy response of a cancer patient
CN110687281B (en) * 2019-08-26 2023-05-23 中国医学科学院肿瘤医院 Application of PD-L1 autoantibody in tumor prognosis evaluation
US20210088523A1 (en) * 2019-09-23 2021-03-25 Sri International Methods for detecting circulating tumor cells in non-small cell lung cancer
BR112022007386A2 (en) * 2019-10-21 2022-07-05 Celgene Corp METHODS TO TREAT HEMATOLOGICAL CANCER AND THE USE OF COMPANION BIOMARKERS FOR 2-(2,6-DIOXOPIPERIDIN-3-IL)-4-((2-FLUORO-4-((3-MORPOLINOAZETIDIN-1-YL)METHYL)BENZYL )AMINO)ISOINDOLINE-1,3-DIONE
CN110927389B (en) * 2019-11-29 2021-07-16 中国科学院苏州生物医学工程技术研究所 Cancer biomarker and application
KR102371903B1 (en) * 2019-12-24 2022-03-08 주식회사 테라젠바이오 Methods for poviding information about responses to cancer immunotherapy and devices using the same
WO2021202959A1 (en) * 2020-04-03 2021-10-07 Genentech, Inc. Therapeutic and diagnostic methods for cancer
CN111521796A (en) * 2020-04-21 2020-08-11 山东第一医科大学(山东省医学科学院) Immunofluorescence kit and detection method for detecting expression of peripheral blood circulating tumor cells PD-L1 of renal cancer patient
CN111521792A (en) * 2020-04-21 2020-08-11 山东第一医科大学(山东省医学科学院) Immunofluorescence kit and method for detecting non-small cell lung cancer patient peripheral blood circulating tumor cell PD-L1 gene mutation
WO2021222167A1 (en) 2020-04-28 2021-11-04 Genentech, Inc. Methods and compositions for non-small cell lung cancer immunotherapy
WO2021228888A1 (en) 2020-05-12 2021-11-18 Asylia Diagnostics Biomarkers for hyperprogressive disease and therapy response after immunotherapy
CN111863126B (en) * 2020-05-28 2024-03-26 上海市生物医药技术研究院 Method for constructing colorectal tumor state evaluation model and application
US20230203485A1 (en) * 2020-06-01 2023-06-29 Patrick C. Lee Methods for modulating mhc-i expression and immunotherapy uses thereof
WO2022135402A1 (en) * 2020-12-24 2022-06-30 信达生物制药(苏州)有限公司 Use of pd-l1 and/or mhc-2 biomarker in prediction of therapeutic efficacy in lung cancer patients
CN113109565B (en) * 2021-04-12 2024-02-02 中国人民解放军空军军医大学 Detection box for evaluating sensitivity of patient to PD-1 monoclonal antibody product and application thereof
RU2766739C1 (en) * 2021-04-12 2022-03-15 Федеральное государственное бюджетное учреждение "Национальный медицинский исследовательский центр онкологии имени Н.Н. Блохина" Министерства здравоохранения Российской Федерации (ФГБУ "НМИЦ онкологии им. Н.Н. Блохина" Минздрава России) Method for prediction of clinical effectiveness in melanoma
CN113358872B (en) * 2021-06-03 2022-10-21 中山大学肿瘤防治中心（中山大学附属肿瘤医院、中山大学肿瘤研究所） Marker group and system for evaluating curative effect of tumor immunotherapy
AU2022315526A1 (en) 2021-07-22 2024-02-29 Asylia Diagnostics Bv Biomarkers for therapy response after immunotherapy
WO2023017525A1 (en) 2021-08-11 2023-02-16 OncoHost Ltd. Predicting patient response
CN114022472B (en) * 2021-11-17 2022-05-20 深圳裕策生物科技有限公司 Tumor infiltrating lymphocyte analysis method, device and storage medium
WO2024011295A1 (en) * 2022-07-14 2024-01-18 University Of South Australia Methods and products for determining responsiveness to anti-pd1 immune checkpoint inhibitor immunotherapy
CN117701719B (en) * 2024-02-04 2024-05-31 北京肿瘤医院(北京大学肿瘤医院) Tumor targeting CLDN18.2 therapeutic drug-resistant marker and application thereof
CN117741148B (en) * 2024-02-19 2024-06-14 苏州颐坤生物科技有限公司 Marker combination for predicting curative effect of immunotherapy and model construction method and application

Family Cites Families (183)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4018653A (en) 1971-10-29 1977-04-19 U.S. Packaging Corporation Instrument for the detection of Neisseria gonorrhoeae without culture
US4016043A (en) 1975-09-04 1977-04-05 Akzona Incorporated Enzymatic immunological method for the determination of antigens and antibodies
US4275149A (en) 1978-11-24 1981-06-23 Syva Company Macromolecular environment control in specific receptor assays
US4318980A (en) 1978-04-10 1982-03-09 Miles Laboratories, Inc. Heterogenous specific binding assay employing a cycling reactant as label
US4424279A (en) 1982-08-12 1984-01-03 Quidel Rapid plunger immunoassay method and apparatus
WO1984003506A1 (en) 1983-03-08 1984-09-13 Commw Serum Lab Commission Antigenically active amino acid sequences
US4708871A (en) 1983-03-08 1987-11-24 Commonwealth Serum Laboratories Commission Antigenically active amino acid sequences
NZ207394A (en) 1983-03-08 1987-03-06 Commw Serum Lab Commission Detecting or determining sequence of amino acids
US4816567A (en) 1983-04-08 1989-03-28 Genentech, Inc. Recombinant immunoglobin preparations
US4683195A (en) 1986-01-30 1987-07-28 Cetus Corporation Process for amplifying, detecting, and/or-cloning nucleic acid sequences
DE3587814T2 (en) 1985-03-30 1994-11-10 Marc Ballivet METHOD FOR OBTAINING DNA, RNS, PEPTIDES, POLYPEPTIDES OR PROTEINS BY THE DNA RECOMBINANT METHOD.
NZ215865A (en) 1985-04-22 1988-10-28 Commw Serum Lab Commission Method of determining the active site of a receptor-binding analogue
US4737456A (en) 1985-05-09 1988-04-12 Syntex (U.S.A.) Inc. Reducing interference in ligand-receptor binding assays
US4676980A (en) 1985-09-23 1987-06-30 The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services Target specific cross-linked heteroantibodies
US6548640B1 (en) 1986-03-27 2003-04-15 Btg International Limited Altered antibodies
US5763192A (en) 1986-11-20 1998-06-09 Ixsys, Incorporated Process for obtaining DNA, RNA, peptides, polypeptides, or protein, by recombinant DNA technique
IL85035A0 (en) 1987-01-08 1988-06-30 Int Genetic Eng Polynucleotide molecule,a chimeric antibody with specificity for human b cell surface antigen,a process for the preparation and methods utilizing the same
WO1988007089A1 (en) 1987-03-18 1988-09-22 Medical Research Council Altered antibodies
US5606040A (en) 1987-10-30 1997-02-25 American Cyanamid Company Antitumor and antibacterial substituted disulfide derivatives prepared from compounds possessing a methyl-trithio group
US5770701A (en) 1987-10-30 1998-06-23 American Cyanamid Company Process for preparing targeted forms of methyltrithio antitumor agents
US5266684A (en) 1988-05-02 1993-11-30 The Reagents Of The University Of California Peptide mixtures
US5571689A (en) 1988-06-16 1996-11-05 Washington University Method of N-acylating peptide and proteins with diheteroatom substituted analogs of myristic acid
US5663143A (en) 1988-09-02 1997-09-02 Dyax Corp. Engineered human-derived kunitz domains that inhibit human neutrophil elastase
US5223409A (en) 1988-09-02 1993-06-29 Protein Engineering Corp. Directed evolution of novel binding proteins
JP2919890B2 (en) 1988-11-11 1999-07-19 メディカル リサーチ カウンスル Single domain ligand, receptor consisting of the ligand, method for producing the same, and use of the ligand and the receptor
DE3920358A1 (en) 1989-06-22 1991-01-17 Behringwerke Ag BISPECIFIC AND OLIGO-SPECIFIC, MONO- AND OLIGOVALENT ANTI-BODY CONSTRUCTS, THEIR PRODUCTION AND USE
CA2026147C (en) 1989-10-25 2006-02-07 Ravi J. Chari Cytotoxic agents comprising maytansinoids and their therapeutic use
US5208020A (en) 1989-10-25 1993-05-04 Immunogen Inc. Cytotoxic agents comprising maytansinoids and their therapeutic use
US6075181A (en) 1990-01-12 2000-06-13 Abgenix, Inc. Human antibodies derived from immunized xenomice
US6150584A (en) 1990-01-12 2000-11-21 Abgenix, Inc. Human antibodies derived from immunized xenomice
US5498538A (en) 1990-02-15 1996-03-12 The University Of North Carolina At Chapel Hill Totally synthetic affinity reagents
US5427908A (en) 1990-05-01 1995-06-27 Affymax Technologies N.V. Recombinant library screening methods
US5723286A (en) 1990-06-20 1998-03-03 Affymax Technologies N.V. Peptide library and screening systems
US5770429A (en) 1990-08-29 1998-06-23 Genpharm International, Inc. Transgenic non-human animals capable of producing heterologous antibodies
US5698426A (en) 1990-09-28 1997-12-16 Ixsys, Incorporated Surface expression libraries of heteromeric receptors
US5770434A (en) 1990-09-28 1998-06-23 Ixsys Incorporated Soluble peptides having constrained, secondary conformation in solution and method of making same
WO1992009300A1 (en) 1990-11-21 1992-06-11 Iterex Pharmaceuticals Ltd. Partnership Synthesis of equimolar multiple oligomer mixtures, especially of oligopeptide mixtures
CA2405246A1 (en) 1990-12-03 1992-06-11 Genentech, Inc. Enrichment method for variant proteins with alterred binding properties
US5571894A (en) 1991-02-05 1996-11-05 Ciba-Geigy Corporation Recombinant antibodies specific for a growth factor receptor
CA2103059C (en) 1991-06-14 2005-03-22 Paul J. Carter Method for making humanized antibodies
GB9114948D0 (en) 1991-07-11 1991-08-28 Pfizer Ltd Process for preparing sertraline intermediates
US5587458A (en) 1991-10-07 1996-12-24 Aronex Pharmaceuticals, Inc. Anti-erbB-2 antibodies, combinations thereof, and therapeutic and diagnostic uses thereof
US5270170A (en) 1991-10-16 1993-12-14 Affymax Technologies N.V. Peptide library and screening method
WO1993008829A1 (en) 1991-11-04 1993-05-13 The Regents Of The University Of California Compositions that mediate killing of hiv-infected cells
CA2129663C (en) 1992-02-06 2005-07-05 James S. Huston Biosynthetic binding protein for cancer marker
NZ258392A (en) 1992-11-13 1997-09-22 Idec Pharma Corp Chimeric and radiolabelled antibodies to the b lymphocyte cellsurface antigen bp35 (cd-20) and their use in the treatment of b cell lymphona
US5635483A (en) 1992-12-03 1997-06-03 Arizona Board Of Regents Acting On Behalf Of Arizona State University Tumor inhibiting tetrapeptide bearing modified phenethyl amides
US5780588A (en) 1993-01-26 1998-07-14 Arizona Board Of Regents Elucidation and synthesis of selected pentapeptides
AU691811B2 (en) 1993-06-16 1998-05-28 Celltech Therapeutics Limited Antibodies
US5922855A (en) 1993-12-17 1999-07-13 Oregon Health Sciences University Mammalian DNA mismatch repair genes MLH1 and PMS1
US5773001A (en) 1994-06-03 1998-06-30 American Cyanamid Company Conjugates of methyltrithio antitumor agents and intermediates for their synthesis
AU7104294A (en) 1994-06-10 1996-01-05 Symbiotech, Inc. Method of detecting compounds utilizing genetically modified lambdoid bacteriophage
US5627024A (en) 1994-08-05 1997-05-06 The Scripps Research Institute Lambdoid bacteriophage vectors for expression and display of foreign proteins
US5731168A (en) 1995-03-01 1998-03-24 Genentech, Inc. Method for making heteromultimeric polypeptides
US5869046A (en) 1995-04-14 1999-02-09 Genentech, Inc. Altered polypeptides with increased half-life
US5714586A (en) 1995-06-07 1998-02-03 American Cyanamid Company Methods for the preparation of monomeric calicheamicin derivative/carrier conjugates
US5712374A (en) 1995-06-07 1998-01-27 American Cyanamid Company Method for the preparation of substantiallly monomeric calicheamicin derivative/carrier conjugates
US6267958B1 (en) 1995-07-27 2001-07-31 Genentech, Inc. Protein formulation
DK0854933T3 (en) 1995-09-07 2003-07-21 Novozymes As Professional presentation for detergent enzyme activity
GB9603256D0 (en) 1996-02-16 1996-04-17 Wellcome Found Antibodies
AU715608B2 (en) 1996-03-20 2000-02-03 Morphosys Ag Purification of tissue plasminogen activator (tPA)
EP0954531A1 (en) 1996-06-06 1999-11-10 Lajolla Pharmaceutical Company aPL IMMUNOREACTIVE PEPTIDES, CONJUGATES THEREOF AND METHODS OF TREATMENT FOR aPL ANTIBODY-MEDIATED PATHOLOGIES
WO1997047314A1 (en) 1996-06-10 1997-12-18 The Scripps Research Institute Use of substrate subtraction libraries to distinguish enzyme specificities
US5766905A (en) 1996-06-14 1998-06-16 Associated Universities Inc. Cytoplasmic bacteriophage display system
EP0929361A4 (en) 1996-10-04 2000-07-19 Whatman Inc Device and method for simultaneous multiple chemical syntheses
AU4474497A (en) 1996-10-08 1998-05-05 U-Bisys B.V. Methods and means for selecting peptides and proteins having specific affinity for a target
AU745101B2 (en) 1996-11-06 2002-03-14 Genentech Inc. Constrained helical peptides and methods of making same
IL119586A (en) 1996-11-07 2001-09-13 Univ Ramot Discontinuous library of a single biological unit and a method for its preparation
IL119587A (en) 1996-11-07 2000-12-06 Univ Ramot Method of preparing and for obtaining bimolecular interactions
US6171586B1 (en) 1997-06-13 2001-01-09 Genentech, Inc. Antibody formulation
DE69830315T2 (en) 1997-06-24 2006-02-02 Genentech Inc., San Francisco GALACTOSYLATED GLYCOPROTEIN CONTAINING COMPOSITIONS AND METHOD FOR THE PRODUCTION THEREOF
CA2307330A1 (en) 1997-10-21 1999-04-29 The University Court Of The University Of Glasgow Jmy, a co-activator for p300/cbp, nucleic acid encoding jmy and uses thereof
WO1999022764A1 (en) 1997-10-31 1999-05-14 Genentech, Inc. Methods and compositions comprising glycoprotein glycoforms
US6610833B1 (en) 1997-11-24 2003-08-26 The Institute For Human Genetics And Biochemistry Monoclonal human natural antibodies
DK1034298T3 (en) 1997-12-05 2012-01-30 Scripps Research Inst Humanization of murine antibody
US6194551B1 (en) 1998-04-02 2001-02-27 Genentech, Inc. Polypeptide variants
JP2002510481A (en) 1998-04-02 2002-04-09 ジェネンテック・インコーポレーテッド Antibody variants and fragments thereof
ATE458007T1 (en) 1998-04-20 2010-03-15 Glycart Biotechnology Ag GLYCOSYLATION ENGINEERING OF ANTIBODIES TO IMPROVE ANTIBODIES-DEPENDENT CELL-MEDIATED CYTOTOXICITY
US6335155B1 (en) 1998-06-26 2002-01-01 Sunesis Pharmaceuticals, Inc. Methods for rapidly identifying small organic molecule ligands for binding to biological target molecules
JP2002533726A (en) 1998-12-28 2002-10-08 サネシス ファーマシューティカルス インコーポレイテッド Identification of small organic molecule ligands for binding
US6737056B1 (en) 1999-01-15 2004-05-18 Genentech, Inc. Polypeptide variants with altered effector function
ES2694002T3 (en) 1999-01-15 2018-12-17 Genentech, Inc. Polypeptide comprising an Fc region of variant human IgG1
CA2704600C (en) 1999-04-09 2016-10-25 Kyowa Hakko Kirin Co., Ltd. A method for producing antibodies with increased adcc activity
BR0013542A (en) 1999-08-23 2002-05-14 Dana Farber Cancer Inst Inc B7-4 molecules and uses for them
JP4668498B2 (en) 1999-10-19 2011-04-13 協和発酵キリン株式会社 Method for producing polypeptide
CA3016482A1 (en) 1999-11-30 2001-06-07 Mayo Foundation For Medical Education And Research B7-h1, a novel immunoregulatory molecule
US6803192B1 (en) 1999-11-30 2004-10-12 Mayo Foundation For Medical Education And Research B7-H1, a novel immunoregulatory molecule
US20030180714A1 (en) 1999-12-15 2003-09-25 Genentech, Inc. Shotgun scanning
ATE344801T1 (en) 1999-12-29 2006-11-15 Immunogen Inc CYTOTOXIC AGENTS CONTAINING DOXORUBICIN AND DAUNORUBICIN AND THEIR THERAPEUTIC USE
AU2001247616B2 (en) 2000-04-11 2007-06-14 Genentech, Inc. Multivalent antibodies and uses therefor
US7064191B2 (en) 2000-10-06 2006-06-20 Kyowa Hakko Kogyo Co., Ltd. Process for purifying antibody
US6946292B2 (en) 2000-10-06 2005-09-20 Kyowa Hakko Kogyo Co., Ltd. Cells producing antibody compositions with increased antibody dependent cytotoxic activity
HU231090B1 (en) 2000-10-06 2020-07-28 Kyowa Kirin Co., Ltd. Cells producing antibody compositions
US6596541B2 (en) 2000-10-31 2003-07-22 Regeneron Pharmaceuticals, Inc. Methods of modifying eukaryotic cells
US7041870B2 (en) 2000-11-30 2006-05-09 Medarex, Inc. Transgenic transchromosomal rodents for making human antibodies
US7754208B2 (en) 2001-01-17 2010-07-13 Trubion Pharmaceuticals, Inc. Binding domain-immunoglobulin fusion proteins
CA2838062C (en) 2001-08-03 2015-12-22 Roche Glycart Ag Antibody glycosylation variants having increased antibody-dependent cellular cytotoxicity
HUP0600342A3 (en) 2001-10-25 2011-03-28 Genentech Inc Glycoprotein compositions
US20040093621A1 (en) 2001-12-25 2004-05-13 Kyowa Hakko Kogyo Co., Ltd Antibody composition which specifically binds to CD20
US20040259150A1 (en) 2002-04-09 2004-12-23 Kyowa Hakko Kogyo Co., Ltd. Method of enhancing of binding activity of antibody composition to Fcgamma receptor IIIa
BR0309145A (en) 2002-04-09 2005-02-01 Kyowa Hakko Kogyo Kk Cells from which the genome is modified
AU2003236020B2 (en) 2002-04-09 2009-03-19 Kyowa Hakko Kirin Co., Ltd. Cell with depression or deletion of the activity of protein participating in GDP-fucose transport
JPWO2003085118A1 (en) 2002-04-09 2005-08-11 協和醗酵工業株式会社 Method for producing antibody composition
JPWO2003084569A1 (en) 2002-04-09 2005-08-11 協和醗酵工業株式会社 Antibody composition-containing medicine
WO2003084570A1 (en) 2002-04-09 2003-10-16 Kyowa Hakko Kogyo Co., Ltd. DRUG CONTAINING ANTIBODY COMPOSITION APPROPRIATE FOR PATIENT SUFFERING FROM FcϜRIIIa POLYMORPHISM
EP1513879B1 (en) 2002-06-03 2018-08-22 Genentech, Inc. Synthetic antibody phage libraries
DE60200248T2 (en) * 2002-08-01 2005-01-27 Mtm Laboratories Ag Procedure for solution-based diagnosis
US7361740B2 (en) 2002-10-15 2008-04-22 Pdl Biopharma, Inc. Alteration of FcRn binding affinities or serum half-lives of antibodies by mutagenesis
TWI335821B (en) 2002-12-16 2011-01-11 Genentech Inc Immunoglobulin variants and uses thereof
US20050079574A1 (en) 2003-01-16 2005-04-14 Genentech, Inc. Synthetic antibody phage libraries
US7871607B2 (en) 2003-03-05 2011-01-18 Halozyme, Inc. Soluble glycosaminoglycanases and methods of preparing and using soluble glycosaminoglycanases
US20060104968A1 (en) 2003-03-05 2006-05-18 Halozyme, Inc. Soluble glycosaminoglycanases and methods of preparing and using soluble glycosaminogly ycanases
US20080241884A1 (en) 2003-10-08 2008-10-02 Kenya Shitara Fused Protein Composition
EP1705251A4 (en) 2003-10-09 2009-10-28 Kyowa Hakko Kirin Co Ltd PROCESS FOR PRODUCING ANTIBODY COMPOSITION BY USING RNA INHIBITING THE FUNCTION OF a1,6-FUCOSYLTRANSFERASE
WO2005044859A2 (en) 2003-11-05 2005-05-19 Glycart Biotechnology Ag Cd20 antibodies with increased fc receptor binding affinity and effector function
SI1725249T1 (en) 2003-11-06 2014-04-30 Seattle Genetics, Inc. Monomethylvaline compounds capable of conjugation to ligands
JPWO2005053742A1 (en) 2003-12-04 2007-06-28 協和醗酵工業株式会社 Medicament containing antibody composition
AU2005230848B9 (en) 2004-03-31 2011-06-02 Genentech, Inc. Humanized anti-TGF-beta antibodies
US7785903B2 (en) 2004-04-09 2010-08-31 Genentech, Inc. Variable domain library and uses
ES2403055T3 (en) 2004-04-13 2013-05-13 F. Hoffmann-La Roche Ag Anti-P-selectin antibodies
AU2012211347B9 (en) * 2004-07-20 2015-06-18 Alexion Pharmaceuticals, Inc. Polypeptides and antibodies derived from chronic lymphocytic leukemia cells and uses thereof
TWI380996B (en) 2004-09-17 2013-01-01 Hoffmann La Roche Anti-ox40l antibodies
WO2006034488A2 (en) 2004-09-23 2006-03-30 Genentech, Inc. Cysteine engineered antibodies and conjugates
AU2005295038B2 (en) * 2004-10-06 2012-05-17 Mayo Foundation For Medical Education And Research B7-H1 and methods of diagnosis, prognosis, and treatment of cancer
ZA200703482B (en) * 2004-10-06 2008-09-25 Mayo Foundation B7-H1 and methods of diagnosis, prognosis, and treatment of cancer
JO3000B1 (en) 2004-10-20 2016-09-05 Genentech Inc Antibody Formulations.
CN101213297B (en) * 2005-05-09 2013-02-13 小野药品工业株式会社 Human monoclonal antibodies to programmed death 1 (PD-1) and methods for treating cancer using anti-PD-1 antibodies alone or in combination with other immunotherapeutics
CA2981431C (en) 2005-06-08 2021-04-13 Dana-Farber Cancer Institute Inc. Use of compounds that reduce activity or expression of programmed cell death-1 to treat lymphoma
KR101411165B1 (en) * 2005-07-01 2014-06-25 메다렉스, 엘.엘.시. Human monoclonal antibodies to programmed death ligand 1(pd-l1)
EP1777523A1 (en) * 2005-10-19 2007-04-25 INSERM (Institut National de la Santé et de la Recherche Médicale) An in vitro method for the prognosis of progression of a cancer and of the outcome in a patient and means for performing said method
AU2006304764A1 (en) 2005-10-21 2007-04-26 Bayer Healthcare Llc Methods for prediction and prognosis of cancer, and monitoring cancer therapy
EP2465870A1 (en) 2005-11-07 2012-06-20 Genentech, Inc. Binding polypeptides with diversified and consensus VH/VL hypervariable sequences
US20070237764A1 (en) 2005-12-02 2007-10-11 Genentech, Inc. Binding polypeptides with restricted diversity sequences
WO2007082144A2 (en) * 2006-01-05 2007-07-19 Mayo Foundation For Medical Education And Research B7-h1 and survivin in cancer
US20090215084A1 (en) 2006-01-05 2009-08-27 Mayo Foundation For Medical Education And Research B7-h1 and b7-h4 in cancer
JP5093097B2 (en) * 2006-03-03 2012-12-05 小野薬品工業株式会社 Extracellular domain multimers of cell surface functional molecules
CA2651567A1 (en) 2006-05-09 2007-11-22 Genentech, Inc. Binding polypeptides with optimized scaffolds
CN101104640A (en) 2006-07-10 2008-01-16 苏州大学 Preparation for anti human PD-L1 monoclonal antibody and application thereof
US7895540B2 (en) 2006-08-02 2011-02-22 Georgia Tech Research Corporation Multilayer finite difference methods for electrical modeling of packages and printed circuit boards
US20080226635A1 (en) 2006-12-22 2008-09-18 Hans Koll Antibodies against insulin-like growth factor I receptor and uses thereof
BRPI0808150A2 (en) * 2007-02-28 2014-07-01 Procter & Gamble METHODS AND TARGETS FOR IDENTIFYING COMPOUNDS FOR REGULATING RHINOVIRUS INFECTION
CN100592373C (en) 2007-05-25 2010-02-24 群康科技(深圳)有限公司 Liquid crystal panel drive device and its drive method
DK2235064T3 (en) 2008-01-07 2016-01-11 Amgen Inc A process for the preparation of heterodimeric Fc molecules using electrostatic control effects
MX349463B (en) 2008-09-26 2017-07-31 Univ Emory Human anti-pd-1, pd-l1, and pd-l2 antibodies and uses therefor.
WO2010056735A1 (en) * 2008-11-11 2010-05-20 The Trustees Of The University Of Pennsylvania Compositions and methods for inhibiting an oncogenic protein to enhance immunogenicity
PE20120341A1 (en) 2008-12-09 2012-04-24 Genentech Inc ANTI-PD-L1 ANTIBODIES AND ITS USE TO IMPROVE T-CELL FUNCTION
EP3192811A1 (en) 2009-02-09 2017-07-19 Université d'Aix-Marseille Pd-1 antibodies and pd-l1 antibodies and uses thereof
CN107090437A (en) 2009-03-06 2017-08-25 国立大学法人三重大学 Method for strengthening T cell function
EP2482849B1 (en) 2009-09-30 2018-06-06 Memorial Sloan-Kettering Cancer Center Combination immunotherapy for the treatment of cancer
MX343747B (en) 2009-11-24 2016-11-22 Medimmune Ltd Targeted binding agents against b7-h1.
JP2013531801A (en) 2010-07-02 2013-08-08 ヴェンタナ メディカル システムズ， インク． Hapten conjugates for target detection
WO2012006589A2 (en) * 2010-07-08 2012-01-12 Infinity Pharmaceuticals, Inc. Methods and compositions for identification, assessment and treatment of cancers associated with hedgehog signaling
AU2011295919A1 (en) * 2010-08-31 2013-03-07 Genentech, Inc. Biomarkers and methods of treatment
CN106978480A (en) * 2010-09-15 2017-07-25 阿尔玛克诊断有限公司 Molecular diagnostic assay for cancer
SI2699264T1 (en) * 2011-04-20 2018-08-31 Medimmune Llc Antibodies and other molecules that bind b7-h1 and pd-1
CN102250911A (en) * 2011-05-31 2011-11-23 苏州大学 Soluble B7-H1 quantitative detection kit
EA026924B1 (en) * 2011-08-01 2017-05-31 Дженентек, Инк. Methods of treating cancer using pd-1 axis binding antagonists and mek inhibitors
RS61033B1 (en) 2011-11-28 2020-12-31 Merck Patent Gmbh Anti-pd-l1 antibodies and uses thereof
WO2013172926A1 (en) 2012-05-14 2013-11-21 Yale University Immune biomarkers and assays predictive of clinical response to immunotherapy for cancer
BR122022015975B1 (en) * 2012-05-15 2024-01-02 Bristol-Myers Squibb Company MONOCLONAL ANTIBODIES, KIT FOR THE TREATMENT OF AN INDIVIDUAL AFFLICTED WITH A CANCER, PROCESS FOR MEASURING MEMBRANOUS PD-L1 ON ISOLATED TUMOR CELLS AND USE OF THE ANTIBODY OR A PORTION THAT BIDS TO THE ANTIGEN THEREOF
WO2013173233A1 (en) 2012-05-17 2013-11-21 Baker Hughes Incorporated Dendritic surfactants and extended surfactants for drilling fluid formulations
US9845356B2 (en) 2012-08-03 2017-12-19 Dana-Farber Cancer Institute, Inc. Single agent anti-PD-L1 and PD-L2 dual binding antibodies and methods of use
SG11201500903XA (en) 2012-08-07 2015-03-30 Genentech Inc Combination therapy for the treatment of glioblastoma
CA2889298C (en) 2012-11-30 2024-01-02 Anton Belousov Identification of patients in need of pd-l1 inhibitor cotherapy
AR093984A1 (en) 2012-12-21 2015-07-01 Merck Sharp & Dohme ANTIBODIES THAT JOIN LEGEND 1 OF SCHEDULED DEATH (PD-L1) HUMAN
WO2014165082A2 (en) 2013-03-13 2014-10-09 Medimmune, Llc Antibodies and methods of detection
KR20230070054A (en) 2013-03-15 2023-05-19 제넨테크, 인크. Biomarkers and methods of treating pd-1 and pd-l1 related conditions
AR095363A1 (en) 2013-03-15 2015-10-14 Genentech Inc BIOMARKERS AND METHODS FOR THE TREATMENT OF CONDITIONS RELATED TO PD-1 AND PD-L1
EP2981821B2 (en) 2013-04-02 2021-11-03 Merck Sharp & Dohme Corp. Immunohistochemical assay for detecting expression of programmed death ligand 1 (pd-l1) in tumor tissue
WO2014194293A1 (en) 2013-05-30 2014-12-04 Amplimmune, Inc. Improved methods for the selection of patients for pd-1 or b7-h4 targeted therapies, and combination therapies thereof
US20160215052A1 (en) 2013-07-24 2016-07-28 Dana-Farber Cancer Institute, Inc. Anti-galectin-1 (gal1) monoclonal antibodies and fragments thereof for neutralizing gal1
GB201316024D0 (en) 2013-09-09 2013-10-23 Almac Diagnostics Ltd Molecular diagnostic test for lung cancer
GB201316027D0 (en) 2013-09-09 2013-10-23 Almac Diagnostics Ltd Molecular diagnostic test for oesophageal cancer
WO2015038538A1 (en) 2013-09-10 2015-03-19 Medimmune, Llc Compositions and methods for treating sepsis
DK3043816T3 (en) 2013-09-11 2019-10-14 Medimmune Ltd ANTI-B7-H1 ANTIBODIES FOR TREATMENT OF TUMORS
CA2926856A1 (en) 2013-10-25 2015-04-30 Dana-Farber Cancer Institute, Inc. Anti-pd-l1 monoclonal antibodies and fragments thereof
EP3079772B1 (en) 2013-12-10 2020-02-05 Merck Sharp & Dohme Corp. Immunohistochemical proximity assay for pd-1 positive cells and pd-ligand positive cells in tumor tissue
DK3111224T3 (en) 2014-02-24 2019-03-18 Ventana Med Syst Inc Quinonmethidanalog-signal gain
US20150322184A1 (en) 2014-05-07 2015-11-12 Chevron Phillips Chemical Company Lp High Performance Moisture Barrier Films at Lower Densities
CN106232793A (en) 2014-05-12 2016-12-14 宝洁公司 antimicrobial cleansing compositions
JP6666905B2 (en) 2014-05-29 2020-03-18 スプリング バイオサイエンス コーポレーション PD-L1 antibody and use thereof
EP3149481B1 (en) 2014-05-30 2019-01-09 Ventana Medical Systems, Inc. Multiplex assay for improved scoring of tumor tissues stained for pd-l1
US20160009805A1 (en) 2014-07-11 2016-01-14 Genentech, Inc. Anti-pd-l1 antibodies and diagnostic uses thereof

Also Published As

Publication number Publication date
NZ712314A (en) 2021-07-30
RU2015139224A (en) 2017-04-21
AU2017225061B2 (en) 2019-11-21
KR20180103192A (en) 2018-09-18
EP2972373A2 (en) 2016-01-20
AU2019271922B2 (en) 2022-03-17
AU2014235453A1 (en) 2015-10-08
ES2761260T3 (en) 2020-05-19
CN105209919A (en) 2015-12-30
KR20150131269A (en) 2015-11-24
CN110079599A (en) 2019-08-02
RU2015139224A3 (en) 2018-03-12
EP3633377A1 (en) 2020-04-08
JP2016520800A (en) 2016-07-14
IL270943A (en) 2020-01-30
US11299544B2 (en) 2022-04-12
EP2972373B1 (en) 2019-10-09
AU2019271922C1 (en) 2022-11-24
JP6483082B2 (en) 2019-03-13
KR102389677B1 (en) 2022-04-21
KR20200109397A (en) 2020-09-22
CA2905798A1 (en) 2014-09-25
MX2020008976A (en) 2020-09-28
RU2701378C2 (en) 2019-09-26
BR112015023120A2 (en) 2017-11-21
CA3180286A1 (en) 2014-09-25
CA2905798C (en) 2023-01-24
WO2014151006A2 (en) 2014-09-25
EP4356960A3 (en) 2024-07-10
JP2019060883A (en) 2019-04-18
IL241309B (en) 2019-12-31
WO2014151006A3 (en) 2014-11-27
AU2017225061A1 (en) 2017-09-28
PL2972373T3 (en) 2020-03-31
SG10201701380TA (en) 2017-04-27
AU2022203671A1 (en) 2022-06-16
US20220363764A1 (en) 2022-11-17
MY197809A (en) 2023-07-18
US20160222118A1 (en) 2016-08-04
NZ751264A (en) 2021-07-30
HK1212769A1 (en) 2016-06-17
JP6845840B2 (en) 2021-03-24
KR102158924B1 (en) 2020-09-22
MX2015011774A (en) 2015-12-01
CN110079599B (en) 2024-06-04
AU2019271922A1 (en) 2019-12-19
NZ751260A (en) 2021-07-30
IL241309A0 (en) 2015-11-30
EP4356960A2 (en) 2024-04-24
KR20230070054A (en) 2023-05-19
CN105209919B (en) 2019-03-05
KR20240093812A (en) 2024-06-24
KR20220053691A (en) 2022-04-29
MY176706A (en) 2020-08-19

Similar Documents

Publication Publication Date Title
IL270943A (en) Biomarkers and methods of treating pd-1 and pd-l1 related conditions
IL283429A (en) Methods of treating cancer using pd-1 axis binding antagonists and tigit inhibitors
HK1218506A1 (en) Methods of treating melanoma
HK1219975A1 (en) Cell lines for virus production and methods of use
HK1217908A1 (en) Methods of treating cholangiocarcinoma
EP2970317A4 (en) Pyrimido-diazepinone compounds and methods of treating disorders
HK1216546A1 (en) Method of assessing risk of pml pml
GB2513304B (en) Peripheral apparatus and method of construction
SG11201602585XA (en) Methods of detection and removal of rhabdoviruses from cell lines
ZA201600927B (en) Structural assembly and method of assembly thereof
EP3063310A4 (en) Method of treating metal surfaces
HK1223844A1 (en) Method for the management of cancer and treatment of cancer comorbidities
HK1220453A1 (en) Methods of treating dyskinesia and related disorders
HK1212999A1 (en) Methods for treating and or limiting development of diabetes
HK1222323A1 (en) Compositions and methods for treating conditions that affect epidermis
HK1200093A1 (en) Methods of treating melanoma with pak1 inhibitors pak1
GB201910300D0 (en) Method of and apparatuses for indentifying geological characteristics
GB201321104D0 (en) Method and plant for treatment of dispersion
AU2013904630A0 (en) Method of treating melanoma