SG11201504315WA - Compositions comprising anti-cd38 antibodies and lenalidomide - Google Patents

Compositions comprising anti-cd38 antibodies and lenalidomide

Info

Publication number
SG11201504315WA
SG11201504315WA SG11201504315WA SG11201504315WA SG11201504315WA SG 11201504315W A SG11201504315W A SG 11201504315WA SG 11201504315W A SG11201504315W A SG 11201504315WA SG 11201504315W A SG11201504315W A SG 11201504315WA SG 11201504315W A SG11201504315W A SG 11201504315WA
Authority
SG
Singapore
Prior art keywords
lenalidomide
antibodies
compositions
Prior art date
Application number
SG11201504315WA
Other languages
English (en)
Inventor
Byron C Hann
Iii Thomas G Martin
Blake T Aftab
Blake Tomkinson
Original Assignee
Sanofi Sa
Univ California
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sanofi Sa, Univ California filed Critical Sanofi Sa
Publication of SG11201504315WA publication Critical patent/SG11201504315WA/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2896—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against molecules with a "CD"-designation, not provided for elsewhere
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/365—Lactones
    • A61K31/366—Lactones having six-membered rings, e.g. delta-lactones
    • A61K31/37—Coumarins, e.g. psoralen
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
    • A61K31/454—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. pimozide, domperidone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/57—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone
    • A61K31/573—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone substituted in position 21, e.g. cortisone, dexamethasone, prednisone or aldosterone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/60—Salicylic acid; Derivatives thereof
    • A61K31/612—Salicylic acid; Derivatives thereof having the hydroxy group in position 2 esterified, e.g. salicylsulfuric acid
    • A61K31/616—Salicylic acid; Derivatives thereof having the hydroxy group in position 2 esterified, e.g. salicylsulfuric acid by carboxylic acids, e.g. acetylsalicylic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
    • A61K31/726—Glycosaminoglycans, i.e. mucopolysaccharides
    • A61K31/727—Heparin; Heparan
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/32—Immunoglobulins specific features characterized by aspects of specificity or valency specific for a neo-epitope on a complex, e.g. antibody-antigen or ligand-receptor
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Immunology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Hematology (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Dermatology (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Diabetes (AREA)
  • Neurosurgery (AREA)
  • Oncology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
SG11201504315WA 2012-12-07 2013-12-06 Compositions comprising anti-cd38 antibodies and lenalidomide SG11201504315WA (en)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US201261734524P 2012-12-07 2012-12-07
US201361769247P 2013-02-26 2013-02-26
US201361808372P 2013-04-04 2013-04-04
PCT/US2013/073540 WO2014089416A1 (en) 2012-12-07 2013-12-06 Compositions comprising anti-cd38 antibodies and lenalidomide

Publications (1)

Publication Number Publication Date
SG11201504315WA true SG11201504315WA (en) 2015-07-30

Family

ID=50884019

Family Applications (3)

Application Number Title Priority Date Filing Date
SG11201504315WA SG11201504315WA (en) 2012-12-07 2013-12-06 Compositions comprising anti-cd38 antibodies and lenalidomide
SG10201704536PA SG10201704536PA (en) 2012-12-07 2013-12-06 Compositions comprising anti-cd38 antibodies and lenalidomide
SG10201913783PA SG10201913783PA (en) 2012-12-07 2013-12-06 Compositions comprising anti-cd38 antibodies and lenalidomide

Family Applications After (2)

Application Number Title Priority Date Filing Date
SG10201704536PA SG10201704536PA (en) 2012-12-07 2013-12-06 Compositions comprising anti-cd38 antibodies and lenalidomide
SG10201913783PA SG10201913783PA (en) 2012-12-07 2013-12-06 Compositions comprising anti-cd38 antibodies and lenalidomide

Country Status (31)

Country Link
EP (2) EP2928495B1 (enrdf_load_html_response)
JP (2) JP6499971B2 (enrdf_load_html_response)
KR (2) KR20200143503A (enrdf_load_html_response)
CN (1) CN105263520B (enrdf_load_html_response)
AR (1) AR093844A1 (enrdf_load_html_response)
AU (2) AU2013355064B2 (enrdf_load_html_response)
BR (1) BR112015012987A2 (enrdf_load_html_response)
CA (1) CA2893946A1 (enrdf_load_html_response)
CL (2) CL2015001558A1 (enrdf_load_html_response)
CY (2) CY1122478T1 (enrdf_load_html_response)
DK (1) DK2928495T3 (enrdf_load_html_response)
ES (1) ES2731548T3 (enrdf_load_html_response)
HR (1) HRP20191034T1 (enrdf_load_html_response)
HU (3) HUE044142T2 (enrdf_load_html_response)
IL (2) IL239234B (enrdf_load_html_response)
LT (2) LT2928495T (enrdf_load_html_response)
LU (1) LUC00187I2 (enrdf_load_html_response)
MX (2) MX366296B (enrdf_load_html_response)
MY (1) MY191601A (enrdf_load_html_response)
NL (1) NL301079I2 (enrdf_load_html_response)
NZ (1) NZ709215A (enrdf_load_html_response)
PH (1) PH12015501263A1 (enrdf_load_html_response)
PL (1) PL2928495T3 (enrdf_load_html_response)
PT (1) PT2928495T (enrdf_load_html_response)
RS (1) RS58829B1 (enrdf_load_html_response)
RU (1) RU2698911C2 (enrdf_load_html_response)
SG (3) SG11201504315WA (enrdf_load_html_response)
SI (1) SI2928495T1 (enrdf_load_html_response)
TW (2) TWI670062B (enrdf_load_html_response)
UA (1) UA118255C2 (enrdf_load_html_response)
WO (1) WO2014089416A1 (enrdf_load_html_response)

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UA112170C2 (uk) 2010-12-10 2016-08-10 Санофі Протипухлинна комбінація, що містить антитіло, яке специфічно розпізнає cd38, і бортезоміб
JOP20210044A1 (ar) 2010-12-30 2017-06-16 Takeda Pharmaceuticals Co الأجسام المضادة لـ cd38
US10342869B2 (en) 2012-12-07 2019-07-09 The Regents Of The University Of California Compositions comprising anti-CD38 antibodies and lenalidomide
US9732154B2 (en) 2014-02-28 2017-08-15 Janssen Biotech, Inc. Anti-CD38 antibodies for treatment of acute lymphoblastic leukemia
US9603927B2 (en) 2014-02-28 2017-03-28 Janssen Biotech, Inc. Combination therapies with anti-CD38 antibodies
WO2015195555A1 (en) * 2014-06-16 2015-12-23 The United States Of America, As Represented By The Secretary, Department Of Health & Human Services Blocking cd38 using anti-cd38 antibody conjugated to protein g to protect nk cells
WO2016022589A2 (en) 2014-08-08 2016-02-11 The Regents Of The University Of California Methods for treating multiple myeloma
SG11201704390PA (en) 2014-12-04 2017-06-29 Janssen Biotech Inc Anti-cd38 antibodies for treatment of acute myeloid leukemia
KR102602754B1 (ko) 2015-05-20 2023-11-14 얀센 바이오테크 인코포레이티드 경쇄 아밀로이드증 및 다른 cd38-양성 혈액학적 악성종양을 치료하기 위한 항-cd38 항체
CN107708734B (zh) 2015-06-22 2022-01-11 詹森生物科技公司 用抗cd38抗体和生存素抑制剂联合治疗血红素恶性肿瘤
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WO2019199132A1 (ko) * 2018-04-13 2019-10-17 주식회사 삼양바이오팜 다양한 용량의 레날리도마이드의 경구용 정제 조성물
JP7585043B2 (ja) * 2018-04-13 2024-11-18 サムヤン ホールディングス コーポレイション レナリドミドを含む医薬組成物
KR102286500B1 (ko) * 2018-04-13 2021-08-05 주식회사 삼양홀딩스 레날리도마이드를 포함하는 경구용 고형제제의 제조방법
WO2019199133A1 (ko) * 2018-04-13 2019-10-17 주식회사 삼양바이오팜 레날리도마이드의 경구용 코팅 정제 조성물
KR20210011002A (ko) 2018-05-16 2021-01-29 얀센 바이오테크 인코포레이티드 암을 치료하는 방법 및 t-세포 재유도 치료제의 효능을 향상시키는 방법
AU2019351811B2 (en) * 2018-10-01 2025-01-02 Celgene Corporation Combination therapy for the treatment of cancer
KR20220002891A (ko) * 2019-03-15 2022-01-07 모르포시스 아게 자가항체-매개 자가면역 질병의 치료를 위한 항-cd38 항체 및 이의 약제학적 조성물
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HUE044142T2 (hu) 2019-09-30
MY191601A (en) 2022-07-01
KR102193045B1 (ko) 2020-12-18
PT2928495T (pt) 2019-07-04
EP2928495A4 (en) 2016-05-11
CN105263520A (zh) 2016-01-20
JP6499971B2 (ja) 2019-04-10
LTC2928495I2 (lt) 2024-11-25
HK1215536A1 (en) 2016-09-02
PL2928495T3 (pl) 2019-09-30
IL282542A (en) 2021-06-30
RU2698911C2 (ru) 2019-09-02
JP2016506388A (ja) 2016-03-03
CY1122478T1 (el) 2021-01-27
MX2015007189A (es) 2016-03-21
CL2015001558A1 (es) 2015-10-02
MX2019008065A (es) 2019-09-23
JP2019070020A (ja) 2019-05-09
CY2020040I1 (el) 2021-03-12
KR20200143503A (ko) 2020-12-23
AU2013355064B2 (en) 2018-05-24
HUS2000050I1 (hu) 2020-12-28
TWI670062B (zh) 2019-09-01
LUC00187I2 (enrdf_load_html_response) 2024-07-01
SI2928495T1 (sl) 2019-07-31
NL301079I2 (nl) 2021-03-29
TW201427663A (zh) 2014-07-16
LTPA2020537I1 (lt) 2020-12-28
CL2018003292A1 (es) 2019-02-01
UA118255C2 (uk) 2018-12-26
TW201919699A (zh) 2019-06-01
KR20150091165A (ko) 2015-08-07
MX366296B (es) 2019-07-04
HRP20191034T1 (hr) 2019-08-23
EP2928495B1 (en) 2019-03-27
DK2928495T3 (da) 2019-06-24
WO2014089416A1 (en) 2014-06-12
IL239234A0 (en) 2015-07-30
CN105263520B (zh) 2020-03-13
AU2013355064A1 (en) 2015-07-09
RU2015127089A (ru) 2017-01-13
HUS2000051I1 (hu) 2020-12-28
CY2020040I2 (el) 2021-05-05
AU2018211258A1 (en) 2018-08-16
SG10201704536PA (en) 2017-07-28
EP3597191A1 (en) 2020-01-22
IL239234B (en) 2021-05-31
CA2893946A1 (en) 2014-06-12
PH12015501263A1 (en) 2015-08-17
RS58829B1 (sr) 2019-07-31
AR093844A1 (es) 2015-06-24
ES2731548T3 (es) 2019-11-15
EP2928495A1 (en) 2015-10-14
LT2928495T (lt) 2019-07-10
NZ709215A (en) 2020-08-28
BR112015012987A2 (pt) 2017-09-12
SG10201913783PA (en) 2020-03-30

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