SG11201503497UA - Megastokes amino-triazolyl-bodipy compounds and applications to live neuron staining and human serum albumin fa1 drug site probing - Google Patents
Megastokes amino-triazolyl-bodipy compounds and applications to live neuron staining and human serum albumin fa1 drug site probingInfo
- Publication number
- SG11201503497UA SG11201503497UA SG11201503497UA SG11201503497UA SG11201503497UA SG 11201503497U A SG11201503497U A SG 11201503497UA SG 11201503497U A SG11201503497U A SG 11201503497UA SG 11201503497U A SG11201503497U A SG 11201503497UA SG 11201503497U A SG11201503497U A SG 11201503497UA
- Authority
- SG
- Singapore
- Prior art keywords
- megastokes
- triazolyl
- amino
- applications
- serum albumin
- Prior art date
Links
- 102000008100 Human Serum Albumin Human genes 0.000 title 1
- 108091006905 Human Serum Albumin Proteins 0.000 title 1
- 150000001875 compounds Chemical class 0.000 title 1
- 239000003814 drug Substances 0.000 title 1
- 229940079593 drug Drugs 0.000 title 1
- 210000002569 neuron Anatomy 0.000 title 1
- 238000010186 staining Methods 0.000 title 1
Classifications
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/58—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances
- G01N33/582—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances with fluorescent label
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F5/00—Compounds containing elements of Groups 3 or 13 of the Periodic Table
- C07F5/02—Boron compounds
- C07F5/022—Boron compounds without C-boron linkages
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/001—Preparation for luminescence or biological staining
- A61K49/0013—Luminescence
- A61K49/0017—Fluorescence in vivo
- A61K49/0019—Fluorescence in vivo characterised by the fluorescent group, e.g. oligomeric, polymeric or dendritic molecules
- A61K49/0021—Fluorescence in vivo characterised by the fluorescent group, e.g. oligomeric, polymeric or dendritic molecules the fluorescent group being a small organic molecule
-
- C—CHEMISTRY; METALLURGY
- C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
- C09B—ORGANIC DYES OR CLOSELY-RELATED COMPOUNDS FOR PRODUCING DYES, e.g. PIGMENTS; MORDANTS; LAKES
- C09B23/00—Methine or polymethine dyes, e.g. cyanine dyes
- C09B23/0008—Methine or polymethine dyes, e.g. cyanine dyes substituted on the polymethine chain
-
- C—CHEMISTRY; METALLURGY
- C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
- C09B—ORGANIC DYES OR CLOSELY-RELATED COMPOUNDS FOR PRODUCING DYES, e.g. PIGMENTS; MORDANTS; LAKES
- C09B23/00—Methine or polymethine dyes, e.g. cyanine dyes
- C09B23/02—Methine or polymethine dyes, e.g. cyanine dyes the polymethine chain containing an odd number of >CH- or >C[alkyl]- groups
- C09B23/04—Methine or polymethine dyes, e.g. cyanine dyes the polymethine chain containing an odd number of >CH- or >C[alkyl]- groups one >CH- group, e.g. cyanines, isocyanines, pseudocyanines
-
- C—CHEMISTRY; METALLURGY
- C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
- C09B—ORGANIC DYES OR CLOSELY-RELATED COMPOUNDS FOR PRODUCING DYES, e.g. PIGMENTS; MORDANTS; LAKES
- C09B57/00—Other synthetic dyes of known constitution
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
- G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
- G01N21/64—Fluorescence; Phosphorescence
- G01N21/6428—Measuring fluorescence of fluorescent products of reactions or of fluorochrome labelled reactive substances, e.g. measuring quenching effects, using measuring "optrodes"
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
- G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
- G01N33/5044—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics involving specific cell types
- G01N33/5058—Neurological cells
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/52—Use of compounds or compositions for colorimetric, spectrophotometric or fluorometric investigation, e.g. use of reagent paper and including single- and multilayer analytical elements
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/531—Production of immunochemical test materials
- G01N33/532—Production of labelled immunochemicals
- G01N33/533—Production of labelled immunochemicals with fluorescent label
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/58—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
- G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
- G01N2333/76—Assays involving albumins other than in routine use for blocking surfaces or for anchoring haptens during immunisation
- G01N2333/765—Serum albumin, e.g. HSA
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2458/00—Labels used in chemical analysis of biological material
- G01N2458/30—Electrochemically active labels
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Immunology (AREA)
- Biomedical Technology (AREA)
- Hematology (AREA)
- Molecular Biology (AREA)
- Urology & Nephrology (AREA)
- General Health & Medical Sciences (AREA)
- Physics & Mathematics (AREA)
- Organic Chemistry (AREA)
- General Physics & Mathematics (AREA)
- Analytical Chemistry (AREA)
- Biochemistry (AREA)
- Pathology (AREA)
- Cell Biology (AREA)
- Medicinal Chemistry (AREA)
- Food Science & Technology (AREA)
- Microbiology (AREA)
- Biotechnology (AREA)
- Tropical Medicine & Parasitology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Veterinary Medicine (AREA)
- Toxicology (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Public Health (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Optics & Photonics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Plural Heterocyclic Compounds (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Investigating Or Analysing Materials By The Use Of Chemical Reactions (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201261745916P | 2012-12-26 | 2012-12-26 | |
PCT/SG2013/000550 WO2014104975A1 (en) | 2012-12-26 | 2013-12-26 | Megastokes amino-triazolyl-bodipy compounds and applications to live neuron staining and human serum albumin fa1 drug site probing |
Publications (1)
Publication Number | Publication Date |
---|---|
SG11201503497UA true SG11201503497UA (en) | 2015-06-29 |
Family
ID=51021837
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
SG11201503497UA SG11201503497UA (en) | 2012-12-26 | 2013-12-26 | Megastokes amino-triazolyl-bodipy compounds and applications to live neuron staining and human serum albumin fa1 drug site probing |
Country Status (7)
Country | Link |
---|---|
US (1) | US9513294B2 (ja) |
EP (1) | EP2938619B1 (ja) |
JP (1) | JP6300380B2 (ja) |
KR (1) | KR101715543B1 (ja) |
CN (1) | CN105102464B (ja) |
SG (1) | SG11201503497UA (ja) |
WO (1) | WO2014104975A1 (ja) |
Families Citing this family (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP6983660B2 (ja) | 2015-05-08 | 2021-12-17 | スペクトラル プラットフォームス インコーポレイテッド | アルブミンに基づく非共有結合性複合体およびその使用方法 |
US11105747B2 (en) | 2017-03-20 | 2021-08-31 | Spectral Platforms, Inc. | Spectroscopic methods to detect and characterize microorganisms |
CN107033621A (zh) * | 2017-05-12 | 2017-08-11 | 华东理工大学 | 一种具有大Stokes位移近红外BODIPY染料及其制备和应用 |
CN108484651B (zh) * | 2018-02-07 | 2020-08-11 | 四川大学 | 一种3-吗啉基-8-对甲基苯基氟硼荧类衍生物及其制备方法和应用 |
CN108299484B (zh) * | 2018-02-07 | 2020-07-24 | 四川大学 | 一种3,5-二吗啉基-8-对甲基苯基氟硼荧类衍生物及其制备方法和应用 |
CN109187403B (zh) * | 2018-10-19 | 2021-07-23 | 海南师范大学 | 一种5-苯基-1-(对甲基苯基)-1h-三唑与血清作用的差异蛋白检测方法 |
WO2020120636A1 (en) | 2018-12-14 | 2020-06-18 | Rheinisch-Westfälische Technische Hochschule (Rwth) Aachen | Fluorescence dye |
Family Cites Families (19)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CA2158782C (en) | 1994-09-23 | 2010-01-12 | Pierrette Gaudreau | Marker for growth hormone-releasing factor receptors |
US5804395A (en) | 1995-12-01 | 1998-09-08 | The United States Of America As Represented By The Secretary Of The Navy | Fluorescence polarization assays of enzymes and substrates therefore |
US6106999A (en) * | 1997-08-12 | 2000-08-22 | Mitsui Chemicals | Photosensitizer, visible light curable resin composition using the same, and use of the composition |
JP3987628B2 (ja) * | 1997-08-12 | 2007-10-10 | 関西ペイント株式会社 | 可視光硬化性樹脂組成物およびその用途 |
US7968306B2 (en) | 2002-02-13 | 2011-06-28 | Wisconsin Alumni Research Foundation | Method for measuring activity of a specific fraction of albumin |
CN101059507B (zh) | 2006-04-18 | 2011-05-11 | 中国科学院大连化学物理研究所 | 一种bodipy类荧光试剂在生物大分子标记中的应用 |
CN1944540A (zh) * | 2006-09-15 | 2007-04-11 | 大连理工大学 | 生物分析用近红外氟化硼络合二吡咯甲川类荧光染料 |
US7858598B2 (en) * | 2007-03-12 | 2010-12-28 | Morningside Ventures Limited & Versitech Limited | Reagents for detection of hypochlorous acid |
WO2009025767A1 (en) * | 2007-08-17 | 2009-02-26 | Research Foundation Of The City University Of New York | Boron dipyrromethene difluoro (bodipy) conjugates |
US8598311B2 (en) | 2007-11-21 | 2013-12-03 | The University Of The Sciences In Philadelphia | Complexation of fatty acid-conjugated molecules with albumin |
KR101135449B1 (ko) | 2009-03-10 | 2012-04-13 | 한국과학기술연구원 | 헤파라나제 활성 측정용 이온 복합체 나노 입자 및 그 제조방법 |
EP2431738A4 (en) | 2009-05-12 | 2013-05-22 | Innopharmascreen Inc | SCREENING PROCESS FOR OSTEOPONTIN INHIBITOR AND INHIBITOR MANUFACTURED THEREWITH |
CN102061103A (zh) * | 2009-11-11 | 2011-05-18 | 大连理工大学 | 一类氟化硼络合二吡咯甲川染料、制备方法及其应用 |
US8835641B2 (en) | 2010-07-19 | 2014-09-16 | University Of Ottawa | Fluorescent markers and use thereof for labeling specific protein targets |
CN103298820B (zh) * | 2010-11-24 | 2016-08-03 | 新加坡国立大学 | 用作神经干细胞探针的氟硼二吡咯结构荧光染料 |
WO2012118444A1 (en) | 2011-03-01 | 2012-09-07 | Agency For Science, Technology And Research | Novel compounds with photoluminescnce properties and applications thereof |
CN102286213A (zh) * | 2011-05-12 | 2011-12-21 | 河南大学 | 近红外氮杂-bodipy染料及其制备方法和应用 |
EP2721038B1 (en) * | 2011-06-15 | 2017-07-26 | National University of Singapore | Alkylamino bodipy dyes as selective fluorescent probes for proteins and mouse embryonic stem cells |
CN102352118B (zh) * | 2011-07-18 | 2014-02-19 | 南京邮电大学 | 一种近红外荧光染料及制备和应用 |
-
2013
- 2013-12-26 US US14/648,309 patent/US9513294B2/en active Active
- 2013-12-26 CN CN201380067802.8A patent/CN105102464B/zh not_active Expired - Fee Related
- 2013-12-26 JP JP2015550363A patent/JP6300380B2/ja active Active
- 2013-12-26 WO PCT/SG2013/000550 patent/WO2014104975A1/en active Application Filing
- 2013-12-26 KR KR1020157018666A patent/KR101715543B1/ko active IP Right Grant
- 2013-12-26 SG SG11201503497UA patent/SG11201503497UA/en unknown
- 2013-12-26 EP EP13866739.9A patent/EP2938619B1/en active Active
Also Published As
Publication number | Publication date |
---|---|
KR20150098639A (ko) | 2015-08-28 |
US20150309040A1 (en) | 2015-10-29 |
EP2938619A4 (en) | 2016-11-16 |
EP2938619A1 (en) | 2015-11-04 |
JP6300380B2 (ja) | 2018-03-28 |
WO2014104975A1 (en) | 2014-07-03 |
WO2014104975A9 (en) | 2017-06-22 |
JP2016511746A (ja) | 2016-04-21 |
EP2938619B1 (en) | 2018-02-21 |
CN105102464B (zh) | 2017-03-29 |
CN105102464A (zh) | 2015-11-25 |
KR101715543B1 (ko) | 2017-03-10 |
US9513294B2 (en) | 2016-12-06 |
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