SG11201503497UA - Megastokes amino-triazolyl-bodipy compounds and applications to live neuron staining and human serum albumin fa1 drug site probing - Google Patents

Megastokes amino-triazolyl-bodipy compounds and applications to live neuron staining and human serum albumin fa1 drug site probing

Info

Publication number
SG11201503497UA
SG11201503497UA SG11201503497UA SG11201503497UA SG11201503497UA SG 11201503497U A SG11201503497U A SG 11201503497UA SG 11201503497U A SG11201503497U A SG 11201503497UA SG 11201503497U A SG11201503497U A SG 11201503497UA SG 11201503497U A SG11201503497U A SG 11201503497UA
Authority
SG
Singapore
Prior art keywords
megastokes
triazolyl
amino
applications
serum albumin
Prior art date
Application number
SG11201503497UA
Other languages
English (en)
Inventor
Young-Tae Chang
Jun Cheng Er
Cheryl Kit Mun Leong
Seong Wook Yun
Escobar Marc Vendrell
Mui Kee Tang
Original Assignee
Univ Singapore
Agency Science Tech & Res
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Singapore, Agency Science Tech & Res filed Critical Univ Singapore
Publication of SG11201503497UA publication Critical patent/SG11201503497UA/en

Links

Classifications

    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/58Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances
    • G01N33/582Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances with fluorescent label
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07FACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F5/00Compounds containing elements of Groups 3 or 13 of the Periodic Table
    • C07F5/02Boron compounds
    • C07F5/022Boron compounds without C-boron linkages
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00Preparations for testing in vivo
    • A61K49/001Preparation for luminescence or biological staining
    • A61K49/0013Luminescence
    • A61K49/0017Fluorescence in vivo
    • A61K49/0019Fluorescence in vivo characterised by the fluorescent group, e.g. oligomeric, polymeric or dendritic molecules
    • A61K49/0021Fluorescence in vivo characterised by the fluorescent group, e.g. oligomeric, polymeric or dendritic molecules the fluorescent group being a small organic molecule
    • CCHEMISTRY; METALLURGY
    • C09DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
    • C09BORGANIC DYES OR CLOSELY-RELATED COMPOUNDS FOR PRODUCING DYES, e.g. PIGMENTS; MORDANTS; LAKES
    • C09B23/00Methine or polymethine dyes, e.g. cyanine dyes
    • C09B23/0008Methine or polymethine dyes, e.g. cyanine dyes substituted on the polymethine chain
    • CCHEMISTRY; METALLURGY
    • C09DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
    • C09BORGANIC DYES OR CLOSELY-RELATED COMPOUNDS FOR PRODUCING DYES, e.g. PIGMENTS; MORDANTS; LAKES
    • C09B23/00Methine or polymethine dyes, e.g. cyanine dyes
    • C09B23/02Methine or polymethine dyes, e.g. cyanine dyes the polymethine chain containing an odd number of >CH- or >C[alkyl]- groups
    • C09B23/04Methine or polymethine dyes, e.g. cyanine dyes the polymethine chain containing an odd number of >CH- or >C[alkyl]- groups one >CH- group, e.g. cyanines, isocyanines, pseudocyanines
    • CCHEMISTRY; METALLURGY
    • C09DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
    • C09BORGANIC DYES OR CLOSELY-RELATED COMPOUNDS FOR PRODUCING DYES, e.g. PIGMENTS; MORDANTS; LAKES
    • C09B57/00Other synthetic dyes of known constitution
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/64Fluorescence; Phosphorescence
    • G01N21/6428Measuring fluorescence of fluorescent products of reactions or of fluorochrome labelled reactive substances, e.g. measuring quenching effects, using measuring "optrodes"
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
    • G01N33/5008Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
    • G01N33/5044Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics involving specific cell types
    • G01N33/5058Neurological cells
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/52Use of compounds or compositions for colorimetric, spectrophotometric or fluorometric investigation, e.g. use of reagent paper and including single- and multilayer analytical elements
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/531Production of immunochemical test materials
    • G01N33/532Production of labelled immunochemicals
    • G01N33/533Production of labelled immunochemicals with fluorescent label
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/58Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/435Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
    • G01N2333/76Assays involving albumins other than in routine use for blocking surfaces or for anchoring haptens during immunisation
    • G01N2333/765Serum albumin, e.g. HSA
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2458/00Labels used in chemical analysis of biological material
    • G01N2458/30Electrochemically active labels

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Biomedical Technology (AREA)
  • Hematology (AREA)
  • Molecular Biology (AREA)
  • Urology & Nephrology (AREA)
  • General Health & Medical Sciences (AREA)
  • Physics & Mathematics (AREA)
  • Organic Chemistry (AREA)
  • General Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • Pathology (AREA)
  • Cell Biology (AREA)
  • Medicinal Chemistry (AREA)
  • Food Science & Technology (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Toxicology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Optics & Photonics (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Investigating Or Analysing Materials By The Use Of Chemical Reactions (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
SG11201503497UA 2012-12-26 2013-12-26 Megastokes amino-triazolyl-bodipy compounds and applications to live neuron staining and human serum albumin fa1 drug site probing SG11201503497UA (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201261745916P 2012-12-26 2012-12-26
PCT/SG2013/000550 WO2014104975A1 (en) 2012-12-26 2013-12-26 Megastokes amino-triazolyl-bodipy compounds and applications to live neuron staining and human serum albumin fa1 drug site probing

Publications (1)

Publication Number Publication Date
SG11201503497UA true SG11201503497UA (en) 2015-06-29

Family

ID=51021837

Family Applications (1)

Application Number Title Priority Date Filing Date
SG11201503497UA SG11201503497UA (en) 2012-12-26 2013-12-26 Megastokes amino-triazolyl-bodipy compounds and applications to live neuron staining and human serum albumin fa1 drug site probing

Country Status (7)

Country Link
US (1) US9513294B2 (de)
EP (1) EP2938619B1 (de)
JP (1) JP6300380B2 (de)
KR (1) KR101715543B1 (de)
CN (1) CN105102464B (de)
SG (1) SG11201503497UA (de)
WO (1) WO2014104975A1 (de)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP6983660B2 (ja) 2015-05-08 2021-12-17 スペクトラル プラットフォームス インコーポレイテッド アルブミンに基づく非共有結合性複合体およびその使用方法
EP3602065A4 (de) 2017-03-20 2020-12-23 Spectral Platforms, Inc. Spektroskopische verfahren zur detektion und charakterisierung von mikroorganismen
CN107033621A (zh) * 2017-05-12 2017-08-11 华东理工大学 一种具有大Stokes位移近红外BODIPY染料及其制备和应用
CN108299484B (zh) * 2018-02-07 2020-07-24 四川大学 一种3,5-二吗啉基-8-对甲基苯基氟硼荧类衍生物及其制备方法和应用
CN108484651B (zh) * 2018-02-07 2020-08-11 四川大学 一种3-吗啉基-8-对甲基苯基氟硼荧类衍生物及其制备方法和应用
CN109187403B (zh) * 2018-10-19 2021-07-23 海南师范大学 一种5-苯基-1-(对甲基苯基)-1h-三唑与血清作用的差异蛋白检测方法
EP3894482A1 (de) 2018-12-14 2021-10-20 Rheinisch-Westfälische Technische Hochschule (RWTH) Aachen Fluoreszenzfarbstoff

Family Cites Families (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2158782C (en) 1994-09-23 2010-01-12 Pierrette Gaudreau Marker for growth hormone-releasing factor receptors
US5804395A (en) 1995-12-01 1998-09-08 The United States Of America As Represented By The Secretary Of The Navy Fluorescence polarization assays of enzymes and substrates therefore
US6106999A (en) * 1997-08-12 2000-08-22 Mitsui Chemicals Photosensitizer, visible light curable resin composition using the same, and use of the composition
JP3987628B2 (ja) * 1997-08-12 2007-10-10 関西ペイント株式会社 可視光硬化性樹脂組成物およびその用途
US7968306B2 (en) 2002-02-13 2011-06-28 Wisconsin Alumni Research Foundation Method for measuring activity of a specific fraction of albumin
CN101059507B (zh) 2006-04-18 2011-05-11 中国科学院大连化学物理研究所 一种bodipy类荧光试剂在生物大分子标记中的应用
CN1944540A (zh) * 2006-09-15 2007-04-11 大连理工大学 生物分析用近红外氟化硼络合二吡咯甲川类荧光染料
US7858598B2 (en) * 2007-03-12 2010-12-28 Morningside Ventures Limited & Versitech Limited Reagents for detection of hypochlorous acid
WO2009025767A1 (en) * 2007-08-17 2009-02-26 Research Foundation Of The City University Of New York Boron dipyrromethene difluoro (bodipy) conjugates
WO2009070234A2 (en) 2007-11-21 2009-06-04 The University Of The Sciences In Philadelphia Complexation of fatty acid-conjugated molecules with albumin
KR101135449B1 (ko) 2009-03-10 2012-04-13 한국과학기술연구원 헤파라나제 활성 측정용 이온 복합체 나노 입자 및 그 제조방법
WO2010131826A1 (ko) 2009-05-12 2010-11-18 주식회사 이노파마스크린 오스테오폰틴 억제제 스크리닝 방법 및 그에 따른 억제제
CN102061103A (zh) * 2009-11-11 2011-05-18 大连理工大学 一类氟化硼络合二吡咯甲川染料、制备方法及其应用
US8835641B2 (en) 2010-07-19 2014-09-16 University Of Ottawa Fluorescent markers and use thereof for labeling specific protein targets
SG190173A1 (en) 2010-11-24 2013-07-31 Univ Singapore Bodipy structure fluorescence dye for neural stem cell probe
WO2012118444A1 (en) 2011-03-01 2012-09-07 Agency For Science, Technology And Research Novel compounds with photoluminescnce properties and applications thereof
CN102286213A (zh) * 2011-05-12 2011-12-21 河南大学 近红外氮杂-bodipy染料及其制备方法和应用
US9267949B2 (en) * 2011-06-15 2016-02-23 National University Of Singapore Alkylamino BODIPY dyes as selective fluorescent probes for proteins and mouse embryonic stem cells
CN102352118B (zh) * 2011-07-18 2014-02-19 南京邮电大学 一种近红外荧光染料及制备和应用

Also Published As

Publication number Publication date
CN105102464A (zh) 2015-11-25
EP2938619A1 (de) 2015-11-04
WO2014104975A1 (en) 2014-07-03
EP2938619B1 (de) 2018-02-21
CN105102464B (zh) 2017-03-29
KR20150098639A (ko) 2015-08-28
WO2014104975A9 (en) 2017-06-22
JP2016511746A (ja) 2016-04-21
KR101715543B1 (ko) 2017-03-10
EP2938619A4 (de) 2016-11-16
JP6300380B2 (ja) 2018-03-28
US9513294B2 (en) 2016-12-06
US20150309040A1 (en) 2015-10-29

Similar Documents

Publication Publication Date Title
IL274988A (en) Carbamoylpyridone-polycyclic compounds and their pharmaceutical use
HK1205690A1 (en) Pharmaceutical composition and administration thereof
BR112015003125A2 (pt) ingrediente hidrante cosmético ou7 farmacêutico
SG11201503497UA (en) Megastokes amino-triazolyl-bodipy compounds and applications to live neuron staining and human serum albumin fa1 drug site probing
BR112015011111A2 (pt) proteína multifuncional e formulação farmacêutica
DK3181128T3 (da) Farmaceutisk nilotinib-sammensætning
BR112015001211A2 (pt) novos ácidos 5-aminotetra-hidroquinolina-2-carboxílicos e sua utilização
IL238713A0 (en) Self-regulating active pharmaceutical ingredient release
PL2842945T3 (pl) Pochodna sulfonamidowa i jej zastosowanie medyczne
DK2834348T3 (da) 3d in vitro bifasisk brusk-knogle-konstruktion
BR112013014644A2 (pt) composição farmacêutica e complexo
DK2652652T3 (da) Medikmentadministration
DK2819648T3 (da) Farmaceutisk præparat omfattende et antiviralt virksomt dihydroquinazolinderivat
HK1203815A1 (en) Pharmaceutical compositions and methods for their preparation
DK2897594T3 (da) Farmaceutisk sammensætning
DK3473255T3 (da) Farmaceutisk formulering omfattende ciclesonid
BR112015002646A2 (pt) composto e composição farmacêutica
EP2832724A4 (de) Nicotinsäurederivat und verwendung davon für medizinische zwecke
BR302012005250S1 (pt) "configuração aplicada em dispositivo médico"
FR2991169B1 (fr) Composition cosmetique ou dermatologique et son utilisation
SG11201406942SA (en) Trans-2-decenoic acid derivative and drug containing same
FR2997300B1 (fr) Composition cosmetique ou dermatologique et son utilisation
ITMI20131485A1 (it) Composizione farmaceutica comprendente lacipidina e processo di preparazione
FR2973696B1 (fr) Composition cosmetique et/ou dermatologique
PL398988A1 (pl) (Z)-6-O-ß-D-glukopiranozylo-4'-hydroksy-4-metoksy-7-prenyloauron i sposób jego wytwarzania