SG11201406664SA - Crystallization methods for purification of monoclonal antibodies - Google Patents

Crystallization methods for purification of monoclonal antibodies

Info

Publication number
SG11201406664SA
SG11201406664SA SG11201406664SA SG11201406664SA SG11201406664SA SG 11201406664S A SG11201406664S A SG 11201406664SA SG 11201406664S A SG11201406664S A SG 11201406664SA SG 11201406664S A SG11201406664S A SG 11201406664SA SG 11201406664S A SG11201406664S A SG 11201406664SA
Authority
SG
Singapore
Prior art keywords
purification
monoclonal antibodies
crystallization methods
crystallization
methods
Prior art date
Application number
SG11201406664SA
Other languages
English (en)
Inventor
Dariusch Hekmat
Bernhard Helk
Henk Konrad Schulz
Benjamin Smejkal
Original Assignee
Novartis Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Novartis Ag filed Critical Novartis Ag
Publication of SG11201406664SA publication Critical patent/SG11201406664SA/en

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K16/00Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K1/00General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/14Extraction; Separation; Purification
    • C07K1/30Extraction; Separation; Purification by precipitation
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01DSEPARATION
    • B01D9/00Crystallisation
    • B01D9/005Selection of auxiliary, e.g. for control of crystallisation nuclei, of crystal growth, of adherence to walls; Arrangements for introduction thereof
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K1/00General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/14Extraction; Separation; Purification
    • C07K1/30Extraction; Separation; Purification by precipitation
    • C07K1/306Extraction; Separation; Purification by precipitation by crystallization
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K16/00Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/16Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from plants
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/10Immunoglobulins specific features characterized by their source of isolation or production
    • C07K2317/14Specific host cells or culture conditions, e.g. components, pH or temperature
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02PCLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00Technologies relating to chemical industry
    • Y02P20/50Improvements relating to the production of bulk chemicals
    • Y02P20/54Improvements relating to the production of bulk chemicals using solvents, e.g. supercritical solvents or ionic liquids

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Immunology (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Botany (AREA)
  • Analytical Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
SG11201406664SA 2012-05-11 2013-05-10 Crystallization methods for purification of monoclonal antibodies SG11201406664SA (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201261645855P 2012-05-11 2012-05-11
PCT/EP2013/059696 WO2013167720A1 (en) 2012-05-11 2013-05-10 Crystallization methods for purification of monoclonal antibodies

Publications (1)

Publication Number Publication Date
SG11201406664SA true SG11201406664SA (en) 2014-11-27

Family

ID=48326319

Family Applications (1)

Application Number Title Priority Date Filing Date
SG11201406664SA SG11201406664SA (en) 2012-05-11 2013-05-10 Crystallization methods for purification of monoclonal antibodies

Country Status (14)

Country Link
US (2) US20150133642A1 (OSRAM)
EP (1) EP2846830A1 (OSRAM)
JP (1) JP2015517306A (OSRAM)
KR (1) KR20150016503A (OSRAM)
CN (1) CN104284676B (OSRAM)
AU (1) AU2013258006B2 (OSRAM)
BR (1) BR112014027994A2 (OSRAM)
CA (1) CA2872145A1 (OSRAM)
IL (1) IL235483A0 (OSRAM)
IN (1) IN2014DN09097A (OSRAM)
MX (1) MX2014013754A (OSRAM)
RU (1) RU2014150071A (OSRAM)
SG (1) SG11201406664SA (OSRAM)
WO (1) WO2013167720A1 (OSRAM)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP3015542A1 (de) * 2015-05-07 2016-05-04 Bayer Technology Services GmbH Modulare anlage und verfahren zur kontinuierlichen, keimreduzierten produktion und/oder aufbereitung eines produktes
EA201991293A1 (ru) * 2016-12-23 2020-01-22 Арла Фудс Амба Получение новых препаратов на основе бета-лактоглобулина и связанные с ними способы, варианты применения и продукты питания
US11958882B2 (en) * 2017-03-14 2024-04-16 Amgen Inc. Methods directed to crystalline biomolecules
JP7550058B2 (ja) 2018-06-27 2024-09-12 アーラ フーズ エイエムビーエイ 酸性βラクトグロブリン飲料調製物
IT202100004496A1 (it) 2021-02-25 2022-08-25 Univ Della Calabria Recupero di farmaci biologici o loro frammenti da soluzioni impure mediante cristallizzazione o precipitazione con membrane
CN116949036B (zh) * 2023-09-11 2023-12-15 成都斯马特科技有限公司 一种快速从腹水中提取核酸的试剂盒及提取方法

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR20030074693A (ko) * 2000-12-28 2003-09-19 알투스 바이올로직스 인코포레이티드 전항체 및 이의 단편의 결정과 이의 제조 및 사용 방법
US7741282B2 (en) * 2001-11-13 2010-06-22 Genentech, Inc. ApO2 ligand/TRAIL formulations
US7087719B2 (en) * 2002-11-19 2006-08-08 Gtc Biotherapeutics, Inc. Method for the crystallization of human serum albumin
RU2010130467A (ru) * 2007-12-21 2012-01-27 Дженентек, Инк. (Us) Кристаллизация анти-cd20-антител
CN101320006B (zh) * 2008-07-17 2010-12-01 西北工业大学 蛋白质结晶条件的筛选方法

Also Published As

Publication number Publication date
EP2846830A1 (en) 2015-03-18
IL235483A0 (en) 2014-12-31
JP2015517306A (ja) 2015-06-22
US20170198028A1 (en) 2017-07-13
US20150133642A1 (en) 2015-05-14
BR112014027994A2 (pt) 2017-06-27
CN104284676B (zh) 2018-11-27
AU2013258006A1 (en) 2014-11-06
CN104284676A (zh) 2015-01-14
KR20150016503A (ko) 2015-02-12
AU2013258006B2 (en) 2016-04-28
CA2872145A1 (en) 2013-11-14
RU2014150071A (ru) 2016-07-10
IN2014DN09097A (OSRAM) 2015-05-22
WO2013167720A1 (en) 2013-11-14
MX2014013754A (es) 2015-02-12

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