SG11201404677TA - Process of expanding t cells - Google Patents
Process of expanding t cellsInfo
- Publication number
- SG11201404677TA SG11201404677TA SG11201404677TA SG11201404677TA SG11201404677TA SG 11201404677T A SG11201404677T A SG 11201404677TA SG 11201404677T A SG11201404677T A SG 11201404677TA SG 11201404677T A SG11201404677T A SG 11201404677TA SG 11201404677T A SG11201404677T A SG 11201404677TA
- Authority
- SG
- Singapore
- Prior art keywords
- expanding
- cells
- Prior art date
Links
- 210000001744 T-lymphocyte Anatomy 0.000 title 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0634—Cells from the blood or the immune system
- C12N5/0636—T lymphocytes
- C12N5/0638—Cytotoxic T lymphocytes [CTL] or lymphokine activated killer cells [LAK]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
- A61K35/14—Blood; Artificial blood
- A61K35/15—Cells of the myeloid line, e.g. granulocytes, basophils, eosinophils, neutrophils, leucocytes, monocytes, macrophages or mast cells; Myeloid precursor cells; Antigen-presenting cells, e.g. dendritic cells
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
- A61K35/14—Blood; Artificial blood
- A61K35/17—Lymphocytes; B-cells; T-cells; Natural killer cells; Interferon-activated or cytokine-activated lymphocytes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/46—Cellular immunotherapy
- A61K39/461—Cellular immunotherapy characterised by the cell type used
- A61K39/4611—T-cells, e.g. tumor infiltrating lymphocytes [TIL], lymphokine-activated killer cells [LAK] or regulatory T cells [Treg]
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/46—Cellular immunotherapy
- A61K39/464—Cellular immunotherapy characterised by the antigen targeted or presented
- A61K39/464838—Viral antigens
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0634—Cells from the blood or the immune system
- C12N5/0636—T lymphocytes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
- A61K2035/124—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells the cells being hematopoietic, bone marrow derived or blood cells
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2239/00—Indexing codes associated with cellular immunotherapy of group A61K39/46
- A61K2239/46—Indexing codes associated with cellular immunotherapy of group A61K39/46 characterised by the cancer treated
- A61K2239/48—Blood cells, e.g. leukemia or lymphoma
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/20—Cytokines; Chemokines
- C12N2501/23—Interleukins [IL]
- C12N2501/2302—Interleukin-2 (IL-2)
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/20—Cytokines; Chemokines
- C12N2501/23—Interleukins [IL]
- C12N2501/2304—Interleukin-4 (IL-4)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/20—Cytokines; Chemokines
- C12N2501/23—Interleukins [IL]
- C12N2501/2307—Interleukin-7 (IL-7)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/20—Cytokines; Chemokines
- C12N2501/23—Interleukins [IL]
- C12N2501/2315—Interleukin-15 (IL-15)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/50—Cell markers; Cell surface determinants
- C12N2501/51—B7 molecules, e.g. CD80, CD86, CD28 (ligand), CD152 (ligand)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2502/00—Coculture with; Conditioned medium produced by
- C12N2502/11—Coculture with; Conditioned medium produced by blood or immune system cells
- C12N2502/1121—Dendritic cells
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2510/00—Genetically modified cells
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Immunology (AREA)
- Engineering & Computer Science (AREA)
- Chemical & Material Sciences (AREA)
- Biomedical Technology (AREA)
- General Health & Medical Sciences (AREA)
- Biotechnology (AREA)
- Zoology (AREA)
- Cell Biology (AREA)
- Organic Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Genetics & Genomics (AREA)
- Wood Science & Technology (AREA)
- Microbiology (AREA)
- Hematology (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Epidemiology (AREA)
- General Engineering & Computer Science (AREA)
- Biochemistry (AREA)
- Virology (AREA)
- Mycology (AREA)
- Developmental Biology & Embryology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201161569577P | 2011-12-12 | 2011-12-12 | |
PCT/GB2012/050896 WO2013088114A1 (en) | 2011-12-12 | 2012-04-23 | Process of expanding t cells |
Publications (1)
Publication Number | Publication Date |
---|---|
SG11201404677TA true SG11201404677TA (en) | 2014-11-27 |
Family
ID=46146968
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
SG11201404677TA SG11201404677TA (en) | 2011-12-12 | 2012-04-23 | Process of expanding t cells |
Country Status (9)
Country | Link |
---|---|
US (2) | US10351824B2 (ja) |
EP (1) | EP2791322A1 (ja) |
JP (3) | JP6081483B2 (ja) |
KR (1) | KR101749195B1 (ja) |
CN (3) | CN109182266A (ja) |
AU (1) | AU2012351347B2 (ja) |
BR (1) | BR112014014591A8 (ja) |
SG (1) | SG11201404677TA (ja) |
WO (1) | WO2013088114A1 (ja) |
Families Citing this family (51)
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EP2791322A1 (en) * | 2011-12-12 | 2014-10-22 | Cell Medica Limited | Process of expanding t cells |
GB201121308D0 (en) | 2011-12-12 | 2012-01-25 | Cell Medica Ltd | Process |
WO2013119947A1 (en) | 2012-02-09 | 2013-08-15 | Baylor College Of Medicine | Pepmixes to generate multiviral ctls with broad specificity |
IL302514A (en) * | 2012-06-11 | 2023-07-01 | Wilson Wolf Mfg Corporation | Improved cell culture methods for stress cell therapy |
EP3201321A1 (en) * | 2014-10-02 | 2017-08-09 | The U.S.A. As Represented By The Secretary, Department Of Health And Human Services | Methods of isolating t cells having antigenic specificity for a cancer-specific mutation |
AU2016215175B2 (en) * | 2015-02-06 | 2021-09-16 | Heat Biologics, Inc. | Vector co-expressing vaccine and costimulatory molecules |
AU2016235388B2 (en) * | 2015-03-20 | 2022-02-03 | Children's National Medical Center | Generating virus or other antigen-specific T cells from a naive T cell population |
CN104830793A (zh) * | 2015-05-05 | 2015-08-12 | 杨光华 | 基于lmp-1抗原的dc细胞、靶向性免疫细胞群及其制备方法和用途 |
CN108472314A (zh) | 2015-07-31 | 2018-08-31 | 明尼苏达大学董事会 | 修饰的细胞和治疗方法 |
IL258090B2 (en) | 2015-09-18 | 2023-04-01 | Baylor College Medicine | Immunogenic detection of antigen from a pathogen and adjustment of effective clinical treatment |
EP3360961B1 (en) * | 2015-10-08 | 2023-11-22 | National University Corporation Tokai National Higher Education and Research System | Method for preparing genetically-modified t cells which express chimeric antigen receptor |
JP7092662B2 (ja) | 2015-10-30 | 2022-06-28 | チルドレンズ ナショナル メディカル センター | ナイーブt細胞集団からのhpv抗原特異的t細胞の生成 |
ITUB20154769A1 (it) * | 2015-11-04 | 2017-05-04 | Centro Di Riferimento Oncologico Cro Irccs Aviano | Anticorpo monoclonale anti-BARF1 |
EP3922716A1 (en) * | 2016-03-17 | 2021-12-15 | Berkeley Lights, Inc. | Selection and cloning of t lymphocytes in a microfluidic device |
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EP3463398A4 (en) * | 2016-05-25 | 2020-03-11 | The Council of the Queensland Institute of Medical Research | IMMUNITY CHECKPOINT INHIBITORS AND CYTOTOXIC T CELLS FOR TREATING CANCER |
SG11201809534UA (en) * | 2016-05-25 | 2018-12-28 | Council Queensland Inst Medical Res | Methods of treating autoimmune disease using allogeneic t cells |
BR112018072305A2 (pt) | 2016-05-25 | 2019-02-12 | The Council Of The Queensland Institute Of Medical Research | métodos de imunoterapia |
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JP7002769B2 (ja) * | 2016-09-16 | 2022-02-04 | ベイラー カレッジ オブ メディスン | ウイルス特異的t細胞の活性化および拡大のためのプラットフォーム |
US9642906B2 (en) * | 2016-09-16 | 2017-05-09 | Baylor College Of Medicine | Generation of HPV-specific T-cells |
WO2018206794A1 (en) * | 2017-05-11 | 2018-11-15 | Servicio Andaluz De Salud | Diagnostic and therapeutic uses of an in vitro system of autologous lymphocytes culture |
JP7364237B2 (ja) * | 2017-08-10 | 2023-10-18 | グッド ティー セルズ、 インコーポレイテッド | 癌治療のためのt細胞の活性化方法 |
KR20210032924A (ko) | 2017-09-05 | 2021-03-25 | 토크 테라퓨틱스, 인코포레이티드 | 치료용 단백질 조성물 및 그의 제조 및 사용 방법 |
US20210238255A1 (en) | 2018-04-23 | 2021-08-05 | Baylor College Of Medicine | Chimeric hla accessory receptor |
JP2021526826A (ja) * | 2018-06-13 | 2021-10-11 | ザ カウンシル オブ ザ クイーンズランド インスティテュート オブ メディカル リサーチ | ウイルス検出アッセイ |
US20210290742A1 (en) * | 2018-09-27 | 2021-09-23 | Arizona Board Of Regents On Behalf Of The University Of Arizona | Methods of using lysine deacetylase (kdac) inhibition to generate antigen specific memory t cell responses for durable immunotherapy |
WO2020077200A1 (en) * | 2018-10-12 | 2020-04-16 | Georgia Tech Research Corporation | Methods and systems for dynamic predictive modeling and control of inflammation |
BR112021008963A2 (pt) | 2018-11-08 | 2021-09-14 | Neximmune, Inc. | Composições de célula t com propriedades fenotípicas melhoradas |
WO2020128908A2 (en) * | 2018-12-20 | 2020-06-25 | Medimmune, Llc | Methods for selection and expansion of t cells expressing pd-1 |
CN113597430A (zh) * | 2019-02-08 | 2021-11-02 | 古德T细胞有限公司 | 激活t细胞用于癌症治疗的方法 |
GB201911066D0 (en) | 2019-08-02 | 2019-09-18 | Achilles Therapeutics Ltd | T cell therapy |
CN110646619A (zh) * | 2019-09-25 | 2020-01-03 | 格源致善(上海)生物科技有限公司 | 检测肺癌或肠癌中特异性t细胞分泌的细胞因子的方法 |
JP7340144B2 (ja) * | 2019-10-02 | 2023-09-07 | アメリカ合衆国 | がん特異的突然変異に対し抗原特異性を有するt細胞を単離する方法 |
JP6878544B2 (ja) * | 2019-10-02 | 2021-05-26 | アメリカ合衆国 | がん特異的突然変異に対し抗原特異性を有するt細胞を単離する方法 |
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CN111856020B (zh) * | 2020-06-19 | 2022-09-27 | 南方医科大学南方医院 | 乙型肝炎病毒(hbv)特异性t细胞检测方法及其应用 |
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GB202109886D0 (en) | 2021-07-08 | 2021-08-25 | Achilles Therapeutics Uk Ltd | Assay |
CA3218235A1 (en) | 2021-04-27 | 2022-11-03 | Baylor College Of Medicine | Virus-specific immune cells expressing chimeric antigen receptors |
CN117580946A (zh) | 2021-06-22 | 2024-02-20 | 阿基里斯治疗英国有限公司 | 用于产生抗原特异性t细胞的方法 |
WO2023094993A1 (en) * | 2021-11-23 | 2023-06-01 | Baylor College Of Medicine | Improved virus-specific t cell |
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-
2012
- 2012-04-23 EP EP12722476.4A patent/EP2791322A1/en not_active Ceased
- 2012-04-23 AU AU2012351347A patent/AU2012351347B2/en active Active
- 2012-04-23 KR KR1020147019227A patent/KR101749195B1/ko active IP Right Review Request
- 2012-04-23 JP JP2014546625A patent/JP6081483B2/ja not_active Ceased
- 2012-04-23 US US14/364,592 patent/US10351824B2/en active Active
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- 2012-04-23 BR BR112014014591A patent/BR112014014591A8/pt not_active Application Discontinuation
- 2012-04-23 CN CN201811136709.9A patent/CN109182266A/zh active Pending
- 2012-04-23 SG SG11201404677TA patent/SG11201404677TA/en unknown
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CN104769104A (zh) | 2015-07-08 |
AU2012351347A1 (en) | 2014-08-07 |
KR101749195B1 (ko) | 2017-06-20 |
WO2013088114A1 (en) | 2013-06-20 |
US11155784B2 (en) | 2021-10-26 |
JP6081483B2 (ja) | 2017-02-15 |
BR112014014591A8 (pt) | 2017-07-04 |
US20190270966A1 (en) | 2019-09-05 |
JP2017038621A (ja) | 2017-02-23 |
CN109182266A (zh) | 2019-01-11 |
KR20140123489A (ko) | 2014-10-22 |
JP2015501651A (ja) | 2015-01-19 |
AU2012351347B2 (en) | 2016-05-19 |
US20150017723A1 (en) | 2015-01-15 |
EP2791322A1 (en) | 2014-10-22 |
US10351824B2 (en) | 2019-07-16 |
JP2020054348A (ja) | 2020-04-09 |
CN110241080A (zh) | 2019-09-17 |
BR112014014591A2 (pt) | 2017-06-13 |
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