SG10202103618XA - Binding molecules directed against influenza hemagglutinin and uses thereof - Google Patents
Binding molecules directed against influenza hemagglutinin and uses thereofInfo
- Publication number
- SG10202103618XA SG10202103618XA SG10202103618XA SG10202103618XA SG10202103618XA SG 10202103618X A SG10202103618X A SG 10202103618XA SG 10202103618X A SG10202103618X A SG 10202103618XA SG 10202103618X A SG10202103618X A SG 10202103618XA SG 10202103618X A SG10202103618X A SG 10202103618XA
- Authority
- SG
- Singapore
- Prior art keywords
- directed against
- binding molecules
- influenza hemagglutinin
- against influenza
- molecules directed
- Prior art date
Links
- 101710154606 Hemagglutinin Proteins 0.000 title 1
- 101710093908 Outer capsid protein VP4 Proteins 0.000 title 1
- 101710135467 Outer capsid protein sigma-1 Proteins 0.000 title 1
- 101710176177 Protein A56 Proteins 0.000 title 1
- 239000000185 hemagglutinin Substances 0.000 title 1
- 206010022000 influenza Diseases 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/08—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/12—Viral antigens
- A61K39/145—Orthomyxoviridae, e.g. influenza virus
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/16—Antivirals for RNA viruses for influenza or rhinoviruses
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/08—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from viruses
- C07K16/10—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from viruses from RNA viruses
- C07K16/1018—Orthomyxoviridae, e.g. influenza virus
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/569—Immunoassay; Biospecific binding assay; Materials therefor for microorganisms, e.g. protozoa, bacteria, viruses
- G01N33/56983—Viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/54—Medicinal preparations containing antigens or antibodies characterised by the route of administration
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/54—Medicinal preparations containing antigens or antibodies characterised by the route of administration
- A61K2039/541—Mucosal route
- A61K2039/543—Mucosal route intranasal
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/545—Medicinal preparations containing antigens or antibodies characterised by the dose, timing or administration schedule
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/22—Immunoglobulins specific features characterized by taxonomic origin from camelids, e.g. camel, llama or dromedary
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/31—Immunoglobulins specific features characterized by aspects of specificity or valency multispecific
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/33—Crossreactivity, e.g. for species or epitope, or lack of said crossreactivity
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/52—Constant or Fc region; Isotype
- C07K2317/526—CH3 domain
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
- C07K2317/569—Single domain, e.g. dAb, sdAb, VHH, VNAR or nanobody®
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
- C07K2317/62—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
- C07K2317/64—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising a combination of variable region and constant region components
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
- C07K2317/732—Antibody-dependent cellular cytotoxicity [ADCC]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
- G01N2333/005—Assays involving biological materials from specific organisms or of a specific nature from viruses
- G01N2333/08—RNA viruses
- G01N2333/11—Orthomyxoviridae, e.g. influenza virus
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2800/00—Detection or diagnosis of diseases
- G01N2800/26—Infectious diseases, e.g. generalised sepsis
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Virology (AREA)
- Organic Chemistry (AREA)
- Immunology (AREA)
- Molecular Biology (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Pulmonology (AREA)
- Communicable Diseases (AREA)
- Engineering & Computer Science (AREA)
- Urology & Nephrology (AREA)
- Hematology (AREA)
- Biomedical Technology (AREA)
- Microbiology (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Analytical Chemistry (AREA)
- Physics & Mathematics (AREA)
- Biotechnology (AREA)
- Cell Biology (AREA)
- Pathology (AREA)
- General Physics & Mathematics (AREA)
- Tropical Medicine & Parasitology (AREA)
- Food Science & Technology (AREA)
- Oncology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Mycology (AREA)
- Epidemiology (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP15153957 | 2015-02-05 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| SG10202103618XA true SG10202103618XA (en) | 2021-05-28 |
Family
ID=52484335
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SG10202103618XA SG10202103618XA (en) | 2015-02-05 | 2016-02-05 | Binding molecules directed against influenza hemagglutinin and uses thereof |
| SG11201705614QA SG11201705614QA (en) | 2015-02-05 | 2016-02-05 | Binding molecules directed against influenza hemagglutinin and uses thereof |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SG11201705614QA SG11201705614QA (en) | 2015-02-05 | 2016-02-05 | Binding molecules directed against influenza hemagglutinin and uses thereof |
Country Status (17)
| Country | Link |
|---|---|
| US (3) | US10370435B2 (fr) |
| EP (1) | EP3253411A1 (fr) |
| JP (2) | JP6772157B2 (fr) |
| KR (1) | KR20170107562A (fr) |
| CN (1) | CN107207611B (fr) |
| AU (1) | AU2016214304B2 (fr) |
| BR (1) | BR112017016417A2 (fr) |
| CA (1) | CA2975655C (fr) |
| EA (1) | EA038407B1 (fr) |
| HK (1) | HK1243925A1 (fr) |
| IL (1) | IL253653B (fr) |
| MX (1) | MX2017010009A (fr) |
| MY (1) | MY186585A (fr) |
| PH (1) | PH12017501216A1 (fr) |
| SG (2) | SG10202103618XA (fr) |
| WO (1) | WO2016124768A1 (fr) |
| ZA (1) | ZA201705300B (fr) |
Families Citing this family (24)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US10053513B2 (en) | 2009-11-30 | 2018-08-21 | Janssen Biotech, Inc. | Antibody Fc mutants with ablated effector functions |
| WO2016124768A1 (fr) * | 2015-02-05 | 2016-08-11 | Janssen Vaccines & Prevention B.V. | Molécules de liaison dirigées contre l'hémagglutinine de la grippe et leurs utilisations |
| AU2016275909A1 (en) | 2015-05-13 | 2017-11-09 | The Trustees Of The University Of Pennsylvania | AAV-mediated expression of anti-influenza antibodies and methods of use thereof |
| KR20190080992A (ko) | 2015-05-21 | 2019-07-08 | 하푼 테라퓨틱스, 인크. | 삼중특이성 결합 단백질 및 사용 방법 |
| US11623958B2 (en) | 2016-05-20 | 2023-04-11 | Harpoon Therapeutics, Inc. | Single chain variable fragment CD3 binding proteins |
| EP3493844A4 (fr) | 2016-05-20 | 2021-03-24 | Harpoon Therapeutics Inc. | Protéine de liaison à l'albumine sérique à domaine unique |
| CN110234337A (zh) * | 2016-10-27 | 2019-09-13 | 扬森疫苗与预防公司 | 中和流感病毒的化合物 |
| EP3544629A4 (fr) | 2016-11-23 | 2020-06-17 | Harpoon Therapeutics, Inc. | Protéines trispécifiques ciblang le psma et procédés d'utilisation |
| CN110198955A (zh) | 2016-11-23 | 2019-09-03 | 哈普恩治疗公司 | 前列腺特异性膜抗原结合蛋白质 |
| CN106822887A (zh) * | 2017-01-26 | 2017-06-13 | 中国科学院微生物研究所 | 一种流感病毒四价亚单位疫苗及其应用 |
| US11535668B2 (en) | 2017-02-28 | 2022-12-27 | Harpoon Therapeutics, Inc. | Inducible monovalent antigen binding protein |
| JP2020510430A (ja) | 2017-02-28 | 2020-04-09 | ザ・トラステイーズ・オブ・ザ・ユニバーシテイ・オブ・ペンシルベニア | Ａａｖベクターに基づくインフルエンザワクチン |
| SI3589730T1 (sl) | 2017-02-28 | 2024-04-30 | The Trustees Of The University Of Pennsylvania | Adeno-povezan virus (AAV) clade F vektor in njihova uporaba |
| JOP20190200A1 (ar) | 2017-02-28 | 2019-08-27 | Univ Pennsylvania | تركيبات نافعة في معالجة ضمور العضل النخاعي |
| US10730954B2 (en) | 2017-05-12 | 2020-08-04 | Harpoon Therapeutics, Inc. | MSLN targeting trispecific proteins and methods of use |
| SG10202107880XA (en) | 2017-05-12 | 2021-09-29 | Harpoon Therapeutics Inc | Mesothelin binding proteins |
| US10927180B2 (en) | 2017-10-13 | 2021-02-23 | Harpoon Therapeutics, Inc. | B cell maturation antigen binding proteins |
| CR20200196A (es) | 2017-10-13 | 2020-06-05 | Harpoon Therapeutics Inc | Proteínas trispecìficas y mètodos de uso |
| WO2020061482A1 (fr) * | 2018-09-21 | 2020-03-26 | Harpoon Therapeutics, Inc. | Protéines de liaison egfr et méthodes d'utilisation |
| KR20210086623A (ko) | 2018-09-25 | 2021-07-08 | 하푼 테라퓨틱스, 인크. | Ddl3 결합 단백질 및 사용 방법 |
| IL295448A (en) | 2020-02-21 | 2022-10-01 | Harpoon Therapeutics Inc | flt3 binding proteins and methods of use |
| KR20230135569A (ko) * | 2020-11-23 | 2023-09-25 | 비르 바이오테크놀로지, 인코포레이티드 | 인플루엔자 a 바이러스에 대한 항체 |
| EP4314076A1 (fr) * | 2021-03-31 | 2024-02-07 | Kisoji Biotechnology Inc. | Agents de liaison ciblant des cellules tumorales et/ou immunitaires |
| WO2024073435A2 (fr) * | 2022-09-27 | 2024-04-04 | Anwita Biosciences, Inc. | Protéines de fusion anti-lag-3/il-2, polynucléotides codants, compositions pharmaceutiques et applications thérapeutiques |
Family Cites Families (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| NZ207394A (en) | 1983-03-08 | 1987-03-06 | Commw Serum Lab Commission | Detecting or determining sequence of amino acids |
| NL9101953A (nl) | 1991-11-21 | 1993-06-16 | Seed Capital Investments | Testinrichting omvattende een plaat met een veelvoud van putjes met een bijbehorende doseerinrichting, alsmede een kit die deze inrichtingen omvat en toepassing van de inrichtingen. |
| EP1533380B1 (fr) | 1999-04-15 | 2009-11-04 | Crucell Holland B.V. | Production de protéine de recombinaison dans une cellule humaine comprenant au moins une protéine E1 d'adénovirus |
| GB0522460D0 (en) | 2005-11-03 | 2005-12-14 | Prendergast Patrick T | Composition and method for the treatment of avian influenza |
| US8192927B2 (en) | 2006-09-07 | 2012-06-05 | Crucell Holland B.V. | Human bind molecules capable of neutralizing influenza virus h5n1 and uses thereof |
| AU2009228058A1 (en) * | 2008-03-28 | 2009-10-01 | Sea Lane Biotechnologies, Llc | Neutralizing molecules to viral antigens |
| US9193780B2 (en) * | 2008-06-05 | 2015-11-24 | Ablynx N.V. | Amino acid sequences directed against envelope proteins of a virus and polypeptides comprising the same for the treatment of viral diseases |
| US8871207B2 (en) | 2008-07-25 | 2014-10-28 | Humabs, LLC | Neutralizing anti-influenza A virus antibodies and uses thereof |
| WO2010037046A1 (fr) * | 2008-09-28 | 2010-04-01 | Fraunhofer Usa, Inc. | Anticorps anti-neuraminidase humanisé et procédés d’utilisation de celui-ci |
| US8563305B2 (en) | 2009-04-30 | 2013-10-22 | Oklahoma Medical Research Foundation | Rapid generation of antibodies |
| CN102276719B (zh) * | 2010-06-09 | 2014-12-24 | 中国科学院生物物理研究所 | 禽流感病毒单域抗体、五聚抗体及其制备和应用 |
| CN102023212B (zh) | 2010-09-28 | 2014-04-02 | 汕头大学医学院 | 一种流感病毒神经氨酸酶抗体的快速检测方法 |
| ES2608321T3 (es) * | 2011-07-14 | 2017-04-07 | Janssen Vaccines & Prevention B.V. | Moléculas de unión humanas capaces de neutralizar virus de la gripe A del grupo filogenético 1 y del grupo filogenético 2 y virus de la gripe B |
| PL2734545T3 (pl) * | 2011-07-18 | 2019-09-30 | Institute For Research In Biomedicine | Neutralizujące przeciwciała przeciwko wirusowi grypy A i ich zastosowania |
| GB201115214D0 (en) | 2011-09-02 | 2011-10-19 | Health Prot Agency | Influenza virus antibody compositions |
| DK2822968T3 (en) | 2012-03-08 | 2018-04-16 | Janssen Vaccines & Prevention Bv | HUMAN BINDING MOLECULES ABLE TO BIND AND NEUTRALIZE INFLUENZA-B-VIRA, AND APPLICATIONS THEREOF |
| US9969794B2 (en) | 2012-05-10 | 2018-05-15 | Visterra, Inc. | HA binding agents |
| CN104507500A (zh) | 2012-05-10 | 2015-04-08 | 麻省理工学院 | 流感中和药剂 |
| CN104098692B (zh) * | 2013-04-02 | 2018-11-30 | 厦门大学 | 识别流感病毒血凝素蛋白ha1结构域的广谱单克隆抗体 |
| WO2016124768A1 (fr) * | 2015-02-05 | 2016-08-11 | Janssen Vaccines & Prevention B.V. | Molécules de liaison dirigées contre l'hémagglutinine de la grippe et leurs utilisations |
-
2016
- 2016-02-05 WO PCT/EP2016/052556 patent/WO2016124768A1/fr active Application Filing
- 2016-02-05 EP EP16703151.7A patent/EP3253411A1/fr not_active Ceased
- 2016-02-05 CA CA2975655A patent/CA2975655C/fr active Active
- 2016-02-05 US US15/548,843 patent/US10370435B2/en active Active
- 2016-02-05 BR BR112017016417-5A patent/BR112017016417A2/pt active Search and Examination
- 2016-02-05 SG SG10202103618XA patent/SG10202103618XA/en unknown
- 2016-02-05 AU AU2016214304A patent/AU2016214304B2/en active Active
- 2016-02-05 MY MYPI2017702861A patent/MY186585A/en unknown
- 2016-02-05 CN CN201680008842.9A patent/CN107207611B/zh active Active
- 2016-02-05 EA EA201791735A patent/EA038407B1/ru unknown
- 2016-02-05 SG SG11201705614QA patent/SG11201705614QA/en unknown
- 2016-02-05 KR KR1020177024174A patent/KR20170107562A/ko not_active Application Discontinuation
- 2016-02-05 JP JP2017541117A patent/JP6772157B2/ja active Active
- 2016-02-05 MX MX2017010009A patent/MX2017010009A/es unknown
-
2017
- 2017-06-29 PH PH12017501216A patent/PH12017501216A1/en unknown
- 2017-07-25 IL IL253653A patent/IL253653B/en unknown
- 2017-08-04 ZA ZA2017/05300A patent/ZA201705300B/en unknown
-
2018
- 2018-03-12 HK HK18103393.7A patent/HK1243925A1/zh unknown
-
2019
- 2019-06-27 US US16/455,151 patent/US10703804B2/en active Active
-
2020
- 2020-06-05 JP JP2020098605A patent/JP2020171288A/ja active Pending
- 2020-06-05 US US16/946,092 patent/US11136379B2/en active Active
Also Published As
| Publication number | Publication date |
|---|---|
| CA2975655A1 (fr) | 2016-08-11 |
| CA2975655C (fr) | 2023-09-19 |
| PH12017501216A1 (en) | 2018-01-15 |
| JP6772157B2 (ja) | 2020-10-21 |
| JP2020171288A (ja) | 2020-10-22 |
| AU2016214304A1 (en) | 2017-07-20 |
| HK1243925A1 (zh) | 2018-07-27 |
| US20180016323A1 (en) | 2018-01-18 |
| JP2018505677A (ja) | 2018-03-01 |
| KR20170107562A (ko) | 2017-09-25 |
| EA201791735A1 (ru) | 2017-11-30 |
| US20200299364A1 (en) | 2020-09-24 |
| MX2017010009A (es) | 2017-10-24 |
| EP3253411A1 (fr) | 2017-12-13 |
| US10703804B2 (en) | 2020-07-07 |
| CN107207611A (zh) | 2017-09-26 |
| BR112017016417A2 (pt) | 2018-03-27 |
| WO2016124768A1 (fr) | 2016-08-11 |
| IL253653A0 (en) | 2017-09-28 |
| IL253653B (en) | 2021-10-31 |
| US11136379B2 (en) | 2021-10-05 |
| AU2016214304B2 (en) | 2021-11-11 |
| EA038407B1 (ru) | 2021-08-24 |
| ZA201705300B (en) | 2021-05-26 |
| MY186585A (en) | 2021-07-28 |
| SG11201705614QA (en) | 2017-08-30 |
| US20190359693A1 (en) | 2019-11-28 |
| CN107207611B (zh) | 2021-11-09 |
| US10370435B2 (en) | 2019-08-06 |
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