SG10202011469UA - Methods for treating conditions associated with masp-2 dependent complement activation - Google Patents

Methods for treating conditions associated with masp-2 dependent complement activation

Info

Publication number
SG10202011469UA
SG10202011469UA SG10202011469UA SG10202011469UA SG10202011469UA SG 10202011469U A SG10202011469U A SG 10202011469UA SG 10202011469U A SG10202011469U A SG 10202011469UA SG 10202011469U A SG10202011469U A SG 10202011469UA SG 10202011469U A SG10202011469U A SG 10202011469UA
Authority
SG
Singapore
Prior art keywords
masp
methods
conditions associated
complement activation
treating conditions
Prior art date
Application number
SG10202011469UA
Other languages
English (en)
Inventor
Gregory Demopulos
Thomas Dudler
Hans-Wilhelm Schwaeble
Original Assignee
Omeros Corp
Univ Leicester
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Omeros Corp, Univ Leicester filed Critical Omeros Corp
Publication of SG10202011469UA publication Critical patent/SG10202011469UA/en

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    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K16/00Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/40Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against enzymes
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K39/395Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00Drugs for disorders of the urinary system
    • A61P13/12Drugs for disorders of the urinary system of the kidneys
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • A61P37/02Immunomodulators
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00Drugs for disorders of the blood or the extracellular fluid
    • A61P7/06Antianaemics
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12YENZYMES
    • C12Y304/00Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
    • C12Y304/21Serine endopeptidases (3.4.21)
    • C12Y304/21104Mannan-binding lectin-associated serine protease-2 (3.4.21.104)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K2039/505Medicinal preparations containing antigens or antibodies comprising antibodies
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/20Immunoglobulins specific features characterized by taxonomic origin
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/20Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/21Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/30Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/33Crossreactivity, e.g. for species or epitope, or lack of said crossreactivity
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/50Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/55Fab or Fab'
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/50Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565Complementarity determining region [CDR]
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/60Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
    • C07K2317/62Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
    • C07K2317/622Single chain antibody (scFv)
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/70Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76Antagonist effect on antigen, e.g. neutralization or inhibition of binding
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/90Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • General Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Mycology (AREA)
  • Microbiology (AREA)
  • Epidemiology (AREA)
  • Urology & Nephrology (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Power Steering Mechanism (AREA)
  • Exhaust Gas After Treatment (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
SG10202011469UA 2015-11-09 2016-11-09 Methods for treating conditions associated with masp-2 dependent complement activation SG10202011469UA (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201562252814P 2015-11-09 2015-11-09
US201662406726P 2016-10-11 2016-10-11

Publications (1)

Publication Number Publication Date
SG10202011469UA true SG10202011469UA (en) 2020-12-30

Family

ID=58691444

Family Applications (2)

Application Number Title Priority Date Filing Date
SG10202011469UA SG10202011469UA (en) 2015-11-09 2016-11-09 Methods for treating conditions associated with masp-2 dependent complement activation
SG11201803834UA SG11201803834UA (en) 2015-11-09 2016-11-09 Methods for treating conditions associated with masp-2 dependent complement activation

Family Applications After (1)

Application Number Title Priority Date Filing Date
SG11201803834UA SG11201803834UA (en) 2015-11-09 2016-11-09 Methods for treating conditions associated with masp-2 dependent complement activation

Country Status (20)

Country Link
US (2) US20170137537A1 (fr)
EP (1) EP3373963A4 (fr)
JP (2) JP6814802B2 (fr)
KR (2) KR102432062B1 (fr)
CN (2) CN108472347B (fr)
AU (2) AU2016354117B2 (fr)
BR (1) BR112018009311A8 (fr)
CA (1) CA3004753C (fr)
CL (1) CL2018001258A1 (fr)
EA (1) EA201891132A1 (fr)
GE (2) GEP20247583B (fr)
IL (2) IL259225B (fr)
MD (1) MD4685C1 (fr)
MX (2) MX2018005165A (fr)
MY (1) MY197758A (fr)
NZ (1) NZ742987A (fr)
PH (1) PH12018501009A1 (fr)
SG (2) SG10202011469UA (fr)
UA (1) UA124094C2 (fr)
WO (1) WO2017083371A1 (fr)

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NZ709997A (en) 2011-04-08 2016-03-31 Univ Leicester Methods for treating conditions associated with masp-2 dependent complement activation
ES2829913T3 (es) 2013-10-17 2021-06-02 Omeros Corp Procedimientos de tratamiento de afecciones asociadas con la activación del complemento dependiente de MASP-2
AU2017293767B2 (en) * 2016-07-06 2021-12-16 Microoptx Inc. Glaucoma treatment devices and methods
JOP20170170B1 (ar) 2016-08-31 2022-09-15 Omeros Corp صيغ لجسم مضاد تثبيطية لـ masp-2 بتركيز عالي ولزوجة منخفضة وأطقم، وطرق
TWI818919B (zh) * 2017-08-15 2023-10-21 美商歐米諾斯公司 用於治療和/ 或預防與造血幹細胞移植有關的移植物抗宿主病和/ 或瀰漫性肺泡出血和/ 或靜脈閉塞性病的方法
BR112020003632A2 (pt) * 2017-08-25 2020-10-27 Omeros Corporation método de tratamento de um indivíduo que sofre ou corre risco de desenvolver ahus
EP3836965A4 (fr) * 2018-06-22 2022-04-20 Omeros Corporation Compositions et procédés d'inhibition de masp-2 pour le traitement de divers troubles et maladies thrombotiques
CA3159159A1 (fr) 2019-12-04 2021-06-10 Neil S. Cutshall Inhibiteurs de masp-2 et procedes d'utilisation
IL293551A (en) 2019-12-04 2022-08-01 Omeros Corp 2-masp inhibitor compounds, preparations containing them and their uses
AU2020398241A1 (en) 2019-12-04 2022-06-30 Omeros Corporation MASP-2 inhibitors and methods of use
EP4069238A1 (fr) 2019-12-04 2022-10-12 Omeros Corporation Inhibiteurs de masp-2 et procédés d'utilisation

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Also Published As

Publication number Publication date
UA124094C2 (uk) 2021-07-21
JP6814802B2 (ja) 2021-01-20
PH12018501009A1 (en) 2019-01-28
BR112018009311A2 (pt) 2018-11-06
KR102432062B1 (ko) 2022-08-12
CL2018001258A1 (es) 2018-10-12
MD4685B1 (ro) 2020-03-31
WO2017083371A1 (fr) 2017-05-18
EP3373963A4 (fr) 2019-07-10
CA3004753C (fr) 2023-02-28
AU2016354117A1 (en) 2018-05-10
EA201891132A1 (ru) 2018-10-31
AU2020201500A1 (en) 2020-03-19
GEP20247583B (en) 2024-01-10
CN108472347A (zh) 2018-08-31
CA3004753A1 (fr) 2017-05-18
KR102277166B1 (ko) 2021-07-15
IL259225A (en) 2018-07-31
KR20210090283A (ko) 2021-07-19
US20170137537A1 (en) 2017-05-18
EP3373963A1 (fr) 2018-09-19
MX2018005165A (es) 2020-11-11
JP2018533592A (ja) 2018-11-15
IL295200A (en) 2022-10-01
AU2016354117B2 (en) 2019-11-28
JP2021063093A (ja) 2021-04-22
MD4685C1 (ro) 2020-12-31
MY197758A (en) 2023-07-13
CN117398458A (zh) 2024-01-16
US11981749B2 (en) 2024-05-14
GEP20237574B (en) 2023-12-25
MD20180042A2 (ro) 2018-09-30
MX2023001193A (es) 2023-08-11
IL259225B (en) 2022-09-01
BR112018009311A8 (pt) 2019-02-26
KR20180074789A (ko) 2018-07-03
NZ742987A (en) 2019-12-20
US20210047433A1 (en) 2021-02-18
CN108472347B (zh) 2023-09-05
SG11201803834UA (en) 2018-06-28

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