MD4685B1 - Metodă de tratament al stărilor asociate cu activarea complementului dependentă de MASP-2 - Google Patents

Metodă de tratament al stărilor asociate cu activarea complementului dependentă de MASP-2 Download PDF

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Publication number
MD4685B1
MD4685B1 MDA20180042A MD20180042A MD4685B1 MD 4685 B1 MD4685 B1 MD 4685B1 MD A20180042 A MDA20180042 A MD A20180042A MD 20180042 A MD20180042 A MD 20180042A MD 4685 B1 MD4685 B1 MD 4685B1
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MD
Moldova
Prior art keywords
masp
complement activation
treatment
conditions associated
activation dependent
Prior art date
Application number
MDA20180042A
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English (en)
Russian (ru)
Other versions
MD4685C1 (ro
MD20180042A2 (ro
Inventor
Грегори А. ДЕМОПУЛОС
Томас Дадлер
Ганс-Вильгельм ШВАБЛЕ
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Omeros Corporation
University Of Leicester
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Application filed by Omeros Corporation, University Of Leicester filed Critical Omeros Corporation
Publication of MD20180042A2 publication Critical patent/MD20180042A2/ro
Publication of MD4685B1 publication Critical patent/MD4685B1/ro
Publication of MD4685C1 publication Critical patent/MD4685C1/ro

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/06—Antianaemics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/40—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against enzymes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y304/00—Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
    • C12Y304/21—Serine endopeptidases (3.4.21)
    • C12Y304/21104—Mannan-binding lectin-associated serine protease-2 (3.4.21.104)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/33—Crossreactivity, e.g. for species or epitope, or lack of said crossreactivity
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/55—Fab or Fab'
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565—Complementarity determining region [CDR]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
    • C07K2317/62—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
    • C07K2317/622—Single chain antibody (scFv)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biochemistry (AREA)
  • Genetics & Genomics (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • General Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Mycology (AREA)
  • Microbiology (AREA)
  • Epidemiology (AREA)
  • Urology & Nephrology (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Power Steering Mechanism (AREA)
  • Exhaust Gas After Treatment (AREA)

Abstract

Invenţia se referă la metode de inhibare a efectelor activării complementului dependente de MASP-2 la un subiect uman, care suferă de microangiopatie trombotică (TMA) asociată cu transplantul de celule stem hematopoietice. Metodele includ etapa de administrare la subiectul, care are nevoie de aceasta, a unei cantităţi de agent inhibitor al MASP-2, care inhibă eficient activarea complementului dependentă de MASP-2.Secvenţe: 71
MDA20180042A 2015-11-09 2016-11-09 Metodă de tratament al stărilor asociate cu activarea complementului dependentă de MASP-2 MD4685C1 (ro)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201562252814P 2015-11-09 2015-11-09
US201662406726P 2016-10-11 2016-10-11
PCT/US2016/061113 WO2017083371A1 (en) 2015-11-09 2016-11-09 Methods for treating conditions associated with masp-2 dependent complement activation

Publications (3)

Publication Number Publication Date
MD20180042A2 MD20180042A2 (ro) 2018-09-30
MD4685B1 true MD4685B1 (ro) 2020-03-31
MD4685C1 MD4685C1 (ro) 2020-12-31

Family

ID=58691444

Family Applications (1)

Application Number Title Priority Date Filing Date
MDA20180042A MD4685C1 (ro) 2015-11-09 2016-11-09 Metodă de tratament al stărilor asociate cu activarea complementului dependentă de MASP-2

Country Status (19)

Country Link
US (3) US20170137537A1 (ro)
EP (1) EP3373963A4 (ro)
JP (2) JP6814802B2 (ro)
KR (2) KR102277166B1 (ro)
CN (2) CN117398458A (ro)
AU (2) AU2016354117B2 (ro)
CA (1) CA3004753C (ro)
CL (1) CL2018001258A1 (ro)
EA (1) EA201891132A1 (ro)
GE (3) GEP20237574B (ro)
IL (2) IL295200B2 (ro)
MD (1) MD4685C1 (ro)
MX (2) MX2018005165A (ro)
MY (1) MY197758A (ro)
NZ (1) NZ742987A (ro)
PH (1) PH12018501009A1 (ro)
SG (2) SG11201803834UA (ro)
UA (1) UA124094C2 (ro)
WO (1) WO2017083371A1 (ro)

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RS61351B1 (sr) 2013-10-17 2021-02-26 Omeros Corp Postupci za lečenje stanja udruženih sa aktivacijom komplementa zavisnom od masp-2
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WO2025153000A1 (zh) * 2024-01-17 2025-07-24 信立泰(成都)生物技术有限公司 一种抗masp2抗体或其抗原结合片段及用途

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Also Published As

Publication number Publication date
CN108472347B (zh) 2023-09-05
US20170137537A1 (en) 2017-05-18
UA124094C2 (uk) 2021-07-21
JP7629300B2 (ja) 2025-02-13
KR20210090283A (ko) 2021-07-19
MD4685C1 (ro) 2020-12-31
GEP20237574B (en) 2023-12-25
SG11201803834UA (en) 2018-06-28
EP3373963A4 (en) 2019-07-10
IL295200A (en) 2022-10-01
KR20180074789A (ko) 2018-07-03
EA201891132A1 (ru) 2018-10-31
MD20180042A2 (ro) 2018-09-30
CA3004753C (en) 2023-02-28
WO2017083371A1 (en) 2017-05-18
SG10202011469UA (en) 2020-12-30
JP2018533592A (ja) 2018-11-15
CA3004753A1 (en) 2017-05-18
US11981749B2 (en) 2024-05-14
JP2021063093A (ja) 2021-04-22
AU2016354117B2 (en) 2019-11-28
IL259225B (en) 2022-09-01
AU2020201500A1 (en) 2020-03-19
NZ742987A (en) 2019-12-20
AU2016354117A1 (en) 2018-05-10
MY197758A (en) 2023-07-13
GEAP202314803A (en) 2023-06-26
CN108472347A (zh) 2018-08-31
EP3373963A1 (en) 2018-09-19
BR112018009311A2 (pt) 2018-11-06
IL295200B1 (en) 2024-12-01
MX2023001193A (es) 2023-08-11
MX2018005165A (es) 2020-11-11
GEP20247583B (en) 2024-01-10
CN117398458A (zh) 2024-01-16
US20210047433A1 (en) 2021-02-18
PH12018501009A1 (en) 2019-01-28
KR102432062B1 (ko) 2022-08-12
CL2018001258A1 (es) 2018-10-12
KR102277166B1 (ko) 2021-07-15
IL259225A (en) 2018-07-31
US20240343830A1 (en) 2024-10-17
BR112018009311A8 (pt) 2019-02-26
IL295200B2 (en) 2025-04-01
JP6814802B2 (ja) 2021-01-20

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