MD4685B1 - Metodă de tratament al stărilor asociate cu activarea complementului dependentă de MASP-2 - Google Patents

Metodă de tratament al stărilor asociate cu activarea complementului dependentă de MASP-2

Info

Publication number
MD4685B1
MD4685B1 MDA20180042A MD20180042A MD4685B1 MD 4685 B1 MD4685 B1 MD 4685B1 MD A20180042 A MDA20180042 A MD A20180042A MD 20180042 A MD20180042 A MD 20180042A MD 4685 B1 MD4685 B1 MD 4685B1
Authority
MD
Moldova
Prior art keywords
masp
complement activation
methods
dependent complement
conditions associated
Prior art date
Application number
MDA20180042A
Other languages
English (en)
Russian (ru)
Other versions
MD20180042A2 (ro
MD4685C1 (ro
Inventor
Грегори А. ДЕМОПУЛОС
Томас Дадлер
Ганс-Вильгельм ШВАБЛЕ
Original Assignee
Omeros Corporation
University Of Leicester
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Omeros Corporation, University Of Leicester filed Critical Omeros Corporation
Publication of MD20180042A2 publication Critical patent/MD20180042A2/ro
Publication of MD4685B1 publication Critical patent/MD4685B1/ro
Publication of MD4685C1 publication Critical patent/MD4685C1/ro

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/06—Antianaemics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/40—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against enzymes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y304/00—Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
    • C12Y304/21—Serine endopeptidases (3.4.21)
    • C12Y304/21104—Mannan-binding lectin-associated serine protease-2 (3.4.21.104)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/33—Crossreactivity, e.g. for species or epitope, or lack of said crossreactivity
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/55—Fab or Fab'
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565—Complementarity determining region [CDR]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
    • C07K2317/62—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
    • C07K2317/622—Single chain antibody (scFv)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • General Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Epidemiology (AREA)
  • Urology & Nephrology (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Power Steering Mechanism (AREA)
  • Exhaust Gas After Treatment (AREA)

Abstract

Invenţia se referă la metode de inhibare a efectelor activării complementului dependente de MASP-2 la un subiect uman, care suferă de microangiopatie trombotică (TMA) asociată cu transplantul de celule stem hematopoietice. Metodele includ etapa de administrare la subiectul, care are nevoie de aceasta, a unei cantităţi de agent inhibitor al MASP-2, care inhibă eficient activarea complementului dependentă de MASP-2.Secvenţe: 71
MDA20180042A 2015-11-09 2016-11-09 Metodă de tratament al stărilor asociate cu activarea complementului dependentă de MASP-2 MD4685C1 (ro)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201562252814P 2015-11-09 2015-11-09
US201662406726P 2016-10-11 2016-10-11
PCT/US2016/061113 WO2017083371A1 (en) 2015-11-09 2016-11-09 Methods for treating conditions associated with masp-2 dependent complement activation

Publications (3)

Publication Number Publication Date
MD20180042A2 MD20180042A2 (ro) 2018-09-30
MD4685B1 true MD4685B1 (ro) 2020-03-31
MD4685C1 MD4685C1 (ro) 2020-12-31

Family

ID=58691444

Family Applications (1)

Application Number Title Priority Date Filing Date
MDA20180042A MD4685C1 (ro) 2015-11-09 2016-11-09 Metodă de tratament al stărilor asociate cu activarea complementului dependentă de MASP-2

Country Status (20)

Country Link
US (2) US20170137537A1 (ro)
EP (1) EP3373963A4 (ro)
JP (2) JP6814802B2 (ro)
KR (2) KR102432062B1 (ro)
CN (2) CN108472347B (ro)
AU (2) AU2016354117B2 (ro)
BR (1) BR112018009311A8 (ro)
CA (1) CA3004753C (ro)
CL (1) CL2018001258A1 (ro)
EA (1) EA201891132A1 (ro)
GE (2) GEP20237574B (ro)
IL (2) IL295200A (ro)
MD (1) MD4685C1 (ro)
MX (2) MX2018005165A (ro)
MY (1) MY197758A (ro)
NZ (1) NZ742987A (ro)
PH (1) PH12018501009A1 (ro)
SG (2) SG10202011469UA (ro)
UA (1) UA124094C2 (ro)
WO (1) WO2017083371A1 (ro)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2683307T3 (es) 2011-04-08 2018-09-26 University Of Leicester Métodos para tratar afecciones asociadas con la activación de complemento dependiente de MASP-2
IL283373B2 (en) 2013-10-17 2024-08-01 Omeros Corp Pharmaceutical preparations containing substances that suppress MASP-2 to suppress complement activation that depends on MASP-2 and related diseases
EP3481453A4 (en) * 2016-07-06 2020-07-22 Microoptx Inc. METHOD AND DEVICES FOR TREATING GLAUCOMA
JOP20170170B1 (ar) 2016-08-31 2022-09-15 Omeros Corp صيغ لجسم مضاد تثبيطية لـ masp-2 بتركيز عالي ولزوجة منخفضة وأطقم، وطرق
TWI818919B (zh) * 2017-08-15 2023-10-21 美商歐米諾斯公司 用於治療和／ 或預防與造血幹細胞移植有關的移植物抗宿主病和／ 或瀰漫性肺泡出血和／ 或靜脈閉塞性病的方法
BR112020003632A2 (pt) * 2017-08-25 2020-10-27 Omeros Corporation método de tratamento de um indivíduo que sofre ou corre risco de desenvolver ahus
KR20210024003A (ko) * 2018-06-22 2021-03-04 오메로스 코포레이션 다양한 혈전성 질환 및 장애의 치료를 위한 masp-2 억제 조성물 및 방법
CA3159172A1 (en) 2019-12-04 2021-06-10 Michael Cicirelli Masp-2 inhibitors and methods of use
JP2023504541A (ja) 2019-12-04 2023-02-03 オメロス コーポレーション Ｍａｓｐ－２阻害剤および使用方法
WO2021113686A1 (en) 2019-12-04 2021-06-10 Omeros Corporation Masp-2 inhibitors and methods of use
AU2020397894A1 (en) 2019-12-04 2022-06-30 Omeros Corporation MASP-2 inhibitors and methods of use
US20240228499A1 (en) 2022-11-30 2024-07-11 Omeros Corporation Masp-2 inhibitors and methods of use

Family Cites Families (43)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4331647A (en) 1980-03-03 1982-05-25 Goldenberg Milton David Tumor localization and therapy with labeled antibody fragments specific to tumor-associated markers
US4394370A (en) 1981-09-21 1983-07-19 Jefferies Steven R Bone graft material for osseous defects and method of making same
US4816567A (en) 1983-04-08 1989-03-28 Genentech, Inc. Recombinant immunoglobin preparations
US4526909A (en) 1984-01-09 1985-07-02 Regents Of The University Of California Polymethylmethacrylate delivery system for bone morphogenetic protein
US4563489A (en) 1984-02-10 1986-01-07 University Of California Biodegradable organic polymer delivery system for bone morphogenetic protein
JPH0662679B2 (ja) 1985-06-21 1994-08-17 新田ゼラチン株式会社 組織親和性コラ−ゲンとその製法
US5453566A (en) 1986-03-28 1995-09-26 Calgene, Inc. Antisense regulation of gene expression in plant/cells
US4946778A (en) 1987-09-21 1990-08-07 Genex Corporation Single polypeptide chain binding molecules
US4987071A (en) 1986-12-03 1991-01-22 University Patents, Inc. RNA ribozyme polymerases, dephosphorylases, restriction endoribonucleases and methods
EP0640688A1 (en) 1987-12-15 1995-03-01 Gene Shears Pty. Limited Ribozymes
US5223409A (en) 1988-09-02 1993-06-29 Protein Engineering Corp. Directed evolution of novel binding proteins
GB8822492D0 (en) 1988-09-24 1988-10-26 Considine J Apparatus for removing tumours from hollow organs of body
US5211657A (en) 1988-11-07 1993-05-18 The United States Government As Represented By The Secretary Of The Department Of Health And Human Services Laminin a chain deduced amino acid sequence, expression vectors and active synthetic peptides
US5530101A (en) 1988-12-28 1996-06-25 Protein Design Labs, Inc. Humanized immunoglobulins
US5549910A (en) 1989-03-31 1996-08-27 The Regents Of The University Of California Preparation of liposome and lipid complex compositions
EP0438803B1 (en) 1990-01-26 1997-03-12 Immunomedics, Inc. Vaccines against cancer and infectious diseases
JP3218637B2 (ja) 1990-07-26 2001-10-15 大正製薬株式会社 安定なリポソーム水懸濁液
US5789573A (en) 1990-08-14 1998-08-04 Isis Pharmaceuticals, Inc. Antisense inhibition of ICAM-1, E-selectin, and CMV IE1/IE2
JP2958076B2 (ja) 1990-08-27 1999-10-06 株式会社ビタミン研究所 遺伝子導入用多重膜リポソーム及び遺伝子捕捉多重膜リポソーム製剤並びにその製法
IL108367A0 (en) 1993-01-27 1994-04-12 Hektoen Inst For Medical Resea Antisense polynzcleotide inhibition of human growth factor-sensitive cancer cells
US5801154A (en) 1993-10-18 1998-09-01 Isis Pharmaceuticals, Inc. Antisense oligonucleotide modulation of multidrug resistance-associated protein
US5856121A (en) 1994-02-24 1999-01-05 Case Western Reserve University Growth arrest homebox gene
US5741516A (en) 1994-06-20 1998-04-21 Inex Pharmaceuticals Corporation Sphingosomes for enhanced drug delivery
AU4467396A (en) 1994-12-12 1996-07-10 Omeros Medical Systems, Inc. Irrigation solution and method for inhibition of pain, inflammation and spasm
US5795587A (en) 1995-01-23 1998-08-18 University Of Pittsburgh Stable lipid-comprising drug delivery complexes and methods for their production
US5738868A (en) 1995-07-18 1998-04-14 Lipogenics Ltd. Liposome compositions and kits therefor
US5739119A (en) 1996-11-15 1998-04-14 Galli; Rachel L. Antisense oligonucleotides specific for the muscarinic type 2 acetylcholine receptor MRNA
ATE399025T1 (de) 1999-07-21 2008-07-15 Omeros Corp Spüllösungen und verfahren zur schmerzhemmung, entzündungshemmung und hemmung des knorpelabbaus
EP1204419A1 (en) * 1999-08-13 2002-05-15 The Brigham And Women's Hospital, Inc. Inhibitors of the lectin complement pathway (lcp) and their use
US6649592B1 (en) 2000-01-14 2003-11-18 Science & Technology Corporation @ Unm Peptide inhibitors of LFA-1/ICAM-1 interaction
SG98393A1 (en) 2000-05-19 2003-09-19 Inst Materials Research & Eng Injectable drug delivery systems with cyclodextrin-polymer based hydrogels
JP2005519917A (ja) 2002-02-01 2005-07-07 オメロス コーポレイション 軟骨分解の全身阻害のための組成物および方法
EP1531757B1 (en) 2002-07-19 2016-09-07 Omeros Corporation Biodegradable triblock copolymers, synthesis methods therefor, and hydrogels and biomaterials made there from
US7919094B2 (en) 2004-06-10 2011-04-05 Omeros Corporation Methods for treating conditions associated with MASP-2 dependent complement activation
US20130266559A1 (en) 2004-06-10 2013-10-10 University Of Leicester Methods for Treating Conditions Associated with MASP-2 Dependent Complement Activation
US20150166676A1 (en) * 2011-04-08 2015-06-18 Omeros Corporation Methods for Treating Conditions Associated with MASP-2 Dependent Complement Activation
ES2683307T3 (es) * 2011-04-08 2018-09-26 University Of Leicester Métodos para tratar afecciones asociadas con la activación de complemento dependiente de MASP-2
LT2704743T (lt) 2011-05-04 2020-09-10 Omeros Corporation Kompozicijos, skirtos nuo masp-2 priklausančio komplemento aktyvinimo slopinimui
CN115040653A (zh) * 2012-06-18 2022-09-13 奥默罗斯公司 抑制masp-1和/或masp-2和/或masp-3的组合物和方法
AU2013334229B2 (en) 2012-10-25 2018-02-15 Bioverativ Usa Inc. Anti-complement C1s antibodies and uses thereof
CA2921856A1 (en) * 2013-09-16 2015-03-19 Children's Hospital Medical Center Compositions and methods for treatment of hsct-associated thrombotic microangiopathy
IL283373B2 (en) * 2013-10-17 2024-08-01 Omeros Corp Pharmaceutical preparations containing substances that suppress MASP-2 to suppress complement activation that depends on MASP-2 and related diseases
KR102011118B1 (ko) * 2018-04-13 2019-08-14 김정범 개선된 스냅 단추

Also Published As

Publication number Publication date
JP2018533592A (ja) 2018-11-15
EP3373963A1 (en) 2018-09-19
IL259225A (en) 2018-07-31
KR102432062B1 (ko) 2022-08-12
KR102277166B1 (ko) 2021-07-15
MX2018005165A (es) 2020-11-11
UA124094C2 (uk) 2021-07-21
MD20180042A2 (ro) 2018-09-30
CL2018001258A1 (es) 2018-10-12
KR20210090283A (ko) 2021-07-19
GEP20247583B (en) 2024-01-10
BR112018009311A2 (pt) 2018-11-06
NZ742987A (en) 2019-12-20
BR112018009311A8 (pt) 2019-02-26
JP6814802B2 (ja) 2021-01-20
PH12018501009A1 (en) 2019-01-28
CN117398458A (zh) 2024-01-16
IL259225B (en) 2022-09-01
AU2020201500A1 (en) 2020-03-19
EA201891132A1 (ru) 2018-10-31
KR20180074789A (ko) 2018-07-03
WO2017083371A1 (en) 2017-05-18
SG10202011469UA (en) 2020-12-30
US20170137537A1 (en) 2017-05-18
CN108472347B (zh) 2023-09-05
US11981749B2 (en) 2024-05-14
CA3004753C (en) 2023-02-28
SG11201803834UA (en) 2018-06-28
MD4685C1 (ro) 2020-12-31
GEP20237574B (en) 2023-12-25
AU2016354117A1 (en) 2018-05-10
MX2023001193A (es) 2023-08-11
EP3373963A4 (en) 2019-07-10
IL295200A (en) 2022-10-01
AU2016354117B2 (en) 2019-11-28
CA3004753A1 (en) 2017-05-18
CN108472347A (zh) 2018-08-31
MY197758A (en) 2023-07-13
JP2021063093A (ja) 2021-04-22
US20210047433A1 (en) 2021-02-18

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