MD4685C1 - Metodă de tratament al stărilor asociate cu activarea complementului dependentă de MASP-2 - Google Patents

Metodă de tratament al stărilor asociate cu activarea complementului dependentă de MASP-2

Info

Publication number
MD4685C1
MD4685C1 MDA20180042A MD20180042A MD4685C1 MD 4685 C1 MD4685 C1 MD 4685C1 MD A20180042 A MDA20180042 A MD A20180042A MD 20180042 A MD20180042 A MD 20180042A MD 4685 C1 MD4685 C1 MD 4685C1
Authority
MD
Moldova
Prior art keywords
masp
complement activation
methods
dependent complement
conditions associated
Prior art date
Application number
MDA20180042A
Other languages
English (en)
Russian (ru)
Other versions
MD20180042A2 (ro
MD4685B1 (ro
Inventor
Грегори А. ДЕМОПУЛОС
Томас Дадлер
Ганс-Вильгельм ШВАБЛЕ
Original Assignee
Omeros Corporation
University Of Leicester
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Omeros Corporation, University Of Leicester filed Critical Omeros Corporation
Publication of MD20180042A2 publication Critical patent/MD20180042A2/ro
Publication of MD4685B1 publication Critical patent/MD4685B1/ro
Publication of MD4685C1 publication Critical patent/MD4685C1/ro

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/40—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against enzymes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/06—Antianaemics
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y304/00—Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
    • C12Y304/21—Serine endopeptidases (3.4.21)
    • C12Y304/21104—Mannan-binding lectin-associated serine protease-2 (3.4.21.104)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/33—Crossreactivity, e.g. for species or epitope, or lack of said crossreactivity
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/55—Fab or Fab'
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565—Complementarity determining region [CDR]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
    • C07K2317/62—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
    • C07K2317/622—Single chain antibody (scFv)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • General Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Epidemiology (AREA)
  • Mycology (AREA)
  • Urology & Nephrology (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Power Steering Mechanism (AREA)
  • Exhaust Gas After Treatment (AREA)

Abstract

Invenţia se referă la metode de inhibare a efectelor activării complementului dependente de MASP-2 la un subiect uman, care suferă de microangiopatie trombotică (TMA) asociată cu transplantul de celule stem hematopoietice. Metodele includ etapa de administrare la subiectul, care are nevoie de aceasta, a unei cantităţi de agent inhibitor al MASP-2, care inhibă eficient activarea complementului dependentă de MASP-2.Revendicări: 10Figuri: 60Secvenţe: 71
MDA20180042A 2015-11-09 2016-11-09 Metodă de tratament al stărilor asociate cu activarea complementului dependentă de MASP-2 MD4685C1 (ro)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201562252814P 2015-11-09 2015-11-09
US201662406726P 2016-10-11 2016-10-11
PCT/US2016/061113 WO2017083371A1 (en) 2015-11-09 2016-11-09 Methods for treating conditions associated with masp-2 dependent complement activation

Publications (3)

Publication Number Publication Date
MD20180042A2 MD20180042A2 (ro) 2018-09-30
MD4685B1 MD4685B1 (ro) 2020-03-31
MD4685C1 true MD4685C1 (ro) 2020-12-31

Family

ID=58691444

Family Applications (1)

Application Number Title Priority Date Filing Date
MDA20180042A MD4685C1 (ro) 2015-11-09 2016-11-09 Metodă de tratament al stărilor asociate cu activarea complementului dependentă de MASP-2

Country Status (20)

Country Link
US (3) US20170137537A1 (ro)
EP (1) EP3373963A4 (ro)
JP (2) JP6814802B2 (ro)
KR (2) KR102277166B1 (ro)
CN (2) CN108472347B (ro)
AU (2) AU2016354117B2 (ro)
BR (1) BR112018009311A8 (ro)
CA (1) CA3004753C (ro)
CL (1) CL2018001258A1 (ro)
EA (1) EA201891132A1 (ro)
GE (2) GEP20247583B (ro)
IL (2) IL259225B (ro)
MD (1) MD4685C1 (ro)
MX (2) MX2018005165A (ro)
MY (1) MY197758A (ro)
NZ (1) NZ742987A (ro)
PH (1) PH12018501009A1 (ro)
SG (2) SG10202011469UA (ro)
UA (1) UA124094C2 (ro)
WO (1) WO2017083371A1 (ro)

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CA3076975C (en) 2011-04-08 2024-06-18 Omeros Corporation Methods for treating conditions associated with masp-2 dependent complement activation
SI3057993T1 (sl) 2013-10-17 2021-03-31 Omeros Corporation Postopki za zdravljenje bolezenskih stanj, povezanih z aktivacijo komplementov, odvisnih od MASP-2
US20200078215A1 (en) * 2016-07-06 2020-03-12 MicroOptx Inc. Glaucoma treatment devices and methods
JOP20170170B1 (ar) 2016-08-31 2022-09-15 Omeros Corp صيغ لجسم مضاد تثبيطية لـ masp-2 بتركيز عالي ولزوجة منخفضة وأطقم، وطرق
TW202402809A (zh) * 2017-08-15 2024-01-16 美商歐米諾斯公司 用於治療和／或預防與造血幹細胞移植有關的移植物抗宿主病和／或瀰漫性肺泡出血和／或靜脈閉塞性病的方法
CA3072913A1 (en) * 2017-08-25 2019-02-28 Omeros Corporation Highly concentrated low viscosity masp-2 inhibitory antibody formulations, kits, and methods of treating subjects suffering from atypical hemolytic syndrome
MA53234A (fr) * 2018-06-22 2022-04-20 Omeros Corp Compositions et procédés d'inhibition de masp-2 pour le traitement de divers troubles et maladies thrombotiques
IL293363A (en) * 2019-11-26 2022-07-01 Omeros Corp masp-2 inhibitors for use in the treatment and/or prevention of idiopathic pneumonia syndrome (ips) and/or capillary leak syndrome (cls) and/or transplantation syndrome (es) and/or fluid overload (fo) associated with hematopoietic stem cell transplantation
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WO2021113698A1 (en) 2019-12-04 2021-06-10 Omeros Corporation Masp-2 inhibitors and methods of use
JP2023504543A (ja) 2019-12-04 2023-02-03 オメロス コーポレーション Ｍａｓｐ－２阻害剤および使用方法
CA3159176A1 (en) 2019-12-04 2021-06-10 Neil S. Cutshall Masp-2 inhibitors and methods of use
CA3240483A1 (en) 2021-12-10 2023-06-15 Thomas Dudler Therapeutic antibodies that bind to the serine protease domain of masp-2 and uses thereof
US20240228499A1 (en) 2022-11-30 2024-07-11 Omeros Corporation Masp-2 inhibitors and methods of use

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Also Published As

Publication number Publication date
WO2017083371A1 (en) 2017-05-18
AU2016354117A1 (en) 2018-05-10
US20240343830A1 (en) 2024-10-17
CA3004753A1 (en) 2017-05-18
PH12018501009A1 (en) 2019-01-28
CN117398458A (zh) 2024-01-16
KR20210090283A (ko) 2021-07-19
US20170137537A1 (en) 2017-05-18
MY197758A (en) 2023-07-13
JP2021063093A (ja) 2021-04-22
IL295200A (en) 2022-10-01
KR102277166B1 (ko) 2021-07-15
GEP20247583B (en) 2024-01-10
CN108472347A (zh) 2018-08-31
JP2018533592A (ja) 2018-11-15
AU2016354117B2 (en) 2019-11-28
IL259225B (en) 2022-09-01
BR112018009311A8 (pt) 2019-02-26
GEP20237574B (en) 2023-12-25
US20210047433A1 (en) 2021-02-18
MD20180042A2 (ro) 2018-09-30
EP3373963A4 (en) 2019-07-10
MD4685B1 (ro) 2020-03-31
UA124094C2 (uk) 2021-07-21
SG11201803834UA (en) 2018-06-28
KR20180074789A (ko) 2018-07-03
CL2018001258A1 (es) 2018-10-12
NZ742987A (en) 2019-12-20
IL259225A (en) 2018-07-31
SG10202011469UA (en) 2020-12-30
CA3004753C (en) 2023-02-28
EA201891132A1 (ru) 2018-10-31
MX2023001193A (es) 2023-08-11
CN108472347B (zh) 2023-09-05
BR112018009311A2 (pt) 2018-11-06
AU2020201500A1 (en) 2020-03-19
US11981749B2 (en) 2024-05-14
MX2018005165A (es) 2020-11-11
EP3373963A1 (en) 2018-09-19
KR102432062B1 (ko) 2022-08-12
JP6814802B2 (ja) 2021-01-20

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