SG10201903822XA - Method for the enrichment of circulating tumor dna - Google Patents
Method for the enrichment of circulating tumor dnaInfo
- Publication number
- SG10201903822XA SG10201903822XA SG10201903822XA SG10201903822XA SG10201903822XA SG 10201903822X A SG10201903822X A SG 10201903822XA SG 10201903822X A SG10201903822X A SG 10201903822XA SG 10201903822X A SG10201903822X A SG 10201903822XA SG 10201903822X A SG10201903822X A SG 10201903822XA
- Authority
- SG
- Singapore
- Prior art keywords
- circulating tumor
- enrichment
- tumor dna
- relates
- binding agents
- Prior art date
Links
- 206010028980 Neoplasm Diseases 0.000 title abstract 4
- 238000000034 method Methods 0.000 title abstract 3
- 108010033040 Histones Proteins 0.000 abstract 2
- 239000011230 binding agent Substances 0.000 abstract 2
- 108010047956 Nucleosomes Proteins 0.000 abstract 1
- 239000012472 biological sample Substances 0.000 abstract 1
- 210000004027 cell Anatomy 0.000 abstract 1
- 210000001623 nucleosome Anatomy 0.000 abstract 1
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
- G01N33/6875—Nucleoproteins
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
- C12N15/1003—Extracting or separating nucleic acids from biological samples, e.g. pure separation or isolation methods; Conditions, buffers or apparatuses therefor
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N27/00—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means
- G01N27/62—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating the ionisation of gases, e.g. aerosols; by investigating electric discharges, e.g. emission of cathode
- G01N27/622—Ion mobility spectrometry
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2560/00—Chemical aspects of mass spectrometric analysis of biological material
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2800/00—Detection or diagnosis of diseases
- G01N2800/70—Mechanisms involved in disease identification
- G01N2800/7023—(Hyper)proliferation
- G01N2800/7028—Cancer
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Chemical & Material Sciences (AREA)
- Biomedical Technology (AREA)
- Immunology (AREA)
- Molecular Biology (AREA)
- Physics & Mathematics (AREA)
- Urology & Nephrology (AREA)
- Hematology (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- Analytical Chemistry (AREA)
- Biotechnology (AREA)
- General Physics & Mathematics (AREA)
- Pathology (AREA)
- Microbiology (AREA)
- Genetics & Genomics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Cell Biology (AREA)
- Medicinal Chemistry (AREA)
- Food Science & Technology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Engineering & Computer Science (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Organic Chemistry (AREA)
- Crystallography & Structural Chemistry (AREA)
- Electrochemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Spectroscopy & Molecular Physics (AREA)
- Plant Pathology (AREA)
- Biophysics (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Peptides Or Proteins (AREA)
- Investigating Or Analysing Biological Materials (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB1419225.6A GB201419225D0 (en) | 2014-10-29 | 2014-10-29 | Method for the enrichment of circulating tumor DNA |
| GB201419299A GB201419299D0 (en) | 2014-10-30 | 2014-10-30 | Method for the enrichment of circulating tumour DNA |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| SG10201903822XA true SG10201903822XA (en) | 2019-05-30 |
Family
ID=54427791
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SG10201903822XA SG10201903822XA (en) | 2014-10-29 | 2015-10-29 | Method for the enrichment of circulating tumor dna |
| SG11201702978VA SG11201702978VA (en) | 2014-10-29 | 2015-10-29 | Method for the enrichment of circulating tumor dna |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SG11201702978VA SG11201702978VA (en) | 2014-10-29 | 2015-10-29 | Method for the enrichment of circulating tumor dna |
Country Status (12)
| Country | Link |
|---|---|
| US (2) | US20180024141A1 (https=) |
| EP (2) | EP3809140A1 (https=) |
| JP (1) | JP6721599B2 (https=) |
| CN (2) | CN107209190B (https=) |
| AU (1) | AU2015340378B2 (https=) |
| CA (1) | CA2965752C (https=) |
| DK (1) | DK3213084T4 (https=) |
| ES (1) | ES2839973T3 (https=) |
| IL (1) | IL251896A0 (https=) |
| PL (1) | PL3213084T3 (https=) |
| SG (2) | SG10201903822XA (https=) |
| WO (1) | WO2016067029A1 (https=) |
Families Citing this family (31)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2820129A1 (en) | 2012-03-02 | 2015-01-07 | Sequenom, Inc. | Methods and processes for non-invasive assessment of genetic variations |
| US11060145B2 (en) | 2013-03-13 | 2021-07-13 | Sequenom, Inc. | Methods and compositions for identifying presence or absence of hypermethylation or hypomethylation locus |
| EP3736344A1 (en) | 2014-03-13 | 2020-11-11 | Sequenom, Inc. | Methods and processes for non-invasive assessment of genetic variations |
| CN106544341A (zh) * | 2017-01-17 | 2017-03-29 | 上海亿康医学检验所有限公司 | 高效检测样本中的ctDNA的方法 |
| WO2019053243A1 (en) | 2017-09-18 | 2019-03-21 | Santersus Sa | METHOD AND DEVICE FOR PURIFYING BLOOD OF FREE CIRCULATING DNA |
| CN109932224A (zh) * | 2017-12-18 | 2019-06-25 | 中国科学院大连化学物理研究所 | 一种富集提取循环肿瘤dna的方法 |
| CN112119166B (zh) * | 2018-03-13 | 2025-08-22 | 耶路撒冷希伯来大学伊萨姆研发有限公司 | 无细胞dna染色质免疫沉淀的诊断应用 |
| CN112805563B (zh) * | 2018-05-18 | 2025-06-13 | 约翰·霍普金斯大学 | 用于评估和/或治疗癌症的无细胞dna |
| GB201818963D0 (en) | 2018-11-21 | 2019-01-09 | Belgian Volition Sprl | Methof for the detection of prostate cancer |
| GB201818965D0 (en) | 2018-11-21 | 2019-01-09 | Belgian Volition Sprl | Method for the detection of colorectal cancer |
| CN109841265B (zh) * | 2019-02-22 | 2021-09-21 | 清华大学 | 使用片段化模式确定血浆游离核酸分子组织来源的方法和系统及应用 |
| GB201906201D0 (en) | 2019-05-02 | 2019-06-19 | Belgian Voltion Sprl | Method for the detection of protate cancer |
| GB201906199D0 (en) | 2019-05-02 | 2019-06-19 | Belgian Volition Sprl | Method for the detection of cancer |
| US12571051B2 (en) * | 2019-08-27 | 2026-03-10 | Belgian Volition Srl | Method of isolating circulating nucleosomes |
| EP4041914A1 (en) * | 2019-10-04 | 2022-08-17 | Santersus AG | Method for isolating and analyzing cell free dna |
| JP7349104B2 (ja) * | 2019-11-13 | 2023-09-22 | 株式会社島津製作所 | ベロ毒素の検出方法 |
| IL293342B1 (en) | 2019-12-02 | 2026-01-01 | Belgian Volition Srl | Using cell-free nucleosomes as biomarkers |
| WO2021236993A1 (en) * | 2020-05-22 | 2021-11-25 | Bloodq, Inc. | Methods for characterizing cell-free nucleic acid fragments |
| GB202117799D0 (en) | 2021-12-09 | 2022-01-26 | Belgian Volition Srl | Method for the detection of blood cancer |
| EP4453241A1 (en) * | 2021-12-21 | 2024-10-30 | Guardant Health, Inc. | Methods and systems for combinatorial chromatin-ip sequencing |
| WO2023126672A1 (en) | 2021-12-27 | 2023-07-06 | Santersus Ag | Method and device for removal of circulating cell free dna |
| EP4490323A1 (en) | 2022-03-11 | 2025-01-15 | Belgian Volition SRL | Differential diagnosis method |
| WO2024042210A1 (en) * | 2022-08-25 | 2024-02-29 | Belgian Volition Srl | Method for measuring cell free chromatin |
| EP4646208A1 (en) | 2023-01-06 | 2025-11-12 | Ideaya Biosciences, Inc. | Treatment of er+ breast cancer comprising homologous recombination deficiency using parg inhibitor |
| WO2024223947A1 (en) | 2023-04-28 | 2024-10-31 | Belgian Volition Srl | Use of cell free nucleosomes as biomarkers of carcinomas |
| GB202307768D0 (en) | 2023-05-24 | 2023-07-05 | Belgian Volition Srl | Use of cell free nucleosomes as biomarkers |
| GB202310137D0 (en) | 2023-07-03 | 2023-08-16 | Belgian Volition Srl | Method for the detection of cancer |
| WO2025012440A1 (en) | 2023-07-13 | 2025-01-16 | Belgian Volition Srl | Method for detection of the potential of a body fluid sample to produce extracellular traps |
| WO2025061853A1 (en) | 2023-09-19 | 2025-03-27 | Belgian Volition Srl | Lateral flow test device |
| WO2025073909A1 (en) | 2023-10-04 | 2025-04-10 | Belgian Volition Srl | Pcr method for detecting ctcf occupied cfdna fragments |
| WO2025093747A1 (en) | 2023-11-02 | 2025-05-08 | Belgian Volition Srl | Novel rapid high-throughput method of netosis induction and inhibition with physiologically relevant molecules |
Family Cites Families (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB0319376D0 (en) * | 2003-08-18 | 2003-09-17 | Chroma Therapeutics Ltd | Histone modification detection |
| US20060115482A1 (en) * | 2004-04-27 | 2006-06-01 | The Regents Of The University Of California | Modifications of histone proteins as indicators of cell proliferation and differentiation |
| WO2007121276A2 (en) * | 2006-04-12 | 2007-10-25 | Biocept, Inc. | Enrichment of circulating fetal dna |
| EP2062912A1 (en) * | 2007-11-26 | 2009-05-27 | Koninklijke Philips Electronics N.V. | Selective enrichment of post-translationally modified proteins and/or peptides |
| US20100240054A1 (en) * | 2008-09-22 | 2010-09-23 | Biocept, Inc. | Identification and isolation of fetal cells and nucleic acid |
| WO2010120942A2 (en) * | 2009-04-14 | 2010-10-21 | The Regents Of The University Of California | Histone modification patterns for clinical diagnosis and prognosis of cancer |
| WO2013010181A2 (en) * | 2011-07-14 | 2013-01-17 | University Of Massachusetts | Methods of diagnosing cancer using epigenetic biomarkers |
| GB201115095D0 (en) | 2011-09-01 | 2011-10-19 | Singapore Volition Pte Ltd | Method for detecting nucleosomes containing nucleotides |
| GB201115098D0 (en) | 2011-09-01 | 2011-10-19 | Belgian Volition Sa | Method for detecting nucleosomes containing histone variants |
| EP2782928B1 (en) | 2011-11-21 | 2017-01-04 | The Royal Institution for the Advancement of Learning / McGill University | Mutations of histone proteins associated with proliferative disorders |
| PT2788767T (pt) * | 2011-12-07 | 2017-12-06 | Belgian Volition Sprl | Método de detecção de adutos de nucleosoma |
| EP2820129A1 (en) | 2012-03-02 | 2015-01-07 | Sequenom, Inc. | Methods and processes for non-invasive assessment of genetic variations |
| US9388213B2 (en) * | 2012-09-10 | 2016-07-12 | The Rockefeller University | Polycomb repressive complex 2 (PRC2) inhibitors and uses thereof |
-
2015
- 2015-10-29 CN CN201580058989.4A patent/CN107209190B/zh active Active
- 2015-10-29 SG SG10201903822XA patent/SG10201903822XA/en unknown
- 2015-10-29 AU AU2015340378A patent/AU2015340378B2/en active Active
- 2015-10-29 EP EP20203154.8A patent/EP3809140A1/en not_active Withdrawn
- 2015-10-29 CN CN202010018617.1A patent/CN111505305B/zh active Active
- 2015-10-29 US US15/523,280 patent/US20180024141A1/en not_active Abandoned
- 2015-10-29 ES ES15790214T patent/ES2839973T3/es active Active
- 2015-10-29 WO PCT/GB2015/053238 patent/WO2016067029A1/en not_active Ceased
- 2015-10-29 DK DK15790214.9T patent/DK3213084T4/da active
- 2015-10-29 SG SG11201702978VA patent/SG11201702978VA/en unknown
- 2015-10-29 PL PL15790214T patent/PL3213084T3/pl unknown
- 2015-10-29 EP EP15790214.9A patent/EP3213084B2/en active Active
- 2015-10-29 CA CA2965752A patent/CA2965752C/en active Active
- 2015-10-29 JP JP2017542357A patent/JP6721599B2/ja active Active
-
2017
- 2017-04-25 IL IL251896A patent/IL251896A0/en active IP Right Grant
-
2022
- 2022-06-07 US US17/834,701 patent/US20220334128A1/en active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| US20220334128A1 (en) | 2022-10-20 |
| PL3213084T3 (pl) | 2021-07-26 |
| JP2017534300A (ja) | 2017-11-24 |
| US20180024141A1 (en) | 2018-01-25 |
| CN111505305B (zh) | 2023-10-17 |
| HK1243764A1 (en) | 2018-07-20 |
| CN111505305A (zh) | 2020-08-07 |
| IL251896A0 (en) | 2017-06-29 |
| EP3213084A1 (en) | 2017-09-06 |
| CA2965752C (en) | 2024-04-02 |
| CA2965752A1 (en) | 2016-05-06 |
| NZ731116A (en) | 2024-03-22 |
| EP3213084B2 (en) | 2023-12-13 |
| DK3213084T3 (da) | 2021-01-18 |
| WO2016067029A1 (en) | 2016-05-06 |
| ES2839973T3 (es) | 2021-07-06 |
| JP6721599B2 (ja) | 2020-07-15 |
| EP3213084B1 (en) | 2020-11-25 |
| CN107209190A (zh) | 2017-09-26 |
| EP3809140A1 (en) | 2021-04-21 |
| AU2015340378B2 (en) | 2021-08-12 |
| AU2015340378A1 (en) | 2017-05-11 |
| CN107209190B (zh) | 2021-07-16 |
| SG11201702978VA (en) | 2017-05-30 |
| DK3213084T4 (da) | 2024-03-18 |
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