SG10201902203VA - Eutectic formulations of cyclobenzaprine hydrochloride - Google Patents

Eutectic formulations of cyclobenzaprine hydrochloride

Info

Publication number
SG10201902203VA
SG10201902203VA SG10201902203VA SG10201902203VA SG10201902203VA SG 10201902203V A SG10201902203V A SG 10201902203VA SG 10201902203V A SG10201902203V A SG 10201902203VA SG 10201902203V A SG10201902203V A SG 10201902203VA SG 10201902203V A SG10201902203V A SG 10201902203VA
Authority
SG
Singapore
Prior art keywords
eutectic
cyclobenzaprine hydrochloride
formulations
eutectic formulations
cyclobenzaprine
Prior art date
Application number
SG10201902203VA
Other languages
English (en)
Inventor
Seth Lederman
Marino Nebuloni
Original Assignee
Tonix Pharma Holdings Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Tonix Pharma Holdings Ltd filed Critical Tonix Pharma Holdings Ltd
Publication of SG10201902203VA publication Critical patent/SG10201902203VA/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/02—Inorganic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/12—Carboxylic acids; Salts or anhydrides thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1617—Organic compounds, e.g. phospholipids, fats
    • A61K9/1623—Sugars or sugar alcohols, e.g. lactose; Derivatives thereof; Homeopathic globules
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2013—Organic compounds, e.g. phospholipids, fats
    • A61K9/2018—Sugars, or sugar alcohols, e.g. lactose, mannitol; Derivatives thereof, e.g. polysorbates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A61P21/02—Muscle relaxants, e.g. for tetanus or cramps
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Neurology (AREA)
  • Organic Chemistry (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Epidemiology (AREA)
  • Pain & Pain Management (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Psychiatry (AREA)
  • Anesthesiology (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Inorganic Chemistry (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicinal Preparation (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
SG10201902203VA 2014-09-18 2015-09-18 Eutectic formulations of cyclobenzaprine hydrochloride SG10201902203VA (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US201462052238P 2014-09-18 2014-09-18

Publications (1)

Publication Number Publication Date
SG10201902203VA true SG10201902203VA (en) 2019-04-29

Family

ID=55533932

Family Applications (2)

Application Number Title Priority Date Filing Date
SG11201701995PA SG11201701995PA (en) 2014-09-18 2015-09-18 Eutectic formulations of cyclobenzaprine hydrochloride
SG10201902203VA SG10201902203VA (en) 2014-09-18 2015-09-18 Eutectic formulations of cyclobenzaprine hydrochloride

Family Applications Before (1)

Application Number Title Priority Date Filing Date
SG11201701995PA SG11201701995PA (en) 2014-09-18 2015-09-18 Eutectic formulations of cyclobenzaprine hydrochloride

Country Status (12)

Country Link
US (2) US10357465B2 (enExample)
EP (1) EP3193854A4 (enExample)
JP (6) JP6614724B2 (enExample)
CN (2) CN107072968B (enExample)
AU (2) AU2015317336B2 (enExample)
BR (1) BR112017005231A2 (enExample)
IL (2) IL251218B (enExample)
MX (1) MX387402B (enExample)
MY (1) MY186047A (enExample)
SG (2) SG11201701995PA (enExample)
WO (1) WO2016044796A1 (enExample)
ZA (1) ZA201701637B (enExample)

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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2649022T3 (es) 2009-11-20 2018-01-09 Tonix Pharma Holdings Limited Procedimientos y composiciones para tratar los síntomas asociados con el trastorno de estrés postraumático con ciclobenzaprina
US20110319389A1 (en) 2010-06-24 2011-12-29 Tonix Pharmaceuticals, Inc. Methods and compositions for treating fatigue associated with disordered sleep using very low dose cyclobenzaprine
US11998516B2 (en) 2011-03-07 2024-06-04 Tonix Pharma Holdings Limited Methods and compositions for treating depression using cyclobenzaprine
RS60015B1 (sr) 2013-03-15 2020-04-30 Tonix Pharma Holdings Ltd Eutektičke formulacije ciklobenzapirin hidrohlorida i manitola
SG11201701995PA (en) 2014-09-18 2017-04-27 Tonix Pharma Holdings Ltd Eutectic formulations of cyclobenzaprine hydrochloride
WO2019116091A1 (en) 2017-12-11 2019-06-20 Tonix Pharma Holdings Limited Cyclobenzaprine treatment for agitation, psychosis and cognitive decline in dementia and neurodegenerative conditions
TW202019400A (zh) * 2018-08-20 2020-06-01 愛爾蘭商托尼克製藥控股有限公司 治療急性壓力症候群及創傷後壓力症候群之方法
NL2023661B1 (en) * 2019-08-19 2021-04-21 Seranovo Holding B V Pharmaceutical Eutectic Salt Formulation
WO2021207561A1 (en) 2020-04-08 2021-10-14 Tonix Pharmaceuticals Holding Corp. Cyclobenzaprine treatment for sexual dysfunction
AU2021382668A1 (en) * 2020-11-20 2023-06-22 Tonix Pharmaceuticals Holding Corp. Cyclobenzaprine treatment for alcohol use disorder
AU2021396509A1 (en) * 2020-12-07 2023-06-29 Tonix Pharmaceuticals Holding Corp. Cyclobenzaprine treatment for fibromyalgia
EP4412602A1 (en) * 2021-10-06 2024-08-14 Tonix Pharmaceuticals Holding Corp. Cyclobenzaprine for treatment or prevention of sexual dysfunction associated with mental health conditions in female patients
CN120379655A (zh) 2022-06-21 2025-07-25 通尼克斯医药控股公司 (sars)-cov-2感染的急性后后遗症(pasc)的环苯扎林治疗
WO2025160302A1 (en) 2024-01-25 2025-07-31 Tonix Pharmaceuticals Holding Corp. Cyclobenzaprine treatment for acute stress reaction or acute stress disorder

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Also Published As

Publication number Publication date
JP2018193409A (ja) 2018-12-06
US10357465B2 (en) 2019-07-23
US11026898B2 (en) 2021-06-08
JP6614724B2 (ja) 2019-12-04
AU2020289838A1 (en) 2021-01-28
CN107072968A (zh) 2017-08-18
IL251218A0 (en) 2017-05-29
JP2017532374A (ja) 2017-11-02
US20190336458A1 (en) 2019-11-07
JP6717902B2 (ja) 2020-07-08
WO2016044796A1 (en) 2016-03-24
NZ730379A (en) 2023-10-27
MX387402B (es) 2025-03-18
AU2020289838B2 (en) 2022-11-24
IL277814A (en) 2020-11-30
SG11201701995PA (en) 2017-04-27
JP2025107355A (ja) 2025-07-17
JP2022001605A (ja) 2022-01-06
ZA201701637B (en) 2020-11-25
US20170281568A1 (en) 2017-10-05
NZ768064A (en) 2023-10-27
IL251218B (en) 2020-10-29
JP2023126486A (ja) 2023-09-07
EP3193854A4 (en) 2018-05-02
JP2020059757A (ja) 2020-04-16
CN112618494A (zh) 2021-04-09
MX2017003644A (es) 2017-10-31
CN112618494B (zh) 2023-06-30
EP3193854A1 (en) 2017-07-26
JP6717902B6 (ja) 2020-08-05
CA2961822A1 (en) 2016-03-24
AU2015317336B2 (en) 2021-01-21
MY186047A (en) 2021-06-17
IL277814B (en) 2021-12-01
AU2015317336A1 (en) 2017-04-13
BR112017005231A2 (pt) 2018-03-13
CN107072968B (zh) 2021-01-12

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