SG10201900536TA - Piperidine derivatives as orexin receptor antagonist - Google Patents
Piperidine derivatives as orexin receptor antagonistInfo
- Publication number
- SG10201900536TA SG10201900536TA SG10201900536TA SG10201900536TA SG10201900536TA SG 10201900536T A SG10201900536T A SG 10201900536TA SG 10201900536T A SG10201900536T A SG 10201900536TA SG 10201900536T A SG10201900536T A SG 10201900536TA SG 10201900536T A SG10201900536T A SG 10201900536TA
- Authority
- SG
- Singapore
- Prior art keywords
- piperidine derivatives
- orexin receptor
- receptor antagonist
- hypersomnia
- obsessive
- Prior art date
Links
- 229940123730 Orexin receptor antagonist Drugs 0.000 title abstract 3
- 150000003053 piperidines Chemical class 0.000 title abstract 2
- 208000019901 Anxiety disease Diseases 0.000 abstract 1
- 208000006545 Chronic Obstructive Pulmonary Disease Diseases 0.000 abstract 1
- 208000007590 Disorders of Excessive Somnolence Diseases 0.000 abstract 1
- 206010057852 Nicotine dependence Diseases 0.000 abstract 1
- 208000021384 Obsessive-Compulsive disease Diseases 0.000 abstract 1
- 206010033664 Panic attack Diseases 0.000 abstract 1
- NQRYJNQNLNOLGT-UHFFFAOYSA-N Piperidine Chemical class C1CCNCC1 NQRYJNQNLNOLGT-UHFFFAOYSA-N 0.000 abstract 1
- 208000013738 Sleep Initiation and Maintenance disease Diseases 0.000 abstract 1
- 208000025569 Tobacco Use disease Diseases 0.000 abstract 1
- 230000036506 anxiety Effects 0.000 abstract 1
- 208000014679 binge eating disease Diseases 0.000 abstract 1
- 229940079593 drug Drugs 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 206010020765 hypersomnia Diseases 0.000 abstract 1
- 206010022437 insomnia Diseases 0.000 abstract 1
- 238000002483 medication Methods 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 208000001797 obstructive sleep apnea Diseases 0.000 abstract 1
- 208000019906 panic disease Diseases 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D451/00—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
- C07D451/02—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/46—8-Azabicyclo [3.2.1] octane; Derivatives thereof, e.g. atropine, cocaine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/08—Bronchodilators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A61P25/34—Tobacco-abuse
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Addiction (AREA)
- Psychiatry (AREA)
- Pulmonology (AREA)
- Epidemiology (AREA)
- Emergency Medicine (AREA)
- Anesthesiology (AREA)
- Diabetes (AREA)
- Obesity (AREA)
- Hematology (AREA)
- Child & Adolescent Psychology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Hydrogenated Pyridines (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201410081220 | 2014-03-06 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| SG10201900536TA true SG10201900536TA (en) | 2019-02-27 |
Family
ID=54054589
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SG10201900536TA SG10201900536TA (en) | 2014-03-06 | 2015-02-27 | Piperidine derivatives as orexin receptor antagonist |
| SG11201607183PA SG11201607183PA (en) | 2014-03-06 | 2015-02-27 | Piperidine derivatives as orexin receptor antagonist |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SG11201607183PA SG11201607183PA (en) | 2014-03-06 | 2015-02-27 | Piperidine derivatives as orexin receptor antagonist |
Country Status (16)
| Country | Link |
|---|---|
| US (1) | US10100047B2 (zh) |
| EP (1) | EP3115362B1 (zh) |
| JP (1) | JP6262885B2 (zh) |
| KR (1) | KR101920472B1 (zh) |
| CN (1) | CN106414439B (zh) |
| AU (1) | AU2015226679B2 (zh) |
| CA (1) | CA2941663C (zh) |
| CL (1) | CL2016002240A1 (zh) |
| IL (1) | IL247584A0 (zh) |
| MX (1) | MX2016011549A (zh) |
| NZ (1) | NZ723671A (zh) |
| PE (1) | PE20170184A1 (zh) |
| RU (1) | RU2669701C2 (zh) |
| SG (2) | SG10201900536TA (zh) |
| WO (1) | WO2015131773A1 (zh) |
| ZA (1) | ZA201606141B (zh) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EA034922B1 (ru) | 2013-03-15 | 2020-04-07 | Глобал Блад Терапьютикс, Инк. | Соединения и их применения для модуляции гемоглобина |
| EA201992707A1 (ru) | 2013-11-18 | 2020-06-30 | Глобал Блад Терапьютикс, Инк. | Соединения и их применения для модуляции гемоглобина |
| AU2016295693B2 (en) | 2015-07-17 | 2020-05-21 | Sunshine Lake Pharma Co., Ltd. | Substituted quinazoline compounds and preparation and uses thereof |
| DK3336088T3 (da) | 2015-08-14 | 2021-06-28 | Shanghai Haiyan Pharmaceutical Tech Co Ltd | Krystalform af orexinreceptorantagonistforbindelse, og fremgangsmåde til fremstilling og anvendelse af denne |
| AU2016360245B2 (en) | 2015-11-23 | 2020-07-09 | Sunshine Lake Pharma Co., Ltd. | Octahydropyrrolo [3, 4-c] pyrrole derivatives and uses thereof |
| PT3411358T (pt) | 2016-02-04 | 2022-01-19 | Takeda Pharmaceuticals Co | Composto de piperidina substituído e a sua utilização |
| CA3174409A1 (en) * | 2020-04-17 | 2021-10-21 | Shanghai Haiyan Pharmaceutical Technology Co., Ltd. | Solid pharmaceutical preparation, preparation method therefor and use thereof |
| CN112480107B (zh) * | 2020-11-30 | 2022-08-16 | 上海海雁医药科技有限公司 | 取代的氮杂双环辛烷化合物及其中间体和制备方法 |
Family Cites Families (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| TW200510405A (en) * | 2003-05-13 | 2005-03-16 | Schering Corp | Bridged n-arylsulfonylpiperidines as gamma-secretase inhibitors |
| WO2008024284A2 (en) * | 2006-08-21 | 2008-02-28 | Merck & Co., Inc. | Sulfonylated piperazines as cannabinoid-1 receptor modulators |
| AU2008255005B2 (en) * | 2007-05-18 | 2013-05-02 | Merck Sharp & Dohme Corp. | OXO bridged diazepan orexin receptor antagonists |
| PT2152690E (pt) * | 2007-05-23 | 2012-03-30 | Merck Sharp & Dohme | Antagonistas piridil piperidina de receptor de orexina |
| EP2150115B1 (en) * | 2007-05-23 | 2013-09-18 | Merck Sharp & Dohme Corp. | Cyclopropyl pyrrolidine orexin receptor antagonists |
| CA2711399C (en) * | 2008-02-06 | 2016-10-11 | Banyu Pharmaceutical Co., Ltd. | 3-substituted sulfonylpiperidine derivative |
| CA2713184A1 (en) * | 2008-02-21 | 2009-08-27 | Actelion Pharmaceuticals Ltd | 2-aza-bicyclo[2.2.1]heptane derivatives |
| WO2010048010A1 (en) * | 2008-10-21 | 2010-04-29 | Merck Sharp & Dohme Corp. | 2,5-disubstituted piperidine orexin receptor antagonists |
| WO2010048016A1 (en) * | 2008-10-21 | 2010-04-29 | Merck Sharp & Dohme Corp. | 2,3-disubstituted piperidine orexin receptor antagonists |
| CA2739916A1 (en) * | 2008-10-21 | 2010-04-29 | Merck Sharp & Dohme Corp. | 2,5-disubstituted piperidine orexin receptor antagonists |
| WO2010048014A1 (en) * | 2008-10-21 | 2010-04-29 | Merck Sharp & Dohme Corp. | 2,4-disubstituted pyrrolidine orexin receptor antagonists |
| EP2563780B1 (en) * | 2010-04-29 | 2015-05-06 | The University Of Edinburgh | 3,3-disubstituted-(8-aza-bicyclo[3.2.1]oct-8-yl)-[5-(1h-pyrazol-4-yl)-thiophen-3-yl]-methanones as inhibitors of 11(beta)-hsd1 |
| US8791136B2 (en) * | 2010-07-29 | 2014-07-29 | Rigel Pharmaceuticals, Inc. | Substituted pyridine, pyridazine, pyrazine and pyrimidine compounds and methods for using the same |
| JPWO2013005755A1 (ja) * | 2011-07-05 | 2015-02-23 | 大正製薬株式会社 | メチルピペリジン誘導体 |
| AR088352A1 (es) * | 2011-10-19 | 2014-05-28 | Merck Sharp & Dohme | Antagonistas del receptor de 2-piridiloxi-4-nitrilo orexina |
| WO2013061977A1 (ja) * | 2011-10-25 | 2013-05-02 | 塩野義製薬株式会社 | Ｐｇｄ２受容体アンタゴニスト活性を有するへテロ環誘導体 |
| JOP20130213B1 (ar) * | 2012-07-17 | 2021-08-17 | Takeda Pharmaceuticals Co | معارضات لمستقبلht3-5 |
| JP6297582B2 (ja) * | 2012-11-16 | 2018-03-20 | メルク・シャープ・アンド・ドーム・コーポレーションＭｅｒｃｋ Ｓｈａｒｐ ＆ Ｄｏｈｍｅ Ｃｏｒｐ． | ヒトホスファチジルイノシトール３−キナーゼデルタのプリン阻害剤 |
| TW201444849A (zh) | 2013-03-13 | 2014-12-01 | Janssen Pharmaceutica Nv | 經取代的7-氮雜雙環類及其作為食慾激素受體調節劑之用途 |
| TWI621618B (zh) * | 2013-03-13 | 2018-04-21 | 比利時商健生藥品公司 | 經取代２－氮雜雙環類及其作為食慾素受體調控劑之用途 |
-
2015
- 2015-02-27 SG SG10201900536TA patent/SG10201900536TA/en unknown
- 2015-02-27 WO PCT/CN2015/073330 patent/WO2015131773A1/zh active Application Filing
- 2015-02-27 JP JP2016572879A patent/JP6262885B2/ja active Active
- 2015-02-27 CA CA2941663A patent/CA2941663C/en active Active
- 2015-02-27 MX MX2016011549A patent/MX2016011549A/es unknown
- 2015-02-27 KR KR1020167027668A patent/KR101920472B1/ko active IP Right Grant
- 2015-02-27 RU RU2016130937A patent/RU2669701C2/ru active
- 2015-02-27 SG SG11201607183PA patent/SG11201607183PA/en unknown
- 2015-02-27 NZ NZ723671A patent/NZ723671A/en unknown
- 2015-02-27 EP EP15758792.4A patent/EP3115362B1/en active Active
- 2015-02-27 US US15/123,014 patent/US10100047B2/en active Active
- 2015-02-27 CN CN201580012396.4A patent/CN106414439B/zh active Active
- 2015-02-27 PE PE2016001578A patent/PE20170184A1/es not_active Application Discontinuation
- 2015-02-27 AU AU2015226679A patent/AU2015226679B2/en active Active
-
2016
- 2016-08-31 IL IL247584A patent/IL247584A0/en unknown
- 2016-09-05 ZA ZA2016/06141A patent/ZA201606141B/en unknown
- 2016-09-06 CL CL2016002240A patent/CL2016002240A1/es unknown
Also Published As
| Publication number | Publication date |
|---|---|
| AU2015226679A1 (en) | 2016-09-15 |
| CA2941663A1 (en) | 2015-09-11 |
| US10100047B2 (en) | 2018-10-16 |
| CN106414439A (zh) | 2017-02-15 |
| EP3115362A1 (en) | 2017-01-11 |
| JP6262885B2 (ja) | 2018-01-17 |
| KR101920472B1 (ko) | 2019-02-08 |
| MX2016011549A (es) | 2017-05-08 |
| RU2669701C2 (ru) | 2018-10-15 |
| CA2941663C (en) | 2020-02-18 |
| AU2015226679B2 (en) | 2017-05-25 |
| ZA201606141B (en) | 2017-05-31 |
| CL2016002240A1 (es) | 2017-02-17 |
| EP3115362B1 (en) | 2019-06-12 |
| US20170233385A1 (en) | 2017-08-17 |
| KR20160143668A (ko) | 2016-12-14 |
| WO2015131773A1 (zh) | 2015-09-11 |
| CN106414439B (zh) | 2017-12-08 |
| RU2016130937A (ru) | 2018-04-09 |
| PE20170184A1 (es) | 2017-04-07 |
| JP2017507185A (ja) | 2017-03-16 |
| NZ723671A (en) | 2017-05-26 |
| IL247584A0 (en) | 2016-11-30 |
| SG11201607183PA (en) | 2016-10-28 |
| EP3115362A4 (en) | 2017-08-16 |
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