SG10201809427SA - Insulin receptor partial agonists - Google Patents
Insulin receptor partial agonistsInfo
- Publication number
- SG10201809427SA SG10201809427SA SG10201809427SA SG10201809427SA SG10201809427SA SG 10201809427S A SG10201809427S A SG 10201809427SA SG 10201809427S A SG10201809427S A SG 10201809427SA SG 10201809427S A SG10201809427S A SG 10201809427SA SG 10201809427S A SG10201809427S A SG 10201809427SA
- Authority
- SG
- Singapore
- Prior art keywords
- partial agonists
- insulin receptor
- receptor partial
- insulin
- dimers
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/62—Insulins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/22—Hormones
- A61K38/28—Insulins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/54—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound
- A61K47/55—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound the modifying agent being also a pharmacologically or therapeutically active agent, i.e. the entire conjugate being a codrug, i.e. a dimer, oligomer or polymer of pharmacologically or therapeutically active compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
- A61K47/59—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes
- A61K47/60—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes the organic macromolecular compound being a polyoxyalkylene oligomer, polymer or dendrimer, e.g. PEG, PPG, PEO or polyglycerol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Epidemiology (AREA)
- Diabetes (AREA)
- Organic Chemistry (AREA)
- Endocrinology (AREA)
- Gastroenterology & Hepatology (AREA)
- Zoology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Genetics & Genomics (AREA)
- Toxicology (AREA)
- Molecular Biology (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Immunology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Hematology (AREA)
- Emergency Medicine (AREA)
- Obesity (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Medicinal Preparation (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201462082857P | 2014-11-21 | 2014-11-21 | |
US201562242503P | 2015-10-16 | 2015-10-16 |
Publications (1)
Publication Number | Publication Date |
---|---|
SG10201809427SA true SG10201809427SA (en) | 2018-11-29 |
Family
ID=54838417
Family Applications (4)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
SG10201809457YA SG10201809457YA (en) | 2014-11-21 | 2015-11-19 | Insulin receptor partial agonists |
SG10201809428UA SG10201809428UA (en) | 2014-11-21 | 2015-11-19 | Insulin receptor partial agonists |
SG10201809427SA SG10201809427SA (en) | 2014-11-21 | 2015-11-19 | Insulin receptor partial agonists |
SG11201704064TA SG11201704064TA (en) | 2014-11-21 | 2015-11-19 | Insulin receptor partial agonists |
Family Applications Before (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
SG10201809457YA SG10201809457YA (en) | 2014-11-21 | 2015-11-19 | Insulin receptor partial agonists |
SG10201809428UA SG10201809428UA (en) | 2014-11-21 | 2015-11-19 | Insulin receptor partial agonists |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
SG11201704064TA SG11201704064TA (en) | 2014-11-21 | 2015-11-19 | Insulin receptor partial agonists |
Country Status (27)
Country | Link |
---|---|
US (4) | US20170355743A1 (ko) |
EP (4) | EP3666792A3 (ko) |
JP (5) | JP6484337B2 (ko) |
KR (2) | KR102049647B1 (ko) |
CN (2) | CN112494656B (ko) |
AR (1) | AR102712A1 (ko) |
AU (3) | AU2015349890B2 (ko) |
BR (2) | BR122024000903A2 (ko) |
CA (2) | CA2966765C (ko) |
CL (3) | CL2017001288A1 (ko) |
CO (1) | CO2017004976A2 (ko) |
CR (1) | CR20170208A (ko) |
DO (1) | DOP2017000124A (ko) |
EA (1) | EA036714B1 (ko) |
ES (1) | ES2946247T3 (ko) |
GT (1) | GT201700104A (ko) |
IL (1) | IL252257A0 (ko) |
MX (3) | MX2017006651A (ko) |
NI (1) | NI201700060A (ko) |
PE (1) | PE20170957A1 (ko) |
PH (1) | PH12017500935A1 (ko) |
SG (4) | SG10201809457YA (ko) |
SV (1) | SV2017005445A (ko) |
TN (1) | TN2017000178A1 (ko) |
TW (1) | TW201625673A (ko) |
WO (1) | WO2016081670A2 (ko) |
ZA (1) | ZA201703238B (ko) |
Families Citing this family (25)
Publication number | Priority date | Publication date | Assignee | Title |
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PE20170682A1 (es) | 2014-08-04 | 2017-06-15 | Nuevolution As | Derivados de pirimidina sustituidos con heterociclilo opcionalmente condensados utiles para el tratamiento de enfermedades inflamatorias, metabolicas, oncologicas y autoinmunitarias |
US20170355743A1 (en) | 2014-11-21 | 2017-12-14 | Merck Sharp & Dohme Corp. | Insulin receptor partial agonists |
AR105616A1 (es) | 2015-05-07 | 2017-10-25 | Lilly Co Eli | Proteínas de fusión |
EP3463429A4 (en) * | 2016-05-24 | 2020-07-22 | Merck Sharp & Dohme Corp. | PARTIAL INSULIN RECEPTOR AGONISTS AND GLP-1 ANALOGUES |
WO2017205309A1 (en) | 2016-05-25 | 2017-11-30 | Merck Sharp & Dohme Corp. | Insulin receptor partial agonists |
CN109891237B (zh) * | 2016-10-24 | 2022-08-23 | 诺和诺德股份有限公司 | 胰岛素制剂的生物测定法 |
EP3668892A1 (en) | 2017-08-17 | 2020-06-24 | Novo Nordisk A/S | Novel acylated insulin analogues and uses thereof |
SG11202100934PA (en) | 2018-08-02 | 2021-02-25 | Dyne Therapeutics Inc | Muscle targeting complexes and uses thereof for treating dystrophinopathies |
US11168141B2 (en) | 2018-08-02 | 2021-11-09 | Dyne Therapeutics, Inc. | Muscle targeting complexes and uses thereof for treating dystrophinopathies |
WO2020028864A1 (en) | 2018-08-02 | 2020-02-06 | Dyne Therapeutics, Inc. | Muscle targeting complexes and uses thereof for treating facioscapulohumeral muscular dystrophy |
US11911484B2 (en) | 2018-08-02 | 2024-02-27 | Dyne Therapeutics, Inc. | Muscle targeting complexes and uses thereof for treating myotonic dystrophy |
US12018087B2 (en) | 2018-08-02 | 2024-06-25 | Dyne Therapeutics, Inc. | Muscle-targeting complexes comprising an anti-transferrin receptor antibody linked to an oligonucleotide and methods of delivering oligonucleotide to a subject |
CN112898172B (zh) * | 2019-12-04 | 2022-05-31 | 中国科学院大连化学物理研究所 | 可被羧肽酶酶解的双亲和功能团化合物的合成方法 |
US11447479B2 (en) | 2019-12-20 | 2022-09-20 | Nuevolution A/S | Compounds active towards nuclear receptors |
JP2023519605A (ja) | 2020-03-31 | 2023-05-11 | ヌエヴォリューション・アクティーゼルスカブ | 核内受容体に対して活性な化合物 |
WO2021198955A1 (en) | 2020-03-31 | 2021-10-07 | Nuevolution A/S | Compounds active towards nuclear receptors |
WO2022046747A1 (en) * | 2020-08-26 | 2022-03-03 | Merck Sharp & Dohme Corp. | Insulin receptor partial agonists |
KR20230079068A (ko) * | 2020-09-03 | 2023-06-05 | 다인 세라퓨틱스, 인크. | 단백질-올리고뉴클레오티드 복합체의 제조 방법 |
EP4210729A2 (en) * | 2020-09-09 | 2023-07-19 | Merck Sharp & Dohme LLC | Insulin receptor partial agonists |
US11771776B2 (en) | 2021-07-09 | 2023-10-03 | Dyne Therapeutics, Inc. | Muscle targeting complexes and uses thereof for treating dystrophinopathies |
US11638761B2 (en) | 2021-07-09 | 2023-05-02 | Dyne Therapeutics, Inc. | Muscle targeting complexes and uses thereof for treating Facioscapulohumeral muscular dystrophy |
US11672872B2 (en) | 2021-07-09 | 2023-06-13 | Dyne Therapeutics, Inc. | Anti-transferrin receptor antibody and uses thereof |
US11969475B2 (en) | 2021-07-09 | 2024-04-30 | Dyne Therapeutics, Inc. | Muscle targeting complexes and uses thereof for treating facioscapulohumeral muscular dystrophy |
US11633498B2 (en) | 2021-07-09 | 2023-04-25 | Dyne Therapeutics, Inc. | Muscle targeting complexes and uses thereof for treating myotonic dystrophy |
US11931421B2 (en) | 2022-04-15 | 2024-03-19 | Dyne Therapeutics, Inc. | Muscle targeting complexes and formulations for treating myotonic dystrophy |
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US20090197800A1 (en) | 2004-10-27 | 2009-08-06 | Novo Nordisk A/S | Insulin Receptor Binding Peptides with Non-Insulin Gene Activation Profiles and Uses Thereof |
ES2545533T3 (es) | 2004-11-01 | 2015-09-11 | The Regents Of The University Of California | Composiciones y métodos para modificación de biomoléculas |
JP2008533100A (ja) | 2005-03-18 | 2008-08-21 | ノボ ノルディスク アクティーゼルスカブ | Peg化された単鎖インスリン |
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WO2007104734A1 (en) | 2006-03-13 | 2007-09-20 | Novo Nordisk A/S | Acylated single chain insulin |
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EP1996223A1 (en) | 2006-03-13 | 2008-12-03 | Novo Nordisk A/S | Acylated single chain insulin |
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TWI394580B (zh) * | 2008-04-28 | 2013-05-01 | Halozyme Inc | 超快起作用胰島素組成物 |
DK2349324T3 (en) * | 2008-10-17 | 2017-12-11 | Sanofi Aventis Deutschland | COMBINATION OF AN INSULIN AND A GLP-1 AGONIST |
EP2376521B1 (en) | 2008-12-19 | 2016-04-13 | Indiana University Research and Technology Corporation | Amide-based insulin prodrugs |
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WO2011159895A2 (en) | 2010-06-16 | 2011-12-22 | Indiana University Research And Technology Corporation | Single chain insulin agonists exhibiting high activity at the insulin receptor |
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MX366852B (es) * | 2013-10-04 | 2019-07-25 | Merck Sharp & Dohme | Conjugados de insulina sensibles a glucosa. |
EP3068443B1 (en) * | 2013-11-12 | 2019-04-10 | Centre for Probe Development and Commercialization | Residualizing linkers and uses thereof |
US10253082B2 (en) | 2014-01-20 | 2019-04-09 | Hanmi Pharm. Co., Ltd | Long-acting insulin and use thereof |
US20170355743A1 (en) | 2014-11-21 | 2017-12-14 | Merck Sharp & Dohme Corp. | Insulin receptor partial agonists |
-
2015
- 2015-11-19 US US15/527,363 patent/US20170355743A1/en not_active Abandoned
- 2015-11-19 CR CR20170208A patent/CR20170208A/es unknown
- 2015-11-19 AU AU2015349890A patent/AU2015349890B2/en active Active
- 2015-11-19 SG SG10201809457YA patent/SG10201809457YA/en unknown
- 2015-11-19 EP EP19211801.6A patent/EP3666792A3/en active Pending
- 2015-11-19 US US14/945,461 patent/US10017556B2/en active Active
- 2015-11-19 BR BR122024000903-0A patent/BR122024000903A2/pt active Search and Examination
- 2015-11-19 KR KR1020177016516A patent/KR102049647B1/ko active IP Right Grant
- 2015-11-19 CN CN202011335828.4A patent/CN112494656B/zh active Active
- 2015-11-19 CN CN201580074165.6A patent/CN108064173B/zh active Active
- 2015-11-19 JP JP2017526961A patent/JP6484337B2/ja active Active
- 2015-11-19 EA EA201791117A patent/EA036714B1/ru unknown
- 2015-11-19 SG SG10201809428UA patent/SG10201809428UA/en unknown
- 2015-11-19 PE PE2017000888A patent/PE20170957A1/es unknown
- 2015-11-19 ES ES19211799T patent/ES2946247T3/es active Active
- 2015-11-19 WO PCT/US2015/061445 patent/WO2016081670A2/en active Application Filing
- 2015-11-19 MX MX2017006651A patent/MX2017006651A/es unknown
- 2015-11-19 EP EP19211799.2A patent/EP3660041B1/en active Active
- 2015-11-19 KR KR1020197016746A patent/KR102101136B1/ko active IP Right Grant
- 2015-11-19 EP EP15807730.5A patent/EP3221343B1/en active Active
- 2015-11-19 PH PH12017500935A patent/PH12017500935A1/en unknown
- 2015-11-19 SG SG10201809427SA patent/SG10201809427SA/en unknown
- 2015-11-19 TN TN2017000178A patent/TN2017000178A1/en unknown
- 2015-11-19 CA CA2966765A patent/CA2966765C/en active Active
- 2015-11-19 TW TW104138282A patent/TW201625673A/zh unknown
- 2015-11-19 BR BR122024000898-0A patent/BR122024000898A2/pt active Search and Examination
- 2015-11-19 AR ARP150103770A patent/AR102712A1/es unknown
- 2015-11-19 CA CA3014641A patent/CA3014641C/en active Active
- 2015-11-19 SG SG11201704064TA patent/SG11201704064TA/en unknown
- 2015-11-19 EP EP19211793.5A patent/EP3660040A3/en active Pending
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2017
- 2017-05-10 ZA ZA2017/03238A patent/ZA201703238B/en unknown
- 2017-05-11 IL IL252257A patent/IL252257A0/en unknown
- 2017-05-18 CL CL2017001288A patent/CL2017001288A1/es unknown
- 2017-05-18 CO CONC2017/0004976A patent/CO2017004976A2/es unknown
- 2017-05-19 MX MX2020014120A patent/MX2020014120A/es unknown
- 2017-05-19 MX MX2020014121A patent/MX2020014121A/es unknown
- 2017-05-19 GT GT201700104A patent/GT201700104A/es unknown
- 2017-05-19 DO DO2017000124A patent/DOP2017000124A/es unknown
- 2017-05-19 NI NI201700060A patent/NI201700060A/es unknown
- 2017-05-19 SV SV2017005445A patent/SV2017005445A/es unknown
-
2018
- 2018-06-13 US US16/007,046 patent/US10183981B2/en active Active
- 2018-07-31 AU AU2018211207A patent/AU2018211207B2/en active Active
- 2018-07-31 AU AU2018211208A patent/AU2018211208B2/en active Active
- 2018-09-28 JP JP2018183314A patent/JP2019014734A/ja not_active Withdrawn
- 2018-09-28 JP JP2018183316A patent/JP6703068B2/ja active Active
- 2018-09-28 JP JP2018183315A patent/JP6943825B2/ja active Active
- 2018-11-26 US US16/199,774 patent/US10800827B2/en active Active
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2019
- 2019-04-26 CL CL2019001144A patent/CL2019001144A1/es unknown
- 2019-04-26 CL CL2019001143A patent/CL2019001143A1/es unknown
- 2019-11-12 JP JP2019204409A patent/JP6931033B2/ja active Active
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