SG10201806715TA - Use of inos inhibitors to increase viral yield in culture - Google Patents
Use of inos inhibitors to increase viral yield in cultureInfo
- Publication number
- SG10201806715TA SG10201806715TA SG10201806715TA SG10201806715TA SG10201806715TA SG 10201806715T A SG10201806715T A SG 10201806715TA SG 10201806715T A SG10201806715T A SG 10201806715TA SG 10201806715T A SG10201806715T A SG 10201806715TA SG 10201806715T A SG10201806715T A SG 10201806715TA
- Authority
- SG
- Singapore
- Prior art keywords
- culture
- inos inhibitors
- viral yield
- increase viral
- increase
- Prior art date
Links
- 239000003112 inhibitor Substances 0.000 title abstract 3
- 230000003612 virological effect Effects 0.000 title abstract 2
- 101100396994 Drosophila melanogaster Inos gene Proteins 0.000 title 1
- 102100029438 Nitric oxide synthase, inducible Human genes 0.000 abstract 2
- 101710089543 Nitric oxide synthase, inducible Proteins 0.000 abstract 2
- NIJJYAXOARWZEE-UHFFFAOYSA-N Valproic acid Chemical compound CCCC(C(O)=O)CCC NIJJYAXOARWZEE-UHFFFAOYSA-N 0.000 abstract 2
- 241000700605 Viruses Species 0.000 abstract 1
- GIXWDMTZECRIJT-UHFFFAOYSA-N aurintricarboxylic acid Chemical compound C1=CC(=O)C(C(=O)O)=CC1=C(C=1C=C(C(O)=CC=1)C(O)=O)C1=CC=C(O)C(C(O)=O)=C1 GIXWDMTZECRIJT-UHFFFAOYSA-N 0.000 abstract 1
- UREBDLICKHMUKA-CXSFZGCWSA-N dexamethasone Chemical compound C1CC2=CC(=O)C=C[C@]2(C)[C@]2(F)[C@@H]1[C@@H]1C[C@@H](C)[C@@](C(=O)CO)(O)[C@@]1(C)C[C@@H]2O UREBDLICKHMUKA-CXSFZGCWSA-N 0.000 abstract 1
- 229960003957 dexamethasone Drugs 0.000 abstract 1
- 241001529453 unidentified herpesvirus Species 0.000 abstract 1
- 229960000604 valproic acid Drugs 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/12—Viral antigens
- A61K39/245—Herpetoviridae, e.g. herpes simplex virus
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N7/00—Viruses; Bacteriophages; Compositions thereof; Preparation or purification thereof
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
- C12N2710/00011—Details
- C12N2710/16011—Herpesviridae
- C12N2710/16611—Simplexvirus, e.g. human herpesvirus 1, 2
- C12N2710/16641—Use of virus, viral particle or viral elements as a vector
- C12N2710/16643—Use of virus, viral particle or viral elements as a vector viral genome or elements thereof as genetic vector
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
- C12N2710/00011—Details
- C12N2710/16011—Herpesviridae
- C12N2710/16611—Simplexvirus, e.g. human herpesvirus 1, 2
- C12N2710/16651—Methods of production or purification of viral material
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Genetics & Genomics (AREA)
- Zoology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Organic Chemistry (AREA)
- Wood Science & Technology (AREA)
- Virology (AREA)
- Immunology (AREA)
- Microbiology (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Biochemistry (AREA)
- General Engineering & Computer Science (AREA)
- Biotechnology (AREA)
- Biomedical Technology (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Mycology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201361750175P | 2013-01-08 | 2013-01-08 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| SG10201806715TA true SG10201806715TA (en) | 2018-09-27 |
Family
ID=51167323
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SG11201505333PA SG11201505333PA (en) | 2013-01-08 | 2014-01-07 | Use of inos inhibitors to increase viral yield in culture |
| SG10201913130PA SG10201913130PA (en) | 2013-01-08 | 2014-01-07 | Use of inos inhibitors to increase viral yield in culture |
| SG10201806715TA SG10201806715TA (en) | 2013-01-08 | 2014-01-07 | Use of inos inhibitors to increase viral yield in culture |
Family Applications Before (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SG11201505333PA SG11201505333PA (en) | 2013-01-08 | 2014-01-07 | Use of inos inhibitors to increase viral yield in culture |
| SG10201913130PA SG10201913130PA (en) | 2013-01-08 | 2014-01-07 | Use of inos inhibitors to increase viral yield in culture |
Country Status (20)
Families Citing this family (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP6401871B2 (ja) | 2014-11-05 | 2018-10-10 | ボイジャー セラピューティクス インコーポレイテッドＶｏｙａｇｅｒ Ｔｈｅｒａｐｅｕｔｉｃｓ，Ｉｎｃ． | パーキンソン病の治療のためのａａｄｃポリヌクレオチド |
| US10597660B2 (en) | 2014-11-14 | 2020-03-24 | Voyager Therapeutics, Inc. | Compositions and methods of treating amyotrophic lateral sclerosis (ALS) |
| RU2749882C2 (ru) | 2014-11-14 | 2021-06-18 | Вояджер Терапьютикс, Инк. | Модулирующие полинуклеотиды |
| US11697825B2 (en) | 2014-12-12 | 2023-07-11 | Voyager Therapeutics, Inc. | Compositions and methods for the production of scAAV |
| CA3018380A1 (en) | 2016-03-28 | 2017-10-05 | Dimension Therapeutics, Inc. | Methods of heat inactivation of adenovirus |
| JP7066635B2 (ja) | 2016-05-18 | 2022-05-13 | ボイジャー セラピューティクス インコーポレイテッド | 調節性ポリヌクレオチド |
| ES3012649T3 (en) | 2016-10-14 | 2025-04-09 | Ultragenyx Pharmaceutical Inc | Use of tonicifying agents to enhance recombinant adeno-associated virus yield |
| WO2018175775A1 (en) | 2017-03-22 | 2018-09-27 | Dimension Therapeutics | Cell culture methods involving hdac inhibitors or rep proteins |
| JOP20190269A1 (ar) | 2017-06-15 | 2019-11-20 | Voyager Therapeutics Inc | بولي نوكليوتيدات aadc لعلاج مرض باركنسون |
| AU2019268330A1 (en) | 2018-05-15 | 2020-11-26 | Voyager Therapeutics, Inc. | Compositions and methods for the treatment of Parkinson's disease |
| CN110835622B (zh) * | 2018-08-16 | 2021-04-27 | 上海药明生物技术有限公司 | 用于调节哺乳动物细胞乳酸代谢的培养基及其应用 |
| KR20210068068A (ko) | 2018-09-28 | 2021-06-08 | 보이저 테라퓨틱스, 인크. | 조작된 프로모터를 갖는 프라탁신 발현 구축물 및 그의 사용 방법 |
| AU2021239973A1 (en) | 2020-03-16 | 2022-10-06 | Ultragenyx Pharmaceutical Inc. | Methods for enhancing recombinant adeno-associated virus yield |
| US20250163456A1 (en) * | 2022-02-21 | 2025-05-22 | Nippon Medical School Foundation | Agent for enhancing production of viral vector and method for producing viral vector |
Family Cites Families (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5139941A (en) | 1985-10-31 | 1992-08-18 | University Of Florida Research Foundation, Inc. | AAV transduction vectors |
| WO1992001070A1 (en) | 1990-07-09 | 1992-01-23 | The United States Of America, As Represented By The Secretary, U.S. Department Of Commerce | High efficiency packaging of mutant adeno-associated virus using amber suppressions |
| US5173414A (en) | 1990-10-30 | 1992-12-22 | Applied Immune Sciences, Inc. | Production of recombinant adeno-associated virus vectors |
| RU2012335C1 (ru) * | 1991-07-04 | 1994-05-15 | Уфимский научно-исследовательский институт глазных болезней | Ингибитор вируса простого герпеса |
| JP3534749B2 (ja) | 1991-08-20 | 2004-06-07 | アメリカ合衆国 | アデノウイルスが介在する胃腸管への遺伝子の輸送 |
| US7223411B1 (en) | 1992-07-31 | 2007-05-29 | Dana-Farber Cancer Institute | Herpesvirus replication defective mutants |
| ATE228008T1 (de) * | 1992-07-31 | 2002-12-15 | Harvard College | Herpesvirus impfstoffe |
| US6833271B2 (en) | 1996-12-04 | 2004-12-21 | Medi-Cult A/S | Serum-free cell culture media |
| GB9816856D0 (en) * | 1998-08-03 | 1998-09-30 | Univ London | Cell lines for virus growth |
| US6783972B1 (en) * | 1998-09-22 | 2004-08-31 | University Of Florida Research Foundation | Methods for large-scale production of recombinant AAV vectors |
| US6593123B1 (en) | 2000-08-07 | 2003-07-15 | Avigen, Inc. | Large-scale recombinant adeno-associated virus (rAAV) production and purification |
| US7091029B2 (en) | 2002-09-23 | 2006-08-15 | Applied Genetics Technologies Corporation | High titer recombinant AAV production |
| US7427396B2 (en) | 2004-06-03 | 2008-09-23 | Genzyme Corporation | AAV vectors for gene delivery to the lung |
| CN100348718C (zh) * | 2005-10-18 | 2007-11-14 | 中国人民解放军军事医学科学院生物工程研究所 | 一种支持hek293细胞贴附培养的无动物来源成分无血清培养基 |
| EA200971115A1 (ru) * | 2007-06-29 | 2010-04-30 | Корея Рисерч Инститьют Оф Кемикал Текнолоджи | Новые ингибиторы обратной транскриптазы вич |
-
2014
- 2014-01-07 HU HUE14703459A patent/HUE037482T2/hu unknown
- 2014-01-07 EP EP17184746.0A patent/EP3266866B1/en active Active
- 2014-01-07 BR BR112015016328-9A patent/BR112015016328B1/pt active IP Right Grant
- 2014-01-07 DK DK14703459.9T patent/DK2943567T3/en active
- 2014-01-07 JP JP2015551846A patent/JP6534933B2/ja active Active
- 2014-01-07 EP EP14703459.9A patent/EP2943567B1/en active Active
- 2014-01-07 MX MX2018013366A patent/MX378877B/es unknown
- 2014-01-07 EP EP19160865.2A patent/EP3521420A1/en not_active Withdrawn
- 2014-01-07 AU AU2014205604A patent/AU2014205604B2/en not_active Ceased
- 2014-01-07 CN CN201480012376.2A patent/CN105008523B/zh active Active
- 2014-01-07 MX MX2015008861A patent/MX360470B/es active IP Right Grant
- 2014-01-07 SG SG11201505333PA patent/SG11201505333PA/en unknown
- 2014-01-07 TW TW103100466A patent/TWI608102B/zh active
- 2014-01-07 US US14/758,785 patent/US11299715B2/en active Active
- 2014-01-07 CA CA2897444A patent/CA2897444A1/en not_active Abandoned
- 2014-01-07 KR KR1020157021175A patent/KR102307279B1/ko active Active
- 2014-01-07 RU RU2015133205A patent/RU2676733C2/ru active
- 2014-01-07 SG SG10201913130PA patent/SG10201913130PA/en unknown
- 2014-01-07 SG SG10201806715TA patent/SG10201806715TA/en unknown
- 2014-01-07 BR BR122020002822-0A patent/BR122020002822B1/pt active IP Right Grant
- 2014-01-07 WO PCT/US2014/010553 patent/WO2014110053A1/en active Application Filing
- 2014-01-07 ES ES14703459.9T patent/ES2651763T3/es active Active
- 2014-01-08 AR ARP140100065A patent/AR094389A1/es unknown
- 2014-09-26 NO NO14781027A patent/NO3050055T3/no unknown
-
2015
- 2015-07-07 IL IL239824A patent/IL239824B/en active IP Right Grant
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2018
- 2018-07-10 HK HK18108963.6A patent/HK1249544A1/en unknown
-
2019
- 2019-05-28 JP JP2019098958A patent/JP6837094B2/ja active Active
-
2022
- 2022-03-03 US US17/686,245 patent/US20220340883A1/en active Pending
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