SG10201801956SA - Antimicrobial compounds and methods of making and using the same - Google Patents

Antimicrobial compounds and methods of making and using the same

Info

Publication number
SG10201801956SA
SG10201801956SA SG10201801956SA SG10201801956SA SG10201801956SA SG 10201801956S A SG10201801956S A SG 10201801956SA SG 10201801956S A SG10201801956S A SG 10201801956SA SG 10201801956S A SG10201801956S A SG 10201801956SA SG 10201801956S A SG10201801956S A SG 10201801956SA
Authority
SG
Singapore
Prior art keywords
making
methods
same
antimicrobial compounds
antimicrobial
Prior art date
Application number
SG10201801956SA
Other languages
English (en)
Inventor
Zoltan F Kanyo
Ashoke Bhattacharjee
Erin Duffy
Andrea Marra
Original Assignee
Melinta Therapeutics Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Melinta Therapeutics Inc filed Critical Melinta Therapeutics Inc
Publication of SG10201801956SA publication Critical patent/SG10201801956SA/en

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D487/00Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04Ortho-condensed systems
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/41641,3-Diazoles
    • A61K31/41881,3-Diazoles condensed with other heterocyclic ring systems, e.g. biotin, sorbinil
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04Antibacterial agents
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D239/00Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/46Two or more oxygen, sulphur or nitrogen atoms
    • C07D239/47One nitrogen atom and one oxygen or sulfur atom, e.g. cytosine
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D519/00Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Oncology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Communicable Diseases (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
SG10201801956SA 2013-09-09 2014-09-09 Antimicrobial compounds and methods of making and using the same SG10201801956SA (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US201361875643P 2013-09-09 2013-09-09

Publications (1)

Publication Number Publication Date
SG10201801956SA true SG10201801956SA (en) 2018-04-27

Family

ID=52629046

Family Applications (2)

Application Number Title Priority Date Filing Date
SG10201801956SA SG10201801956SA (en) 2013-09-09 2014-09-09 Antimicrobial compounds and methods of making and using the same
SG11201601654TA SG11201601654TA (en) 2013-09-09 2014-09-09 Antimicrobial compunds and methods of making and using the same

Family Applications After (1)

Application Number Title Priority Date Filing Date
SG11201601654TA SG11201601654TA (en) 2013-09-09 2014-09-09 Antimicrobial compunds and methods of making and using the same

Country Status (12)

Country Link
US (2) US10106543B2 (de)
EP (1) EP3039025A4 (de)
JP (1) JP2016536338A (de)
KR (1) KR20160070066A (de)
CN (1) CN106103442A (de)
AU (1) AU2014315050A1 (de)
CA (1) CA2923214A1 (de)
IL (1) IL244416A0 (de)
MX (1) MX2016002975A (de)
PH (1) PH12016500453A1 (de)
SG (2) SG10201801956SA (de)
WO (1) WO2015035426A1 (de)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2011047320A2 (en) 2009-10-16 2011-04-21 Rib-X Pharmaceuticals, Inc. Antimicrobial compounds and methods of making and using the same
CN102725274A (zh) 2009-10-16 2012-10-10 Rib-X制药公司 抗微生物化合物和其制备和使用方法
JO3078B1 (ar) 2009-11-27 2017-03-15 Janssen Pharmaceutica Nv مورفولينوثيازولات بصفتها منظمات الوستيرية نوع الفا 7 موجبة
AU2014315050A1 (en) 2013-09-09 2016-03-24 Melinta Therapeutics, Inc. Antimicrobial compunds and methods of making and using the same
JP2016529325A (ja) 2013-09-09 2016-09-23 メリンタ セラピューティクス,インコーポレイテッド 抗微生物化合物ならびにそれの製造方法および使用方法
MX2017011616A (es) 2015-03-11 2018-04-11 Melinta Therapeutics Inc Compuestos antimicrobianos y métodos para hacerlos y usarlos.
WO2017193023A1 (en) * 2016-05-06 2017-11-09 Melinta Therapeutics, Inc. Antimicrobials and methods of making and using same
CA3023444A1 (en) * 2016-05-06 2017-11-09 Melinta Therapeutics, Inc. Antimicrobials and methods of making and using same
US11098047B2 (en) * 2016-05-06 2021-08-24 BioVersys AG Antimicrobials and methods of making and using same
US20210403473A1 (en) * 2018-02-21 2021-12-30 BioVersys AG Antimicrobial compounds and methods of making and using the same
WO2019234508A1 (en) 2018-06-06 2019-12-12 BioVersys AG Biodefense agents
WO2019234509A2 (en) * 2018-06-06 2019-12-12 BioVersys AG Aminomethylamidine and methylamidine antimicrobial compounds
WO2020115547A2 (en) * 2018-12-07 2020-06-11 BioVersys AG Pyrrolo[2,3-d]pyrimidin-2-one antimicrobial compounds
CA3158103A1 (en) * 2019-11-13 2021-05-20 Curza Global, Llc Antimicrobial compounds and methods

Family Cites Families (84)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2624731A (en) 1953-01-06 S-phenylpyrimidkn e x derivativesx
US3980781A (en) 1966-03-31 1976-09-14 Imperial Chemical Industries Limited Fungicidal composition and method containing 2-amino-pyrimidines
US3673184A (en) 1970-09-02 1972-06-27 Dainippon Pharmaceutical Co Certain 2-substituted-5,8-dihydro-5-oxopyrido{8 2,3-d{9 pyrimidine-6-carboxylic acid derivatives
US4361557A (en) 1980-01-28 1982-11-30 Schering Corporation 1-Aryl-2-acylamido-3-fluoro-1-propanol acylates, methods for their use as anti-bacterial agents and compositions useful therefor
EP0067610A1 (de) 1981-06-16 1982-12-22 Beecham Group Plc Penicilline, ein Verfahren zu ihrer Herstellung und sie enthaltende Zusammensetzungen
US4522811A (en) 1982-07-08 1985-06-11 Syntex (U.S.A.) Inc. Serial injection of muramyldipeptides and liposomes enhances the anti-infective activity of muramyldipeptides
US5332835A (en) 1984-02-03 1994-07-26 Zambon S.P.A. Process for fluorinating 1-phenyl-2-amino-1,3-propanediol compounds and new oxazoline compounds useful in this process
JPS6191184A (ja) 1984-10-08 1986-05-09 Morishita Seiyaku Kk 2−アニリノ−5−(1h−テトラゾ−ル−5−イル)ピリミジン−4(3h)−オン誘導体
JP2873340B2 (ja) 1988-04-29 1999-03-24 武田薬品工業株式会社 抗生物質tan―1057,その製造法および用途
JP2991382B2 (ja) 1990-07-18 1999-12-20 大日本製薬株式会社 縮合三環式化合物およびその塩
US5208141A (en) 1990-10-09 1993-05-04 Konica Corporation Silver halide color photographic light-sensitive material
US5958930A (en) 1991-04-08 1999-09-28 Duquesne University Of The Holy Ghost Pyrrolo pyrimidine and furo pyrimidine derivatives
US6451968B1 (en) 1991-05-24 2002-09-17 Isis Pharmaceuticals, Inc. Peptide nucleic acids
US5766855A (en) 1991-05-24 1998-06-16 Buchardt, Deceased; Ole Peptide nucleic acids having enhanced binding affinity and sequence specificity
US5434257A (en) 1992-06-01 1995-07-18 Gilead Sciences, Inc. Binding compentent oligomers containing unsaturated 3',5' and 2',5' linkages
US5646163A (en) 1992-10-30 1997-07-08 The Procter & Gamble Company Quinolone 5-(N-heterosubstituted amino) antimicrobials
PL174704B1 (pl) 1993-05-12 1998-09-30 Du Pont Nowe 4(3H)-chinazolinony i środek grzybobójczy do zwalczania mączniaka pszenicy
US5502177A (en) 1993-09-17 1996-03-26 Gilead Sciences, Inc. Pyrimidine derivatives for labeled binding partners
US5567884A (en) 1994-03-09 1996-10-22 International Business Machines Corporation Circuit board assembly torsion tester and method
US5668127A (en) 1995-06-26 1997-09-16 Pathogenesis Corporation Nitroimidazole antibacterial compounds and methods of use thereof
TW424090B (en) 1995-08-18 2001-03-01 Nat Science Council Pyrimidines as folate antimetabolites with selective activity against human brain cancer
US5763263A (en) 1995-11-27 1998-06-09 Dehlinger; Peter J. Method and apparatus for producing position addressable combinatorial libraries
US7282327B2 (en) 1996-01-23 2007-10-16 Affymetrix, Inc. Nucleic acid labeling compounds
GB9708611D0 (en) 1997-04-28 1997-06-18 Univ Cardiff Chemical compounds
US6110925A (en) 1997-08-07 2000-08-29 Research Corporation Technologies, Inc. Antibiotic for methicillin resistant bacteria
US6028183A (en) 1997-11-07 2000-02-22 Gilead Sciences, Inc. Pyrimidine derivatives and oligonucleotides containing same
CA2309340C (en) 1997-11-07 2006-02-21 Isis Pharmaceuticals Inc. Pyrimidine derivatives for labeled binding partners
DE19838998A1 (de) 1998-08-27 2000-03-09 Bayer Ag Neue Naturstoffderivate
SE9903894D0 (sv) 1999-10-28 1999-10-28 New Pharma Research Ab Novel compounds
EP1113008A1 (de) 1999-12-29 2001-07-04 Pfizer Products Inc. 4-Oxo-2-Ureido-1,4,5,6-Tetrahydropyrimidinderivate als Antibakterielle und Antiprotozoen Mittel
KR100358083B1 (ko) 2000-02-17 2002-10-25 에스케이케미칼주식회사 피롤로피리미디논 유도체와 이의 제조방법, 그리고 이의용도
CN1646141B (zh) 2000-10-18 2014-06-25 吉利德制药有限责任公司 用于治疗病毒感染和异常细胞增殖的修饰核苷类化合物
DE10061542A1 (de) 2000-12-11 2002-06-13 Bayer Ag Alkanoylamino-pyrimidine
DE10061537A1 (de) 2000-12-11 2002-06-20 Bayer Ag beta-Alanin-Derivate
DE10061541A1 (de) 2000-12-11 2002-06-20 Bayer Ag Arylamino-Dihydropyrimidinone
DE10061538A1 (de) 2000-12-11 2002-06-20 Bayer Ag Ureido-Dihydropyrimidinone
AU3089102A (en) 2000-12-14 2002-06-24 Procter & Gamble Antimicrobial quinolones
US6900215B2 (en) 2000-12-15 2005-05-31 Merck Sharp & Dohme Ltd. Imidazo-pyrimidine derivatives as ligands for gaba receptors
EP1363640B1 (de) 2001-01-29 2010-04-28 Bio-Rad Laboratories, Inc. Nukleinsäurederivative
TWI248936B (en) 2001-03-21 2006-02-11 Merck Sharp & Dohme Imidazo-pyrimidine derivatives as ligands for GABA receptors
US20030207804A1 (en) 2001-05-25 2003-11-06 Muthiah Manoharan Modified peptide nucleic acids
US20030158403A1 (en) 2001-07-03 2003-08-21 Isis Pharmaceuticals, Inc. Nuclease resistant chimeric oligonucleotides
JP2005504020A (ja) 2001-07-03 2005-02-10 アイシス・ファーマシューティカルス・インコーポレーテッド ヌクレアーゼ耐性キメラオリゴヌクレオチド
DE10133277A1 (de) 2001-07-09 2003-01-23 Bayer Ag ß-Alanin-Derivate
DE10141271A1 (de) 2001-08-23 2003-03-06 Bayer Ag Neue Tetrahydro-1,3,5-triazin-2-on-Derivate und ihre Verwendung
DE10208256A1 (de) 2002-02-26 2003-09-04 Bayer Ag Piperidinouracile
WO2003077828A2 (en) 2002-03-08 2003-09-25 Schering-Plough, Ltd. Novel florfenicol-type antibiotics
WO2004080466A1 (en) 2003-03-07 2004-09-23 Ribapharm Inc. Cytidine analogs and methods of use
KR20060069836A (ko) 2003-08-12 2006-06-22 아칠리온 파르마세우티칼스 인코포레이티드 항-감염제로서의 이소티아졸로퀴놀론 및 관련 화합물
MXPA06002001A (es) 2003-08-26 2006-06-20 Teijin Pharma Ltd Derivados pirrolopirimidinona.
TW200524880A (en) 2003-10-21 2005-08-01 Sankyo Co Pyrimidine compounds
EP1781788A2 (de) 2004-06-30 2007-05-09 ZGene A/S Desoxycytidinkinase- und desoxyadenosinkinase-enzyme aus huhn und deren verwendung
ATE482219T1 (de) 2005-07-27 2010-10-15 Achillion Pharmaceuticals Inc 8-methoxy-9h-isothiazoloä5,4-büchinolin-3,4-dio e und verwandte verbindungen als antiinfektive mittel
CN101360720A (zh) 2005-11-15 2009-02-04 阿斯利康(瑞典)有限公司 新颖的2-氨基嘧啶酮衍生物及其用途
NZ544187A (en) 2005-12-15 2008-07-31 Ind Res Ltd Deazapurine analogs of 1'-aza-l-nucleosides
JO2660B1 (en) 2006-01-20 2012-06-17 نوفارتيس ايه جي Pi-3 inhibitors and methods of use
JP2007270087A (ja) 2006-03-31 2007-10-18 Fujifilm Corp 硬化性組成物、インク組成物、インクジェット記録方法、印刷物、平版印刷版の製造方法、及び平版印刷版
ATE496766T1 (de) 2006-03-03 2011-02-15 Fujifilm Corp Härtbare zusammensetzung, tintenzusammensetzung, tintenstrahlaufzeichnungsverfahren und flachdruckplatte
KR20080003599A (ko) 2006-07-03 2008-01-08 에스케이케미칼주식회사 피롤로피리미디논 유도체의 겐티세이트 염 및 이의제조방법
AU2007270276A1 (en) 2006-07-03 2008-01-10 Sk Chemicals Co., Ltd. Salts of pyrrolopyrimidinone derivatives and process for preparing the same
US20100112561A1 (en) 2006-08-25 2010-05-06 Stefan Lutz Fluorescent nucleoside analogues
AU2007293774C1 (en) 2006-09-07 2014-12-18 Albert Einstein College Of Medicine, Inc. Acyclic amine inhibitors of nucleoside phosphorylases and hydrolases
EP1964841A1 (de) 2007-02-28 2008-09-03 sanofi-aventis Imidazo[1,2-a]azine und deren pharmazeutische Verwendung
WO2008143729A2 (en) 2007-02-28 2008-11-27 Rib-X Pharmaceuticals, Inc. Macrolide compounds and methods of making and using the same
US20080221094A1 (en) 2007-03-07 2008-09-11 Harald Bluhm Metalloprotease inhibitors containing a squaramide moiety
JP2008222557A (ja) 2007-03-08 2008-09-25 Kotobuki Seiyaku Kk ピロロ[3,2−d]ピリミジン誘導体及びこれを有効成分とする医薬組成物
PE20090758A1 (es) 2007-05-30 2009-06-24 Schering Plough Ltd Un proceso para la preparacion de compuestos de aminodiol protegidos con oxazolina, utiles como intermediarios para florfenicol
TWI519508B (zh) 2007-06-12 2016-02-01 Achaogen Inc 抗菌劑
US20110046142A1 (en) 2007-06-13 2011-02-24 Northeastern University Antibiotic compounds
GB0724342D0 (en) 2007-12-13 2008-01-30 Prolysis Ltd Anitbacterial compositions
KR20090098710A (ko) 2008-03-14 2009-09-17 주식회사 씨티아이바이오 세포투과성과 핵산 결합력이 좋은 펩타이드 핵산 유도체
WO2010087467A1 (en) 2009-01-27 2010-08-05 Takeda Pharmaceutical Company Limited Delta-5-desaturase inhibitors
WO2011017319A1 (en) 2009-08-03 2011-02-10 University Of Pittsburgh - Of The Commonwealth System Of Higher Education Methods of treating disorders associated with protein polymerization
EP2501696B1 (de) 2009-10-15 2016-12-28 Guerbet Kontrastmittel und ihre verwendung zur in-vivo-diagnose von neurodegenerativen erkrankungen, im besonderen morbus alzheimer und daraus resultierende erkrankungen
TW201726630A (zh) 2009-10-16 2017-08-01 梅林塔療法公司 抗微生物性化合物及其製造與使用方法
CN102725274A (zh) 2009-10-16 2012-10-10 Rib-X制药公司 抗微生物化合物和其制备和使用方法
KR101972992B1 (ko) 2009-10-16 2019-04-29 멜린타 서브시디어리 코프. 항미생물성 화합물 및 이의 제조 방법 및 사용 방법
WO2011047320A2 (en) 2009-10-16 2011-04-21 Rib-X Pharmaceuticals, Inc. Antimicrobial compounds and methods of making and using the same
WO2012125832A2 (en) 2011-03-15 2012-09-20 Rib-X Pharmaceuticals, Inc. Antimicrobial agents
CA2833169A1 (en) * 2011-04-15 2012-12-20 Rib-X Pharmaceuticals, Inc. Antimicrobial compounds and methods of making and using the same
JP2016529325A (ja) 2013-09-09 2016-09-23 メリンタ セラピューティクス,インコーポレイテッド 抗微生物化合物ならびにそれの製造方法および使用方法
AU2014315050A1 (en) 2013-09-09 2016-03-24 Melinta Therapeutics, Inc. Antimicrobial compunds and methods of making and using the same
FR3014513B1 (fr) * 2013-12-09 2017-04-28 Chassis Brakes Int Bv Frein a tambour muni d'un organe de retenue d'un segment de freinage.
MX2017011616A (es) 2015-03-11 2018-04-11 Melinta Therapeutics Inc Compuestos antimicrobianos y métodos para hacerlos y usarlos.

Also Published As

Publication number Publication date
SG11201601654TA (en) 2016-04-28
US20190284190A1 (en) 2019-09-19
US10815238B2 (en) 2020-10-27
MX2016002975A (es) 2016-10-21
CA2923214A1 (en) 2015-03-12
US20160214988A1 (en) 2016-07-28
KR20160070066A (ko) 2016-06-17
CN106103442A (zh) 2016-11-09
EP3039025A1 (de) 2016-07-06
EP3039025A4 (de) 2017-05-31
JP2016536338A (ja) 2016-11-24
AU2014315050A1 (en) 2016-03-24
US10106543B2 (en) 2018-10-23
PH12016500453A1 (en) 2016-05-16
WO2015035426A1 (en) 2015-03-12
IL244416A0 (en) 2016-04-21

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