SG10201710578TA - Crystalline (8s,9r)-5-fluoro-8-(4-fluorophenyl)-9-(1-methyl-1h-1,2,4-triazol-5-yl)-8,9-dihydro-2h-pyrido[4,3,2-de]phthalazin-3(7h)-one tosylate salt - Google Patents
Crystalline (8s,9r)-5-fluoro-8-(4-fluorophenyl)-9-(1-methyl-1h-1,2,4-triazol-5-yl)-8,9-dihydro-2h-pyrido[4,3,2-de]phthalazin-3(7h)-one tosylate saltInfo
- Publication number
- SG10201710578TA SG10201710578TA SG10201710578TA SG10201710578TA SG10201710578TA SG 10201710578T A SG10201710578T A SG 10201710578TA SG 10201710578T A SG10201710578T A SG 10201710578TA SG 10201710578T A SG10201710578T A SG 10201710578TA SG 10201710578T A SG10201710578T A SG 10201710578TA
- Authority
- SG
- Singapore
- Prior art keywords
- phthalazin
- pyrido
- triazol
- fluorophenyl
- dihydro
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/06—Peri-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/50—Pyridazines; Hydrogenated pyridazines
- A61K31/5025—Pyridazines; Hydrogenated pyridazines ortho- or peri-condensed with heterocyclic ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/13—Crystalline forms, e.g. polymorphs
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Epidemiology (AREA)
- Hematology (AREA)
- Oncology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US40547610P | 2010-10-21 | 2010-10-21 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| SG10201710578TA true SG10201710578TA (en) | 2018-02-27 |
Family
ID=44903424
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SG10201710578TA SG10201710578TA (en) | 2010-10-21 | 2011-10-20 | Crystalline (8s,9r)-5-fluoro-8-(4-fluorophenyl)-9-(1-methyl-1h-1,2,4-triazol-5-yl)-8,9-dihydro-2h-pyrido[4,3,2-de]phthalazin-3(7h)-one tosylate salt |
| SG2013029731A SG189939A1 (en) | 2010-10-21 | 2011-10-20 | Crystalline (8s,9r)-5-fluoro-8-(4-fluorophenyl)-9-(1-methyl-1h-1,2,4-triazol-5-yl)-8,9-dihydro-2h-pyrido[4,3,2-de]phthalazin-3(7h)-one tosylate salt |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SG2013029731A SG189939A1 (en) | 2010-10-21 | 2011-10-20 | Crystalline (8s,9r)-5-fluoro-8-(4-fluorophenyl)-9-(1-methyl-1h-1,2,4-triazol-5-yl)-8,9-dihydro-2h-pyrido[4,3,2-de]phthalazin-3(7h)-one tosylate salt |
Country Status (24)
| Country | Link |
|---|---|
| US (3) | US8735392B2 (ja) |
| EP (2) | EP3757106A1 (ja) |
| JP (5) | JP2013540158A (ja) |
| KR (4) | KR20210028747A (ja) |
| CN (1) | CN103282365B (ja) |
| AR (1) | AR083502A1 (ja) |
| AU (2) | AU2011317040B2 (ja) |
| BR (1) | BR112013009117A2 (ja) |
| CA (1) | CA2814581C (ja) |
| CY (1) | CY1123356T1 (ja) |
| DK (1) | DK2630146T3 (ja) |
| ES (1) | ES2816600T3 (ja) |
| HU (1) | HUE051535T2 (ja) |
| IL (2) | IL225789B (ja) |
| MX (1) | MX362563B (ja) |
| NZ (1) | NZ609490A (ja) |
| PL (1) | PL2630146T3 (ja) |
| PT (1) | PT2630146T (ja) |
| RU (1) | RU2598606C3 (ja) |
| SG (2) | SG10201710578TA (ja) |
| SI (1) | SI2630146T1 (ja) |
| TW (2) | TWI643858B (ja) |
| WO (1) | WO2012054698A1 (ja) |
| ZA (1) | ZA201302810B (ja) |
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| DK2448582T3 (en) | 2009-06-29 | 2017-07-17 | Agios Pharmaceuticals Inc | QUINOLIN-8 SULPHONAMIDE DERIVATIVES WITH ANTICANCER ACTIVITY |
| EP3561077B1 (en) | 2009-10-21 | 2022-12-21 | Les Laboratoires Servier | Methods for cell-proliferation-related disorders |
| CN102869258A (zh) | 2010-02-03 | 2013-01-09 | 生物马林药物股份有限公司 | 用于pten基因缺失相关疾病的治疗的聚（adp-核糖）聚合酶（parp）的二氢吡啶并酞嗪酮抑制剂 |
| HUE030794T2 (en) * | 2010-02-08 | 2017-06-28 | Medivation Technologies Inc | Synthesis Processes of Dihydro-Pyrido-Phthalazinone Derivatives |
| TWI643858B (zh) | 2010-10-21 | 2018-12-11 | 美商梅迪維新技術有限責任公司 | 結晶型（８Ｓ，９Ｒ）－５－氟－８－（４－氟苯基）－９－（１－甲基－１Ｈ－１，２，４－三唑－５－基）－８，９－二氫－２Ｈ－吡啶并［４，３，２－ｄｅ］呔－３（７Ｈ）－酮甲苯磺酸鹽 |
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| US9474779B2 (en) | 2012-01-19 | 2016-10-25 | Agios Pharmaceuticals, Inc. | Therapeutically active compositions and their methods of use |
| AU2013331626B2 (en) | 2012-10-15 | 2018-08-02 | Agios Pharmaceuticals, Inc. | Therapeutic compounds and compositions |
| JP6529492B2 (ja) | 2013-07-11 | 2019-06-12 | アジオス ファーマシューティカルズ， インコーポレイテッド | 癌の処置のためのｉｄｈ２突然変異体阻害剤としての２，４−または４，６−ジアミノピリミジン化合物 |
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2011
- 2011-10-20 TW TW105123467A patent/TWI643858B/zh active
- 2011-10-20 KR KR1020217006784A patent/KR20210028747A/ko not_active Application Discontinuation
- 2011-10-20 EP EP20175014.8A patent/EP3757106A1/en not_active Withdrawn
- 2011-10-20 US US13/277,607 patent/US8735392B2/en active Active
- 2011-10-20 AR ARP110103892A patent/AR083502A1/es not_active Application Discontinuation
- 2011-10-20 KR KR1020137012297A patent/KR20140009181A/ko active Application Filing
- 2011-10-20 DK DK11777005.7T patent/DK2630146T3/da active
- 2011-10-20 PL PL11777005T patent/PL2630146T3/pl unknown
- 2011-10-20 SG SG10201710578TA patent/SG10201710578TA/en unknown
- 2011-10-20 BR BR112013009117A patent/BR112013009117A2/pt not_active Application Discontinuation
- 2011-10-20 KR KR1020197030773A patent/KR20190120458A/ko not_active Application Discontinuation
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2013
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