SG10201610881UA - Differentiation of primate pluripotent stem cells to hematopoietic lineage cells - Google Patents
Differentiation of primate pluripotent stem cells to hematopoietic lineage cellsInfo
- Publication number
- SG10201610881UA SG10201610881UA SG10201610881UA SG10201610881UA SG10201610881UA SG 10201610881U A SG10201610881U A SG 10201610881UA SG 10201610881U A SG10201610881U A SG 10201610881UA SG 10201610881U A SG10201610881U A SG 10201610881UA SG 10201610881U A SG10201610881U A SG 10201610881UA
- Authority
- SG
- Singapore
- Prior art keywords
- cells
- differentiation
- pluripotent stem
- hematopoietic lineage
- primate pluripotent
- Prior art date
Links
- 241000288906 Primates Species 0.000 title 1
- 210000004027 cell Anatomy 0.000 title 1
- 230000004069 differentiation Effects 0.000 title 1
- 230000003394 haemopoietic effect Effects 0.000 title 1
- 210000001778 pluripotent stem cell Anatomy 0.000 title 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0603—Embryonic cells ; Embryoid bodies
- C12N5/0606—Pluripotent embryonic cells, e.g. embryonic stem cells [ES]
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0634—Cells from the blood or the immune system
- C12N5/0639—Dendritic cells, e.g. Langherhans cells in the epidermis
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/475—Growth factors; Growth regulators
- C07K14/51—Bone morphogenetic factor; Osteogenins; Osteogenic factor; Bone-inducing factor
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/52—Cytokines; Lymphokines; Interferons
- C07K14/53—Colony-stimulating factor [CSF]
- C07K14/535—Granulocyte CSF; Granulocyte-macrophage CSF
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
- A61K2039/515—Animal cells
- A61K2039/5154—Antigen presenting cells [APCs], e.g. dendritic cells or macrophages
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/02—Compounds of the arachidonic acid pathway, e.g. prostaglandins, leukotrienes
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/10—Growth factors
- C12N2501/125—Stem cell factor [SCF], c-kit ligand [KL]
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/10—Growth factors
- C12N2501/155—Bone morphogenic proteins [BMP]; Osteogenins; Osteogenic factor; Bone inducing factor
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/10—Growth factors
- C12N2501/165—Vascular endothelial growth factor [VEGF]
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/20—Cytokines; Chemokines
- C12N2501/22—Colony stimulating factors (G-CSF, GM-CSF)
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/20—Cytokines; Chemokines
- C12N2501/23—Interleukins [IL]
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/20—Cytokines; Chemokines
- C12N2501/24—Interferons [IFN]
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/50—Cell markers; Cell surface determinants
- C12N2501/52—CD40, CD40-ligand (CD154)
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2506/00—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells
- C12N2506/02—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells from embryonic cells
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Chemical & Material Sciences (AREA)
- Genetics & Genomics (AREA)
- Organic Chemistry (AREA)
- Zoology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biotechnology (AREA)
- Wood Science & Technology (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- Immunology (AREA)
- General Engineering & Computer Science (AREA)
- Microbiology (AREA)
- Cell Biology (AREA)
- Molecular Biology (AREA)
- Gynecology & Obstetrics (AREA)
- Developmental Biology & Embryology (AREA)
- Reproductive Health (AREA)
- Hematology (AREA)
- Biophysics (AREA)
- Toxicology (AREA)
- Medicinal Chemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Gastroenterology & Hepatology (AREA)
- Plant Pathology (AREA)
- Physics & Mathematics (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US3983508P | 2008-03-27 | 2008-03-27 | |
US8124208P | 2008-07-16 | 2008-07-16 |
Publications (1)
Publication Number | Publication Date |
---|---|
SG10201610881UA true SG10201610881UA (en) | 2017-03-30 |
Family
ID=41114730
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
SG2013050216A SG192449A1 (en) | 2008-03-27 | 2009-03-26 | Differentiation of primate pluripotent stem cells to hematopoietic lineage cells |
SG10201610881UA SG10201610881UA (en) | 2008-03-27 | 2009-03-26 | Differentiation of primate pluripotent stem cells to hematopoietic lineage cells |
Family Applications Before (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
SG2013050216A SG192449A1 (en) | 2008-03-27 | 2009-03-26 | Differentiation of primate pluripotent stem cells to hematopoietic lineage cells |
Country Status (12)
Country | Link |
---|---|
US (3) | US8093049B2 (de) |
EP (2) | EP3293255A1 (de) |
JP (4) | JP5734836B2 (de) |
KR (4) | KR102116658B1 (de) |
CN (3) | CN102016007B (de) |
AU (2) | AU2009228215B2 (de) |
CA (2) | CA3123228A1 (de) |
ES (1) | ES2647533T3 (de) |
GB (1) | GB2470689A (de) |
IL (1) | IL208116A (de) |
SG (2) | SG192449A1 (de) |
WO (1) | WO2009120891A2 (de) |
Families Citing this family (28)
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US20040224403A1 (en) * | 2001-12-07 | 2004-11-11 | Robarts Research Institute | Reconstituting hematopoietic cell function using human embryonic stem cells |
US8283163B2 (en) * | 2007-05-17 | 2012-10-09 | Dnavec Corporation | Method for production of dendritic cell |
EP3293255A1 (de) * | 2008-03-27 | 2018-03-14 | Asterias Biotherapeutics, Inc. | Differenzierung von pluripotenten primatenstammzellen und zellen der hämatopoietischen abstammungslinie |
WO2010055900A1 (ja) | 2008-11-14 | 2010-05-20 | ディナベック株式会社 | 樹状細胞の製造方法 |
CA2753679C (en) * | 2009-02-27 | 2021-03-02 | Cellular Dynamics International, Inc. | Differentiation of pluripotent cells |
AU2010266016B2 (en) | 2009-06-25 | 2016-05-26 | Asterias Biotherapeutics, Inc. | Differentiated pluripotent stem cell progeny depleted of extraneous phenotypes |
CA2781969A1 (en) * | 2009-12-04 | 2011-06-09 | Stem Cell & Regenerative Medicine International, Inc. | Method of generating natural killer cells and dendritic cells from human embryonic stem cell-derived hemangioblasts |
US8652845B2 (en) | 2010-03-18 | 2014-02-18 | Kyoto University | Method for producing mesodermal cells by culturing under adherent conditions and without co-culture with cells from a different species in a serum-free medium |
DE102010037622B4 (de) | 2010-09-17 | 2012-07-12 | Lophius Biosciences Gmbh | Verfahren zum Nachweis, Differenzieren und Quantifizieren von T-Zellpopulationen mittels der Reverse Transkription quantitativen Real-Time PCR (RT-qPCR) Technologie |
EP2647698A4 (de) * | 2010-12-03 | 2015-10-07 | Univ Kyoto | Verfahren zur herstellung von eosinophil aus pluripotenten stammzellen |
AU2012211793A1 (en) * | 2011-01-31 | 2013-09-12 | Dnavec Corporation | Highly functional liver cells derived from pluripotent stem cells, method for producing same, and method for testing metabolism/toxicity of drug |
JP5995247B2 (ja) * | 2011-02-23 | 2016-09-21 | 国立大学法人京都大学 | 多能性幹細胞から樹状細胞を製造する方法 |
WO2013086029A1 (en) | 2011-12-05 | 2013-06-13 | Primorigen Biosciences Inc. | Compositions and methods for differentiating pluripotent stem cells into primitive blood cells and uses thereof |
WO2013142237A1 (en) * | 2012-03-23 | 2013-09-26 | Aastrom Biosciences, Inc. | Cell compositions and methods of using same |
CN104428411B (zh) * | 2012-05-08 | 2018-11-23 | 健康科学西部大学 | 用于cd4+t细胞群之抗原特异性扩增的标准化离体平台 |
FR3009312A1 (fr) * | 2013-07-31 | 2015-02-06 | Fabre Pierre Dermo Cosmetique | Reactif de stimulation, substitut cutane, et procede pour reproduire la physiopathologie de la dermatite atopique |
WO2015112120A1 (en) * | 2014-01-21 | 2015-07-30 | Empire Technology Development Llc | Methods and devices for high throughput screening of conditions affecting stem cell differentiation |
EP3929302A1 (de) | 2014-07-14 | 2021-12-29 | Chugai Seiyaku Kabushiki Kaisha | Verfahren zur identifizierung eines epitops auf einem protein |
KR101518972B1 (ko) | 2014-08-01 | 2015-05-18 | 제이더블유크레아젠 주식회사 | 수지상세포의 제조방법, 이에 의해 제조된 수지상세포 및 그 용도 |
CN104388382B (zh) * | 2014-11-21 | 2017-05-10 | 吉林大学 | 利用搅拌式细胞培养转瓶机快速制备饲养层细胞的方法 |
CN106085960A (zh) * | 2016-07-28 | 2016-11-09 | 广州赛莱拉干细胞科技股份有限公司 | 一种培养dc细胞的培养基及培养方法 |
CN109963940A (zh) * | 2016-09-02 | 2019-07-02 | 宝生物工程株式会社 | 从多能干细胞获得小胶质细胞的方法 |
GB201711379D0 (en) * | 2017-07-14 | 2017-08-30 | Univ Cape Town | Maturation of dendritic cells |
EP3976765A1 (de) * | 2019-05-28 | 2022-04-06 | F. Hoffmann-La Roche AG | Verfahren zur erzeugung monozytärer vorläuferzellen |
WO2021007180A1 (en) * | 2019-07-05 | 2021-01-14 | Case Western Reserve University | Priming media and methods for stem cell culture and therapy |
JP2022542247A (ja) * | 2019-07-24 | 2022-09-30 | エスエルバイジェン インコ―ポレイテッド | 不死化幹細胞株の製造方法およびその用途 |
EP4151723A4 (de) * | 2020-05-13 | 2024-06-19 | Agc Inc. | Verfahren zur herstellung menschlicher professionell antigenpräsentierender zellen |
CN113444688B (zh) * | 2021-06-24 | 2022-09-09 | 广西中医药大学 | 用于抗病毒抗肿瘤的人树突状细胞诱导方法及组合物 |
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JP2007517841A (ja) | 2004-01-08 | 2007-07-05 | ジェンフィット | 1,3−ジフェニルプロプ−2−エン−1−オン誘導体化合物、その調製方法およびその使用 |
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EP1885845A2 (de) * | 2005-06-01 | 2008-02-13 | Wisconsin Alumni Research Foundation | Methode zur herstellung dendritischer zellen aus embryonalen stammzellen |
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WO2008056779A1 (fr) | 2006-11-09 | 2008-05-15 | Japan As Represented By The President Of International Medical Center Of Japan | Procédé destiné à la culture et au passage d'une cellule souche embryonnaire de primate, et procédé destiné à induire la différenciation de la cellule souche embryonnaire |
EP3293255A1 (de) * | 2008-03-27 | 2018-03-14 | Asterias Biotherapeutics, Inc. | Differenzierung von pluripotenten primatenstammzellen und zellen der hämatopoietischen abstammungslinie |
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2009
- 2009-03-26 EP EP17184582.9A patent/EP3293255A1/de active Pending
- 2009-03-26 JP JP2011502069A patent/JP5734836B2/ja active Active
- 2009-03-26 SG SG2013050216A patent/SG192449A1/en unknown
- 2009-03-26 CN CN200980116566.8A patent/CN102016007B/zh active Active
- 2009-03-26 CA CA3123228A patent/CA3123228A1/en active Pending
- 2009-03-26 CA CA2718438A patent/CA2718438C/en active Active
- 2009-03-26 KR KR1020197003321A patent/KR102116658B1/ko active IP Right Grant
- 2009-03-26 CN CN202310875852.4A patent/CN116875549A/zh active Pending
- 2009-03-26 US US12/412,183 patent/US8093049B2/en active Active
- 2009-03-26 WO PCT/US2009/038442 patent/WO2009120891A2/en active Application Filing
- 2009-03-26 CN CN201910227901.7A patent/CN109988749B/zh active Active
- 2009-03-26 KR KR1020107021271A patent/KR101689124B1/ko active IP Right Grant
- 2009-03-26 GB GB1015471A patent/GB2470689A/en not_active Withdrawn
- 2009-03-26 EP EP09724052.7A patent/EP2268794B1/de active Active
- 2009-03-26 ES ES09724052.7T patent/ES2647533T3/es active Active
- 2009-03-26 KR KR1020207014889A patent/KR102242305B1/ko active IP Right Grant
- 2009-03-26 SG SG10201610881UA patent/SG10201610881UA/en unknown
- 2009-03-26 KR KR1020167035394A patent/KR101946785B1/ko active IP Right Grant
- 2009-03-26 AU AU2009228215A patent/AU2009228215B2/en active Active
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2010
- 2010-09-13 IL IL208116A patent/IL208116A/en active IP Right Grant
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2011
- 2011-12-06 US US13/312,349 patent/US20120107931A1/en not_active Abandoned
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2015
- 2015-04-15 JP JP2015083475A patent/JP6106705B2/ja active Active
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2016
- 2016-03-09 AU AU2016201540A patent/AU2016201540B2/en active Active
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2017
- 2017-02-06 US US15/426,030 patent/US10344262B2/en active Active
- 2017-03-06 JP JP2017042005A patent/JP6494677B2/ja active Active
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2019
- 2019-03-05 JP JP2019039322A patent/JP6942746B2/ja active Active
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