SG10201610881UA - Differentiation of primate pluripotent stem cells to hematopoietic lineage cells - Google Patents

Differentiation of primate pluripotent stem cells to hematopoietic lineage cells

Info

Publication number
SG10201610881UA
SG10201610881UA SG10201610881UA SG10201610881UA SG10201610881UA SG 10201610881U A SG10201610881U A SG 10201610881UA SG 10201610881U A SG10201610881U A SG 10201610881UA SG 10201610881U A SG10201610881U A SG 10201610881UA SG 10201610881U A SG10201610881U A SG 10201610881UA
Authority
SG
Singapore
Prior art keywords
cells
differentiation
pluripotent stem
hematopoietic lineage
primate pluripotent
Prior art date
Application number
SG10201610881UA
Inventor
Tseng Suyi
Sen Majumdar Anish
Nishimoto Kevin
Reddy Anita
Lebkowski Jane
Original Assignee
Asterias Biotherapeutics Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Asterias Biotherapeutics Inc filed Critical Asterias Biotherapeutics Inc
Publication of SG10201610881UA publication Critical patent/SG10201610881UA/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0603—Embryonic cells ; Embryoid bodies
    • C12N5/0606—Pluripotent embryonic cells, e.g. embryonic stem cells [ES]
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0634—Cells from the blood or the immune system
    • C12N5/0639—Dendritic cells, e.g. Langherhans cells in the epidermis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/475—Growth factors; Growth regulators
    • C07K14/51—Bone morphogenetic factor; Osteogenins; Osteogenic factor; Bone-inducing factor
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52—Cytokines; Lymphokines; Interferons
    • C07K14/53—Colony-stimulating factor [CSF]
    • C07K14/535—Granulocyte CSF; Granulocyte-macrophage CSF
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
    • A61K2039/515—Animal cells
    • A61K2039/5154—Antigen presenting cells [APCs], e.g. dendritic cells or macrophages
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/02—Compounds of the arachidonic acid pathway, e.g. prostaglandins, leukotrienes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/10—Growth factors
    • C12N2501/125—Stem cell factor [SCF], c-kit ligand [KL]
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/10—Growth factors
    • C12N2501/155—Bone morphogenic proteins [BMP]; Osteogenins; Osteogenic factor; Bone inducing factor
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/10—Growth factors
    • C12N2501/165—Vascular endothelial growth factor [VEGF]
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/20—Cytokines; Chemokines
    • C12N2501/22—Colony stimulating factors (G-CSF, GM-CSF)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/20—Cytokines; Chemokines
    • C12N2501/23—Interleukins [IL]
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/20—Cytokines; Chemokines
    • C12N2501/24—Interferons [IFN]
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/50—Cell markers; Cell surface determinants
    • C12N2501/52—CD40, CD40-ligand (CD154)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2506/00—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells
    • C12N2506/02—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells from embryonic cells

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Biotechnology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Immunology (AREA)
  • General Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Cell Biology (AREA)
  • Molecular Biology (AREA)
  • Developmental Biology & Embryology (AREA)
  • Reproductive Health (AREA)
  • Gynecology & Obstetrics (AREA)
  • Hematology (AREA)
  • Biophysics (AREA)
  • Toxicology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Medicinal Chemistry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Physics & Mathematics (AREA)
  • Plant Pathology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
SG10201610881UA 2008-03-27 2009-03-26 Differentiation of primate pluripotent stem cells to hematopoietic lineage cells SG10201610881UA (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US3983508P 2008-03-27 2008-03-27
US8124208P 2008-07-16 2008-07-16

Publications (1)

Publication Number Publication Date
SG10201610881UA true SG10201610881UA (en) 2017-03-30

Family

ID=41114730

Family Applications (2)

Application Number Title Priority Date Filing Date
SG2013050216A SG192449A1 (en) 2008-03-27 2009-03-26 Differentiation of primate pluripotent stem cells to hematopoietic lineage cells
SG10201610881UA SG10201610881UA (en) 2008-03-27 2009-03-26 Differentiation of primate pluripotent stem cells to hematopoietic lineage cells

Family Applications Before (1)

Application Number Title Priority Date Filing Date
SG2013050216A SG192449A1 (en) 2008-03-27 2009-03-26 Differentiation of primate pluripotent stem cells to hematopoietic lineage cells

Country Status (12)

Country Link
US (3) US8093049B2 (en)
EP (2) EP2268794B1 (en)
JP (4) JP5734836B2 (en)
KR (4) KR101689124B1 (en)
CN (3) CN116875549A (en)
AU (2) AU2009228215B2 (en)
CA (2) CA3123228A1 (en)
ES (1) ES2647533T3 (en)
GB (1) GB2470689A (en)
IL (1) IL208116A (en)
SG (2) SG192449A1 (en)
WO (1) WO2009120891A2 (en)

Families Citing this family (29)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20040224403A1 (en) * 2001-12-07 2004-11-11 Robarts Research Institute Reconstituting hematopoietic cell function using human embryonic stem cells
CN101755045B (en) * 2007-05-17 2014-02-12 生物载体株式会社 Method for production of dendritic cell
SG192449A1 (en) * 2008-03-27 2013-08-30 Geron Corp Differentiation of primate pluripotent stem cells to hematopoietic lineage cells
EP2351599A4 (en) * 2008-11-14 2013-05-08 Dnavec Corp Method for producing dendritic cells
EP2401364B1 (en) 2009-02-27 2015-04-22 Cellular Dynamics International, Inc. Differentiation of pluripotent cells
CA2766164A1 (en) 2009-06-25 2010-12-29 Geron Corporation Differentiated pluripotent stem cell progeny depleted of extraneous phenotypes
RU2012127811A (en) * 2009-12-04 2014-01-10 Стем Селл Энд Ридженерэйтив Медсин Интернэшнл, Инк. METHOD FOR PRODUCING CELL-NATURAL KILLERS AND DENDRIT CELLS FROM HUMAN EMBRYONAL HEMANGIO REGIONS OBTAINED FROM STEM CELLS
EP2547764B1 (en) 2010-03-18 2019-01-23 Kyoto University Method for inducing differentiation of pluripotent stem cells into mesodermal cells
DE102010037622B4 (en) * 2010-09-17 2012-07-12 Lophius Biosciences Gmbh Method for detecting, differentiating and quantifying T-cell populations using reverse transcription quantitative real-time PCR (RT-qPCR) technology
EP2647698A4 (en) * 2010-12-03 2015-10-07 Univ Kyoto Method for production of eosinophil from pluripotent stem cell
EP2671944A4 (en) * 2011-01-31 2014-12-03 Nat Ct For Global Health & Medicine Highly functional liver cells derived from pluripotent stem cells, method for producing same, and method for testing metabolism/toxicity of drug
EP2678425B1 (en) * 2011-02-23 2017-08-23 Kyoto University Method for producing dendritic cells from pluripotent stem cells
US9428732B2 (en) 2011-12-05 2016-08-30 Primorigen Biosciences, Inc. Compositions and methods for differentiating pluripotent stem cells into primitive blood cells and uses thereof
EP2828379A1 (en) * 2012-03-23 2015-01-28 Aastrom Biosciences, Inc. Cell compositions and methods of using same
WO2013169922A1 (en) 2012-05-08 2013-11-14 Western University Of Health Sciences Standardized ex vivo platforms for the antigen-specific expansion of cd4+ t cell populations
FR3009312A1 (en) * 2013-07-31 2015-02-06 Fabre Pierre Dermo Cosmetique STIMULATION REAGENT, SKIN SUBSTITUTE, AND PROCESS FOR REPRODUCING THE PHYSIOPATHOLOGY OF ATOPIC DERMATITIS
US10114008B2 (en) 2014-01-21 2018-10-30 Empire Technology Development Llc Methods and devices for high throughput screening of conditions affecting stem cell differentiation
EP3929302A1 (en) 2014-07-14 2021-12-29 Chugai Seiyaku Kabushiki Kaisha Method for identifying epitope on protein
KR101518972B1 (en) 2014-08-01 2015-05-18 제이더블유크레아젠 주식회사 Method of Preparing Dendritic Cell, Dendritic Cell Prepared by the Same and Use Thereof
CN104388382B (en) * 2014-11-21 2017-05-10 吉林大学 Method for rapidly preparing Feeder cells by using stirring-type cell culturing bottle rolling machine
CN106085960A (en) * 2016-07-28 2016-11-09 广州赛莱拉干细胞科技股份有限公司 A kind of culture medium cultivating DC cell and cultural method
WO2018043714A1 (en) * 2016-09-02 2018-03-08 塩野義製薬株式会社 Method for obtaining microglia from pluripotent stem cells
GB201711379D0 (en) * 2017-07-14 2017-08-30 Univ Cape Town Maturation of dendritic cells
JP2022534249A (en) * 2019-05-28 2022-07-28 エフ．ホフマン－ラ ロシュ アーゲー Methods for generating monocyte progenitor cells
EP3994245A1 (en) * 2019-07-05 2022-05-11 Case Western Reserve University Priming media and methods for stem cell culture and therapy
KR20210012966A (en) * 2019-07-24 2021-02-03 주식회사 에스엘바이젠 Method for producing immortalized stem cell and use thereof
JP7138841B2 (en) * 2019-11-15 2022-09-20 公立大学法人横浜市立大学 Highly sensitive detection method for undifferentiated marker genes
JPWO2021230304A1 (en) * 2020-05-13 2021-11-18
CN113444688B (en) * 2021-06-24 2022-09-09 广西中医药大学 Human dendritic cell induction method and composition for resisting virus and tumor

Family Cites Families (35)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4491632A (en) 1979-10-22 1985-01-01 The Massachusetts General Hospital Process for producing antibodies to hepatitis virus and cell lines therefor
US4444887A (en) 1979-12-10 1984-04-24 Sloan-Kettering Institute Process for making human antibody producing B-lymphocytes
DE3167442D1 (en) 1980-07-07 1985-01-10 Nat Res Dev Improvements in or relating to cell lines
DE69531432T2 (en) 1994-09-23 2004-07-29 Becton Dickinson And Co. Method of distinguishing granulomoncytic progenitors in a population of CD34 + cells
US5843780A (en) 1995-01-20 1998-12-01 Wisconsin Alumni Research Foundation Primate embryonic stem cells
US7659119B2 (en) * 1996-02-12 2010-02-09 Argos Therapeutics, Inc. Method and compositions for obtaining mature dendritic cells
EP0986635A4 (en) 1997-01-10 2001-11-07 Life Technologies Inc Embryonic stem cell serum replacement
AU1197699A (en) * 1997-10-23 1999-05-10 Geron Corporation Methods and materials for the growth of primate-derived primordial stem cells
US6649158B1 (en) * 1998-10-15 2003-11-18 Canji, Inc. Methods and compositions to induce antitumor response
US6667176B1 (en) 2000-01-11 2003-12-23 Geron Corporation cDNA libraries reflecting gene expression during growth and differentiation of human pluripotent stem cells
US7410798B2 (en) 2001-01-10 2008-08-12 Geron Corporation Culture system for rapid expansion of human embryonic stem cells
US20020168766A1 (en) 2000-01-11 2002-11-14 Gold Joseph D. Genetically altered human pluripotent stem cells
GB9824306D0 (en) * 1998-11-05 1998-12-30 Isis Innovation Method for producing dendritic dells
US6548299B1 (en) * 1999-11-12 2003-04-15 Mark J. Pykett Lymphoid tissue-specific cell production from hematopoietic progenitor cells in three-dimensional devices
US20020046410A1 (en) 2000-09-06 2002-04-18 Robert Lanza Method for generating immune-compatible cells and tissues using nuclear transfer techniques
WO2001051610A1 (en) 2000-01-14 2001-07-19 Bresagen Limited Ectoderm cell production
US20020086005A1 (en) * 2000-11-22 2002-07-04 Choy-Pik Chiu Tolerizing allografts of pluripotent stem cells
KR101073411B1 (en) 2001-07-12 2011-10-17 제론 코포레이션 Cells of the cardiomyocyte lineage produced from human pluripotent stem cells
WO2003050251A2 (en) 2001-12-07 2003-06-19 Geron Corporation Hematopoietic cells from human embryonic stem cells
KR100973453B1 (en) * 2001-12-07 2010-08-02 제론 코포레이션 Chondrocyte precursors derived from human embryonic stem cells
JP2007130026A (en) * 2002-03-27 2007-05-31 Institute Of Gene & Brain Science Method of inducing growth of nerve stem cells
GB0207440D0 (en) * 2002-03-28 2002-05-08 Ppl Therapeutics Scotland Ltd Tolerogenic antigen-presenting cells
KR101144196B1 (en) * 2002-12-06 2012-05-21 노쓰웨스트 바이오써라퓨틱스, 인크. A composition comprising dendritic cells partially matured in vitro for the treatment of tumors
US20050031598A1 (en) 2002-12-10 2005-02-10 Shulamit Levenberg Engineering three-dimensional tissue structures using differentiating embryonic stem cells
WO2004053139A1 (en) * 2002-12-10 2004-06-24 Apollo Life Sciences Limited A method of antibody production
US20030224411A1 (en) 2003-03-13 2003-12-04 Stanton Lawrence W. Genes that are up- or down-regulated during differentiation of human embryonic stem cells
CA2550576A1 (en) * 2004-01-08 2005-08-11 Genfit 1,3-diphenylprop-2-en-1-one derivative compounds, preparation method thereof and uses of same
CA2504451A1 (en) 2004-08-10 2006-02-10 Geron Corporation Dendritic cell vaccines for treating cancer made from embryonic stem cells
WO2006039045A2 (en) * 2004-09-01 2006-04-13 The Government Of The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Adenoviral vectors able to transduce apcs, potential use in immune response generation
CN101155914B (en) * 2005-04-08 2013-03-06 阿戈斯治疗公司 Dendritic cell compositions and methods
US8034613B2 (en) * 2005-06-01 2011-10-11 Wisconsin Alumni Research Foundation Multipotent lymphohematopoietic progenitor cells
AU2006252576B2 (en) 2005-06-01 2011-01-20 Wisconsin Alumni Research Foundation Method of forming dendritic cells from embryonic stem cells
US20080050347A1 (en) * 2006-08-23 2008-02-28 Ichim Thomas E Stem cell therapy for cardiac valvular dysfunction
WO2008056779A1 (en) * 2006-11-09 2008-05-15 Japan As Represented By The President Of International Medical Center Of Japan Method for culture and passage of primate embryonic stem cell, and method for induction of differentiation of the embryonic stem cell
SG192449A1 (en) * 2008-03-27 2013-08-30 Geron Corp Differentiation of primate pluripotent stem cells to hematopoietic lineage cells

Also Published As

Publication number Publication date
KR20100132507A (en) 2010-12-17
KR102242305B1 (en) 2021-04-19
CN109988749A (en) 2019-07-09
EP2268794A4 (en) 2012-04-18
US20170369842A1 (en) 2017-12-28
IL208116A0 (en) 2010-12-30
JP6106705B2 (en) 2017-04-05
CA3123228A1 (en) 2009-10-01
WO2009120891A3 (en) 2010-01-07
AU2009228215A1 (en) 2009-10-01
GB2470689A (en) 2010-12-01
KR20200060550A (en) 2020-05-29
US10344262B2 (en) 2019-07-09
AU2009228215B2 (en) 2015-12-10
CA2718438C (en) 2021-06-29
SG192449A1 (en) 2013-08-30
US20120107931A1 (en) 2012-05-03
JP2015146817A (en) 2015-08-20
CN109988749B (en) 2023-06-16
AU2016201540B2 (en) 2018-02-08
US20090246869A1 (en) 2009-10-01
ES2647533T3 (en) 2017-12-22
KR20190015618A (en) 2019-02-13
KR101689124B1 (en) 2016-12-23
JP2017123867A (en) 2017-07-20
EP2268794B1 (en) 2017-09-13
KR102116658B1 (en) 2020-06-01
US8093049B2 (en) 2012-01-10
CA2718438A1 (en) 2009-10-01
CN116875549A (en) 2023-10-13
JP6942746B2 (en) 2021-09-29
IL208116A (en) 2014-06-30
JP5734836B2 (en) 2015-06-17
CN102016007B (en) 2019-04-19
EP2268794A2 (en) 2011-01-05
JP2011515110A (en) 2011-05-19
KR101946785B1 (en) 2019-02-12
EP3293255A1 (en) 2018-03-14
KR20160148065A (en) 2016-12-23
CN102016007A (en) 2011-04-13
WO2009120891A2 (en) 2009-10-01
JP6494677B2 (en) 2019-04-03
JP2019110915A (en) 2019-07-11
GB201015471D0 (en) 2010-10-27

Similar Documents

Publication Publication Date Title
AU2016201540A1 (en) Differentiation of primate pluripotent stem cells to hematopoietic lineage cells
IL208116A0 (en) Differentiation of primate pluripotent stem cells to hematopoietic lineage cells
ZA201804932B (en) Materials and methods to enhance hematopoietic stem cells engraftment procedures
HK1216905A1 (en) Differentiation of pluripotent stem cells
GB0800264D0 (en) Differentiation of primate pluripotent stem cells to cardiomyocyte-lineage cells
IL214818A (en) Method of differentiation of pluripotent cells into hematopoietic precursor cells or endothelial cells
GB2453074B (en) Differentiation of primate pluripotent cells to hepatocyte-lineage cells
ZA201103985B (en) Differentiation of human embryonic stem cells to the pancreatic endocrine lineage
ZA201103983B (en) Differentiation of human embryonic stem cells to the pancreatic endocrine lineage
PL2611907T3 (en) Differentiation of pluripotent stem cells
HK1203081A1 (en) Compositions and methods for enhanced generation of hematopoietic stem progenitor cells
GB2485113B (en) Differentiation of human embryonic stem cells into cells of the pancreatic endoderm lineage
ZA201206635B (en) Cell culture medium for the growth and differentiation of cells of the hematopoietic lineage
EP2421956A4 (en) Compositions and methods for deriving or culturing pluripotent cells
EP2192908A4 (en) Differentiation of multi-lineage progenitor cells to chondrocytes
IL210638A0 (en) Production of pluripotent cells through inhibition of bright/arid3a function
IL208082A (en) Methods for the in vitro preparation of cardiovascular progenitor cells from primate embryonic stem cells
EP2454368A4 (en) Compositions and methods for genetic modification of cells having cosmetic function to enhance cosmetic appearance
EP2035547A4 (en) Differentiation of multi-lineage progenitor cells to hepatocytes
IL246057A (en) Peptide-presenting surfaces for long-term culture of pluripotent cells
GB2500161B (en) Enhancement of allogeneic hematopoietic stem cell transplantation
EP2615165A4 (en) Culture method related to differentiation of pluripotent stem cells into blood cells
EP2376625A4 (en) Somatic cell-derived pluripotent cells and methods of use therefor
HK1198657A1 (en) Addition of iron to improve cell culture