EP2376625A4 - Somatic cell-derived pluripotent cells and methods of use therefor - Google Patents

Somatic cell-derived pluripotent cells and methods of use therefor

Info

Publication number
EP2376625A4
EP2376625A4 EP09832539A EP09832539A EP2376625A4 EP 2376625 A4 EP2376625 A4 EP 2376625A4 EP 09832539 A EP09832539 A EP 09832539A EP 09832539 A EP09832539 A EP 09832539A EP 2376625 A4 EP2376625 A4 EP 2376625A4
Authority
EP
European Patent Office
Prior art keywords
methods
somatic cell
pluripotent cells
use therefor
derived pluripotent
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP09832539A
Other languages
German (de)
French (fr)
Other versions
EP2376625A1 (en
Inventor
Douglas Dean
Yongqing Liu
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
University of Louisville Research Foundation ULRF
Original Assignee
University of Louisville Research Foundation ULRF
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by University of Louisville Research Foundation ULRF filed Critical University of Louisville Research Foundation ULRF
Publication of EP2376625A1 publication Critical patent/EP2376625A1/en
Publication of EP2376625A4 publication Critical patent/EP2376625A4/en
Withdrawn legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0696—Artificially induced pluripotent stem cells, e.g. iPS
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/40—Regulators of development
    • C12N2501/405—Cell cycle regulated proteins, e.g. cyclins, cyclin-dependant kinases
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2506/00—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells
    • C12N2506/13—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells from connective tissue cells, from mesenchymal cells
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2506/00—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells
    • C12N2506/13—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells from connective tissue cells, from mesenchymal cells
    • C12N2506/1307—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells from connective tissue cells, from mesenchymal cells from adult fibroblasts
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2506/00—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells
    • C12N2506/27—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells from lung cells, from cells of the respiratory tract
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2510/00—Genetically modified cells

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Wood Science & Technology (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Biotechnology (AREA)
  • Zoology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Genetics & Genomics (AREA)
  • Microbiology (AREA)
  • Cell Biology (AREA)
  • Transplantation (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Developmental Biology & Embryology (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
EP09832539A 2008-12-10 2009-12-10 Somatic cell-derived pluripotent cells and methods of use therefor Withdrawn EP2376625A4 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US20142008P 2008-12-10 2008-12-10
PCT/US2009/067503 WO2010068758A1 (en) 2008-12-10 2009-12-10 Somatic cell-derived pluripotent cells and methods of use therefor

Publications (2)

Publication Number Publication Date
EP2376625A1 EP2376625A1 (en) 2011-10-19
EP2376625A4 true EP2376625A4 (en) 2012-10-10

Family

ID=42243067

Family Applications (1)

Application Number Title Priority Date Filing Date
EP09832539A Withdrawn EP2376625A4 (en) 2008-12-10 2009-12-10 Somatic cell-derived pluripotent cells and methods of use therefor

Country Status (3)

Country Link
EP (1) EP2376625A4 (en)
AU (1) AU2009324641A1 (en)
WO (1) WO2010068758A1 (en)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20110243898A1 (en) * 2008-12-10 2011-10-06 The University Of Louisville Research Foundation, Inc. Somatic cell-derived pluripotent cells and methods of use therefor
CN104087551B (en) * 2014-07-17 2016-05-18 济南磐升生物技术有限公司 The method of a kind of Isolation and culture people's epidermal cell
WO2016086092A1 (en) 2014-11-25 2016-06-02 The Penn State Research Foundation Chemical reprogramming of human glial cells into neurons for brain and spinal cord repair
KR102224273B1 (en) * 2019-10-10 2021-03-08 고려대학교 산학협력단 Stem Cell-derived Mature Cardiomyocytes and Cardiovascular Disease Model Using the Same

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20080268054A1 (en) * 2000-12-04 2008-10-30 Eugene Bell Dermal derived human stem cells and compositions and methods thereof

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20040161419A1 (en) * 2002-04-19 2004-08-19 Strom Stephen C. Placental stem cells and uses thereof
CA2460602A1 (en) * 2004-03-05 2005-09-05 Raewyn Seaberg Pancreatic multipotent progenitor cells

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20080268054A1 (en) * 2000-12-04 2008-10-30 Eugene Bell Dermal derived human stem cells and compositions and methods thereof

Non-Patent Citations (6)

* Cited by examiner, † Cited by third party
Title
KATJA SCHENKE-LAYLAND ET AL: "Reprogrammed Mouse Fibroblasts Differentiate into Cells of the Cardiovascular and Hematopoietic Lineages", STEM CELLS, ALPHAMED PRESS, DAYTON, OH, US, vol. 26, no. 6, 1 June 2008 (2008-06-01), pages 1537 - 1546, XP008142741, ISSN: 1066-5099, [retrieved on 20080501], DOI: 10.1634/STEMCELLS.2008-0033 *
KAZUTOSHI TAKAHASHI ET AL: "Induction of Pluripotent Stem Cells from Adult Human Fibroblasts by Defined Factors", CELL, CELL PRESS, US, vol. 131, no. 5, 30 November 2007 (2007-11-30), pages 861 - 872, XP008153593, ISSN: 0092-8674, DOI: 10.1016/J.CELL.2007.11.019 *
LIU YONGQING ET AL: "Mouse Fibroblasts Lacking RB1 Function Form Spheres and Undergo Reprogramming to a Cancer Stem Cell Phenotype", CELL STEM CELL, vol. 4, no. 4, April 2009 (2009-04-01), pages 336 - 347, XP002682618, ISSN: 1934-5909 *
SAGE JULIEN ET AL: "Targeted disruption of the three Rb-related genes leads to loss of G1 control and immortalization", GENES AND DEVELOPMENT, vol. 14, no. 23, 1 December 2000 (2000-12-01), pages 3037 - 3050, XP002682620, ISSN: 0890-9369 *
See also references of WO2010068758A1 *
TE RIELE HEIN: "Recreating Stem Cells: A Novel Entrance to the Fountain of Youth", CELL STEM CELL, vol. 4, no. 4, April 2009 (2009-04-01), pages 279 - 280, XP002682619, ISSN: 1934-5909 *

Also Published As

Publication number Publication date
AU2009324641A1 (en) 2011-07-28
EP2376625A1 (en) 2011-10-19
WO2010068758A1 (en) 2010-06-17

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Legal Events

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PUAI Public reference made under article 153(3) epc to a published international application that has entered the european phase

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Effective date: 20110711

AK Designated contracting states

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Designated state(s): AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO SE SI SK SM TR

AX Request for extension of the european patent

Extension state: AL BA RS

RIN1 Information on inventor provided before grant (corrected)

Inventor name: LIU, YONGQING

Inventor name: DEAN, DOUGLAS

A4 Supplementary search report drawn up and despatched

Effective date: 20120912

RIC1 Information provided on ipc code assigned before grant

Ipc: C12N 5/00 20060101AFI20120903BHEP

Ipc: C12N 5/0735 20100101ALI20120903BHEP

STAA Information on the status of an ep patent application or granted ep patent

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Effective date: 20130426