SG10201606243YA - Long-acting glp-1/glucagon receptor agonists - Google Patents
Long-acting glp-1/glucagon receptor agonistsInfo
- Publication number
- SG10201606243YA SG10201606243YA SG10201606243YA SG10201606243YA SG10201606243YA SG 10201606243Y A SG10201606243Y A SG 10201606243YA SG 10201606243Y A SG10201606243Y A SG 10201606243YA SG 10201606243Y A SG10201606243Y A SG 10201606243YA SG 10201606243Y A SG10201606243Y A SG 10201606243YA
- Authority
- SG
- Singapore
- Prior art keywords
- long
- receptor agonists
- glucagon receptor
- acting glp
- glp
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/22—Hormones
- A61K38/26—Glucagons
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
- A61K47/59—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes
- A61K47/60—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes the organic macromolecular compound being a polyoxyalkylene oligomer, polymer or dendrimer, e.g. PEG, PPG, PEO or polyglycerol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/12—Antidiuretics, e.g. drugs for diabetes insipidus
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/605—Glucagons
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Diabetes (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Endocrinology (AREA)
- Hematology (AREA)
- Epidemiology (AREA)
- Obesity (AREA)
- Zoology (AREA)
- Gastroenterology & Hepatology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Immunology (AREA)
- Emergency Medicine (AREA)
- Child & Adolescent Psychology (AREA)
- Toxicology (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Peptides Or Proteins (AREA)
- Medicinal Preparation (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201161492448P | 2011-06-02 | 2011-06-02 | |
| US201261624589P | 2012-04-16 | 2012-04-16 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| SG10201606243YA true SG10201606243YA (en) | 2016-09-29 |
Family
ID=47259955
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SG10201606243YA SG10201606243YA (en) | 2011-06-02 | 2012-06-04 | Long-acting glp-1/glucagon receptor agonists |
Country Status (16)
| Country | Link |
|---|---|
| US (1) | US20140349922A1 (de) |
| EP (1) | EP2714070B1 (de) |
| JP (1) | JP6182134B2 (de) |
| KR (1) | KR102092206B1 (de) |
| CN (1) | CN104023739A (de) |
| AU (1) | AU2012261869B2 (de) |
| BR (1) | BR112013030933A2 (de) |
| CA (1) | CA2837710C (de) |
| CL (1) | CL2013003450A1 (de) |
| CO (1) | CO6980619A2 (de) |
| EA (1) | EA201391764A1 (de) |
| HK (1) | HK1201478A1 (de) |
| IL (1) | IL229732B (de) |
| MX (1) | MX346957B (de) |
| SG (1) | SG10201606243YA (de) |
| WO (1) | WO2012167251A1 (de) |
Families Citing this family (31)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US9458444B2 (en) | 2006-02-03 | 2016-10-04 | Opko Biologics Ltd. | Long-acting coagulation factors and methods of producing same |
| US20140113860A1 (en) | 2006-02-03 | 2014-04-24 | Prolor Biotech Ltd. | Long-acting polypeptides and methods of producing and administering same |
| US10351615B2 (en) | 2006-02-03 | 2019-07-16 | Opko Biologics Ltd. | Methods of treatment with long-acting growth hormone |
| US8048849B2 (en) | 2006-02-03 | 2011-11-01 | Modigene, Inc. | Long-acting polypeptides and methods of producing same |
| US10221228B2 (en) | 2006-02-03 | 2019-03-05 | Opko Biologics Ltd. | Long-acting polypeptides and methods of producing and administering same |
| US9249407B2 (en) | 2006-02-03 | 2016-02-02 | Opko Biologics Ltd. | Long-acting coagulation factors and methods of producing same |
| US20150038413A1 (en) | 2006-02-03 | 2015-02-05 | Opko Biologics Ltd. | Long-acting polypeptides and methods of producing and administering same |
| US8946155B2 (en) | 2006-02-03 | 2015-02-03 | Opko Biologics Ltd. | Long-acting polypeptides and methods of producing and administering same |
| US9663778B2 (en) | 2009-07-09 | 2017-05-30 | OPKO Biologies Ltd. | Long-acting coagulation factors and methods of producing same |
| US10166295B2 (en) | 2011-06-02 | 2019-01-01 | Opko Biologics Ltd. | Pegylated OXM variants |
| WO2013157002A1 (en) | 2012-04-19 | 2013-10-24 | Prolor Biotech Inc. | Long-acting oxyntomodulin variants and methods of producing same |
| JP6290193B2 (ja) * | 2012-06-04 | 2018-03-07 | オプコ バイオロジクス リミテッド | ペグ化ｏｘｍ変異体 |
| CN112661863A (zh) | 2012-11-20 | 2021-04-16 | 奥普科生物制品有限公司 | 通过连接至促性腺激素羧基端肽来增加多肽的流体动力学体积的方法 |
| US20150158926A1 (en) | 2013-10-21 | 2015-06-11 | Opko Biologics, Ltd. | Long-acting polypeptides and methods of producing and administering same |
| MA39301A1 (fr) | 2014-01-20 | 2018-01-31 | Hanmi Pharmaceutical Co Ltd | Insuline à action prolongée et utilisation associée |
| AR100639A1 (es) | 2014-05-29 | 2016-10-19 | Hanmi Pharm Ind Co Ltd | Composición para tratar diabetes que comprende conjugados de análogos de insulina de acción prolongada y conjugados de péptidos insulinotrópicos de acción prolongada |
| AR100695A1 (es) | 2014-05-30 | 2016-10-26 | Hanmi Pharm Ind Co Ltd | Composición para el tratamiento de diabetes mellitus que comprende insulina y un agonista dual glp-1 / glucagón |
| EP3302571B1 (de) * | 2015-05-29 | 2020-11-18 | OPKO Biologics Ltd. | Pegylierte oxyntomodulin-varianten |
| EP3988113A1 (de) | 2015-06-19 | 2022-04-27 | OPKO Biologics Ltd. | Gerinnungsfaktoren mit langzeitwirkung und verfahren zur herstellung davon |
| AR105284A1 (es) * | 2015-07-10 | 2017-09-20 | Sanofi Sa | Derivados de exendina-4 como agonistas peptídicos duales específicos de los receptores de glp-1 / glucagón |
| UY36870A (es) | 2015-08-28 | 2017-03-31 | Hanmi Pharm Ind Co Ltd | Análogos de insulina novedosos |
| CN108602894A (zh) * | 2015-10-30 | 2018-09-28 | 纽约州立大学研究基金会 | 胃泌酸调节素类似物及其制备和使用方法 |
| CN113456820B (zh) * | 2015-12-29 | 2023-09-08 | 派格生物医药(苏州)股份有限公司 | 包含glp-1受体激动剂和胰高血糖素受体激动剂的组合物及其用途 |
| US20190160152A1 (en) * | 2016-06-09 | 2019-05-30 | Opko Biologics Ltd. | Long-acting oxyntomodulin formulation and methods of producing and administering same |
| BR112019000610A2 (pt) | 2016-07-11 | 2019-07-02 | Opko Biologics Ltd | fator vii de coagulação de longa ação e métodos de produção do mesmo |
| JP7158378B2 (ja) | 2016-09-23 | 2022-10-21 | ハンミ ファーマシューティカル カンパニー リミテッド | インスリン受容体との結合力が減少された、インスリンアナログ及びその用途 |
| US11752216B2 (en) | 2017-03-23 | 2023-09-12 | Hanmi Pharm. Co., Ltd. | Insulin analog complex with reduced affinity for insulin receptor and use thereof |
| EP3713993A1 (de) | 2017-11-23 | 2020-09-30 | Löwenhielm, Peter | Hydrogelzusammensetzung und deren verwendungen |
| US20200262887A1 (en) * | 2018-11-30 | 2020-08-20 | Opko Ireland Global Holdings, Ltd. | Oxyntomodulin peptide analog formulations |
| CN113710692A (zh) | 2019-02-11 | 2021-11-26 | Opko生物科学有限公司 | 长效glp-2类似物 |
| CN117586373A (zh) * | 2022-08-10 | 2024-02-23 | 成都奥达生物科技有限公司 | 一种长效双激动剂化合物 |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IL119029A0 (en) | 1996-08-07 | 1996-11-14 | Yeda Res & Dev | Long-acting drugs and pharamaceutical compositions comprising them |
| CA2521784C (en) * | 2003-04-08 | 2012-03-27 | Yeda Research And Development Co. Ltd. | Reversible pegylated drugs |
| CN101389648B (zh) * | 2006-02-22 | 2013-07-17 | 默沙东公司 | 肽胃泌酸调节素衍生物 |
| WO2010033207A1 (en) * | 2008-09-19 | 2010-03-25 | Nektar Therapeutics | Polymer conjugates of therapeutic peptides |
| BRPI1013626B8 (pt) * | 2009-03-20 | 2021-05-25 | Hanmi Holdings Co Ltd | método para preparar conjugado de polipeptídeo fisiologicamente ativo em sítio específico |
| AR079344A1 (es) * | 2009-12-22 | 2012-01-18 | Lilly Co Eli | Analogo peptidico de oxintomodulina, composicion farmaceutica que lo comprende y uso para preparar un medicamento util para tratar diabetes no insulinodependiente y/u obesidad |
-
2012
- 2012-06-04 AU AU2012261869A patent/AU2012261869B2/en active Active
- 2012-06-04 BR BR112013030933A patent/BR112013030933A2/pt not_active IP Right Cessation
- 2012-06-04 KR KR1020137035156A patent/KR102092206B1/ko active IP Right Grant
- 2012-06-04 CA CA2837710A patent/CA2837710C/en active Active
- 2012-06-04 EA EA201391764A patent/EA201391764A1/ru unknown
- 2012-06-04 SG SG10201606243YA patent/SG10201606243YA/en unknown
- 2012-06-04 MX MX2013014069A patent/MX346957B/es active IP Right Grant
- 2012-06-04 US US14/123,106 patent/US20140349922A1/en active Pending
- 2012-06-04 JP JP2014513790A patent/JP6182134B2/ja active Active
- 2012-06-04 CN CN201280038726.3A patent/CN104023739A/zh active Pending
- 2012-06-04 WO PCT/US2012/040744 patent/WO2012167251A1/en active Application Filing
- 2012-06-04 EP EP12793107.9A patent/EP2714070B1/de active Active
-
2013
- 2013-11-28 IL IL229732A patent/IL229732B/en unknown
- 2013-12-02 CL CL2013003450A patent/CL2013003450A1/es unknown
- 2013-12-27 CO CO13301132A patent/CO6980619A2/es unknown
-
2015
- 2015-03-03 HK HK15102153.2A patent/HK1201478A1/xx unknown
Also Published As
| Publication number | Publication date |
|---|---|
| WO2012167251A1 (en) | 2012-12-06 |
| EA201391764A1 (ru) | 2014-07-30 |
| AU2012261869A1 (en) | 2014-01-16 |
| CO6980619A2 (es) | 2014-06-27 |
| CN104023739A (zh) | 2014-09-03 |
| CA2837710A1 (en) | 2012-12-06 |
| EP2714070A4 (de) | 2015-03-04 |
| MX346957B (es) | 2017-04-06 |
| CL2013003450A1 (es) | 2015-01-16 |
| BR112013030933A2 (pt) | 2018-04-24 |
| KR102092206B1 (ko) | 2020-03-24 |
| JP2014516993A (ja) | 2014-07-17 |
| KR20140083929A (ko) | 2014-07-04 |
| EP2714070A1 (de) | 2014-04-09 |
| CA2837710C (en) | 2022-11-08 |
| US20140349922A1 (en) | 2014-11-27 |
| IL229732B (en) | 2021-10-31 |
| EP2714070B1 (de) | 2024-03-20 |
| AU2012261869B2 (en) | 2017-01-05 |
| MX2013014069A (es) | 2014-08-22 |
| JP6182134B2 (ja) | 2017-08-16 |
| HK1201478A1 (en) | 2015-09-04 |
| IL229732A0 (en) | 2014-01-30 |
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