SG10201505619QA - Scheme for administering n-hydroxy-4-{2-[3-(n,n-dimethylaminomethyl)­benzofuran-2-ylcarbonylamino]ethoxy}benzamide - Google Patents

Scheme for administering n-hydroxy-4-{2-[3-(n,n-dimethylaminomethyl)­benzofuran-2-ylcarbonylamino]ethoxy}benzamide

Info

Publication number
SG10201505619QA
SG10201505619QA SG10201505619QA SG10201505619QA SG10201505619QA SG 10201505619Q A SG10201505619Q A SG 10201505619QA SG 10201505619Q A SG10201505619Q A SG 10201505619QA SG 10201505619Q A SG10201505619Q A SG 10201505619QA SG 10201505619Q A SG10201505619Q A SG 10201505619QA
Authority
SG
Singapore
Prior art keywords
ylcarbonylamino
dimethylaminomethyl
benzofuran
benzamide
ethoxy
Prior art date
Application number
SG10201505619QA
Other languages
English (en)
Inventor
Ioana Kloos
Renata Robert
Anne Jacquet-Bescond
Stéphane Depil
Marylore Chenel
Sylvain Fouliard
Sriram Balasubramanian
Original Assignee
Pharmacyclics Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pharmacyclics Inc filed Critical Pharmacyclics Inc
Publication of SG10201505619QA publication Critical patent/SG10201505619QA/en

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D307/00Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D307/78Benzo [b] furans; Hydrogenated benzo [b] furans
    • C07D307/82Benzo [b] furans; Hydrogenated benzo [b] furans with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the hetero ring
    • C07D307/84Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • C07D307/85Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 2
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/13Amines
    • A61K31/135Amines having aromatic rings, e.g. ketamine, nortriptyline
    • A61K31/138Aryloxyalkylamines, e.g. propranolol, tamoxifen, phenoxybenzamine
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/335Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/34Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide
    • A61K31/343Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide condensed with a carbocyclic ring, e.g. coumaran, bufuralol, befunolol, clobenfurol, amiodarone
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/70Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7028Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages
    • A61K31/7034Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin
    • A61K31/704Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin attached to a condensed carbocyclic ring system, e.g. sennosides, thiocolchicosides, escin, daunorubicin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K33/00Medicinal preparations containing inorganic active ingredients
    • A61K33/24Heavy metals; Compounds thereof
    • A61K33/243Platinum; Compounds thereof
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61NELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N5/00Radiation therapy
    • A61N5/10X-ray therapy; Gamma-ray therapy; Particle-irradiation therapy
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Inorganic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Radiology & Medical Imaging (AREA)
  • Pathology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Furan Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Plural Heterocyclic Compounds (AREA)
SG10201505619QA 2011-09-08 2012-09-07 Scheme for administering n-hydroxy-4-{2-[3-(n,n-dimethylaminomethyl)­benzofuran-2-ylcarbonylamino]ethoxy}benzamide SG10201505619QA (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201161573585P 2011-09-08 2011-09-08
FR1102727 2011-09-08

Publications (1)

Publication Number Publication Date
SG10201505619QA true SG10201505619QA (en) 2015-08-28

Family

ID=47830027

Family Applications (2)

Application Number Title Priority Date Filing Date
SG11201400120UA SG11201400120UA (en) 2011-09-08 2012-09-07 Scheme for administering n-hydroxy-4-{2-[3-(n,n-dimethylaminomethyl)­benzofuran-2-ylcarbonylamino]ethoxy}benzamide
SG10201505619QA SG10201505619QA (en) 2011-09-08 2012-09-07 Scheme for administering n-hydroxy-4-{2-[3-(n,n-dimethylaminomethyl)­benzofuran-2-ylcarbonylamino]ethoxy}benzamide

Family Applications Before (1)

Application Number Title Priority Date Filing Date
SG11201400120UA SG11201400120UA (en) 2011-09-08 2012-09-07 Scheme for administering n-hydroxy-4-{2-[3-(n,n-dimethylaminomethyl)­benzofuran-2-ylcarbonylamino]ethoxy}benzamide

Country Status (17)

Country Link
US (2) US8883199B2 (es)
EP (1) EP2753322B1 (es)
JP (1) JP6014142B2 (es)
KR (1) KR20140073521A (es)
CN (1) CN103889409A (es)
AR (1) AR087803A1 (es)
AU (2) AU2012306122A1 (es)
CA (1) CA2847011A1 (es)
HK (1) HK1201150A1 (es)
MX (1) MX2014002663A (es)
RU (1) RU2600793C2 (es)
SG (2) SG11201400120UA (es)
TW (1) TWI544920B (es)
UA (1) UA113634C2 (es)
UY (1) UY34295A (es)
WO (1) WO2013034863A1 (es)
ZA (1) ZA201401710B (es)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2004092115A2 (en) 2003-04-07 2004-10-28 Axys Pharmaceuticals Inc. Hydroxamates as therapeutic agents
DK2099442T3 (en) * 2006-12-26 2015-02-16 Pharmacyclics Inc Method of using histone deacetylase inhibitors and monitoring biomarkers in combination therapy
NZ579048A (en) * 2007-01-30 2012-05-25 Pharmacyclics Inc Methods for determining cancer resistance to histone deacetylase inhibitors
US8603521B2 (en) 2009-04-17 2013-12-10 Pharmacyclics, Inc. Formulations of histone deacetylase inhibitor and uses thereof
US9492423B2 (en) 2011-09-13 2016-11-15 Pharmacyclics Llc Formulations of histone deacetylase inhibitor in combination with bendamustine and uses thereof
EP3027192A4 (en) 2013-08-02 2017-03-22 Pharmacyclics, LLC Methods for the treatment of solid tumors
KR101684854B1 (ko) * 2016-06-13 2016-12-09 아이오틴 주식회사 보호자 알림기능을 이용한 휴대용 스마트약통 및 이를 포함하는 복용시간 알림시스템
CN114146181B (zh) * 2021-10-29 2022-09-09 徐诺药业(南京)有限公司 含Pan-HDAC和免疫检查点抑制剂的组合及应用

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PT1489078E (pt) * 2002-03-28 2010-02-24 Mitsubishi Tanabe Pharma Corp Derivados de benzofurano
CN100566711C (zh) * 2002-04-15 2009-12-09 斯隆-凯特林癌症研究院 治疗癌症的化合物及其用途
WO2004092115A2 (en) * 2003-04-07 2004-10-28 Axys Pharmaceuticals Inc. Hydroxamates as therapeutic agents
EP1874324A1 (en) * 2005-04-21 2008-01-09 Alza Corporation Method for treating advanced ovarian cancer with doxorubicin entrapped in liposomes

Also Published As

Publication number Publication date
JP2014526457A (ja) 2014-10-06
US20150024040A1 (en) 2015-01-22
US8883199B2 (en) 2014-11-11
AU2016202594B2 (en) 2017-09-14
US20130064880A1 (en) 2013-03-14
TWI544920B (zh) 2016-08-11
AR087803A1 (es) 2014-04-16
AU2016202594A1 (en) 2016-05-19
UA113634C2 (uk) 2017-02-27
SG11201400120UA (en) 2014-09-26
JP6014142B2 (ja) 2016-10-25
WO2013034863A1 (fr) 2013-03-14
CN103889409A (zh) 2014-06-25
CA2847011A1 (fr) 2013-03-14
NZ622112A (en) 2016-07-29
RU2600793C2 (ru) 2016-10-27
EP2753322A1 (fr) 2014-07-16
AU2012306122A1 (en) 2014-03-13
TW201313228A (zh) 2013-04-01
UY34295A (es) 2013-04-30
EP2753322B1 (fr) 2016-08-03
MX2014002663A (es) 2014-08-29
HK1201150A1 (en) 2015-08-28
KR20140073521A (ko) 2014-06-16
RU2014113399A (ru) 2015-10-20
ZA201401710B (en) 2015-01-28

Similar Documents

Publication Publication Date Title
SG10201505619QA (en) Scheme for administering n-hydroxy-4-{2-[3-(n,n-dimethylaminomethyl)­benzofuran-2-ylcarbonylamino]ethoxy}benzamide
IL242279A0 (en) Compounds of 3-chloro-3]-n-(pyrimidine-2-ylamino)phenyl]substituted propanamide and their salts
HK1178387A1 (zh) 種凝膠、含它的耐溫型軟糖及其製備方法
AP3589A (en) A novel 1,2,3,4-tetrahydroquinoline derivative useful for the treatment of diabetes
EP2679592A4 (en) NEW HETEROCYCLIC COMPOUND, PROCESS FOR PRODUCING INTERMEDIATE PRODUCTS THEREOF AND USE THEREOF
PT2734499T (pt) Derivados de merocianina
EP2699091A4 (en) 2 ', 6'-dioxo-3'-deutero-PIPERIDIN-3-YL-isoindoline COMPOUNDS
HK1198535A1 (en) 5-(3-aminophenyl)-5-alkyl-5,6-dihydro-2h-[1,4] oxazin-3-amine derivatives 5-(3-)-5--5,6--2h-[1,4]-3-
CO6870039A2 (es) 3-(bifenil-3-il)-4-hidroxi-8-metoxi-1-azaespiro[4.5]dec-3-en-2-onas sustituidas
HK1201060A1 (zh) -二甲基苯基 -丙醛的製備方法
BR112013019524A2 (pt) método para a produção de 2,3-butanodiol por fermentação
BR112013019525A2 (pt) método para a produção de 2,3-butanodiol por fermentação
FI20116030A (fi) Menetelmä RF-suotimen valmistamiseksi ja RF-suodin
BR112012025490A2 (pt) ''método para produção de 1,5 oebtanodiamina''
HK1190706A1 (en) Sec-hydroxycyclohexyl derivatives as hsl inhibitors for the treatment diabetes hsl -
BR112013018973A2 (pt) processo para a preparação de derivados de 1-h-pirrolidina-2,4-diona
EP2734499A4 (en) MEROCYANINE DERIVATIVES
TH1401006705A (th) วิธีการสำหรับการเตรียม 2-(2,3-ไดเมททิลฟีนิล)-1-โพรพานัล (2-(2,3-dimethylphenyl)-1-propanal)
DK2695103T3 (da) Scoringsfunktion for bindingsaffinitet, der indbefatter en straftildelingsbetingelse
DK2785675T3 (da) 5,5-dimethyl-2-propyl-hexahydro-2,4a-methanonaphthalen-1-on som duftmiddel
PL392868A1 (pl) 2-Metoksyoctany, 2-(2-metoksyetoksy)octany i 2-[2-(2-metoksyetoksy)etoksy]octany cykloheksyloamoniowe oraz sposób ich otrzymywania
TH118939B (th) กรรมวิธีที่ปรับปรุงให้ดีขึ้นแล้วสำหรับการเตรียมอนุพันธ์แทกเซน
PL396024A1 (pl) Sposób wytwarzania 4,2',4' -trihydroksy-6'-metoksy-3'-prenylo-α,ß-dihydrochalkonu
DK2461074T3 (da) Drivtandkrans til maskiner
PL390882A1 (pl) Kompozycja, zwłaszcza do wytwarzania stabilnej emulsji naturalnego bursztynu