SG10201502759TA - Raav-guanylate cyclase compositions and methods for treating leber's congenital amaurosis-1 (lca1) - Google Patents
Raav-guanylate cyclase compositions and methods for treating leber's congenital amaurosis-1 (lca1)Info
- Publication number
- SG10201502759TA SG10201502759TA SG10201502759TA SG10201502759TA SG10201502759TA SG 10201502759T A SG10201502759T A SG 10201502759TA SG 10201502759T A SG10201502759T A SG 10201502759TA SG 10201502759T A SG10201502759T A SG 10201502759TA SG 10201502759T A SG10201502759T A SG 10201502759TA
- Authority
- SG
- Singapore
- Prior art keywords
- lca1
- raav
- methods
- guanylate cyclase
- congenital amaurosis
- Prior art date
Links
- 101710095468 Cyclase Proteins 0.000 title 1
- 201000003533 Leber congenital amaurosis Diseases 0.000 title 1
- 239000000203 mixture Substances 0.000 title 1
Classifications
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- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
- C12N15/86—Viral vectors
- C12N15/861—Adenoviral vectors
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- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
- C12N15/86—Viral vectors
- C12N15/864—Parvoviral vectors, e.g. parvovirus, densovirus
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/43—Enzymes; Proenzymes; Derivatives thereof
- A61K38/51—Lyases (4)
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
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- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
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- C12Y406/00—Phosphorus-oxygen lyases (4.6)
- C12Y406/01—Phosphorus-oxygen lyases (4.6.1)
- C12Y406/01002—Guanylate cyclase (4.6.1.2)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- C12N2750/00011—Details
- C12N2750/14011—Parvoviridae
- C12N2750/14111—Dependovirus, e.g. adenoassociated viruses
- C12N2750/14132—Use of virus as therapeutic agent, other than vaccine, e.g. as cytolytic agent
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- C12N2750/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssDNA viruses
- C12N2750/00011—Details
- C12N2750/14011—Parvoviridae
- C12N2750/14111—Dependovirus, e.g. adenoassociated viruses
- C12N2750/14141—Use of virus, viral particle or viral elements as a vector
- C12N2750/14143—Use of virus, viral particle or viral elements as a vector viral genome or elements thereof as genetic vector
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- C12N2830/00—Vector systems having a special element relevant for transcription
- C12N2830/80—Vector systems having a special element relevant for transcription from vertebrates
- C12N2830/85—Vector systems having a special element relevant for transcription from vertebrates mammalian
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- Engineering & Computer Science (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- General Engineering & Computer Science (AREA)
- Biotechnology (AREA)
- General Health & Medical Sciences (AREA)
- Biomedical Technology (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Microbiology (AREA)
- Medicinal Chemistry (AREA)
- Physics & Mathematics (AREA)
- Biophysics (AREA)
- Plant Pathology (AREA)
- Virology (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Immunology (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Gastroenterology & Hepatology (AREA)
- Ophthalmology & Optometry (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Enzymes And Modification Thereof (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US32752110P | 2010-04-23 | 2010-04-23 |
Publications (1)
Publication Number | Publication Date |
---|---|
SG10201502759TA true SG10201502759TA (en) | 2015-06-29 |
Family
ID=44533055
Family Applications (4)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
SG10201502759TA SG10201502759TA (en) | 2010-04-23 | 2011-04-22 | Raav-guanylate cyclase compositions and methods for treating leber's congenital amaurosis-1 (lca1) |
SG2012076600A SG184876A1 (en) | 2010-04-23 | 2011-04-22 | Raav-guanylate cyclase compositions and methods for treating leber's congenital amaurosis-1 (lca1) |
SG10201800541SA SG10201800541SA (en) | 2010-04-23 | 2011-04-22 | Raav-guanylate cyclase compositions and methods for treating leber's congenital amaurosis-1 (lca1) |
SG10201913135YA SG10201913135YA (en) | 2010-04-23 | 2011-04-23 | Raav-guanylate cyclase compositions and methods for treating leber's congenital amaurosis-1 (lca1) |
Family Applications After (3)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
SG2012076600A SG184876A1 (en) | 2010-04-23 | 2011-04-22 | Raav-guanylate cyclase compositions and methods for treating leber's congenital amaurosis-1 (lca1) |
SG10201800541SA SG10201800541SA (en) | 2010-04-23 | 2011-04-22 | Raav-guanylate cyclase compositions and methods for treating leber's congenital amaurosis-1 (lca1) |
SG10201913135YA SG10201913135YA (en) | 2010-04-23 | 2011-04-23 | Raav-guanylate cyclase compositions and methods for treating leber's congenital amaurosis-1 (lca1) |
Country Status (27)
Country | Link |
---|---|
US (3) | US9816108B2 (de) |
EP (3) | EP4056700A1 (de) |
JP (4) | JP5897549B2 (de) |
KR (3) | KR101984145B1 (de) |
CN (2) | CN102918152B (de) |
AU (1) | AU2011242527B2 (de) |
BR (1) | BR112012026730A8 (de) |
CA (1) | CA2796399C (de) |
CL (1) | CL2012002969A1 (de) |
CO (1) | CO6640236A2 (de) |
CY (1) | CY1123008T1 (de) |
DK (2) | DK2561067T3 (de) |
EA (2) | EA035893B1 (de) |
ES (2) | ES2911185T3 (de) |
HR (1) | HRP20190144T1 (de) |
HU (1) | HUE041571T2 (de) |
IL (2) | IL222651B (de) |
LT (1) | LT2561067T (de) |
MX (1) | MX351865B (de) |
NZ (1) | NZ602897A (de) |
PL (2) | PL3486320T3 (de) |
PT (2) | PT2561067T (de) |
RS (1) | RS58434B1 (de) |
SG (4) | SG10201502759TA (de) |
SI (1) | SI2561067T1 (de) |
TR (1) | TR201901377T4 (de) |
WO (1) | WO2011133933A2 (de) |
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US20120322861A1 (en) | 2007-02-23 | 2012-12-20 | Barry John Byrne | Compositions and Methods for Treating Diseases |
WO2013192317A2 (en) | 2012-06-19 | 2013-12-27 | University Of Florida Research Foundation, Inc. | Compositions and methods for treating diabetes |
WO2013075008A1 (en) | 2011-11-16 | 2013-05-23 | University Of Florida Research Foundation Inc. | Aav dual vector systems for gene therapy |
FR3008618A1 (fr) * | 2013-07-19 | 2015-01-23 | Univ Paris Curie | Utilisation de composes pour restaurer la reponse a la lumiere des cellules de la retine |
PT3024498T (pt) | 2013-07-22 | 2020-03-06 | Childrens Hospital Philadelphia | Variante aav e composições, métodos e usos para transferência genética em células, órgãos e tecidos |
CN105980569A (zh) | 2013-08-05 | 2016-09-28 | 莱顿大学医学中心附属莱顿教学医院 | 重组aav-crumbs同源物组合物及治疗lca-8和进行性rp的方法 |
GB201420139D0 (en) | 2014-11-12 | 2014-12-24 | Ucl Business Plc | Factor IX gene therapy |
AU2016282781A1 (en) | 2015-06-23 | 2018-01-18 | The Children's Hospital Of Philadelphia | Modified Factor IX, and compositions, methods and uses for gene transfer to cells, organs and tissues |
KR20230167138A (ko) * | 2017-05-05 | 2023-12-07 | 유니버시티 오브 플로리다 리서치 파운데이션, 인코포레이티드 | 오토펄린을 발현시키기 위한 조성물 및 방법 |
CA3074466A1 (en) | 2017-08-28 | 2019-03-07 | University Of Florida Research Foundation, Incorporated | Methods and compositions for treating cone-rod retinal dystrophy |
EP3710590B1 (de) * | 2017-11-15 | 2024-07-17 | The Regents of The University of Michigan | Virale vektoren mit rdh12-codierenden regionen und verfahren zur behandlung von retinadystrophien |
JP7287611B2 (ja) * | 2018-02-07 | 2023-06-06 | 学校法人日本医科大学 | 改良型アデノ随伴ウイルスベクター |
US11660353B2 (en) | 2018-04-27 | 2023-05-30 | Decibel Therapeutics, Inc. | Compositions and methods for treating sensorineural hearing loss using otoferlin dual vector systems |
BR112021000358A2 (pt) | 2018-07-11 | 2021-04-06 | Cyclerion Therapeutics, Inc. | Uso de estimulantes de sgc para o tratamento de distúrbios mitocondriais |
US20220133909A1 (en) * | 2019-01-23 | 2022-05-05 | University Of Florida Research Foundation, Incorporated | Highly efficient transduction and lateral spread in the retina by a novel aav virus enhanced by rational design |
EP3924470A4 (de) | 2019-02-15 | 2022-12-14 | Exhaura, Ltd. | Duale leucin-zipper-kinase-inhibitoren für gentherapie |
JP2024016295A (ja) * | 2020-11-30 | 2024-02-07 | タカラバイオ株式会社 | 二価の陽イオンを利用した非エンベロープウイルスの製造方法 |
CN112852976B (zh) * | 2021-03-17 | 2023-10-31 | 湖北省农业科学院畜牧兽医研究所 | 蛋鸡ncs1基因中与后期产蛋性状相关的分子标记及其应用 |
CN117980489A (zh) * | 2021-07-14 | 2024-05-03 | 梅里特斯英国第二有限公司 | Retgc基因疗法 |
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