SE9402528D0 - Hårdvävnadsstimulerande med el - Google Patents

Hårdvävnadsstimulerande med el

Info

Publication number
SE9402528D0
SE9402528D0 SE9402528A SE9402528A SE9402528D0 SE 9402528 D0 SE9402528 D0 SE 9402528D0 SE 9402528 A SE9402528 A SE 9402528A SE 9402528 A SE9402528 A SE 9402528A SE 9402528 D0 SE9402528 D0 SE 9402528D0
Authority
SE
Sweden
Prior art keywords
hard tissue
pct
electricity
sec
date
Prior art date
Application number
SE9402528A
Other languages
English (en)
Swedish (sv)
Inventor
Hans-Arne Hansson
Ruden Gunilla Johansson
Olle Larm
Original Assignee
Astra Ab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Astra Ab filed Critical Astra Ab
Priority to SE9402528A priority Critical patent/SE9402528D0/xx
Publication of SE9402528D0 publication Critical patent/SE9402528D0/xx
Priority to CZ1997140A priority patent/CZ289981B6/cs
Priority to DE69527203T priority patent/DE69527203T2/de
Priority to KR1019970700338A priority patent/KR100395724B1/ko
Priority to PCT/SE1995/000857 priority patent/WO1996002259A1/en
Priority to DK95926565T priority patent/DK0771206T3/da
Priority to NZ290219A priority patent/NZ290219A/en
Priority to BR9508322A priority patent/BR9508322A/pt
Priority to AU30895/95A priority patent/AU696183C/en
Priority to CN95195024A priority patent/CN1081923C/zh
Priority to US08/505,353 priority patent/US5894070A/en
Priority to MX9700443A priority patent/MX9700443A/es
Priority to RU97102352/14A priority patent/RU2153877C2/ru
Priority to EP95926565A priority patent/EP0771206B1/en
Priority to AT95926565T priority patent/ATE219678T1/de
Priority to CA002194462A priority patent/CA2194462C/en
Priority to JP50495596A priority patent/JP3492377B2/ja
Priority to ES95926565T priority patent/ES2178675T3/es
Priority to HU9700160A priority patent/HU220770B1/hu
Priority to PL95318326A priority patent/PL181764B1/pl
Priority to IS4409A priority patent/IS1793B/is
Priority to NO19970215A priority patent/NO310223B1/no
Priority to FI970202A priority patent/FI970202A0/fi

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/70Carbohydrates; Sugars; Derivatives thereof
    • A61K31/715Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/70Carbohydrates; Sugars; Derivatives thereof
    • A61K31/715Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
    • A61K31/726Glycosaminoglycans, i.e. mucopolysaccharides
    • A61K31/727Heparin; Heparan
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/70Carbohydrates; Sugars; Derivatives thereof
    • A61K31/715Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
    • A61K31/737Sulfated polysaccharides, e.g. chondroitin sulfate, dermatan sulfate
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/14Macromolecular materials
    • A61L27/20Polysaccharides
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/28Materials for coating prostheses
    • A61L27/34Macromolecular materials
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L31/00Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
    • A61L31/08Materials for coatings
    • A61L31/10Macromolecular materials
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00Drugs for skeletal disorders
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00Drugs for skeletal disorders
    • A61P19/08Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P41/00Drugs used in surgical methods, e.g. surgery adjuvants for preventing adhesion or for vitreum substitution
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
SE9402528A 1994-07-19 1994-07-19 Hårdvävnadsstimulerande med el SE9402528D0 (sv)

Priority Applications (23)

Application Number Priority Date Filing Date Title
SE9402528A SE9402528D0 (sv) 1994-07-19 1994-07-19 Hårdvävnadsstimulerande med el
PL95318326A PL181764B1 (pl) 1994-07-19 1995-07-13 Powloka implantu do powlekania na implancie do wszczepienia do tkanki twardej PL PL PL
US08/505,353 US5894070A (en) 1994-07-19 1995-07-13 Hard tissue stimulating agent
RU97102352/14A RU2153877C2 (ru) 1994-07-19 1995-07-13 Агент, стимулирующий регенерацию твердой ткани
KR1019970700338A KR100395724B1 (ko) 1994-07-19 1995-07-13 경조직자극제
PCT/SE1995/000857 WO1996002259A1 (en) 1994-07-19 1995-07-13 Hard tissue stimulating agent
DK95926565T DK0771206T3 (da) 1994-07-19 1995-07-13 Hårdt væv stimulerende middel
NZ290219A NZ290219A (en) 1994-07-19 1995-07-13 Osseointegration implant and its use in regenerating hard tissue
BR9508322A BR9508322A (pt) 1994-07-19 1995-07-13 Uso de quitosan e de um polissacarídeo imobilizado no mesmo processo para estimular e/ou acelerar regeneração de tecido rígido e implante destinado para integração em tecido rígido
AU30895/95A AU696183C (en) 1994-07-19 1995-07-13 Hard tissue stimulating agent
CN95195024A CN1081923C (zh) 1994-07-19 1995-07-13 壳聚糖和固定于其上的多糖在生产硬组织刺激剂中的用途
CZ1997140A CZ289981B6 (cs) 1994-07-19 1995-07-13 Prostředek stimulující tvrdou tkáň
MX9700443A MX9700443A (es) 1994-07-19 1995-07-13 Agente que estimula el tejido duro.
DE69527203T DE69527203T2 (de) 1994-07-19 1995-07-13 Wirkstoff zur stimulation von hartem gewebe
EP95926565A EP0771206B1 (en) 1994-07-19 1995-07-13 Hard tissue stimulating agent
AT95926565T ATE219678T1 (de) 1994-07-19 1995-07-13 Wirkstoff zur stimulation von hartem gewebe
CA002194462A CA2194462C (en) 1994-07-19 1995-07-13 Hard tissue stimulating agent
JP50495596A JP3492377B2 (ja) 1994-07-19 1995-07-13 硬組織刺激剤
ES95926565T ES2178675T3 (es) 1994-07-19 1995-07-13 Agente estimulante del tejido duro.
HU9700160A HU220770B1 (hu) 1994-07-19 1995-07-13 Kitozánhoz rögzített poliszacharid alkalmazása keményszövet-regenerációt stimuláló készítmény előállítására
IS4409A IS1793B (is) 1994-07-19 1997-01-06 Notkun á kítósan og fjölsykru í tengslum við endurmyndun á hörðum vef, ásamt ígræðlingi
NO19970215A NO310223B1 (no) 1994-07-19 1997-01-17 Anvendelse av kitosan og et polysakkarid i forbindelse med regenerering av hardt vev, samt implantat
FI970202A FI970202A0 (fi) 1994-07-19 1997-01-17 Kovaa kudosta stimuloiva aine

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
SE9402528A SE9402528D0 (sv) 1994-07-19 1994-07-19 Hårdvävnadsstimulerande med el

Publications (1)

Publication Number Publication Date
SE9402528D0 true SE9402528D0 (sv) 1994-07-19

Family

ID=20394768

Family Applications (1)

Application Number Title Priority Date Filing Date
SE9402528A SE9402528D0 (sv) 1994-07-19 1994-07-19 Hårdvävnadsstimulerande med el

Country Status (22)

Country Link
US (1) US5894070A (ru)
EP (1) EP0771206B1 (ru)
JP (1) JP3492377B2 (ru)
KR (1) KR100395724B1 (ru)
CN (1) CN1081923C (ru)
AT (1) ATE219678T1 (ru)
BR (1) BR9508322A (ru)
CA (1) CA2194462C (ru)
CZ (1) CZ289981B6 (ru)
DE (1) DE69527203T2 (ru)
DK (1) DK0771206T3 (ru)
ES (1) ES2178675T3 (ru)
FI (1) FI970202A0 (ru)
HU (1) HU220770B1 (ru)
IS (1) IS1793B (ru)
MX (1) MX9700443A (ru)
NO (1) NO310223B1 (ru)
NZ (1) NZ290219A (ru)
PL (1) PL181764B1 (ru)
RU (1) RU2153877C2 (ru)
SE (1) SE9402528D0 (ru)
WO (1) WO1996002259A1 (ru)

Families Citing this family (50)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SE9402528D0 (sv) * 1994-07-19 1994-07-19 Astra Ab Hårdvävnadsstimulerande med el
KR100237738B1 (ko) * 1997-04-26 2000-01-15 이용찬 생채 매식용 의료기구 임플란트의 기능 향상방법
DE19724869C2 (de) * 1997-06-12 1999-05-12 Henkel Kgaa Verwendung von Citosanderivaten zur Oberflächenbeschichtung
EP0899247B1 (en) * 1997-08-28 2002-11-06 Ngk Spark Plug Co., Ltd Calcium phosphate cement and calcium phosphate cement composition
JP4215884B2 (ja) * 1998-03-23 2009-01-28 日本特殊陶業株式会社 リン酸カルシウムセメント及びリン酸カルシウムセメント組成物
US20030147860A1 (en) * 2002-02-07 2003-08-07 Marchosky J. Alexander Compositions and methods for forming and strengthening bone
EP1089785A1 (en) 1998-06-22 2001-04-11 Neovasys, Inc. Method, implant and delivery system for enhancing blood flow in tissue
AU755683B2 (en) * 1998-11-10 2002-12-19 Netech Inc. Functional chitosan derivative
FR2791262B1 (fr) 1999-03-22 2001-09-28 Virbac Sa Compositions a base de chondroitine et de chitosan pour la protection, le traitement ou le remplacement des tissus conjonctifs
CA2377435A1 (en) 1999-06-29 2001-01-04 J. Alexander Marchosky Compositions and methods for forming and strengthening bone
GB9920393D0 (en) * 1999-08-27 1999-11-03 Medix Scient Uk Limited Plant extract mixtures and their uses
FI19991852A (fi) 1999-09-01 2001-03-01 Yli Urpo Antti Uusi monikerroksinen materiaali, joka käsittää vaikuttavan ainesosan, ja sen valmistus
WO2001036000A1 (en) * 1999-11-15 2001-05-25 Bio Syntech Canada, Inc. Temperature-controlled and ph-dependant self-gelling biopolymeric aqueous solution
ATE243049T1 (de) * 1999-12-09 2003-07-15 Biosyntech Canada Inc Mineral-polymer hybrid-zusammensetzung
US20030158302A1 (en) * 1999-12-09 2003-08-21 Cyric Chaput Mineral-polymer hybrid composition
JP5089006B2 (ja) * 2000-06-29 2012-12-05 ピラマル ヘルスケア (カナダ) リミテッド 軟骨および他の組織の修復および再生のための組成物および方法
ES2169681B1 (es) * 2000-08-10 2003-10-01 Osfarma S L Metodo de produccion de filmes de quitosan con una alta capacidad de adherencia celular, producto obrenido y aplicaciones.
WO2002040070A2 (en) * 2000-11-15 2002-05-23 Bio Syntech Canada Inc. Method for restoring a damaged or degenerated intervertebral disc
AU2003249805A1 (en) * 2002-07-16 2004-02-02 Bio Syntech Canada Inc. Composition for cytocompatible, injectable, self-gelling chitosan solutions for encapsulating and delivering live cells or biologically active factors
US20040054414A1 (en) 2002-09-18 2004-03-18 Trieu Hai H. Collagen-based materials and methods for augmenting intervertebral discs
FR2844717B1 (fr) * 2002-09-23 2006-07-07 Richard Cancel Plaque de renfort comprenant notamment du chitosane
CN100394989C (zh) * 2002-11-15 2008-06-18 华沙整形外科股份有限公司 包含微粒状基于胶原材料的组合物的制药应用和包含所述组合物的滑膜关节
US20040186471A1 (en) * 2002-12-07 2004-09-23 Sdgi Holdings, Inc. Method and apparatus for intervertebral disc expansion
DE10338110A1 (de) * 2003-08-15 2005-03-10 Biomet Deutschland Gmbh Mit Chitosan beschichteter metallischer Gegenstand sowie Verfahren zu dessen Herstellung
US8734525B2 (en) * 2003-12-31 2014-05-27 Warsaw Orthopedic, Inc. Osteoinductive demineralized cancellous bone
EP1701729B1 (en) 2003-12-31 2018-05-02 Warsaw Orthopedic, Inc. Improved bone matrix compositions and methods
US20070231788A1 (en) * 2003-12-31 2007-10-04 Keyvan Behnam Method for In Vitro Assay of Demineralized Bone Matrix
FR2866571B1 (fr) * 2004-02-20 2007-09-21 Philippe Zanchetta Utilisation d'un melange de polysaccharides specifiques denomme par l'inventeur ezbone, comprenant de l'acide hyaluronique, de la chondroitine 6 sulfate, du dermatane sulfate et de l'heparine en cicatrisation osseuse.
NZ551771A (en) * 2004-05-07 2009-06-26 Univ Queensland Composition for stimulating bone growth and differentiation and method for isolating same
AU2005239977B2 (en) * 2004-05-07 2010-11-11 The University Of Queensland Composition for stimulating bone growth and differentiation and method for isolating same
BRPI0514387B8 (pt) 2004-08-16 2021-05-25 Cellresearch Corp Pte Ltd método para isolar células-tronco epiteliais ou mesenquimais/progenitoras da membrana amniótica do cordão umbilical, método in vitro para cultivar células-tronco mesenquimais/progenitoras, composição farmacêutica e uso de uma célula-tronco epitelial ou mesenquimal/progenitora
EP1838335A1 (en) * 2005-01-19 2007-10-03 Bonoss Medical AB Growth factor composition
EP1937326B1 (en) 2005-10-21 2018-09-12 CellResearch Corporation Pte Ltd Isolation and cultivation of stem/progenitor cells from the amniotic membrane of umbilical cord and uses of cells differentiated therefrom
US8911759B2 (en) * 2005-11-01 2014-12-16 Warsaw Orthopedic, Inc. Bone matrix compositions and methods
EP1945712A4 (en) * 2005-11-04 2013-05-01 Piramal Healthcare Canada Ltd BINDING OF AQUEOUS POLYELECTROLYTE SOLUTIONS BY THERMALLY INDUCED CHANGES IN THE IONIZATION CONDITION
DE102006020035A1 (de) 2006-04-26 2007-10-31 B. Braun Melsungen Ag Herstellung und Verwendung von Poly(hydroxyethylstärke)chitin- und Poly(Carboxymethylstärke)chitin-Verbindungen
US8399619B2 (en) * 2006-06-30 2013-03-19 Warsaw Orthopedic, Inc. Injectable collagen material
US8118779B2 (en) * 2006-06-30 2012-02-21 Warsaw Orthopedic, Inc. Collagen delivery device
EP1977739A1 (en) * 2007-04-03 2008-10-08 Bioiberica, S.A. Nanoparticulate composition of chitosan and chondroitin sulfate
CA2690816C (en) * 2007-06-15 2016-12-06 Osteotech, Inc. Method of treating tissue
US9554920B2 (en) * 2007-06-15 2017-01-31 Warsaw Orthopedic, Inc. Bone matrix compositions having nanoscale textured surfaces
AU2008265850B2 (en) 2007-06-15 2014-06-26 Warsaw Orthopedic, Inc. Bone matrix compositions and methods
US9358113B2 (en) 2007-07-10 2016-06-07 Warsaw Orthopedic, Inc. Delivery system
US20110054408A1 (en) * 2007-07-10 2011-03-03 Guobao Wei Delivery systems, devices, tools, and methods of use
EP2211921B1 (en) 2007-10-19 2013-12-25 Warsaw Orthopedic, Inc. Demineralized bone matrix compositions and methods
GB2463474B (en) 2008-09-11 2012-05-02 Agency Science Tech & Res Therapeutic bone growth and regeneration
WO2010093959A2 (en) * 2009-02-12 2010-08-19 Osteotech, Inc. Delivery systems, tools, and methods of use
RU2014132564A (ru) 2012-01-27 2016-03-20 Ф. Хоффманн-Ля Рош Аг Хитозан, ковалентно связанный с низкомолекулярным антагонистом интегрина, для нацеленной доставки
CN105142399B (zh) 2013-03-14 2018-06-12 金珂生物医疗公司 生物相容的和生物可吸收的衍生的壳聚糖组合物
CN105126165B (zh) * 2015-01-21 2017-12-08 中国人民解放军第三〇七医院 一种钛牙种植体材料及其制备方法与应用

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NL163522B (nl) * 1970-07-20 1980-04-15 Montedison Spa Werkwijze om een katalysator te bereiden voor de polymerisatie van alkenen-1.
US5510418A (en) * 1988-11-21 1996-04-23 Collagen Corporation Glycosaminoglycan-synthetic polymer conjugates
US5256447A (en) * 1991-12-31 1993-10-26 Minnesota Mining And Manufacturing Company Adhesive composition and method
BR9207010A (pt) * 1991-12-31 1995-12-05 Minnesota Mining & Mfg Composição adesiva e processo de aderência de um material restaurador a um substrato
SE9402528D0 (sv) * 1994-07-19 1994-07-19 Astra Ab Hårdvävnadsstimulerande med el

Also Published As

Publication number Publication date
FI970202A (fi) 1997-01-17
CZ289981B6 (cs) 2002-05-15
CZ14097A3 (en) 1997-07-16
RU2153877C2 (ru) 2000-08-10
DE69527203D1 (de) 2002-08-01
HUT77607A (hu) 1998-06-29
NO310223B1 (no) 2001-06-11
BR9508322A (pt) 1998-01-06
KR100395724B1 (ko) 2004-02-18
MX9700443A (es) 1997-04-30
US5894070A (en) 1999-04-13
HU9700160D0 (en) 1997-03-28
AU3089595A (en) 1996-02-16
IS4409A (is) 1997-01-06
DK0771206T3 (da) 2002-08-19
CA2194462A1 (en) 1996-02-01
PL181764B1 (pl) 2001-09-28
NO970215D0 (no) 1997-01-17
FI970202A0 (fi) 1997-01-17
EP0771206A1 (en) 1997-05-07
IS1793B (is) 2001-12-12
PL318326A1 (en) 1997-06-09
HU220770B1 (hu) 2002-05-28
CN1157568A (zh) 1997-08-20
ES2178675T3 (es) 2003-01-01
JPH10502664A (ja) 1998-03-10
CA2194462C (en) 2007-07-10
NO970215L (no) 1997-01-17
NZ290219A (en) 1998-06-26
AU696183B2 (en) 1998-09-03
EP0771206B1 (en) 2002-06-26
DE69527203T2 (de) 2003-01-09
ATE219678T1 (de) 2002-07-15
CN1081923C (zh) 2002-04-03
WO1996002259A1 (en) 1996-02-01
JP3492377B2 (ja) 2004-02-03
KR970704459A (ko) 1997-09-06

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