KR970704459A - 경조직 자극제(Hard Tissue Stimulating Agent) - Google Patents

경조직 자극제(Hard Tissue Stimulating Agent) Download PDF

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KR970704459A
KR970704459A KR1019970700338A KR19970700338A KR970704459A KR 970704459 A KR970704459 A KR 970704459A KR 1019970700338 A KR1019970700338 A KR 1019970700338A KR 19970700338 A KR19970700338 A KR 19970700338A KR 970704459 A KR970704459 A KR 970704459A
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hard tissue
use according
chitosan
polysaccharide
stimulant
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KR1019970700338A
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KR100395724B1 (ko
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한스-아르네 한슨
구닐라 요한슨-루덴
올레 라름
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클래스 빌헬름슨
아스트라 악티에볼라그
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
    • A61K31/726—Glycosaminoglycans, i.e. mucopolysaccharides
    • A61K31/727—Heparin; Heparan
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
    • A61K31/737—Sulfated polysaccharides, e.g. chondroitin sulfate, dermatan sulfate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/14—Macromolecular materials
    • A61L27/20—Polysaccharides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/28—Materials for coating prostheses
    • A61L27/34—Macromolecular materials
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
    • A61L31/08—Materials for coatings
    • A61L31/10—Macromolecular materials
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P41/00—Drugs used in surgical methods, e.g. surgery adjuvants for preventing adhesion or for vitreum substitution
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Epidemiology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Dermatology (AREA)
  • Molecular Biology (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Transplantation (AREA)
  • Oral & Maxillofacial Surgery (AREA)
  • Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Vascular Medicine (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Rheumatology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Materials For Medical Uses (AREA)
  • Medicines Containing Plant Substances (AREA)
  • Saccharide Compounds (AREA)
  • Cosmetics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Chemical Or Physical Treatment Of Fibers (AREA)
  • Dental Preparations (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

본 발명은 경조직의 증진된 재생을 제공할 수 있는 자극제를 제조하기 위한 키토산, 및 그에 고정되고 헤파린, 헤파란 술페이트, 콘드로이틴 술페이트 및 덱스트란 술페이트로 이루어진 군으로부터 선택되는 폴리사카라이드의 용도, 소위 골융합화와 관련하여 경조직의 증진된 재생 방법, 및 경조직, 특히 골조직에 융합될 이식물에 관한 것이다.

Description

경조직 자극제(Hard Tissue Stimulation Agent)
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음

Claims (19)

  1. 경조직의 증진된 재생을 제공할 수 있는 자극제를 제조하기 위한, 키토산, 및 그에 고정되고 헤파린, 헤파란 술페이트, 콘드로이틴술페이트 및 덱스트란 술페이트로 이루어진 군으로부터 선택되는 폴리사카라이드의 용도.
  2. 제1항에 있어서 경조직의 증진된 재생이 경조직, 예를 들어, 골조직에서의 이식물과 관련되어 제공되는 것을 특징으로 하는 용도.
  3. 제1항 또는 2항에 있어서, 폴리사카라이드가 이온 결합에 의해 키토산에 고정되는 것을 특징으로 하는 용도.
  4. 제1항 또는 2항에 있어서, 폴리사카라이드가 공유 결합에 의해 키토산에 고정되는 것을 특징으로 하는 용도.
  5. 제1항 내지 4항 중 어느 한 항에 있어서, 폴리사카라이드가 헤파린 또는 헤파란 술페이트인 것을 특징으로 하는 용도.
  6. 제1항 내지 5항 중 어느 한 항에 있어서, 자극제가 분말 또는 용액 형태인 것을 특징으로 하는 용도.
  7. 제1항 내지 5항 중 어느 한 항에 있어서, 자극제가 겔 형태인 것을 특징으로 하는 용도.
  8. 제1항 내지 5항 중 어느 한 항에 있어서, 자극제가 구슬 형태인 것을 특징으로 하는 용도.
  9. 제1항 내지 8항 중 어느 한 항에 있어서, 키토산이 최대 약 90%, 바람직하게는 최대 약 50%의 N-아세틸화도를 갖는 것을 특징으로 하는 용도.
  10. 제9항 있어서, 키토산이 약 25% 미만의 N-아세틸화도를 갖는 것을 특징으로 하는 용도.
  11. 제2항 내지 10항 중 어느 한 항에 있어서, 이식물이 티타늄으로 이루어진 것을 특징으로 하는 용도.
  12. 키토산 및 그에 고정되고 헤파린, 헤파란 술페이트, 콘드로이틴술페이트 및 덱스트란 술페이트로 구성된 군으로부터 선택되는 폴리사카라이드로 이루어진 자극제의 증진 활성양을 적절한 부위에 도포하는 것을 특징으로 하는 경조직 재생의 증진 및(또는)가속화 방법.
  13. 제12항에 있어서, 재생이 골융합화와 관련된 방법.
  14. 제13항에 있어서, 골융합화가 경조직, 예를 들어, 골조직에서의 이식물과 관련되어 수행되는 것을 특징으로 하는 방법.
  15. 제12항 내지 14항 중 어느 한 항에 있어서, 상기 자극제가 분말 형태로 도포되는 것을 특징으로 하는 방법.
  16. 제12항 내지 14항 중 어느 한 항에 있어서, 상기 자극제가 겔 형태로 도포되는 것을 특징으로 하는 방법.
  17. 제12항 내지 16항 중 어느 한 항에 있어서, 폴리사카라이드가 헤파린 또는 헤파란 술페이트로 구성되는 것을 특징으로 하는 방법.
  18. 제13, 14 및 17항 중 어느 한 항에 있어서, 경조직에 융합될 이식물 부위를 키토산 및 폴리사카라이드의 용액에 침지시킴으로 자극제를 도포시키는 것을 특징으로 하는 방법.
  19. 적어도 융합될 이식물 부위가, 키토산 및 그에 고정되고 헤파린, 헤파란 술페이트, 콘드로이틴술페이트 및 덱스트란 술페이트로 구성된 군으로부터 선택되는 폴리사카라이드로 구성된, 경조직의 재생 자극제로 코팅된 것을 특징으로 하는 경조직 융합용 이식물.
    ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
KR1019970700338A 1994-07-19 1995-07-13 경조직자극제 KR100395724B1 (ko)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
SE9402528-5 1994-07-19
SE9402528A SE9402528D0 (sv) 1994-07-19 1994-07-19 Hårdvävnadsstimulerande med el

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KR970704459A true KR970704459A (ko) 1997-09-06
KR100395724B1 KR100395724B1 (ko) 2004-02-18

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US (1) US5894070A (ko)
EP (1) EP0771206B1 (ko)
JP (1) JP3492377B2 (ko)
KR (1) KR100395724B1 (ko)
CN (1) CN1081923C (ko)
AT (1) ATE219678T1 (ko)
BR (1) BR9508322A (ko)
CA (1) CA2194462C (ko)
CZ (1) CZ289981B6 (ko)
DE (1) DE69527203T2 (ko)
DK (1) DK0771206T3 (ko)
ES (1) ES2178675T3 (ko)
FI (1) FI970202A (ko)
HU (1) HU220770B1 (ko)
IS (1) IS1793B (ko)
MX (1) MX9700443A (ko)
NO (1) NO310223B1 (ko)
NZ (1) NZ290219A (ko)
PL (1) PL181764B1 (ko)
RU (1) RU2153877C2 (ko)
SE (1) SE9402528D0 (ko)
WO (1) WO1996002259A1 (ko)

Families Citing this family (50)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SE9402528D0 (sv) * 1994-07-19 1994-07-19 Astra Ab Hårdvävnadsstimulerande med el
KR100237738B1 (ko) * 1997-04-26 2000-01-15 이용찬 생채 매식용 의료기구 임플란트의 기능 향상방법
DE19724869C2 (de) * 1997-06-12 1999-05-12 Henkel Kgaa Verwendung von Citosanderivaten zur Oberflächenbeschichtung
DE69809158T2 (de) * 1997-08-28 2003-03-20 Ngk Spark Plug Co Calciumphosphatzement und Calciumphosphatzementzusammensetzung
JP4215884B2 (ja) * 1998-03-23 2009-01-28 日本特殊陶業株式会社 リン酸カルシウムセメント及びリン酸カルシウムセメント組成物
US20030147860A1 (en) * 2002-02-07 2003-08-07 Marchosky J. Alexander Compositions and methods for forming and strengthening bone
US6263880B1 (en) 1998-06-22 2001-07-24 Neovasys, Inc. Method of enhancing blood flow in tissue
EP1152013B1 (en) * 1998-11-10 2008-04-23 Netech Inc. Functional chitosan derivative
FR2791262B1 (fr) * 1999-03-22 2001-09-28 Virbac Sa Compositions a base de chondroitine et de chitosan pour la protection, le traitement ou le remplacement des tissus conjonctifs
WO2001000792A1 (en) 1999-06-29 2001-01-04 Marchosky J Alexander Compositions and methods for forming and strengthening bone
GB9920393D0 (en) * 1999-08-27 1999-11-03 Medix Scient Uk Limited Plant extract mixtures and their uses
FI19991852A (fi) 1999-09-01 2001-03-01 Yli Urpo Antti Uusi monikerroksinen materiaali, joka käsittää vaikuttavan ainesosan, ja sen valmistus
ES2491866T3 (es) * 1999-11-15 2014-09-08 Piramal Healthcare (Canada) Limited Disolución biopolimérica acuosa autogelificante controlada por la temperatura y dependiente del pH
US20030158302A1 (en) * 1999-12-09 2003-08-21 Cyric Chaput Mineral-polymer hybrid composition
ATE243049T1 (de) * 1999-12-09 2003-07-15 Biosyntech Canada Inc Mineral-polymer hybrid-zusammensetzung
DK1294414T3 (da) * 2000-06-29 2006-07-24 Biosyntech Canada Inc Præparat og fremgangsmåde til heling og regenerering af brusk og andre væv
ES2169681B1 (es) * 2000-08-10 2003-10-01 Osfarma S L Metodo de produccion de filmes de quitosan con una alta capacidad de adherencia celular, producto obrenido y aplicaciones.
US20040091540A1 (en) * 2000-11-15 2004-05-13 Desrosiers Eric Andre Method for restoring a damaged or degenerated intervertebral disc
CA2493083C (en) * 2002-07-16 2012-11-06 Bio Syntech Canada Inc. Composition for cytocompatible, injectable, self-gelling chitosan solutions for encapsulating and delivering live cells or biologically active factors
US20040054414A1 (en) 2002-09-18 2004-03-18 Trieu Hai H. Collagen-based materials and methods for augmenting intervertebral discs
FR2844717B1 (fr) * 2002-09-23 2006-07-07 Richard Cancel Plaque de renfort comprenant notamment du chitosane
CN100394989C (zh) * 2002-11-15 2008-06-18 华沙整形外科股份有限公司 包含微粒状基于胶原材料的组合物的制药应用和包含所述组合物的滑膜关节
US20040186471A1 (en) * 2002-12-07 2004-09-23 Sdgi Holdings, Inc. Method and apparatus for intervertebral disc expansion
DE10338110A1 (de) * 2003-08-15 2005-03-10 Biomet Deutschland Gmbh Mit Chitosan beschichteter metallischer Gegenstand sowie Verfahren zu dessen Herstellung
WO2005065396A2 (en) * 2003-12-31 2005-07-21 Osteotech, Inc. Improved bone matrix compositions and methods
US20070231788A1 (en) * 2003-12-31 2007-10-04 Keyvan Behnam Method for In Vitro Assay of Demineralized Bone Matrix
FR2866571B1 (fr) * 2004-02-20 2007-09-21 Philippe Zanchetta Utilisation d'un melange de polysaccharides specifiques denomme par l'inventeur ezbone, comprenant de l'acide hyaluronique, de la chondroitine 6 sulfate, du dermatane sulfate et de l'heparine en cicatrisation osseuse.
NZ551771A (en) * 2004-05-07 2009-06-26 Univ Queensland Composition for stimulating bone growth and differentiation and method for isolating same
AU2005239977B2 (en) * 2004-05-07 2010-11-11 The University Of Queensland Composition for stimulating bone growth and differentiation and method for isolating same
DK1789534T3 (en) 2004-08-16 2014-11-17 Cellres Corp Pte Ltd ISOLATION OF stem / progenitor cells FOSTER HINDE FROM an umbilical cord
WO2006078211A1 (en) * 2005-01-19 2006-07-27 Bonoss Medical Ab Growth factor composition
CN101330935B (zh) 2005-10-21 2013-11-13 细胞研究私人有限公司 自脐带羊膜分离和培养干/祖细胞及其分化的细胞的应用
US8911759B2 (en) * 2005-11-01 2014-12-16 Warsaw Orthopedic, Inc. Bone matrix compositions and methods
WO2007051311A1 (en) * 2005-11-04 2007-05-10 Bio Syntech Canada Inc. Gel formation of polyelectrolyte aqueous solutions by thermally induced changes in ionization state
DE102006020035A1 (de) * 2006-04-26 2007-10-31 B. Braun Melsungen Ag Herstellung und Verwendung von Poly(hydroxyethylstärke)chitin- und Poly(Carboxymethylstärke)chitin-Verbindungen
US8399619B2 (en) * 2006-06-30 2013-03-19 Warsaw Orthopedic, Inc. Injectable collagen material
US8118779B2 (en) * 2006-06-30 2012-02-21 Warsaw Orthopedic, Inc. Collagen delivery device
EP1977739A1 (en) * 2007-04-03 2008-10-08 Bioiberica, S.A. Nanoparticulate composition of chitosan and chondroitin sulfate
US8642061B2 (en) * 2007-06-15 2014-02-04 Warsaw Orthopedic, Inc. Method of treating bone tissue
US9554920B2 (en) * 2007-06-15 2017-01-31 Warsaw Orthopedic, Inc. Bone matrix compositions having nanoscale textured surfaces
WO2008157495A2 (en) * 2007-06-15 2008-12-24 Osteotech, Inc. Bone matrix compositions and methods
WO2008157492A2 (en) 2007-06-15 2008-12-24 Osteotech, Inc. Osteoinductive demineralized cancellous bone
US9492278B2 (en) * 2007-07-10 2016-11-15 Warsaw Orthopedic, Inc. Delivery system
US20110054408A1 (en) * 2007-07-10 2011-03-03 Guobao Wei Delivery systems, devices, tools, and methods of use
ES2446544T3 (es) 2007-10-19 2014-03-10 Warsaw Orthopedic, Inc. Composiciones de matrices óseas desmineralizadas y métodos
GB2463474B (en) 2008-09-11 2012-05-02 Agency Science Tech & Res Therapeutic bone growth and regeneration
US9101475B2 (en) * 2009-02-12 2015-08-11 Warsaw Orthopedic, Inc. Segmented delivery system
KR20140120316A (ko) 2012-01-27 2014-10-13 에프. 호프만-라 로슈 아게 표적화된 전달을 위한 소분자 인테그린 안타고니스트와 공유 결합된 키토산
EP3569262A1 (en) 2013-03-14 2019-11-20 Tricol Biomedical, Inc. Biocompatible and bioabsorbable derivatized chitosan compositions
CN105126165B (zh) * 2015-01-21 2017-12-08 中国人民解放军第三〇七医院 一种钛牙种植体材料及其制备方法与应用

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NL163522B (nl) * 1970-07-20 1980-04-15 Montedison Spa Werkwijze om een katalysator te bereiden voor de polymerisatie van alkenen-1.
US5510418A (en) * 1988-11-21 1996-04-23 Collagen Corporation Glycosaminoglycan-synthetic polymer conjugates
US5256447A (en) * 1991-12-31 1993-10-26 Minnesota Mining And Manufacturing Company Adhesive composition and method
CA2117347A1 (en) * 1991-12-31 1993-07-08 Joel D. Oxman Metal filled adhesive composition and method
SE9402528D0 (sv) * 1994-07-19 1994-07-19 Astra Ab Hårdvävnadsstimulerande med el

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HU220770B1 (hu) 2002-05-28
NO970215D0 (no) 1997-01-17
EP0771206A1 (en) 1997-05-07
FI970202A0 (fi) 1997-01-17
MX9700443A (es) 1997-04-30
FI970202A (fi) 1997-01-17
CN1081923C (zh) 2002-04-03
NO970215L (no) 1997-01-17
AU3089595A (en) 1996-02-16
IS4409A (is) 1997-01-06
IS1793B (is) 2001-12-12
US5894070A (en) 1999-04-13
NZ290219A (en) 1998-06-26
KR100395724B1 (ko) 2004-02-18
CA2194462C (en) 2007-07-10
PL181764B1 (pl) 2001-09-28
HUT77607A (hu) 1998-06-29
HU9700160D0 (en) 1997-03-28
NO310223B1 (no) 2001-06-11
CA2194462A1 (en) 1996-02-01
CZ289981B6 (cs) 2002-05-15
CZ14097A3 (en) 1997-07-16
BR9508322A (pt) 1998-01-06
ATE219678T1 (de) 2002-07-15
CN1157568A (zh) 1997-08-20
DK0771206T3 (da) 2002-08-19
PL318326A1 (en) 1997-06-09
SE9402528D0 (sv) 1994-07-19
EP0771206B1 (en) 2002-06-26
RU2153877C2 (ru) 2000-08-10
JPH10502664A (ja) 1998-03-10
AU696183B2 (en) 1998-09-03
ES2178675T3 (es) 2003-01-01
DE69527203T2 (de) 2003-01-09
WO1996002259A1 (en) 1996-02-01
DE69527203D1 (de) 2002-08-01
JP3492377B2 (ja) 2004-02-03

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