SE8904186L - Adenosinderivat, deras framstaellning och anvaendning - Google Patents
Adenosinderivat, deras framstaellning och anvaendningInfo
- Publication number
- SE8904186L SE8904186L SE8904186A SE8904186A SE8904186L SE 8904186 L SE8904186 L SE 8904186L SE 8904186 A SE8904186 A SE 8904186A SE 8904186 A SE8904186 A SE 8904186A SE 8904186 L SE8904186 L SE 8904186L
- Authority
- SE
- Sweden
- Prior art keywords
- alkyl
- derivatives
- preparation
- adenosin
- adenosines
- Prior art date
Links
- OIRDTQYFTABQOQ-KQYNXXCUSA-N adenosine Chemical class C1=NC=2C(N)=NC=NC=2N1[C@@H]1O[C@H](CO)[C@@H](O)[C@H]1O OIRDTQYFTABQOQ-KQYNXXCUSA-N 0.000 title 1
- 125000004178 (C1-C4) alkyl group Chemical group 0.000 abstract 2
- 125000000229 (C1-C4)alkoxy group Chemical group 0.000 abstract 1
- 125000003903 2-propenyl group Chemical group [H]C([*])([H])C([H])=C([H])[H] 0.000 abstract 1
- 150000003838 adenosines Chemical class 0.000 abstract 1
- 125000000217 alkyl group Chemical group 0.000 abstract 1
- 125000000304 alkynyl group Chemical group 0.000 abstract 1
- 239000008280 blood Substances 0.000 abstract 1
- 210000004369 blood Anatomy 0.000 abstract 1
- 230000036772 blood pressure Effects 0.000 abstract 1
- 125000000753 cycloalkyl group Chemical group 0.000 abstract 1
- 210000003989 endothelium vascular Anatomy 0.000 abstract 1
- 229910052736 halogen Inorganic materials 0.000 abstract 1
- 125000005843 halogen group Chemical group 0.000 abstract 1
- 229910052739 hydrogen Inorganic materials 0.000 abstract 1
- 239000001257 hydrogen Substances 0.000 abstract 1
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 1
- 150000002632 lipids Chemical class 0.000 abstract 1
- 125000005394 methallyl group Chemical group 0.000 abstract 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 1
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/16—Purine radicals
- C07H19/167—Purine radicals with ribosyl as the saccharide radical
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/16—Purine radicals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/08—Vasodilators for multiple indications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/14—Vasoprotectives; Antihaemorrhoidals; Drugs for varicose therapy; Capillary stabilisers
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Genetics & Genomics (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Biotechnology (AREA)
- Vascular Medicine (AREA)
- Urology & Nephrology (AREA)
- Obesity (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Saccharide Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE3841881 | 1988-12-13 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| SE8904186D0 SE8904186D0 (sv) | 1989-12-12 |
| SE8904186L true SE8904186L (sv) | 1991-06-13 |
Family
ID=6369027
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SE8904186A SE8904186L (sv) | 1988-12-13 | 1989-12-12 | Adenosinderivat, deras framstaellning och anvaendning |
Country Status (29)
| Country | Link |
|---|---|
| US (1) | US5534503A (it) |
| JP (2) | JPH0725786B2 (it) |
| KR (1) | KR900009647A (it) |
| AT (1) | AT397964B (it) |
| AU (1) | AU618865B2 (it) |
| BE (1) | BE1003632A3 (it) |
| CA (1) | CA2005110A1 (it) |
| CH (1) | CH678327A5 (it) |
| CS (1) | CS411191A3 (it) |
| CY (1) | CY1829A (it) |
| DE (1) | DE3940021C2 (it) |
| DK (1) | DK626989A (it) |
| ES (1) | ES2022771A6 (it) |
| FR (1) | FR2640271B1 (it) |
| GB (1) | GB2226027B (it) |
| HK (1) | HK70895A (it) |
| HU (1) | HU211248A9 (it) |
| IE (1) | IE65506B1 (it) |
| IL (1) | IL92634A (it) |
| IT (1) | IT1237431B (it) |
| LU (1) | LU87639A1 (it) |
| MX (1) | MX9203613A (it) |
| MY (1) | MY106333A (it) |
| NL (1) | NL8903054A (it) |
| NZ (1) | NZ231701A (it) |
| PH (1) | PH27533A (it) |
| SE (1) | SE8904186L (it) |
| SG (1) | SG8695G (it) |
| ZA (1) | ZA899528B (it) |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH0725785B2 (ja) * | 1989-01-11 | 1995-03-22 | 日本臓器製薬株式会社 | アデノシン誘導体及び該化合物を有効成分として含有する医薬組成物 |
| DE4037363A1 (de) * | 1990-04-09 | 1991-10-10 | Europ Lab Molekularbiolog | 2-0-alkylnukleotide sowie polymere, die solche nukleotide enthalten |
| US5561134A (en) * | 1990-09-25 | 1996-10-01 | Rhone-Poulenc Rorer Pharmaceuticals Inc. | Compounds having antihypertensive, cardioprotective, anti-ischemic and antilipolytic properties |
| CA2092305C (en) * | 1990-09-25 | 2003-02-11 | Alfred P. Spada | Compounds having antihypertensive and anti-ischemic properties |
| HUT61567A (en) | 1990-12-07 | 1993-01-28 | Sandoz Ag | Process for producing new pharmaceutical compositions comprising 2'-o-alkyladenosine derivatives and for producing 6-cyclohexyl-2'-o-methyladenosinehydrate |
| GB9111580D0 (en) * | 1991-05-30 | 1991-07-24 | Wellcome Found | Nucleoside derivative |
| EP0601322A3 (en) * | 1992-10-27 | 1994-10-12 | Nippon Zoki Pharmaceutical Co | Adenosine deaminase inhibitor. |
| AU2546195A (en) * | 1994-05-10 | 1995-11-29 | Novartis Ag | Adenosine derivatives |
| US6107300A (en) * | 1996-03-27 | 2000-08-22 | Dupont Pharmaceuticals | Arylamino fused pyrimidines |
| JP3619017B2 (ja) | 1998-06-24 | 2005-02-09 | 日本臓器製薬株式会社 | 新規アラビノシルアデニン誘導体 |
Family Cites Families (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| NL130136C (it) * | 1966-10-20 | |||
| DE2628202A1 (de) * | 1976-06-23 | 1977-12-29 | Max Planck Gesellschaft | Verfahren zur herstellung von 2'-substituierten-d-ribofuranosylpurinderivaten |
| CA1239397A (en) * | 1983-08-01 | 1988-07-19 | James A. Bristol | N.sup.6-substituted adenosines |
| DE3406533A1 (de) * | 1984-02-23 | 1985-08-29 | Boehringer Mannheim Gmbh, 6800 Mannheim | Verwendung von adenosin-derivaten als antiallergica und arzneimittel, die diese enthalten |
| AU575438B2 (en) * | 1984-10-26 | 1988-07-28 | Warner-Lambert Company | N6 - substituted deoxyribose analogues of adenosines |
| US4755594A (en) * | 1986-01-31 | 1988-07-05 | Warner-Lambert Company | N6 -substituted adenosines |
| US4780452A (en) * | 1986-09-08 | 1988-10-25 | Burroughs Wellcome Co. | F-substituted-3-β-D-ribofuranosyl-3H-imidazo[4,5-b]pyridines and pharmaceutical compositions thereof |
| AU8274187A (en) * | 1986-10-31 | 1988-05-25 | Warner-Lambert Company | Heteroaromatic derivatives of adenosine |
| JPH0723394B2 (ja) * | 1986-11-27 | 1995-03-15 | 日本臓器製薬株式会社 | 新規アデノシン誘導体及び該化合物を有効成分として含有する医薬組成物 |
| US4962194A (en) * | 1987-04-02 | 1990-10-09 | Warner-Lambert Company | Method of preparing 51,N6-disubstituted adenosines from inosines |
| GB8729994D0 (en) * | 1987-12-23 | 1988-02-03 | Glaxo Group Ltd | Chemical compounds |
| JPH0725785B2 (ja) * | 1989-01-11 | 1995-03-22 | 日本臓器製薬株式会社 | アデノシン誘導体及び該化合物を有効成分として含有する医薬組成物 |
-
1989
- 1989-11-10 GB GB8925439A patent/GB2226027B/en not_active Expired - Lifetime
- 1989-12-04 DE DE3940021A patent/DE3940021C2/de not_active Expired - Fee Related
- 1989-12-04 FR FR8916087A patent/FR2640271B1/fr not_active Expired - Fee Related
- 1989-12-04 BE BE8901293A patent/BE1003632A3/fr not_active IP Right Cessation
- 1989-12-08 LU LU87639A patent/LU87639A1/fr unknown
- 1989-12-11 CA CA002005110A patent/CA2005110A1/en not_active Abandoned
- 1989-12-11 NZ NZ231701A patent/NZ231701A/xx unknown
- 1989-12-11 AU AU46172/89A patent/AU618865B2/en not_active Ceased
- 1989-12-11 MY MYPI89001738A patent/MY106333A/en unknown
- 1989-12-11 IL IL9263489A patent/IL92634A/en not_active IP Right Cessation
- 1989-12-11 CH CH4442/89A patent/CH678327A5/de not_active IP Right Cessation
- 1989-12-12 AT AT0280489A patent/AT397964B/de not_active IP Right Cessation
- 1989-12-12 SE SE8904186A patent/SE8904186L/xx not_active Application Discontinuation
- 1989-12-12 JP JP1324880A patent/JPH0725786B2/ja not_active Expired - Lifetime
- 1989-12-12 IT IT04864089A patent/IT1237431B/it active IP Right Grant
- 1989-12-12 KR KR1019890018330A patent/KR900009647A/ko not_active Application Discontinuation
- 1989-12-12 PH PH39675A patent/PH27533A/en unknown
- 1989-12-12 IE IE396589A patent/IE65506B1/en not_active IP Right Cessation
- 1989-12-12 DK DK626989A patent/DK626989A/da not_active Application Discontinuation
- 1989-12-13 ES ES8904209A patent/ES2022771A6/es not_active Expired - Lifetime
- 1989-12-13 NL NL8903054A patent/NL8903054A/nl not_active Application Discontinuation
- 1989-12-13 ZA ZA899528A patent/ZA899528B/xx unknown
-
1991
- 1991-12-27 CS CS914111A patent/CS411191A3/cs unknown
-
1992
- 1992-06-26 MX MX9203613A patent/MX9203613A/es unknown
-
1994
- 1994-09-22 JP JP6227610A patent/JPH07223961A/ja active Pending
- 1994-10-27 US US08/330,043 patent/US5534503A/en not_active Expired - Fee Related
-
1995
- 1995-01-18 SG SG8695A patent/SG8695G/en unknown
- 1995-05-11 HK HK70895A patent/HK70895A/xx not_active IP Right Cessation
- 1995-06-02 HU HU95P/P00151P patent/HU211248A9/hu unknown
- 1995-12-01 CY CY182995A patent/CY1829A/xx unknown
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| NAV | Patent application has lapsed |
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