SE8901687D0 - Fibronectin binding protein as well as its preparation - Google Patents

Fibronectin binding protein as well as its preparation

Info

Publication number
SE8901687D0
SE8901687D0 SE8901687A SE8901687A SE8901687D0 SE 8901687 D0 SE8901687 D0 SE 8901687D0 SE 8901687 A SE8901687 A SE 8901687A SE 8901687 A SE8901687 A SE 8901687A SE 8901687 D0 SE8901687 D0 SE 8901687D0
Authority
SE
Sweden
Prior art keywords
preparation
well
fibronectin binding
binding protein
protein
Prior art date
Application number
SE8901687A
Other languages
English (en)
Swedish (sv)
Inventor
M Hoeoek
Original Assignee
Alfa Laval Agri Int
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Alfa Laval Agri Int filed Critical Alfa Laval Agri Int
Priority to SE8901687A priority Critical patent/SE8901687D0/xx
Publication of SE8901687D0 publication Critical patent/SE8901687D0/xx
Priority to EP90850166A priority patent/EP0397633B1/en
Priority to ES90850166T priority patent/ES2077666T3/es
Priority to DE69021263T priority patent/DE69021263T2/de
Priority to AT90850166T priority patent/ATE125867T1/de
Priority to DK90850166.1T priority patent/DK0397633T3/da
Priority to AU54818/90A priority patent/AU630950B2/en
Priority to NZ233614A priority patent/NZ233614A/en
Priority to US07/520,808 priority patent/US5175096A/en
Priority to CA002016521A priority patent/CA2016521C/en
Priority to IE169690A priority patent/IE72968B1/en
Priority to FI902350A priority patent/FI102768B/fi
Priority to NO902082A priority patent/NO300069B1/no
Priority to JP02120158A priority patent/JP3077993B2/ja
Priority to US08/340,458 priority patent/US5652217A/en
Priority to GR950403055T priority patent/GR3017946T3/el
Priority to US08/725,492 priority patent/US5840846A/en

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/195Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
    • C07K14/305Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Micrococcaceae (F)
    • C07K14/31Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Micrococcaceae (F) from Staphylococcus (G)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00Drugs for dermatological disorders
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70546Integrin superfamily
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10STECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S530/00Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof
    • Y10S530/82Proteins from microorganisms
    • Y10S530/825Bacteria

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Zoology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Cell Biology (AREA)
  • Immunology (AREA)
  • Toxicology (AREA)
  • Dermatology (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
SE8901687A 1989-05-11 1989-05-11 Fibronectin binding protein as well as its preparation SE8901687D0 (sv)

Priority Applications (17)

Application Number Priority Date Filing Date Title
SE8901687A SE8901687D0 (sv) 1989-05-11 1989-05-11 Fibronectin binding protein as well as its preparation
EP90850166A EP0397633B1 (en) 1989-05-11 1990-05-04 Fibronectin binding protein as well as its preparation
ES90850166T ES2077666T3 (es) 1989-05-11 1990-05-04 Proteina de union a fibronectina y su preparacion.
DE69021263T DE69021263T2 (de) 1989-05-11 1990-05-04 Fibronektinbindungsprotein und dessen Herstellung.
AT90850166T ATE125867T1 (de) 1989-05-11 1990-05-04 Fibronektinbindungsprotein und dessen herstellung.
DK90850166.1T DK0397633T3 (da) 1989-05-11 1990-05-04 Fibronectinbindende protein samt fremstilling deraf
US07/520,808 US5175096A (en) 1989-05-11 1990-05-09 Dna encoding a fibronectin binding protein as well as its preparation
AU54818/90A AU630950B2 (en) 1989-05-11 1990-05-09 Fibronectin binding protein as well as its preparation
NZ233614A NZ233614A (en) 1989-05-11 1990-05-09 S. aureus fibronectin binding protein (fnbp) from gene 2, recombinant and synthetic processes for its production
CA002016521A CA2016521C (en) 1989-05-11 1990-05-10 Fibronectin binding protein as well as its preparation
IE169690A IE72968B1 (en) 1989-05-11 1990-05-10 Fibronectin binding protein as well as its preparation
FI902350A FI102768B (fi) 1989-05-11 1990-05-10 Hybridi-DNA-molekyyli ja menetelmä fibronektiiniä sitovan proteiinin v almistamiseksi
NO902082A NO300069B1 (no) 1989-05-11 1990-05-10 Hybrid DNA-sekvens kodende for fibronektinbindende protein, vektorer og mikroorganismer inneholdende denne samt fremgangsmåte ved fremstilling derav
JP02120158A JP3077993B2 (ja) 1989-05-11 1990-05-11 フィブロネクチン結合タンパク質並びにその製法
US08/340,458 US5652217A (en) 1989-05-11 1994-11-14 Fibronectin binding protein
GR950403055T GR3017946T3 (en) 1989-05-11 1995-11-01 Fibronectin binding protein as well as its preparation.
US08/725,492 US5840846A (en) 1989-05-11 1996-10-04 Fibronectin binding protein as well as its preparation

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
SE8901687A SE8901687D0 (sv) 1989-05-11 1989-05-11 Fibronectin binding protein as well as its preparation

Publications (1)

Publication Number Publication Date
SE8901687D0 true SE8901687D0 (sv) 1989-05-11

Family

ID=20375920

Family Applications (1)

Application Number Title Priority Date Filing Date
SE8901687A SE8901687D0 (sv) 1989-05-11 1989-05-11 Fibronectin binding protein as well as its preparation

Country Status (15)

Country Link
US (3) US5175096A (xx)
EP (1) EP0397633B1 (xx)
JP (1) JP3077993B2 (xx)
AT (1) ATE125867T1 (xx)
AU (1) AU630950B2 (xx)
CA (1) CA2016521C (xx)
DE (1) DE69021263T2 (xx)
DK (1) DK0397633T3 (xx)
ES (1) ES2077666T3 (xx)
FI (1) FI102768B (xx)
GR (1) GR3017946T3 (xx)
IE (1) IE72968B1 (xx)
NO (1) NO300069B1 (xx)
NZ (1) NZ233614A (xx)
SE (1) SE8901687D0 (xx)

Families Citing this family (67)

* Cited by examiner, † Cited by third party
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SE8801894D0 (sv) * 1988-05-20 1988-05-20 Alfa Laval Agri Int Fibronektinbindande protein
SE8901687D0 (sv) * 1989-05-11 1989-05-11 Alfa Laval Agri Int Fibronectin binding protein as well as its preparation
US5440014A (en) * 1990-08-10 1995-08-08 H+E,Uml/Oo/ K; Magnus Fibronectin binding peptide
US7279162B1 (en) 1990-10-22 2007-10-09 Henry M. Jackson Foundation For The Advancement Of Military Medicine Isolated broadly reactive opsonic immunoglobulin for treating a pathogenic coagulase-negative staphylococcus infection
US5851794A (en) * 1990-10-22 1998-12-22 Alfa Laval Ab Collagen binding protein as well as its preparation
US5629287A (en) * 1991-01-18 1997-05-13 University College London Depot formulations
US5610148A (en) * 1991-01-18 1997-03-11 University College London Macroscopically oriented cell adhesion protein for wound treatment
US5980908A (en) * 1991-12-05 1999-11-09 Alfa Laval Ab Bacterial cell surface protein with fibronectin, fibrinogen, collagen and laminin binding ability, process for the manufacture of the protein and prophylactic treatment
ATE300617T1 (de) * 1993-02-05 2005-08-15 Smithkline Beecham Plc Fibronektinbindungsprotein, monoklonaler antikoerper und ihre verwendung zur verhuetung der adhäsion von bakterien
US5492819A (en) * 1993-09-23 1996-02-20 Genencor International, Inc. Recovery of insoluble biosynthetic products
US6033907A (en) * 1995-09-29 2000-03-07 Indiana University Foundation Enhanced virus-mediated DNA transfer
US7083979B1 (en) * 1994-03-25 2006-08-01 Indiana University Foundation Methods for enhanced retroviral-mediated gene transfer
US6933366B2 (en) * 1996-12-27 2005-08-23 Tripep Ab Specificity exchangers that redirect antibodies to bacterial adhesion receptors
US6040137A (en) * 1995-04-27 2000-03-21 Tripep Ab Antigen/antibody specification exchanger
US6660842B1 (en) 1994-04-28 2003-12-09 Tripep Ab Ligand/receptor specificity exchangers that redirect antibodies to receptors on a pathogen
US20040247611A1 (en) * 1994-05-23 2004-12-09 Montana State University Identification of pathogen-ligand interactions
GB9415902D0 (en) * 1994-08-05 1994-09-28 Smithkline Beecham Plc Method of treatment
JP4365456B2 (ja) * 1995-09-29 2009-11-18 インディアナ・ユニバーシティ・リサーチ・アンド・テクノロジー・コーポレーション ウイルス及び細胞結合部位を持つ分子を用いたウイルス媒介性dna導入を増強する方法
WO1997014801A1 (en) * 1995-10-16 1997-04-24 Smithkline Beecham Plc Novel cell surface protein compounds
US6013482A (en) * 1996-10-15 2000-01-11 Smithkline Beecham Plc Cell surface protein compounds
GB9521146D0 (en) * 1995-10-16 1995-12-20 Smithkline Beecham Plc Novel compounds
US5858709A (en) * 1996-10-15 1999-01-12 Smithkline Beecham P.L.C. Fibronectin binding protein B compounds
US6274376B1 (en) * 1996-02-20 2001-08-14 Smithkline Beecham Corporation ClpL
US6348584B1 (en) * 1996-10-17 2002-02-19 John Edward Hodgson Fibronectin binding protein compounds
US6685943B1 (en) 1997-01-21 2004-02-03 The Texas A&M University System Fibronectin binding protein compositions and methods of use
EP0971740B1 (en) * 1997-01-21 2009-08-19 THE TEXAS A&M UNIVERSITY SYSTEM Fibronectin binding protein derived peptides which do not bind to fibronectin, antibodies thereto, and therapeutic uses
US6610293B1 (en) 1997-06-16 2003-08-26 The Henry M. Jackson Foundation For The Advancement Of Military Medicine Opsonic and protective monoclonal and chimeric antibodies specific for lipoteichoic acid of gram positive bacteria
US6270992B1 (en) * 1997-07-29 2001-08-07 Smithkline Beecham Corporation Histidine kinase of Staphylococcus aureus
GB9720633D0 (en) * 1997-09-29 1997-11-26 Univ Bristol BHV-2 vector
US7250494B2 (en) * 1998-06-15 2007-07-31 Biosynexus Incorporated Opsonic monoclonal and chimeric antibodies specific for lipoteichoic acid of Gram positive bacteria
US6703025B1 (en) 1998-08-31 2004-03-09 Inhibitex, Inc. Multicomponent vaccines
US6692739B1 (en) 1998-08-31 2004-02-17 Inhibitex, Inc. Staphylococcal immunotherapeutics via donor selection and donor stimulation
US20020092987A1 (en) * 1998-09-05 2002-07-18 Taehee Cho Photo detect device using quantum dots and materialization method thereof
SK782002A3 (en) 1999-07-21 2003-08-05 Lexigen Pharm Corp FC fusion proteins for enhancing the immunogenicity of protein and peptide antigens
EP1443957A4 (en) * 2001-05-08 2005-10-12 Texas A & M Univ Sys SURFACE PROTEINS FROM GRAM POSITIVE BACTERIA COMPRISING HIGHLY PRESERVED PATTERNS AND ANTIBODIES RECOGNIZING THESE REASONS
US6835378B2 (en) 2001-05-11 2004-12-28 The Texas A&M University System University Method and compositions for inhibiting thrombin-induced coagulation
JP4424984B2 (ja) 2001-06-15 2010-03-03 インヒビテックス インコーポレーテッド コアグラーゼ陰性ブドウ球菌および黄色ブドウ球菌由来の表面蛋白質を認識する、交差反応性モノクローナルおよびポリクローナル抗体
US7115264B2 (en) * 2001-11-05 2006-10-03 Inhibitex Monoclonal antibodies to the fibronectin binding protein and method of use in treating or preventing infections
US7335359B2 (en) 2003-02-06 2008-02-26 Tripep Ab Glycosylated specificity exchangers
AU2004209457A1 (en) * 2003-02-06 2004-08-19 Tripep Ab Antigen/antibody or ligand/receptor glycosylated specificity exchangers
CA2517439C (en) * 2003-03-07 2013-07-23 Wyeth Holdings Corporation Polysaccharide - staphylococcal surface adhesin carrier protein conjugates for immunization against nosocomial infections
ATE497783T1 (de) 2003-05-06 2011-02-15 Syntonix Pharmaceuticals Inc Gerinnungsfaktor vii-fc chimäre proteine zur behandlung von hämostatischen krankheiten
TWI353991B (en) 2003-05-06 2011-12-11 Syntonix Pharmaceuticals Inc Immunoglobulin chimeric monomer-dimer hybrids
US7348004B2 (en) * 2003-05-06 2008-03-25 Syntonix Pharmaceuticals, Inc. Immunoglobulin chimeric monomer-dimer hybrids
CA2522690A1 (en) * 2003-05-06 2004-11-25 Syntonix Pharmaceuticals, Inc. Inhibition of drug binding to serum albumin
MXPA06013448A (es) * 2004-05-21 2007-01-23 Wyeth Corp Proteina alterada que liga a la fibronectina en staphylococcus aureus.
NZ553776A (en) 2004-09-22 2010-05-28 Glaxosmithkline Biolog Sa Immunogenic composition comprising staphylococcal PNAG and Type 5 and/or 8 Capsular polysaccharide or oligosaccharide.
EP1998802A2 (en) 2006-03-30 2008-12-10 GlaxoSmithKline Biologicals S.A. Immunogenic composition
US20090092631A1 (en) * 2007-03-26 2009-04-09 Tripep Ab Glycosylated specificity exchangers that induce an antibody dependent cellular cytotoxicity (adcc) response
CN101951948B (zh) * 2007-08-31 2015-12-09 芝加哥大学 与针对葡萄球菌性肺部疾病和病症进行免疫相关的方法和组合物
US9181329B2 (en) 2007-08-31 2015-11-10 The University Of Chicago Methods and compositions related to immunizing against Staphylococcal lung diseases and conditions
US8758765B2 (en) * 2008-07-29 2014-06-24 The University Of Chicago Compositions and methods related to Staphylococcal bacterium proteins
CA2739581A1 (en) 2008-10-06 2010-04-15 University Of Chicago Compositions and methods related to bacterial eap, emp, and/or adsa proteins
WO2011005341A2 (en) 2009-04-03 2011-01-13 University Of Chicago Compositions and methods related to protein a (spa) variants
GB0913680D0 (en) 2009-08-05 2009-09-16 Glaxosmithkline Biolog Sa Immunogenic composition
EP2531208A4 (en) * 2010-02-03 2013-07-03 Univ Rochester TREATMENT OF FIBROSIS RELATED DISORDERS USING FIBRONECTIN BINDING PROTEINS AND POLYPEPTIDES
JP2013523818A (ja) 2010-04-05 2013-06-17 ザ・ユニバーシティー・オブ・シカゴ 免疫反応のエンハンサーとしてのプロテインA(SpA)抗体に関連する組成物および方法
CA2803298C (en) 2010-07-02 2020-07-14 The University Of Chicago Compositions and methods related to protein a (spa) variants
US9095540B2 (en) 2010-09-09 2015-08-04 The University Of Chicago Methods and compositions involving protective staphylococcal antigens
US8945588B2 (en) 2011-05-06 2015-02-03 The University Of Chicago Methods and compositions involving protective staphylococcal antigens, such as EBH polypeptides
WO2013025834A2 (en) 2011-08-15 2013-02-21 The University Of Chicago Compositions and methods related to antibodies to staphylococcal protein a
BR112014026861A2 (pt) 2012-04-26 2018-05-15 Univ Chicago antígenos de estafilococos coagulase e métodos de seu uso
EP2841101B1 (en) 2012-04-26 2019-08-07 University Of Chicago Compositions and methods related to antibodies that neutralize coagulase activity during staphylococcus aureus disease
SG11201505926VA (en) 2013-03-15 2015-09-29 Biogen Ma Inc Factor ix polypeptide formulations
CN105384800B (zh) * 2015-12-07 2019-01-25 黑龙江八一农垦大学 金黄色葡萄球菌taf融合蛋白制备方法及其应用
EP3257862A1 (en) * 2016-06-16 2017-12-20 ETH Zürich Fibronectin-binding peptides for use in tumor or fibrosis diagnosis and therapy
MX2022004061A (es) 2019-10-02 2022-07-19 Janssen Vaccines & Prevention Bv Peptidos de estafilococo y metodos de uso.

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US3917818A (en) * 1970-01-14 1975-11-04 Agricura Labor Ltd Treatment of mastitis in cows, the product for this treatment and to the production of said product
DE2644622C3 (de) * 1976-10-02 1979-11-29 Behringwerke Ag, 3550 Marburg Extraktion von Mikroorganismen und diese enthaltende diagnostische Mittel
SE445013B (sv) * 1979-06-21 1986-05-26 Landstingens Inkopscentral Medel for att forebygga eller behandla infektioner hos menniskor och djur
US4425330A (en) * 1981-05-20 1984-01-10 Cornell Research Foundation, Inc. Bovine mastitis vaccine and method for detecting efficacy thereof
SE446688C (sv) * 1982-09-14 1989-10-16 Magnus Hoeoek Medel foer avlaegsnande av mikroorganismer fraan vaevnader, vilket bestaar av ett protein som kan bindas till mikroorganismerna
DK219084D0 (da) * 1984-05-02 1984-05-02 Frederik Carl Peter Lindberg Antigen
US5189015A (en) * 1984-05-30 1993-02-23 Alfa-Laval Agri International Ab Method for prophylactic treatment of the colonization of a Staphylococcus aureus bacterial strain by bacterial cell surface protein with fibronectin and fibrinogen binding ability
SE454403B (sv) * 1984-05-30 1988-05-02 Alfa Laval Agri Int Anvendning av ett cellyteprotein med fibronektin-, fibrinogen-, kollagen-, och/eller lamininbindande egenskaper vid framstellning av sarbehandlingsmedel
SE8702272L (sv) * 1987-06-01 1988-12-02 Alfa Laval Agri Int Fibronektinbindande protein samt dess framstaellning
US5320951A (en) * 1987-06-01 1994-06-14 Hoeoek Magnus Fibronectin binding protein as well as its preparation
US5571514A (en) * 1987-06-01 1996-11-05 Alfa Laval Ab Fibronectin binding protein as well as its preparation
SE8801723D0 (sv) * 1988-05-06 1988-05-06 Staffan Normark Fibronectin binding protein as well as its preparation
SE8801894D0 (sv) * 1988-05-20 1988-05-20 Alfa Laval Agri Int Fibronektinbindande protein
SE8901687D0 (sv) * 1989-05-11 1989-05-11 Alfa Laval Agri Int Fibronectin binding protein as well as its preparation
SE9002617D0 (sv) * 1990-08-10 1990-08-10 Alfa Laval Agri Int A fibronectin binding peptide

Also Published As

Publication number Publication date
NZ233614A (en) 1991-12-23
ATE125867T1 (de) 1995-08-15
NO300069B1 (no) 1997-04-01
DE69021263T2 (de) 1996-01-04
AU5481890A (en) 1990-11-15
DK0397633T3 (da) 1996-01-02
IE72968B1 (en) 1997-05-07
FI102768B1 (fi) 1999-02-15
EP0397633A3 (en) 1991-07-31
AU630950B2 (en) 1992-11-12
ES2077666T3 (es) 1995-12-01
US5840846A (en) 1998-11-24
NO902082D0 (no) 1990-05-10
EP0397633B1 (en) 1995-08-02
JPH03272687A (ja) 1991-12-04
IE901696L (en) 1990-11-11
CA2016521C (en) 2002-02-05
DE69021263D1 (de) 1995-09-07
JP3077993B2 (ja) 2000-08-21
US5652217A (en) 1997-07-29
EP0397633A2 (en) 1990-11-14
FI902350A0 (fi) 1990-05-10
NO902082L (no) 1990-11-12
US5175096A (en) 1992-12-29
GR3017946T3 (en) 1996-02-29
FI102768B (fi) 1999-02-15
CA2016521A1 (en) 1990-11-11

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