SE8802413D0 - polypeptides - Google Patents

polypeptides

Info

Publication number
SE8802413D0
SE8802413D0 SE8802413A SE8802413A SE8802413D0 SE 8802413 D0 SE8802413 D0 SE 8802413D0 SE 8802413 A SE8802413 A SE 8802413A SE 8802413 A SE8802413 A SE 8802413A SE 8802413 D0 SE8802413 D0 SE 8802413D0
Authority
SE
Sweden
Prior art keywords
hydrogen
alkyl
image
sugar residue
alkylene
Prior art date
Application number
SE8802413A
Other languages
Swedish (sv)
Other versions
SE8802413L (en
Inventor
R Albert
W Bauer
Original Assignee
Sandoz Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sandoz Ag filed Critical Sandoz Ag
Publication of SE8802413D0 publication Critical patent/SE8802413D0/en
Publication of SE8802413L publication Critical patent/SE8802413L/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K9/00—Peptides having up to 20 amino acids, containing saccharide radicals and having a fully defined sequence; Derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/655—Somatostatins
    • C07K14/6555—Somatostatins at least 1 amino acid in D-form
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Biochemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Hospice & Palliative Care (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Toxicology (AREA)
  • Endocrinology (AREA)
  • Dermatology (AREA)
  • Pain & Pain Management (AREA)
  • Psychiatry (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Compounds of formula I <IMAGE> wherein A is a radical of formula (???1) or (???1> <IMAGE> wherein R is C1-11 alkylene or C2-11 alkenylene Z is -OH, NR4R5, -NR4R5R6, -NHOH, or guanidino or ureido, R1 is C1-5 alkylene R2 is hydrogen, -CO-NH2, <IMAGE> or a sugar residue R3 is hydrogen or a sugar residue, R4 is hydrogen, C1-3 alkyl or a sugar residue R5 is hydrogen or C1-3 alkyl, and R6 is C1-3 alkyl and >N-CH(Z1)-CO-, A', Y1, Y2, B, C, D, E and F have the meanings recited in Claim 1 in free form, salt form or complex form, have pharmacological activity, in particular GH-, gastric and pancreatic secretion inhibiting activity.
SE8802413A 1987-06-29 1988-06-28 POLYPEPTIDES SE8802413L (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE3721407 1987-06-29
DE3721406 1987-06-29

Publications (2)

Publication Number Publication Date
SE8802413D0 true SE8802413D0 (en) 1988-06-28
SE8802413L SE8802413L (en) 1988-12-30

Family

ID=25857047

Family Applications (1)

Application Number Title Priority Date Filing Date
SE8802413A SE8802413L (en) 1987-06-29 1988-06-28 POLYPEPTIDES

Country Status (15)

Country Link
JP (1) JPS6426599A (en)
KR (1) KR890000520A (en)
AU (1) AU1840988A (en)
BE (1) BE1002663A4 (en)
CH (1) CH679045A5 (en)
DK (1) DK353788A (en)
ES (1) ES2010283A6 (en)
FR (1) FR2617171B1 (en)
GB (1) GB2206352B (en)
IL (1) IL86876A0 (en)
IT (1) IT1221065B (en)
LU (1) LU87262A1 (en)
NL (1) NL8801640A (en)
NZ (1) NZ225188A (en)
SE (1) SE8802413L (en)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HU206890B (en) * 1986-10-13 1993-01-28 Sandoz Ag Process for producing sugar-modified somatostatin peptide derivatives and pharmaceutical compositions containing them as active components
GB8826452D0 (en) * 1988-11-11 1988-12-14 Sandoz Ltd Peptide derivatives
GB8813339D0 (en) * 1988-06-06 1988-07-13 Sandoz Ltd Improvements in/relating to organic compounds
MY106120A (en) * 1988-12-05 1995-03-31 Novartis Ag Peptide derivatives.
US5776894A (en) * 1988-12-05 1998-07-07 Novartis Ag Chelated somatostatin peptides and complexes thereof, pharmaceutical compositions containing them and their use in treating tumors
US5753627A (en) * 1988-12-05 1998-05-19 Novartis Ag Use of certain complexed somatostatin peptides for the invivo imaging of somatostatin receptor-positive tumors and metastasis
KR0173119B1 (en) * 1989-04-26 1999-02-01 닐 에이. 밴스로우 Linear somatostatin analog
US5633263A (en) * 1989-04-26 1997-05-27 The Administrators Of The Tulane Educational Fund Linear somatostatin analogs
GB9004017D0 (en) * 1990-02-22 1990-04-18 Krenning Eric P Improvements in or relating to organic compounds
US5632969A (en) * 1994-10-13 1997-05-27 Merck & Co., Inc. N3 S2 chelating ligands optionally radiolabelled with Tc or Re, useful for diagnostic or therapeutic applications
US5556939A (en) * 1994-10-13 1996-09-17 Merck Frosst Canada, Inc. TC or RE radionuclide labelled chelate, hexapeptide complexes useful for diagnostic or therapeutic applications
AUPN999096A0 (en) * 1996-05-22 1996-06-13 Northstar Biologicals Pty Ltd Peptides, antibodies, vaccines & uses thereof
AU2000265052A1 (en) * 2000-07-31 2002-02-13 Dabur Research Foundation Somatostatin analogs for the treatment of cancer
HUP0401535A3 (en) 2001-03-08 2009-07-28 Univ Tulane Somatostatin antagonists and their use
MXPA03009048A (en) * 2001-04-09 2004-02-12 Univ Tulane Somatostatin agonists.
KR100432178B1 (en) * 2002-01-29 2004-05-22 홍수천 Apparatus for purifying water capable of preventing corrosion of iron-based pipeline
KR100462968B1 (en) * 2002-06-10 2004-12-23 주식회사 리독스 Water treatment apparatus

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
LU85269A1 (en) * 1984-03-26 1985-10-14 Techland S A NOVEL SOMATOSTATIN COMPOUNDS, PROCESS FOR THEIR SYNTHESIS, PREPARATION FOR VETERINARY USE CONTAINING SAID COMPOUNDS AND PROCESS FOR THE TREATMENT OF ANIMALS
HUT42101A (en) * 1985-01-07 1987-06-29 Sandoz Ag Process for preparing stomatostatine derivatives and pharmaceutical compositions containing such compounds

Also Published As

Publication number Publication date
GB8815257D0 (en) 1988-08-03
IT1221065B (en) 1990-06-21
LU87262A1 (en) 1989-03-08
ES2010283A6 (en) 1989-11-01
BE1002663A4 (en) 1991-04-30
KR890000520A (en) 1989-03-15
FR2617171B1 (en) 1994-10-14
FR2617171A1 (en) 1988-12-30
IL86876A0 (en) 1988-11-30
GB2206352A (en) 1989-01-05
DK353788A (en) 1988-12-30
NZ225188A (en) 1991-04-26
NL8801640A (en) 1989-01-16
JPS6426599A (en) 1989-01-27
SE8802413L (en) 1988-12-30
DK353788D0 (en) 1988-06-27
AU1840988A (en) 1989-01-05
GB2206352B (en) 1990-10-31
CH679045A5 (en) 1991-12-13
IT8848133A0 (en) 1988-06-28

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