ES2010283A6 - Peptides - Google Patents

Peptides

Info

Publication number
ES2010283A6
ES2010283A6 ES8802038A ES8802038A ES2010283A6 ES 2010283 A6 ES2010283 A6 ES 2010283A6 ES 8802038 A ES8802038 A ES 8802038A ES 8802038 A ES8802038 A ES 8802038A ES 2010283 A6 ES2010283 A6 ES 2010283A6
Authority
ES
Spain
Prior art keywords
formula
polypeptide
protected
groups
peptides
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES8802038A
Other languages
Spanish (es)
Inventor
Rainer Albert
Wilfried Bauer
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sandoz AG
Original Assignee
Sandoz AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sandoz AG filed Critical Sandoz AG
Publication of ES2010283A6 publication Critical patent/ES2010283A6/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K9/00—Peptides having up to 20 amino acids, containing saccharide radicals and having a fully defined sequence; Derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/655—Somatostatins
    • C07K14/6555—Somatostatins at least 1 amino acid in D-form
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Abstract

Process for preparing somatostatin formula (I) where different radicals have the meaning given in the description. It includes, among other synthesis remove groups guards protegido a polypeptide having the sequence in formula (I); copulate each other, through a link amida, two fragments peptides; oxidizing a compound of formula (I), in which the cys residues mercapto groups are freely to give a polypeptide wherein y1 and y2 together are a direct bond; introducing at least one other sugar in a peptide optionally protected protected or unprotected. Compounds of formula (I) have activity inhibiting secretion of growth hormone. (Machine-translation by Google Translate, not legally binding)
ES8802038A 1987-06-29 1988-06-29 Peptides Expired ES2010283A6 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE3721407 1987-06-29
DE3721406 1987-06-29

Publications (1)

Publication Number Publication Date
ES2010283A6 true ES2010283A6 (en) 1989-11-01

Family

ID=25857047

Family Applications (1)

Application Number Title Priority Date Filing Date
ES8802038A Expired ES2010283A6 (en) 1987-06-29 1988-06-29 Peptides

Country Status (15)

Country Link
JP (1) JPS6426599A (en)
KR (1) KR890000520A (en)
AU (1) AU1840988A (en)
BE (1) BE1002663A4 (en)
CH (1) CH679045A5 (en)
DK (1) DK353788A (en)
ES (1) ES2010283A6 (en)
FR (1) FR2617171B1 (en)
GB (1) GB2206352B (en)
IL (1) IL86876A0 (en)
IT (1) IT1221065B (en)
LU (1) LU87262A1 (en)
NL (1) NL8801640A (en)
NZ (1) NZ225188A (en)
SE (1) SE8802413L (en)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HU906341D0 (en) * 1986-10-13 1991-04-29 Sandoz Ag Process for producing peptonic derivatives modified with sugar and pharmaceutical preparatives containing these compounds as active substance
GB8826452D0 (en) * 1988-11-11 1988-12-14 Sandoz Ltd Peptide derivatives
GB8813339D0 (en) * 1988-06-06 1988-07-13 Sandoz Ltd Improvements in/relating to organic compounds
US5753627A (en) * 1988-12-05 1998-05-19 Novartis Ag Use of certain complexed somatostatin peptides for the invivo imaging of somatostatin receptor-positive tumors and metastasis
US5776894A (en) * 1988-12-05 1998-07-07 Novartis Ag Chelated somatostatin peptides and complexes thereof, pharmaceutical compositions containing them and their use in treating tumors
MY106120A (en) * 1988-12-05 1995-03-31 Novartis Ag Peptide derivatives.
CA2053250A1 (en) * 1989-04-26 1990-10-27 David H. Coy Linear somatostatin analogs
US5633263A (en) * 1989-04-26 1997-05-27 The Administrators Of The Tulane Educational Fund Linear somatostatin analogs
GB9004017D0 (en) * 1990-02-22 1990-04-18 Krenning Eric P Improvements in or relating to organic compounds
US5632969A (en) * 1994-10-13 1997-05-27 Merck & Co., Inc. N3 S2 chelating ligands optionally radiolabelled with Tc or Re, useful for diagnostic or therapeutic applications
US5556939A (en) * 1994-10-13 1996-09-17 Merck Frosst Canada, Inc. TC or RE radionuclide labelled chelate, hexapeptide complexes useful for diagnostic or therapeutic applications
AUPN999096A0 (en) * 1996-05-22 1996-06-13 Northstar Biologicals Pty Ltd Peptides, antibodies, vaccines & uses thereof
CA2385910A1 (en) * 2000-07-31 2002-02-07 Dabur Research Foundation Somatostatin analogs for the treatment of cancer
PL362838A1 (en) 2001-03-08 2004-11-02 The Administrators Of The Tulane Educational Fund Somatostatin antagonists
CN1541102A (en) * 2001-04-09 2004-10-27 Somatostain agonists
KR100432178B1 (en) * 2002-01-29 2004-05-22 홍수천 Apparatus for purifying water capable of preventing corrosion of iron-based pipeline
KR100462968B1 (en) * 2002-06-10 2004-12-23 주식회사 리독스 Water treatment apparatus

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
LU85269A1 (en) * 1984-03-26 1985-10-14 Techland S A NOVEL SOMATOSTATIN COMPOUNDS, PROCESS FOR THEIR SYNTHESIS, PREPARATION FOR VETERINARY USE CONTAINING SAID COMPOUNDS AND PROCESS FOR THE TREATMENT OF ANIMALS
HUT42101A (en) * 1985-01-07 1987-06-29 Sandoz Ag Process for preparing stomatostatine derivatives and pharmaceutical compositions containing such compounds

Also Published As

Publication number Publication date
BE1002663A4 (en) 1991-04-30
JPS6426599A (en) 1989-01-27
CH679045A5 (en) 1991-12-13
GB8815257D0 (en) 1988-08-03
SE8802413D0 (en) 1988-06-28
NL8801640A (en) 1989-01-16
IL86876A0 (en) 1988-11-30
LU87262A1 (en) 1989-03-08
DK353788D0 (en) 1988-06-27
AU1840988A (en) 1989-01-05
NZ225188A (en) 1991-04-26
DK353788A (en) 1988-12-30
GB2206352A (en) 1989-01-05
IT8848133A0 (en) 1988-06-28
FR2617171A1 (en) 1988-12-30
FR2617171B1 (en) 1994-10-14
IT1221065B (en) 1990-06-21
GB2206352B (en) 1990-10-31
SE8802413L (en) 1988-12-30
KR890000520A (en) 1989-03-15

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Legal Events

Date Code Title Description
SA6 Expiration date (snapshot 920101)

Free format text: 2008-06-29

FD1A Patent lapsed

Effective date: 20000201