SE8703225L - MONOCLONAL ANTIBODIES AND PEPTIDES USEFUL IN TREATMENT AND DIAGNOSTIZATION OF HIV INFECTIONS - Google Patents

MONOCLONAL ANTIBODIES AND PEPTIDES USEFUL IN TREATMENT AND DIAGNOSTIZATION OF HIV INFECTIONS

Info

Publication number
SE8703225L
SE8703225L SE8703225A SE8703225A SE8703225L SE 8703225 L SE8703225 L SE 8703225L SE 8703225 A SE8703225 A SE 8703225A SE 8703225 A SE8703225 A SE 8703225A SE 8703225 L SE8703225 L SE 8703225L
Authority
SE
Sweden
Prior art keywords
monoclonal antibodies
peptides
diagnostization
treatment
hiv infections
Prior art date
Application number
SE8703225A
Other languages
Swedish (sv)
Other versions
SE506025C2 (en
SE8703225D0 (en
Inventor
M K Shriver
E K Thomas
W L Cosand
L H Gosting
E S Dickinson
J N M I Mcclure
G J Todaro
R C Nowinski
Original Assignee
Genetic Systems Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Genetic Systems Corp filed Critical Genetic Systems Corp
Publication of SE8703225D0 publication Critical patent/SE8703225D0/en
Publication of SE8703225L publication Critical patent/SE8703225L/en
Publication of SE506025C2 publication Critical patent/SE506025C2/en

Links

Classifications

    • F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
    • F04—POSITIVE - DISPLACEMENT MACHINES FOR LIQUIDS; PUMPS FOR LIQUIDS OR ELASTIC FLUIDS
    • F04B—POSITIVE-DISPLACEMENT MACHINES FOR LIQUIDS; PUMPS
    • F04B25/00—Multi-stage pumps
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/08—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from viruses
    • C07K16/10—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from viruses from RNA viruses
    • C07K16/1036—Retroviridae, e.g. leukemia viruses
    • C07K16/1045—Lentiviridae, e.g. HIV, FIV, SIV
    • C07K16/1054—Lentiviridae, e.g. HIV, FIV, SIV gag-pol, e.g. p17, p24
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/70—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving virus or bacteriophage
    • C12Q1/701—Specific hybridization probes
    • C12Q1/702—Specific hybridization probes for retroviruses
    • C12Q1/703—Viruses associated with AIDS
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2740/00—Reverse transcribing RNA viruses
    • C12N2740/00011—Details
    • C12N2740/10011—Retroviridae
    • C12N2740/16011—Human Immunodeficiency Virus, HIV
    • C12N2740/16111—Human Immunodeficiency Virus, HIV concerning HIV env
    • C12N2740/16122—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2740/00—Reverse transcribing RNA viruses
    • C12N2740/00011—Details
    • C12N2740/10011—Retroviridae
    • C12N2740/16011—Human Immunodeficiency Virus, HIV
    • C12N2740/16211—Human Immunodeficiency Virus, HIV concerning HIV gagpol
    • C12N2740/16222—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Virology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Immunology (AREA)
  • Medicinal Chemistry (AREA)
  • Wood Science & Technology (AREA)
  • AIDS & HIV (AREA)
  • General Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Oncology (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Hematology (AREA)
  • Analytical Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Physics & Mathematics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Mechanical Engineering (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)

Abstract

Disclosed are monoclonal antibodies reactive with one or more neutralizing regions of HIV proteins, peptides or homologs of such neutralizing regions, and nucleic acid segments coding for said peptides. Neutralizing regions include portions of the env and gag genes from various HIV isolates. The monocional antibodies may be used to treat HIV infection or in diagnosis and the peptides may be used to elicit antibodies and to block HIV infection.
SE8703225A 1986-08-20 1987-08-19 Monoclonal antibodies and peptides and their preparations for the treatment and diagnosis of HIV infection as well as cell lines for antibody production SE506025C2 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US89827386A 1986-08-20 1986-08-20
US4502687A 1987-05-01 1987-05-01
US6799687A 1987-06-29 1987-06-29

Publications (3)

Publication Number Publication Date
SE8703225D0 SE8703225D0 (en) 1987-08-19
SE8703225L true SE8703225L (en) 1988-02-21
SE506025C2 SE506025C2 (en) 1997-11-03

Family

ID=27366600

Family Applications (1)

Application Number Title Priority Date Filing Date
SE8703225A SE506025C2 (en) 1986-08-20 1987-08-19 Monoclonal antibodies and peptides and their preparations for the treatment and diagnosis of HIV infection as well as cell lines for antibody production

Country Status (28)

Country Link
JP (1) JPS6485928A (en)
KR (1) KR920008744B1 (en)
AT (1) AT398080B (en)
AU (1) AU616156B2 (en)
BE (1) BE1000811A4 (en)
CH (1) CH675728A5 (en)
CS (1) CS275838B6 (en)
DE (1) DE3727703A1 (en)
DK (1) DK433087A (en)
ES (1) ES2010727A6 (en)
FI (1) FI873553A (en)
FR (1) FR2603107B1 (en)
GB (1) GB2196634B (en)
GR (1) GR871298B (en)
HU (1) HU214439B (en)
IE (1) IE60671B1 (en)
IL (1) IL83580A (en)
IT (1) IT1222518B (en)
LU (1) LU86972A1 (en)
NL (1) NL8701950A (en)
NO (2) NO300462B1 (en)
NZ (1) NZ221440A (en)
OA (1) OA08652A (en)
PL (1) PL155084B1 (en)
PT (1) PT85567B (en)
SE (1) SE506025C2 (en)
YU (1) YU152587A (en)
ZW (1) ZW15487A1 (en)

Families Citing this family (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AP96A (en) * 1986-06-03 1990-08-12 The Usa Dept Of Commerce Small peptides which inhibit binding to T-4 receptors and act as immunogens.
AU625720B2 (en) * 1987-05-01 1992-07-16 Genetic Systems Corporation Monoclonal antibodies to specific antigenic regions of the human immunodeficiency virus and methods for use
US5834599A (en) * 1987-05-29 1998-11-10 Tanox Biosystems, Inc. Immunoconjugates which neutralize HIV-1 infection
JP2520464B2 (en) * 1987-05-29 1996-07-31 タノツクス・バイオシステムズ・インコーポレーテツド Monoclonal antibody that neutralizes HIV-1
US6657050B1 (en) 1987-05-29 2003-12-02 Tanox, Inc. Chimeric viral-neutralizing immunoglobulins
US5981278A (en) * 1987-05-29 1999-11-09 Tanox, Inc. Chimeric monoclonal antibodies which neutralize HIV-1 infection and their applications in therapy and prevention for AIDS
WO1989007112A1 (en) * 1988-01-26 1989-08-10 The United States Of America, As Represented By Th A synthetic antigen evoking anti-hiv response
CA1341285C (en) * 1988-02-12 2001-08-14 Chang Yi Wang Synthetic peptides for the detection of antibodies to hiv gp120 envelope protein for diagnosis of aids and pre-aids conditions and as vaccines
IL90048A0 (en) * 1988-04-25 1989-12-15 Merck & Co Inc Recombinant gag precursor of hiv,its preparation and its use as aids vaccine
EP0339504A3 (en) * 1988-04-26 1990-09-12 The Du Pont Merck Pharmaceutical Company Human immunodeficiency virus (hiv) env-coded peptide capable of eliciting hiv-inhibiting antibodies in mammals
US5562905A (en) * 1988-04-26 1996-10-08 E. I. Du Pont De Nemours And Company Human immunodeficiency virus (hiv) env-coded peptide capable of eliciting hiv-inhibiting antibodies in mammals
FR2632310B1 (en) * 1988-06-06 1992-04-10 Pasteur Institut PEPTIDES HAVING PROTECTIVE PROPERTIES OF A PATHOGENIC VIRUS OF THE HIV TYPE IN SENSITIVE CELLS
AU640619B2 (en) * 1988-10-03 1993-09-02 Repligen Corporation Hiv proteins and peptides useful in the diagnosis, prophylaxis or therapy of aids
EP0421626A1 (en) * 1989-09-19 1991-04-10 Merck & Co. Inc. Vaccine for aids and hepatitis B
SE9000333D0 (en) * 1990-01-31 1990-01-31 Britta Wahren MONOCLONAL ANTIBODY
SE468168B (en) * 1990-02-20 1992-11-16 Replico Medical Ab HIV-1, P24 PEPTIDES, DIAGNOSTIC ANTIGENS AND PROCEDURES FOR DIFFERENTIAL DIAGNOSTICS OF PRELIMINARY HIV-1 POSITIVE SERUM TESTS
JPH03271233A (en) * 1990-03-19 1991-12-03 Inst Pasteur Inducement of protective action against virus infection by synergism between peptides cor- responding to virus envelope glycoprotein and neutral epitope of its glycoprotein
CA2047042A1 (en) * 1990-07-19 1992-01-20 John Hannah Cyclic hiv principal neutralizing determinant peptides
CA2047078A1 (en) * 1990-07-19 1992-01-20 Steven S. Bondy Cyclic hiv principal neutralizing determinant peptides
JPH05310785A (en) * 1991-09-30 1993-11-22 Nitto Denko Corp Hiv-related cyclic peptide and adsorption material obtained by immobilizing the same
ES2222625T3 (en) * 1992-03-27 2005-02-01 Advanced Immuni T, Inc. PEPTIDE T AND ASSOCIATED PEPTIDES INTENDED FOR THE TREATMENT OF INFLAMMATION INCLUDING MULTIPLE SCLEROSIS.
PT1976548E (en) 2005-12-09 2014-10-13 Vectus Biosystems Ltd Vip fragments and compositions thereof
WO2010026940A1 (en) 2008-09-02 2010-03-11 日本特殊陶業株式会社 Spark plug

Family Cites Families (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9328391B1 (en) * 1984-08-22 2016-05-03 The United States Of America As Represented By The Secretary, Department Of Health And Human Services Cloning and expression of HIV-1 DNA
EP0201540B2 (en) * 1984-10-18 2001-10-31 Institut Pasteur Envelope antigens of lymphadenopathy associated virus and their applications
GB8501473D0 (en) * 1985-01-21 1985-02-20 Pasteur Institut Cloned dna sequences
CA1341482C (en) * 1984-10-31 2005-05-10 Paul A. Luciw Process for preparing fragments of aids-associated retroviruses
IE64785B1 (en) * 1985-04-08 1995-09-06 Genetic Systems Corp Expression of immunologically reactive viral proteins
GR860915B (en) * 1985-04-08 1986-07-11 Genetic Systems Corp Expression and diagnostic use of gag encoded peptides which are immunologically reactive with antibodies to lav
DK171119B1 (en) * 1985-04-19 1996-06-17 Hoffmann La Roche AIDS virus envelope protein, expression vector carrying the envelope protein, transformants transformed with the expression vector, method of producing the virus envelope protein, method of detecting AIDS antibodies, method of determining AIDS virus, vaccine against AIDS, antibodies against the virus envelope protein and use of it to prepare a vaccine and for testing
DE3650175T3 (en) * 1985-04-29 2007-09-06 Bio-Rad Laboratories, Inc., Hercules SYNTHETIC ANTIGENIC TO IDENTIFY AIDS.
GB8525615D0 (en) * 1985-10-17 1985-11-20 Hoffmann La Roche Polypeptides
ATE108022T1 (en) * 1985-10-24 1994-07-15 Southwest Found Biomed Res SYNTHETIC PEPTIDES AND THEIR USE IN DIAGNOSIS AND VACCINATION FOR AIDS AND ARC.
WO1987002988A1 (en) * 1985-11-07 1987-05-21 President And Fellows Of Harvard College T-cell lymphotrophic virus protein and assay
US4734362A (en) * 1986-02-03 1988-03-29 Cambridge Bioscience Corporation Process for purifying recombinant proteins, and products thereof
US4772547A (en) * 1986-02-03 1988-09-20 Hoffmann-La Roche Inc. HTLV-III envelope peptides
US4925784A (en) * 1986-04-04 1990-05-15 Hoffmann-La Roche Inc. Expression and purification of an HTLV-III gag/env gene protein
IE63109B1 (en) * 1986-06-23 1995-03-22 Genetic Systems Corp Human monoclonal antibody to lymphadenopathy-associated virus
EP0525828A3 (en) * 1986-08-01 1993-02-24 Repligen Corporation Recombinant polypeptides and their uses, including assay for aids virus
DE3787002T2 (en) * 1986-12-30 1993-11-25 Us Health Synthetic peptides that generate cellular immunity to the AIDS virus and its proteins.

Also Published As

Publication number Publication date
IE872219L (en) 1988-02-20
FI873553A0 (en) 1987-08-17
HU214439B (en) 1998-03-30
NO873495L (en) 1988-02-22
SE506025C2 (en) 1997-11-03
IT8721678A0 (en) 1987-08-19
IT1222518B (en) 1990-09-05
SE8703225D0 (en) 1987-08-19
CS8706136A2 (en) 1990-08-14
PL155084B1 (en) 1991-10-31
NO934897D0 (en) 1993-12-29
FR2603107B1 (en) 1992-04-24
PT85567A (en) 1987-09-01
PT85567B (en) 1991-02-08
ATA208987A (en) 1994-01-15
NO873495D0 (en) 1987-08-19
NO300462B1 (en) 1997-06-02
AT398080B (en) 1994-09-26
NO934897L (en) 1993-12-29
AU7720187A (en) 1988-05-19
YU152587A (en) 1992-09-07
IE60671B1 (en) 1994-08-10
NZ221440A (en) 1991-11-26
PL267401A1 (en) 1988-07-21
KR890002547A (en) 1989-04-10
DK433087D0 (en) 1987-08-19
HUT44619A (en) 1988-03-28
GR871298B (en) 1988-01-12
ES2010727A6 (en) 1989-12-01
OA08652A (en) 1988-11-30
FR2603107A1 (en) 1988-02-26
GB2196634B (en) 1991-05-15
DE3727703A1 (en) 1988-05-05
AU616156B2 (en) 1991-10-24
LU86972A1 (en) 1988-03-02
NL8701950A (en) 1988-03-16
GB8719587D0 (en) 1987-09-23
CS275838B6 (en) 1992-03-18
DK433087A (en) 1988-02-21
KR920008744B1 (en) 1992-10-09
FI873553A (en) 1988-02-21
IL83580A (en) 1992-11-15
JPS6485928A (en) 1989-03-30
GB2196634A (en) 1988-05-05
ZW15487A1 (en) 1988-09-14
CH675728A5 (en) 1990-10-31
BE1000811A4 (en) 1989-04-11
IL83580A0 (en) 1988-01-31
NO302176B1 (en) 1998-02-02

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