SE8703225D0 - MONOCLONAL ANTIBODIES AND PEPTIDES USEFUL IN TREATING AND DIAGNOSING HIV INFECTIONS - Google Patents
MONOCLONAL ANTIBODIES AND PEPTIDES USEFUL IN TREATING AND DIAGNOSING HIV INFECTIONSInfo
- Publication number
- SE8703225D0 SE8703225D0 SE8703225A SE8703225A SE8703225D0 SE 8703225 D0 SE8703225 D0 SE 8703225D0 SE 8703225 A SE8703225 A SE 8703225A SE 8703225 A SE8703225 A SE 8703225A SE 8703225 D0 SE8703225 D0 SE 8703225D0
- Authority
- SE
- Sweden
- Prior art keywords
- monoclonal antibodies
- peptides
- treating
- hiv infections
- peptides useful
- Prior art date
Links
- 102000004196 processed proteins & peptides Human genes 0.000 title abstract 4
- 108090000765 processed proteins & peptides Proteins 0.000 title abstract 4
- 208000031886 HIV Infections Diseases 0.000 title abstract 3
- 230000003472 neutralizing effect Effects 0.000 abstract 3
- 208000037357 HIV infectious disease Diseases 0.000 abstract 2
- 208000033519 human immunodeficiency virus infectious disease Diseases 0.000 abstract 2
- 108010048209 Human Immunodeficiency Virus Proteins Proteins 0.000 abstract 1
- 238000003745 diagnosis Methods 0.000 abstract 1
- 108700004025 env Genes Proteins 0.000 abstract 1
- 108700004026 gag Genes Proteins 0.000 abstract 1
- 102000039446 nucleic acids Human genes 0.000 abstract 1
- 108020004707 nucleic acids Proteins 0.000 abstract 1
- 150000007523 nucleic acids Chemical class 0.000 abstract 1
Classifications
-
- F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
- F04—POSITIVE - DISPLACEMENT MACHINES FOR LIQUIDS; PUMPS FOR LIQUIDS OR ELASTIC FLUIDS
- F04B—POSITIVE-DISPLACEMENT MACHINES FOR LIQUIDS; PUMPS
- F04B25/00—Multi-stage pumps
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/08—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from viruses
- C07K16/10—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from viruses from RNA viruses
- C07K16/1036—Retroviridae, e.g. leukemia viruses
- C07K16/1045—Lentiviridae, e.g. HIV, FIV, SIV
- C07K16/1054—Lentiviridae, e.g. HIV, FIV, SIV gag-pol, e.g. p17, p24
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/70—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving virus or bacteriophage
- C12Q1/701—Specific hybridization probes
- C12Q1/702—Specific hybridization probes for retroviruses
- C12Q1/703—Viruses associated with AIDS
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2740/00—Reverse transcribing RNA viruses
- C12N2740/00011—Details
- C12N2740/10011—Retroviridae
- C12N2740/16011—Human Immunodeficiency Virus, HIV
- C12N2740/16111—Human Immunodeficiency Virus, HIV concerning HIV env
- C12N2740/16122—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2740/00—Reverse transcribing RNA viruses
- C12N2740/00011—Details
- C12N2740/10011—Retroviridae
- C12N2740/16011—Human Immunodeficiency Virus, HIV
- C12N2740/16211—Human Immunodeficiency Virus, HIV concerning HIV gagpol
- C12N2740/16222—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Virology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Engineering & Computer Science (AREA)
- Immunology (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- General Engineering & Computer Science (AREA)
- Medicinal Chemistry (AREA)
- Zoology (AREA)
- AIDS & HIV (AREA)
- Wood Science & Technology (AREA)
- Analytical Chemistry (AREA)
- Physics & Mathematics (AREA)
- Biotechnology (AREA)
- Microbiology (AREA)
- Gastroenterology & Hepatology (AREA)
- Hematology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Oncology (AREA)
- Mechanical Engineering (AREA)
- Peptides Or Proteins (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
Abstract
Disclosed are monoclonal antibodies reactive with one or more neutralizing regions of HIV proteins, peptides or homologs of such neutralizing regions, and nucleic acid segments coding for said peptides. Neutralizing regions include portions of the env and gag genes from various HIV isolates. The monocional antibodies may be used to treat HIV infection or in diagnosis and the peptides may be used to elicit antibodies and to block HIV infection.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US89827386A | 1986-08-20 | 1986-08-20 | |
US4502687A | 1987-05-01 | 1987-05-01 | |
US6799687A | 1987-06-29 | 1987-06-29 |
Publications (3)
Publication Number | Publication Date |
---|---|
SE8703225D0 true SE8703225D0 (en) | 1987-08-19 |
SE8703225L SE8703225L (en) | 1988-02-21 |
SE506025C2 SE506025C2 (en) | 1997-11-03 |
Family
ID=27366600
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
SE8703225A SE506025C2 (en) | 1986-08-20 | 1987-08-19 | Monoclonal antibodies and peptides and their preparations for the treatment and diagnosis of HIV infection as well as cell lines for antibody production |
Country Status (28)
Country | Link |
---|---|
JP (1) | JPS6485928A (en) |
KR (1) | KR920008744B1 (en) |
AT (1) | AT398080B (en) |
AU (1) | AU616156B2 (en) |
BE (1) | BE1000811A4 (en) |
CH (1) | CH675728A5 (en) |
CS (1) | CS275838B6 (en) |
DE (1) | DE3727703A1 (en) |
DK (1) | DK433087A (en) |
ES (1) | ES2010727A6 (en) |
FI (1) | FI873553A (en) |
FR (1) | FR2603107B1 (en) |
GB (1) | GB2196634B (en) |
GR (1) | GR871298B (en) |
HU (1) | HU214439B (en) |
IE (1) | IE60671B1 (en) |
IL (1) | IL83580A (en) |
IT (1) | IT1222518B (en) |
LU (1) | LU86972A1 (en) |
NL (1) | NL8701950A (en) |
NO (2) | NO300462B1 (en) |
NZ (1) | NZ221440A (en) |
OA (1) | OA08652A (en) |
PL (1) | PL155084B1 (en) |
PT (1) | PT85567B (en) |
SE (1) | SE506025C2 (en) |
YU (1) | YU152587A (en) |
ZW (1) | ZW15487A1 (en) |
Families Citing this family (23)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
AP96A (en) * | 1986-06-03 | 1990-08-12 | The Usa Dept Of Commerce | Small peptides which inhibit binding to T-4 receptors and act as immunogens. |
AU625720B2 (en) * | 1987-05-01 | 1992-07-16 | Genetic Systems Corporation | Monoclonal antibodies to specific antigenic regions of the human immunodeficiency virus and methods for use |
JP2520464B2 (en) * | 1987-05-29 | 1996-07-31 | タノツクス・バイオシステムズ・インコーポレーテツド | Monoclonal antibody that neutralizes HIV-1 |
US6657050B1 (en) | 1987-05-29 | 2003-12-02 | Tanox, Inc. | Chimeric viral-neutralizing immunoglobulins |
US5981278A (en) * | 1987-05-29 | 1999-11-09 | Tanox, Inc. | Chimeric monoclonal antibodies which neutralize HIV-1 infection and their applications in therapy and prevention for AIDS |
US5834599A (en) * | 1987-05-29 | 1998-11-10 | Tanox Biosystems, Inc. | Immunoconjugates which neutralize HIV-1 infection |
JP2569185B2 (en) * | 1988-01-26 | 1997-01-08 | アメリカ合衆国 | Synthetic antigen eliciting anti-HIV response |
CA1341285C (en) * | 1988-02-12 | 2001-08-14 | Chang Yi Wang | Synthetic peptides for the detection of antibodies to hiv gp120 envelope protein for diagnosis of aids and pre-aids conditions and as vaccines |
IL90048A0 (en) * | 1988-04-25 | 1989-12-15 | Merck & Co Inc | Recombinant gag precursor of hiv,its preparation and its use as aids vaccine |
EP0339504A3 (en) * | 1988-04-26 | 1990-09-12 | The Du Pont Merck Pharmaceutical Company | Human immunodeficiency virus (hiv) env-coded peptide capable of eliciting hiv-inhibiting antibodies in mammals |
US5562905A (en) * | 1988-04-26 | 1996-10-08 | E. I. Du Pont De Nemours And Company | Human immunodeficiency virus (hiv) env-coded peptide capable of eliciting hiv-inhibiting antibodies in mammals |
FR2632310B1 (en) * | 1988-06-06 | 1992-04-10 | Pasteur Institut | PEPTIDES HAVING PROTECTIVE PROPERTIES OF A PATHOGENIC VIRUS OF THE HIV TYPE IN SENSITIVE CELLS |
JPH04502760A (en) * | 1988-10-03 | 1992-05-21 | レプリゲン・コーポレーション | Novel HIV proteins and peptides effective in the diagnosis, prevention and treatment of AIDS |
EP0421626A1 (en) * | 1989-09-19 | 1991-04-10 | Merck & Co. Inc. | Vaccine for aids and hepatitis B |
SE9000333D0 (en) * | 1990-01-31 | 1990-01-31 | Britta Wahren | MONOCLONAL ANTIBODY |
SE468168B (en) * | 1990-02-20 | 1992-11-16 | Replico Medical Ab | HIV-1, P24 PEPTIDES, DIAGNOSTIC ANTIGENS AND PROCEDURES FOR DIFFERENTIAL DIAGNOSTICS OF PRELIMINARY HIV-1 POSITIVE SERUM TESTS |
JPH03271233A (en) * | 1990-03-19 | 1991-12-03 | Inst Pasteur | Inducement of protective action against virus infection by synergism between peptides cor- responding to virus envelope glycoprotein and neutral epitope of its glycoprotein |
CA2047078A1 (en) * | 1990-07-19 | 1992-01-20 | Steven S. Bondy | Cyclic hiv principal neutralizing determinant peptides |
CA2047042A1 (en) * | 1990-07-19 | 1992-01-20 | John Hannah | Cyclic hiv principal neutralizing determinant peptides |
JPH05310785A (en) * | 1991-09-30 | 1993-11-22 | Nitto Denko Corp | Hiv-related cyclic peptide and adsorption material obtained by immobilizing the same |
ES2149203T3 (en) * | 1992-03-27 | 2000-11-01 | Advanced Immunit T Inc | T-PEPTIDE AND ASSOCIATED PEPTIDES INTENDED FOR THE TREATMENT OF INFLAMMATIONS, PARTICULARLY MULTIPLE SCLEROSIS. |
DK2783697T3 (en) | 2005-12-09 | 2017-04-10 | Vectus Biosystems Ltd | VIP Fragments and uses thereof |
JP5165751B2 (en) | 2008-09-02 | 2013-03-21 | 日本特殊陶業株式会社 | Spark plug |
Family Cites Families (17)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US9328391B1 (en) * | 1984-08-22 | 2016-05-03 | The United States Of America As Represented By The Secretary, Department Of Health And Human Services | Cloning and expression of HIV-1 DNA |
DE3588254T2 (en) * | 1984-10-18 | 2008-06-26 | Institut Pasteur | GAG antigen and its use for the detection of LAV infection, as well as in immunogenic compositions |
GB8501473D0 (en) * | 1985-01-21 | 1985-02-20 | Pasteur Institut | Cloned dna sequences |
CA1341423C (en) * | 1984-10-31 | 2003-03-04 | Paul A. Luciw | Recombinant proteins of viruses associated with lymphadenopathy syndrome and/or acquired immune deficiency syndrome |
IE64785B1 (en) * | 1985-04-08 | 1995-09-06 | Genetic Systems Corp | Expression of immunologically reactive viral proteins |
DE3650011T2 (en) * | 1985-04-08 | 1994-11-17 | Genetic Systems Corp | EXPRESSION AND DIAGNOSIS WITH GAG-CODED PEPTIDES THAT ARE IMMUNOLOGICALLY REACTIVE WITH ANTIBODIES AGAINST LAV. |
DK171119B1 (en) * | 1985-04-19 | 1996-06-17 | Hoffmann La Roche | AIDS virus envelope protein, expression vector carrying the envelope protein, transformants transformed with the expression vector, method of producing the virus envelope protein, method of detecting AIDS antibodies, method of determining AIDS virus, vaccine against AIDS, antibodies against the virus envelope protein and use of it to prepare a vaccine and for testing |
WO1986006414A1 (en) * | 1985-04-29 | 1986-11-06 | Genetic Systems Corporation | Synthetic antigens for the detection of aids-related disease |
GB8525615D0 (en) * | 1985-10-17 | 1985-11-20 | Hoffmann La Roche | Polypeptides |
WO1987002775A1 (en) * | 1985-10-24 | 1987-05-07 | Southwest Foundation For Biomedical Research | Synthetic peptides and use for diagnosis and vaccination for aids and arc |
EP0245459B1 (en) * | 1985-11-07 | 1993-09-29 | The President And Fellows Of Harvard College | T-cell lymphotrophic virus protein and assay |
US4772547A (en) * | 1986-02-03 | 1988-09-20 | Hoffmann-La Roche Inc. | HTLV-III envelope peptides |
US4734362A (en) * | 1986-02-03 | 1988-03-29 | Cambridge Bioscience Corporation | Process for purifying recombinant proteins, and products thereof |
US4925784A (en) * | 1986-04-04 | 1990-05-15 | Hoffmann-La Roche Inc. | Expression and purification of an HTLV-III gag/env gene protein |
DK169582B1 (en) * | 1986-06-23 | 1994-12-12 | Squibb Bristol Myers Co | Human monoclonal antibody capable of reacting with an epitope on the LAV / HTLV-III envelope glycoprotein gp41, cell lines producing such antibody, pharmaceutical preparation containing the antibody, and method for determining the presence of LAV / HTLV-III in a biological sample. and method for separating specific antigenic determinants of LAV / HTLV-III using ant |
EP0525828A3 (en) * | 1986-08-01 | 1993-02-24 | Repligen Corporation | Recombinant polypeptides and their uses, including assay for aids virus |
JPH0762031B2 (en) * | 1986-12-30 | 1995-07-05 | アメリカ合衆国 | Synthetic peptides that induce cell-mediated immunity to AIDS virus and AIDS virus proteins |
-
1987
- 1987-08-13 NZ NZ221440A patent/NZ221440A/en unknown
- 1987-08-14 ZW ZW154/87A patent/ZW15487A1/en unknown
- 1987-08-17 YU YU152587A patent/YU152587A/en unknown
- 1987-08-17 FI FI873553A patent/FI873553A/en not_active Application Discontinuation
- 1987-08-18 ES ES8702431A patent/ES2010727A6/en not_active Expired
- 1987-08-18 IL IL83580A patent/IL83580A/en unknown
- 1987-08-19 IE IE221987A patent/IE60671B1/en not_active IP Right Cessation
- 1987-08-19 IT IT21678/87A patent/IT1222518B/en active
- 1987-08-19 GR GR871298A patent/GR871298B/en unknown
- 1987-08-19 SE SE8703225A patent/SE506025C2/en not_active IP Right Cessation
- 1987-08-19 FR FR878711736A patent/FR2603107B1/en not_active Expired - Fee Related
- 1987-08-19 DK DK433087A patent/DK433087A/en not_active Application Discontinuation
- 1987-08-19 NL NL8701950A patent/NL8701950A/en not_active Application Discontinuation
- 1987-08-19 AU AU77201/87A patent/AU616156B2/en not_active Ceased
- 1987-08-19 DE DE19873727703 patent/DE3727703A1/en not_active Withdrawn
- 1987-08-19 HU HU873707A patent/HU214439B/en not_active IP Right Cessation
- 1987-08-19 LU LU86972A patent/LU86972A1/en unknown
- 1987-08-19 GB GB8719587A patent/GB2196634B/en not_active Expired - Fee Related
- 1987-08-19 NO NO873495A patent/NO300462B1/en unknown
- 1987-08-19 BE BE8700922A patent/BE1000811A4/en not_active IP Right Cessation
- 1987-08-19 KR KR1019870009058A patent/KR920008744B1/en not_active IP Right Cessation
- 1987-08-20 JP JP62207336A patent/JPS6485928A/en active Pending
- 1987-08-20 CS CS876136A patent/CS275838B6/en unknown
- 1987-08-20 PL PL1987267401A patent/PL155084B1/en unknown
- 1987-08-20 AT AT0208987A patent/AT398080B/en not_active IP Right Cessation
- 1987-08-20 CH CH3210/87A patent/CH675728A5/de not_active IP Right Cessation
- 1987-08-20 PT PT85567A patent/PT85567B/en not_active IP Right Cessation
- 1987-08-28 OA OA59183A patent/OA08652A/en unknown
-
1993
- 1993-12-29 NO NO934897A patent/NO302176B1/en unknown
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Legal Events
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