SE8701375D0 - Novel pyridyl- and pyrimidyl derivatives - Google Patents

Novel pyridyl- and pyrimidyl derivatives

Info

Publication number
SE8701375D0
SE8701375D0 SE8701375A SE8701375A SE8701375D0 SE 8701375 D0 SE8701375 D0 SE 8701375D0 SE 8701375 A SE8701375 A SE 8701375A SE 8701375 A SE8701375 A SE 8701375A SE 8701375 D0 SE8701375 D0 SE 8701375D0
Authority
SE
Sweden
Prior art keywords
pct
sec
novel pyridyl
date
pyrimidyl derivatives
Prior art date
Application number
SE8701375A
Other languages
English (en)
Swedish (sv)
Inventor
T Fex
K G Olsson
A L Abramo
E G Christensson
Original Assignee
Leo Ab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Leo Ab filed Critical Leo Ab
Priority to SE8701375A priority Critical patent/SE8701375D0/xx
Publication of SE8701375D0 publication Critical patent/SE8701375D0/xx
Priority to IE86988A priority patent/IE61165B1/en
Priority to NZ224005A priority patent/NZ224005A/en
Priority to JP63503107A priority patent/JPH0819104B2/ja
Priority to AU15796/88A priority patent/AU611147B2/en
Priority to EP88903427A priority patent/EP0308476B1/en
Priority to PCT/SE1988/000144 priority patent/WO1988007528A1/en
Priority to DE8888903427T priority patent/DE3878111T2/de
Priority to US07/282,130 priority patent/US4937245A/en
Priority to AT88903427T priority patent/ATE85334T1/de
Priority to HU882510A priority patent/HU201051B/hu
Priority to IL85932A priority patent/IL85932A/xx
Priority to ES8800998A priority patent/ES2006619A6/es
Priority to CA000563050A priority patent/CA1321997C/en
Priority to KR1019880003734A priority patent/KR920003062B1/ko
Priority to FI885560A priority patent/FI92320C/fi
Priority to DK671588A priority patent/DK161313C/da
Priority to NO885386A priority patent/NO172640C/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D213/79—Acids; Esters
    • C07D213/80—Acids; Esters in position 3
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/26—Psychostimulants, e.g. nicotine, cocaine
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/72—Nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D213/81—Amides; Imides
    • C07D213/82—Amides; Imides in position 3
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D213/84—Nitriles
    • C07D213/85—Nitriles in position 3
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/32—One oxygen, sulfur or nitrogen atom
    • C07D239/42—One nitrogen atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Neurology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biomedical Technology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Neurosurgery (AREA)
  • Public Health (AREA)
  • Psychiatry (AREA)
  • Anesthesiology (AREA)
  • Pain & Pain Management (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyridine Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Plural Heterocyclic Compounds (AREA)
SE8701375A 1987-04-02 1987-04-02 Novel pyridyl- and pyrimidyl derivatives SE8701375D0 (sv)

Priority Applications (18)

Application Number Priority Date Filing Date Title
SE8701375A SE8701375D0 (sv) 1987-04-02 1987-04-02 Novel pyridyl- and pyrimidyl derivatives
IE86988A IE61165B1 (en) 1987-04-02 1988-03-23 Bisphenylalkylpiperazine derivatives, a method of their preparation and a pharmaceutical preparation
NZ224005A NZ224005A (en) 1987-04-02 1988-03-24 Pyridyl- and pyrimidyl-substituted piperazine derivatives and pharmaceutical compositions
AU15796/88A AU611147B2 (en) 1987-04-02 1988-03-25 Bisphenylalkylpiperazine derivatives, a method of their preparation and a pharmaceutical preparation
US07/282,130 US4937245A (en) 1987-04-02 1988-03-25 Bisphenylalkylpiperazine derivatives, a method of their preparation and a pharmaceutical preparation
HU882510A HU201051B (en) 1987-04-02 1988-03-25 Bisphenylalkylpiperazine derivatives, a method of their preparation and a pharmaceutical preparation
EP88903427A EP0308476B1 (en) 1987-04-02 1988-03-25 Bisphenylalkylpiperazine derivatives, a method of their preparation and a pharmaceutical preparation
PCT/SE1988/000144 WO1988007528A1 (en) 1987-04-02 1988-03-25 Bisphenylalkylpiperazine derivatives, a method of their preparation and a pharmaceutical preparation
DE8888903427T DE3878111T2 (de) 1987-04-02 1988-03-25 Bisphenylalkylpiperazin-derivate, verfahren zur herstellung und arzneimittelzubereitung.
JP63503107A JPH0819104B2 (ja) 1987-04-02 1988-03-25 新規なピリジルおよびピリミジル誘導体
AT88903427T ATE85334T1 (de) 1987-04-02 1988-03-25 Bisphenylalkylpiperazin-derivate, verfahren zur herstellung und arzneimittelzubereitung.
IL85932A IL85932A (en) 1987-04-02 1988-03-30 1-pyridyl (or pyrimidyl)-4-diphenylbutyl piperazines, process for their preparation and pharmaceutical compositions containing them
ES8800998A ES2006619A6 (es) 1987-04-02 1988-03-30 Un metodo para preparar derivados de piridil-y pirimidil-piperazinas.
CA000563050A CA1321997C (en) 1987-04-02 1988-03-31 Pyridyl and pyrimidyl derivatives
KR1019880003734A KR920003062B1 (ko) 1987-04-02 1988-04-02 새로운 피리딜 및 피리미딜 유도체와 그의 제조방법 및 이들을 이용한 사람이외의 온혈동물의 스트레스 및 불안 치료 방법
FI885560A FI92320C (fi) 1987-04-02 1988-11-30 Menetelmä uusien terapeuttisesti käyttökelpoisten bisfenyylialkyylipiperatsiinijohdannaisten valmistamiseksi
DK671588A DK161313C (da) 1987-04-02 1988-12-01 4-(bis-fluorphenylbutyl)-1-(pyridyl- eller pyrimidinyl)-piperazin- eller -1,4-diazabicycloheptanforbindelser, fremgangsmaade til fremstilling deraf, farmaceutiske praeparater indeholdende disse samt anvendelse af forbindelserne
NO885386A NO172640C (no) 1987-04-02 1988-12-02 Analogifremgangsmaate ved fremstilling av terapeutisk aktive piperazinderivater

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
SE8701375A SE8701375D0 (sv) 1987-04-02 1987-04-02 Novel pyridyl- and pyrimidyl derivatives

Publications (1)

Publication Number Publication Date
SE8701375D0 true SE8701375D0 (sv) 1987-04-02

Family

ID=20368077

Family Applications (1)

Application Number Title Priority Date Filing Date
SE8701375A SE8701375D0 (sv) 1987-04-02 1987-04-02 Novel pyridyl- and pyrimidyl derivatives

Country Status (18)

Country Link
US (1) US4937245A (no)
EP (1) EP0308476B1 (no)
JP (1) JPH0819104B2 (no)
KR (1) KR920003062B1 (no)
AT (1) ATE85334T1 (no)
AU (1) AU611147B2 (no)
CA (1) CA1321997C (no)
DE (1) DE3878111T2 (no)
DK (1) DK161313C (no)
ES (1) ES2006619A6 (no)
FI (1) FI92320C (no)
HU (1) HU201051B (no)
IE (1) IE61165B1 (no)
IL (1) IL85932A (no)
NO (1) NO172640C (no)
NZ (1) NZ224005A (no)
SE (1) SE8701375D0 (no)
WO (1) WO1988007528A1 (no)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SE8701375D0 (sv) * 1987-04-02 1987-04-02 Leo Ab Novel pyridyl- and pyrimidyl derivatives
US5219855A (en) * 1988-01-29 1993-06-15 Mitsubishi Kasei Corporation Anxiolytic drug
JP2664238B2 (ja) * 1989-03-01 1997-10-15 日清製粉株式会社 ニコチン酸またはそのエステル誘導体
US4994460A (en) * 1989-06-01 1991-02-19 Bristol-Myers Squibb Co. Agents for treatment of brain ischemia
SE9201239D0 (sv) * 1992-04-21 1992-04-21 Kabi Pharmacia Ab Agents for treating substance abuse disorders
JPH0665203A (ja) * 1992-06-25 1994-03-08 Elf Sanofi ピペラジンのヘテロ環誘導体
EP0580465A1 (fr) * 1992-06-25 1994-01-26 Sanofi Nouvelle utilisation thérapeutique d'hétérocyclyl-pipérazines comme 5-HT3 agonistes et nouveaux dérivés
SE9201956D0 (sv) * 1992-06-25 1992-06-25 Kabi Pharmacia Ab Novel nicotinicacid esters
SE9202265D0 (sv) * 1992-07-31 1992-07-31 Kabi Pharmacia Ab Novel- pyridyl and pyrimidylpiperazine derivatives
HU226859B1 (en) 1997-10-27 2009-12-28 Neurosearch As Phenyl- or heteroaryl-homopiperazines, their use and medicaments containing them
US6632823B1 (en) * 1997-12-22 2003-10-14 Merck & Co., Inc. Substituted pyridine compounds useful as modulators of acetylcholine receptors
AU779550B2 (en) 1999-04-09 2005-01-27 Meiji Seika Kaisha Ltd. Nitrogen-containing heterocyclic compounds and benamide compounds and drugs containing the same

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2958694A (en) * 1959-06-22 1960-11-01 Janssen Paul Adriaan Jan 1-(aroylalkyl)-4-(2'-pyridyl) piperazines
US2979508A (en) * 1959-10-12 1961-04-11 Paul A J Janssen Heterocyclic derivatives of 1-phenyl-omega-(piperazine) alkanols
US2985657A (en) * 1959-10-12 1961-05-23 Paul A J Janssen 1-(aroylalkyl)-4-heterocyclylpiperazines
JPS6081167A (ja) * 1983-10-11 1985-05-09 Sumitomo Chem Co Ltd フエニルアセトン誘導体およびその製造法
US4605655A (en) * 1984-03-06 1986-08-12 Bristol-Myers Company Antipsychotic 1-fluorophenylbutyl-4-(2-pyrimidinyl)piperazine derivatives
JPS6175A (ja) * 1984-03-06 1986-01-06 ブリストル−マイア−ズ　コムパニ− 神経弛緩剤、１‐フルオロフェニルブチル‐４‐（５‐ハロ‐２‐ピリミジニル）ピペラジン誘導体
GB8603120D0 (en) * 1986-02-07 1986-03-12 Pfizer Ltd Anti-dysrhythmia agents
JPS63146872A (ja) * 1986-07-08 1988-06-18 Yoshitomi Pharmaceut Ind Ltd ピリミジニルピペラジン化合物
US4766215A (en) * 1987-02-27 1988-08-23 American Home Products Corporation Histamine H1 -receptor antagonists
SE8701375D0 (sv) * 1987-04-02 1987-04-02 Leo Ab Novel pyridyl- and pyrimidyl derivatives

Also Published As

Publication number Publication date
DK161313C (da) 1991-12-30
FI92320C (fi) 1994-10-25
IE61165B1 (en) 1994-10-05
DE3878111D1 (de) 1993-03-18
FI92320B (fi) 1994-07-15
WO1988007528A1 (en) 1988-10-06
NZ224005A (en) 1991-03-26
US4937245A (en) 1990-06-26
AU611147B2 (en) 1991-06-06
DE3878111T2 (de) 1993-07-01
KR920003062B1 (ko) 1992-04-13
JPH0819104B2 (ja) 1996-02-28
EP0308476A1 (en) 1989-03-29
DK161313B (da) 1991-06-24
NO885386L (no) 1988-12-02
FI885560A0 (fi) 1988-11-30
CA1321997C (en) 1993-09-07
ES2006619A6 (es) 1989-05-01
IL85932A (en) 1993-05-13
HU201051B (en) 1990-09-28
NO172640B (no) 1993-05-10
HUT50325A (en) 1990-01-29
NO172640C (no) 1993-08-18
FI885560A (fi) 1988-11-30
DK671588D0 (da) 1988-12-01
DK671588A (da) 1988-12-01
EP0308476B1 (en) 1993-02-03
JPH01502832A (ja) 1989-09-28
KR880012586A (ko) 1988-11-28
IL85932A0 (en) 1988-09-30
ATE85334T1 (de) 1993-02-15
AU1579688A (en) 1988-11-02
IE880869L (en) 1988-10-02
NO885386D0 (no) 1988-12-02

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