DK671588A - Bisphenylalkylpiperazinderivater og fremgangsmaade til fremstilling deraf - Google Patents

Bisphenylalkylpiperazinderivater og fremgangsmaade til fremstilling deraf

Info

Publication number
DK671588A
DK671588A DK671588A DK671588A DK671588A DK 671588 A DK671588 A DK 671588A DK 671588 A DK671588 A DK 671588A DK 671588 A DK671588 A DK 671588A DK 671588 A DK671588 A DK 671588A
Authority
DK
Denmark
Prior art keywords
hydrogen
lower alkyl
different
halogen
image
Prior art date
Application number
DK671588A
Other languages
English (en)
Other versions
DK161313B (da
DK671588D0 (da
DK161313C (da
Inventor
Tomas Fex
Knut Gunnar Olsson
Aina Lisbeth Abramo
Erik Gunnar Christensson
Torbjoern Erik Lundstedt
Original Assignee
Leo Ab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Leo Ab filed Critical Leo Ab
Publication of DK671588D0 publication Critical patent/DK671588D0/da
Publication of DK671588A publication Critical patent/DK671588A/da
Publication of DK161313B publication Critical patent/DK161313B/da
Application granted granted Critical
Publication of DK161313C publication Critical patent/DK161313C/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D213/79—Acids; Esters
    • C07D213/80—Acids; Esters in position 3
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/26—Psychostimulants, e.g. nicotine, cocaine
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/72—Nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D213/81—Amides; Imides
    • C07D213/82—Amides; Imides in position 3
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D213/84—Nitriles
    • C07D213/85—Nitriles in position 3
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/32—One oxygen, sulfur or nitrogen atom
    • C07D239/42—One nitrogen atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Neurology (AREA)
  • General Health & Medical Sciences (AREA)
  • Psychiatry (AREA)
  • Pain & Pain Management (AREA)
  • Anesthesiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyridine Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
DK671588A 1987-04-02 1988-12-01 4-(bis-fluorphenylbutyl)-1-(pyridyl- eller pyrimidinyl)-piperazin- eller -1,4-diazabicycloheptanforbindelser, fremgangsmaade til fremstilling deraf, farmaceutiske praeparater indeholdende disse samt anvendelse af forbindelserne DK161313C (da)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
SE8701375A SE8701375D0 (sv) 1987-04-02 1987-04-02 Novel pyridyl- and pyrimidyl derivatives
SE8701375 1987-04-02
SE8800144 1988-01-18
PCT/SE1988/000144 WO1988007528A1 (en) 1987-04-02 1988-03-25 Bisphenylalkylpiperazine derivatives, a method of their preparation and a pharmaceutical preparation

Publications (4)

Publication Number Publication Date
DK671588D0 DK671588D0 (da) 1988-12-01
DK671588A true DK671588A (da) 1988-12-01
DK161313B DK161313B (da) 1991-06-24
DK161313C DK161313C (da) 1991-12-30

Family

ID=20368077

Family Applications (1)

Application Number Title Priority Date Filing Date
DK671588A DK161313C (da) 1987-04-02 1988-12-01 4-(bis-fluorphenylbutyl)-1-(pyridyl- eller pyrimidinyl)-piperazin- eller -1,4-diazabicycloheptanforbindelser, fremgangsmaade til fremstilling deraf, farmaceutiske praeparater indeholdende disse samt anvendelse af forbindelserne

Country Status (18)

Country Link
US (1) US4937245A (da)
EP (1) EP0308476B1 (da)
JP (1) JPH0819104B2 (da)
KR (1) KR920003062B1 (da)
AT (1) ATE85334T1 (da)
AU (1) AU611147B2 (da)
CA (1) CA1321997C (da)
DE (1) DE3878111T2 (da)
DK (1) DK161313C (da)
ES (1) ES2006619A6 (da)
FI (1) FI92320C (da)
HU (1) HU201051B (da)
IE (1) IE61165B1 (da)
IL (1) IL85932A (da)
NO (1) NO172640C (da)
NZ (1) NZ224005A (da)
SE (1) SE8701375D0 (da)
WO (1) WO1988007528A1 (da)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SE8701375D0 (sv) * 1987-04-02 1987-04-02 Leo Ab Novel pyridyl- and pyrimidyl derivatives
US5219855A (en) * 1988-01-29 1993-06-15 Mitsubishi Kasei Corporation Anxiolytic drug
JP2664238B2 (ja) * 1989-03-01 1997-10-15 日清製粉株式会社 ニコチン酸またはそのエステル誘導体
US4994460A (en) * 1989-06-01 1991-02-19 Bristol-Myers Squibb Co. Agents for treatment of brain ischemia
SE9201239D0 (sv) * 1992-04-21 1992-04-21 Kabi Pharmacia Ab Agents for treating substance abuse disorders
JPH0665203A (ja) * 1992-06-25 1994-03-08 Elf Sanofi ピペラジンのヘテロ環誘導体
EP0580465A1 (fr) * 1992-06-25 1994-01-26 Sanofi Nouvelle utilisation thérapeutique d'hétérocyclyl-pipérazines comme 5-HT3 agonistes et nouveaux dérivés
SE9201956D0 (sv) * 1992-06-25 1992-06-25 Kabi Pharmacia Ab Novel nicotinicacid esters
SE9202265D0 (sv) 1992-07-31 1992-07-31 Kabi Pharmacia Ab Novel- pyridyl and pyrimidylpiperazine derivatives
SK285198B6 (sk) 1997-10-27 2006-08-03 Neurosearch A/S Homopiperazínový derivát, farmaceutická kompozícia obsahujúca tento derivát a jeho použitie
US6632823B1 (en) * 1997-12-22 2003-10-14 Merck & Co., Inc. Substituted pyridine compounds useful as modulators of acetylcholine receptors
EP1180514A4 (en) * 1999-04-09 2003-02-26 Meiji Seika Kaisha NITROGEN-CONTAINING HETEROCYCLIC COMPOUNDS AND BENAMID DERIVATIVES, AND THEIR MEDICINAL PRODUCTS

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2958694A (en) * 1959-06-22 1960-11-01 Janssen Paul Adriaan Jan 1-(aroylalkyl)-4-(2'-pyridyl) piperazines
US2979508A (en) * 1959-10-12 1961-04-11 Paul A J Janssen Heterocyclic derivatives of 1-phenyl-omega-(piperazine) alkanols
US2985657A (en) * 1959-10-12 1961-05-23 Paul A J Janssen 1-(aroylalkyl)-4-heterocyclylpiperazines
JPS6081167A (ja) * 1983-10-11 1985-05-09 Sumitomo Chem Co Ltd フエニルアセトン誘導体およびその製造法
JPS6175A (ja) * 1984-03-06 1986-01-06 ブリストル−マイア−ズ　コムパニ− 神経弛緩剤、１‐フルオロフェニルブチル‐４‐（５‐ハロ‐２‐ピリミジニル）ピペラジン誘導体
US4605655A (en) * 1984-03-06 1986-08-12 Bristol-Myers Company Antipsychotic 1-fluorophenylbutyl-4-(2-pyrimidinyl)piperazine derivatives
GB8603120D0 (en) * 1986-02-07 1986-03-12 Pfizer Ltd Anti-dysrhythmia agents
JPS63146872A (ja) * 1986-07-08 1988-06-18 Yoshitomi Pharmaceut Ind Ltd ピリミジニルピペラジン化合物
US4766215A (en) * 1987-02-27 1988-08-23 American Home Products Corporation Histamine H1 -receptor antagonists
SE8701375D0 (sv) * 1987-04-02 1987-04-02 Leo Ab Novel pyridyl- and pyrimidyl derivatives

Also Published As

Publication number Publication date
IL85932A (en) 1993-05-13
DK161313B (da) 1991-06-24
NO172640B (no) 1993-05-10
KR920003062B1 (ko) 1992-04-13
DE3878111T2 (de) 1993-07-01
FI885560A (fi) 1988-11-30
FI92320B (fi) 1994-07-15
DE3878111D1 (de) 1993-03-18
CA1321997C (en) 1993-09-07
IL85932A0 (en) 1988-09-30
JPH0819104B2 (ja) 1996-02-28
HU201051B (en) 1990-09-28
DK671588D0 (da) 1988-12-01
NO885386L (no) 1988-12-02
KR880012586A (ko) 1988-11-28
JPH01502832A (ja) 1989-09-28
DK161313C (da) 1991-12-30
IE61165B1 (en) 1994-10-05
AU1579688A (en) 1988-11-02
ATE85334T1 (de) 1993-02-15
WO1988007528A1 (en) 1988-10-06
HUT50325A (en) 1990-01-29
FI885560A0 (fi) 1988-11-30
FI92320C (fi) 1994-10-25
EP0308476A1 (en) 1989-03-29
EP0308476B1 (en) 1993-02-03
NO885386D0 (no) 1988-12-02
AU611147B2 (en) 1991-06-06
NO172640C (no) 1993-08-18
SE8701375D0 (sv) 1987-04-02
NZ224005A (en) 1991-03-26
IE880869L (en) 1988-10-02
ES2006619A6 (es) 1989-05-01
US4937245A (en) 1990-06-26

Similar Documents

Publication Publication Date Title
DK148392D0 (da) Heterocykliske forbindelser
DK671588A (da) Bisphenylalkylpiperazinderivater og fremgangsmaade til fremstilling deraf
DK519985D0 (da) Quinoloncarboxylsyrederivater, fremgangsmaade til fremstilling deraf og antibakterielt middel indeholdende saadanne derivater
NO163855C (no) Analogifremgangsmaate for fremstilling av terapeutisk aktive arylcyklobutylalkylaminer.
NO179707C (no) Analogifremgangsmåte for fremstilling av antipicornavirale pyridazinaminer
DK380680A (da) Fremgangsmaade til fremstilling af substituerede oxirancarboxylsyrer
ATE22891T1 (de) Pyrimidinonderivate und diese enthaltende pharmazeutische zusammensetzungen.
ES466366A1 (es) Un procedimiento para preparar derivados de metasulfonamido-benzamida.
DK118287D0 (da) Heteroaryloxy-beta-carbolinderivater, deres fremstilling og deres anvendelse som laegemiddel
NO882334L (no) Fremgangsmaate for fremstilling av terapeutisk aktive alkansulfonanilid-derivater.
DK156655C (da) Pyridazinoner, fremgangsmaade til fremstilling deraf, anvendelse deraf og medikamenter indeholdende pyridazinoner
ATE107301T1 (de) Carbonsäurederivate.
DK1582A (da) Substituerede thienotricycler fremgangsmaade til fremstilling deraf og anvendelse af saadanne forbindelser
DK188183D0 (da) Thiomethylpyridinderivater, fremgangsmade til deres fremstilling og laegemidler indeholdende disse forbindelser
DK160184D0 (da) Bis-(piperazinyl-eller homopiperazinyl)-alkaner og syreadditionssalte deraf,fremgangsmaade til deres fremstilling samt deres anvendelse
NO864665L (no) Nye basisk substituerte pyridinforbindelser, fremgangsmaate til deres fremstilling, legemidler inneholdende dem, og deres anvendelse.
ES464013A1 (es) Procedimiento para preparar derivados sustituidos de orto- fenilendiamina.
ES8308545A1 (es) Procedimiento para la obtencion de derivados de diaril-imidazol.
DK165878C (da) 3-substituerede-5-aminoalkyl-beta-carbolinderivater og fremgangsmaade til deres fremstilling
DK553482A (da) Fremgangsmaade til fremstilling af n,n-disubstituerede alkenamider og phenylalkenamider
DK608586D0 (da) Polysubstituerede pyridin-1-oxider og fysiologisk aktive salte deraf, deres fremstilling og anvendelse som laegemidler
DK104488D0 (da) Acetamider afledt af 2,3-dihydro-3-phenyl-2-benzofuranon, fremgangsmaader til deres fremstilling og farmaceutiske midler indeholdende dem
NO960017L (no) Nye pseudopeptider med trifluormetylsubstituert 2-azabicyklooktan
GEP19971013B (en) Novel pyridyl and pyrimidyl derivatives process for preparing thereof, and treatment method for mental disorder
TH4659EX (th) เพอร์ไฮโดรไธอะเซฟีนและอนุพันธ์ต่างๆ ของเพอร์ไฮโดรอะเซฟีน การเตรียมและการใช้สารเหล่านี้สำหรับรักษาโรค

Legal Events

Date Code Title Description
PBP Patent lapsed

Country of ref document: DK