SE8700913L - THERAPEUTIC COMPOSITION CONTAINING ADENOSIN DERIVATIVES - Google Patents

THERAPEUTIC COMPOSITION CONTAINING ADENOSIN DERIVATIVES

Info

Publication number
SE8700913L
SE8700913L SE8700913A SE8700913A SE8700913L SE 8700913 L SE8700913 L SE 8700913L SE 8700913 A SE8700913 A SE 8700913A SE 8700913 A SE8700913 A SE 8700913A SE 8700913 L SE8700913 L SE 8700913L
Authority
SE
Sweden
Prior art keywords
atoms
acyl radical
radical containing
formula
therapeutic composition
Prior art date
Application number
SE8700913A
Other languages
Swedish (sv)
Other versions
SE8700913D0 (en
SE466238B (en
Inventor
G Stramentinoli
F Gennari
Original Assignee
Bioresearch Srl
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bioresearch Srl filed Critical Bioresearch Srl
Publication of SE8700913D0 publication Critical patent/SE8700913D0/en
Publication of SE8700913L publication Critical patent/SE8700913L/en
Publication of SE466238B publication Critical patent/SE466238B/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/16—Purine radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]

Abstract

A therapeutic composition of antiinflammatory, analgesic and antipyretic activity comprises as its active principle, at least one component of the general formula: <IMAGE> in which R is a linear or branched alkyl radical containing 1-18 C atoms or a phenylalkylene in which the alkylene chain contains 1-6 C atoms; R1 is H, an aliphatic acyl radical containing 1-6 C atoms or an aromatic acyl radical; R2 is H, an aliphatic acyl radical containing 1-6 C atoms, or an aromatic acyl radical, or the radicals R2 together form an isopropylidene chain; and N is 0 or 1, or an acid additive salt of a compound of formula (I) in which R' is hydrogen. Various methods of preparing compounds of formula (I) are disclosed including a method of preparing 5'-deoxy-5'-methylthiodenosine by hydrolysing a concentrated aqueous solution of S-adenosyl-methionine by heating under reflux, neutralising the reaction mixture and cooling it to separate the 5'-deoxy-5'-methylthioadenosine formed.
SE8700913A 1980-04-22 1987-03-04 THERAPEUTIC COMPOSITION CONTAINING ADENOSIN DERIVATIVES SE466238B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
IT21550/80A IT1193529B (en) 1980-04-22 1980-04-22 ADENOSINIC DERIVATIVES FOR ANTI-INFLAMMATORY AND ANALGESIC ACTIVITIES AND THERAPEUTIC COMPOSITIONS THAT CONTAIN THEM AS AN ACTIVE PRINCIPLE

Publications (3)

Publication Number Publication Date
SE8700913D0 SE8700913D0 (en) 1987-03-04
SE8700913L true SE8700913L (en) 1987-03-04
SE466238B SE466238B (en) 1992-01-20

Family

ID=11183457

Family Applications (3)

Application Number Title Priority Date Filing Date
SE8102489A SE460198B (en) 1980-04-22 1981-04-21 PROCEDURES FOR THE PREPARATION OF 5'-DEOXI-5'-METHYLTIOADENOSINE
SE8700913A SE466238B (en) 1980-04-22 1987-03-04 THERAPEUTIC COMPOSITION CONTAINING ADENOSIN DERIVATIVES
SE8700914A SE464635B (en) 1980-04-22 1987-03-04 USE OF AN ADENOSIN DERIVATIVE FOR THE PREPARATION OF A MEDICINE FOR TREATMENT OF INFLAMMATION, PAIN AND FEBRUARY

Family Applications Before (1)

Application Number Title Priority Date Filing Date
SE8102489A SE460198B (en) 1980-04-22 1981-04-21 PROCEDURES FOR THE PREPARATION OF 5'-DEOXI-5'-METHYLTIOADENOSINE

Family Applications After (1)

Application Number Title Priority Date Filing Date
SE8700914A SE464635B (en) 1980-04-22 1987-03-04 USE OF AN ADENOSIN DERIVATIVE FOR THE PREPARATION OF A MEDICINE FOR TREATMENT OF INFLAMMATION, PAIN AND FEBRUARY

Country Status (17)

Country Link
JP (2) JPS56166117A (en)
AR (1) AR231144A1 (en)
BE (1) BE888472A (en)
CA (1) CA1198105A (en)
CH (2) CH645544A5 (en)
DE (1) DE3116067A1 (en)
DK (1) DK159453C (en)
ES (2) ES8206551A1 (en)
FI (1) FI70227C (en)
FR (1) FR2491761A1 (en)
GB (3) GB2074446B (en)
IT (1) IT1193529B (en)
LU (1) LU83307A1 (en)
MX (1) MX9203630A (en)
NL (1) NL192111C (en)
NO (1) NO150515C (en)
SE (3) SE460198B (en)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT1177373B (en) * 1984-12-06 1987-08-26 Bioresearch Spa SALTS OF 5'-METHYLLIUM-5'-DEOXYDENOSINE WITH LONG ALCHYLIC CHAIN SULPHONIC ACIDS
IT1227049B (en) * 1988-07-29 1991-03-14 Bioresearch Spa USE OF ADENOSINIC DERIVATIVES FOR THE PREPARATION OF PHARMACEUTICAL COMPOSITIONS HAVING IMMUNOSTIMULATING ACTIVITIES.
JPH0497287A (en) * 1990-08-10 1992-03-30 Nec Ic Microcomput Syst Ltd Picture display integrated circuit
ES2259552B1 (en) * 2005-03-17 2007-06-16 Proyecto De Biomedicina Cima, S.L. EMPLOYMENT OF 5'-METHYLTIOENENINE (MTA) IN THE PREVENTION AND / OR TREATMENT OF AUTOIMMUNE DISEASES AND / OR REPLACEMENT OF TRANSPLANTS.
WO2006097547A1 (en) * 2005-03-17 2006-09-21 Proyecto De Biomedicina Cima S.L. Use of 5'-methylthioadenosine (mta) in the prevention and/or treatment of autoimmune diseases and/or transplant rejection
DE102010027595A1 (en) * 2010-07-23 2012-01-26 Helmut Vorbrüggen Clinical application of adenosine derivative, preferably (dihydroxyphenyl)ethyl-amino-purin-9-yl-(hydroxymethyl)oxolane-diol, for reducing body temperature during impending ischemia of brain vessels, which occur during heart attacks
DE102011005232A1 (en) * 2011-03-08 2012-09-13 AristoCon GmbH & Co. KG Adenosine and its derivatives for use in pain therapy
KR20150139508A (en) * 2013-04-05 2015-12-11 라이온 가부시키가이샤 Yeast culture, and composition for internal application
WO2014163152A1 (en) * 2013-04-05 2014-10-09 ライオン株式会社 Non-rem sleep-promoting agent, deep sleep-promoting agent and natural sleep-inducing agent
WO2014163150A1 (en) * 2013-04-05 2014-10-09 ライオン株式会社 Composition for internal use

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE1259341B (en) * 1962-12-22 1968-01-25 Boehringer & Soehne Gmbh Process for the preparation of new 5'-sulfoxides of nucleosides
DE1545645A1 (en) * 1965-12-06 1969-08-21 Boehringer Mannheim Gmbh Process for the preparation of disubstituted adenosine derivatives
FR2252405B1 (en) * 1973-11-27 1978-04-28 Ajinomoto Kk
FR2313937A1 (en) * 1975-06-09 1977-01-07 Anvar DRUG BASED ON 5 'THIOETHERS OF ADENOSINE
FR2424027A1 (en) * 1978-04-28 1979-11-23 Merieux Inst NEW MEDICINAL PRODUCT, IN PARTICULAR SEDATIVE AND SLEEP INDUCER AND PHARMACEUTICAL COMPOSITIONS CONTAINING IT

Also Published As

Publication number Publication date
FI811249L (en) 1981-10-23
ES511039A0 (en) 1983-06-01
FI70227C (en) 1986-09-15
NO150515B (en) 1984-07-23
JPH0249288B2 (en) 1990-10-29
GB2074446B (en) 1985-04-11
IT1193529B (en) 1988-07-08
CH650514A5 (en) 1985-07-31
GB2144409A (en) 1985-03-06
SE8700914D0 (en) 1987-03-04
SE8102489L (en) 1981-10-23
SE8700913D0 (en) 1987-03-04
NL8101984A (en) 1981-11-16
GB8413454D0 (en) 1984-07-04
GB2074446A (en) 1981-11-04
JPH01301692A (en) 1989-12-05
GB8321947D0 (en) 1983-09-14
NL192111B (en) 1996-10-01
IT8021550A0 (en) 1980-04-22
NL192111C (en) 1997-02-04
FR2491761B1 (en) 1984-01-06
NO150515C (en) 1984-10-31
AR231144A1 (en) 1984-09-28
JPH0246599B2 (en) 1990-10-16
DE3116067C2 (en) 1992-12-17
DK159453C (en) 1991-03-18
MX9203630A (en) 1992-09-01
SE464635B (en) 1991-05-27
BE888472A (en) 1981-08-17
SE466238B (en) 1992-01-20
CA1198105A (en) 1985-12-17
CH645544A5 (en) 1984-10-15
SE460198B (en) 1989-09-18
ES501539A0 (en) 1982-08-16
ES8306378A1 (en) 1983-06-01
DK159453B (en) 1990-10-15
GB2144409B (en) 1985-09-11
FI70227B (en) 1986-02-28
GB2144038A (en) 1985-02-27
DE3116067A1 (en) 1982-03-11
GB2144038B (en) 1985-08-29
SE8700914L (en) 1987-03-04
ES8206551A1 (en) 1982-08-16
FR2491761A1 (en) 1982-04-16
LU83307A1 (en) 1981-07-24
NO811346L (en) 1981-10-23
JPS56166117A (en) 1981-12-21
DK176481A (en) 1981-10-23

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