SE8302283L - Heterocykliska aminodinosubstituerade ureauforeningar och deras farmaceutiska anvendning - Google Patents
Heterocykliska aminodinosubstituerade ureauforeningar och deras farmaceutiska anvendningInfo
- Publication number
- SE8302283L SE8302283L SE8302283A SE8302283A SE8302283L SE 8302283 L SE8302283 L SE 8302283L SE 8302283 A SE8302283 A SE 8302283A SE 8302283 A SE8302283 A SE 8302283A SE 8302283 L SE8302283 L SE 8302283L
- Authority
- SE
- Sweden
- Prior art keywords
- useful
- treating
- carbamoyl
- aryl
- gastrointestinal
- Prior art date
Links
- 206010020601 Hyperchlorhydria Diseases 0.000 title abstract 2
- 206010037075 Protozoal infections Diseases 0.000 title abstract 2
- 206010003119 arrhythmia Diseases 0.000 title abstract 2
- 230000006793 arrhythmia Effects 0.000 title 1
- 230000002496 gastric effect Effects 0.000 abstract 3
- 125000000217 alkyl group Chemical group 0.000 abstract 2
- 125000004433 nitrogen atom Chemical group N* 0.000 abstract 2
- 125000004430 oxygen atom Chemical group O* 0.000 abstract 2
- 125000004434 sulfur atom Chemical group 0.000 abstract 2
- 241000283690 Bos taurus Species 0.000 abstract 1
- 241000282472 Canis lupus familiaris Species 0.000 abstract 1
- 206010012735 Diarrhoea Diseases 0.000 abstract 1
- 241000283086 Equidae Species 0.000 abstract 1
- 208000018522 Gastrointestinal disease Diseases 0.000 abstract 1
- 206010020772 Hypertension Diseases 0.000 abstract 1
- 206010061217 Infestation Diseases 0.000 abstract 1
- 241001465754 Metazoa Species 0.000 abstract 1
- 208000030852 Parasitic disease Diseases 0.000 abstract 1
- 241001494479 Pecora Species 0.000 abstract 1
- 241000282887 Suidae Species 0.000 abstract 1
- 230000007059 acute toxicity Effects 0.000 abstract 1
- 231100000403 acute toxicity Toxicity 0.000 abstract 1
- 125000003342 alkenyl group Chemical group 0.000 abstract 1
- 125000003545 alkoxy group Chemical group 0.000 abstract 1
- 230000003444 anaesthetic effect Effects 0.000 abstract 1
- 230000002763 arrhythmic effect Effects 0.000 abstract 1
- 125000003710 aryl alkyl group Chemical group 0.000 abstract 1
- 125000003118 aryl group Chemical group 0.000 abstract 1
- 125000000753 cycloalkyl group Chemical group 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 208000035475 disorder Diseases 0.000 abstract 1
- 125000000623 heterocyclic group Chemical group 0.000 abstract 1
- 244000144977 poultry Species 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 230000002048 spasmolytic effect Effects 0.000 abstract 1
- 239000002731 stomach secretion inhibitor Substances 0.000 abstract 1
- 208000024891 symptom Diseases 0.000 abstract 1
- 230000001562 ulcerogenic effect Effects 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D213/36—Radicals substituted by singly-bound nitrogen atoms
- C07D213/40—Acylated substituent nitrogen atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
- A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D213/36—Radicals substituted by singly-bound nitrogen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/72—Nitrogen atoms
- C07D213/75—Amino or imino radicals, acylated by carboxylic or carbonic acids, or by sulfur or nitrogen analogues thereof, e.g. carbamates
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Epidemiology (AREA)
- Tropical Medicine & Parasitology (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pyridine Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| PCT/US1981/001146 WO1983000627A1 (en) | 1981-08-24 | 1981-08-24 | Heterocyclic amidino substituted ureas and their pharmaceutical uses |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| SE8302283D0 SE8302283D0 (sv) | 1983-04-22 |
| SE8302283L true SE8302283L (sv) | 1983-04-22 |
| SE452007B SE452007B (sv) | 1987-11-09 |
Family
ID=22161395
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SE8302283A SE452007B (sv) | 1981-08-24 | 1983-04-22 | Amidinosubstituerade ureaforeningar och en farmaceutisk komposition for behandling av gastrointestinala eller kardiovaskulera rubbningar |
Country Status (12)
| Country | Link |
|---|---|
| US (1) | US4707478A (sv) |
| EP (1) | EP0086775A4 (sv) |
| JP (1) | JPS58501468A (sv) |
| AU (1) | AU543834B2 (sv) |
| CA (1) | CA1210394A (sv) |
| CH (1) | CH656125A5 (sv) |
| DE (1) | DE3152942T1 (sv) |
| DK (1) | DK181583D0 (sv) |
| GB (1) | GB2115419B (sv) |
| NL (1) | NL8120313A (sv) |
| SE (1) | SE452007B (sv) |
| WO (1) | WO1983000627A1 (sv) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3887800D1 (de) * | 1987-08-04 | 1994-03-24 | Ciba Geigy | Substituierte Guanidine. |
| CA2116621C (en) * | 1993-03-03 | 2001-07-24 | Rene C. Gaudreault | Novel anticancer agents |
| US5750547A (en) * | 1995-01-06 | 1998-05-12 | Universite Laval | Certain carbanate anti-cancer agents |
| AUPN193095A0 (en) * | 1995-03-24 | 1995-04-27 | Polychip Pharmaceuticals Pty Ltd | Potassium ion channel blockers |
| JP4206382B2 (ja) * | 2002-11-19 | 2009-01-07 | アキリオン ファーマシューティカルズ，インコーポレーテッド | 置換されたアリールチオウレアおよび関連化合物；ウイルス複製のインヒビター |
| TW200600492A (en) * | 2004-05-18 | 2006-01-01 | Achillion Pharmaceuticals Inc | Substituted aryl acylthioureas and related compounds; inhibitors of viral replication |
| CN114292225B (zh) * | 2022-01-10 | 2023-07-11 | 万华化学集团股份有限公司 | 一种季铵型强碱性阴离子交换树脂及其催化制备甲基丙烯酸缩水甘油酯的方法 |
Family Cites Families (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB1194835A (en) * | 1966-07-07 | 1970-06-10 | Wellcome Found | Novel 1-Amidino-3-Phenyl-Urea Derivatives, the preparation thereof and Compositions containing the same |
| US3798269A (en) * | 1968-08-05 | 1974-03-19 | R Cutler | Amidinoureas and amidinothioureas |
| US3984467A (en) * | 1969-03-03 | 1976-10-05 | Sterling Drug Inc. | Anthelmintic 1-(substituted phenyl)-3-alkanimidoyl ureas |
| US3933794A (en) * | 1971-08-04 | 1976-01-20 | The Upjohn Company | 2-(2-Alkynylamino)-3H-1,4-benzodiazepines |
| US4220658A (en) * | 1972-09-22 | 1980-09-02 | William H. Rorer, Inc. | Treatment of hypertension with amidinoureas |
| US4025652A (en) * | 1975-03-31 | 1977-05-24 | William H. Rorer, Inc. | Amidinoureas |
| US4060635A (en) * | 1975-03-31 | 1977-11-29 | William H. Rorer, Inc. | Amidinoureas for treating diarrhea |
| US4009163A (en) * | 1973-08-24 | 1977-02-22 | Sterling Drug Inc. | Amidinoureas and amidinothioureas |
| US4163022A (en) * | 1975-02-03 | 1979-07-31 | Cooper Laboratories, Inc. | Carbamylguanidine antimicrobial compounds |
| US4088785A (en) * | 1976-03-25 | 1978-05-09 | William H. Rorer, Inc. | Amidinoureas for the treatment of cardinascular disorders |
| US4058557A (en) * | 1976-03-30 | 1977-11-15 | William H. Rorer, Inc. | Amidinoureas |
| US4169155A (en) * | 1976-03-30 | 1979-09-25 | William H. Rorer, Inc. | Method for treatment of gastrointestinal secretory and ulcerogenic disease conditions or symptoms in mammals |
| US4178387A (en) * | 1976-03-30 | 1979-12-11 | William H. Rorer, Inc. | Method for the treatment of arrhythmia |
| JPS53108970A (en) * | 1977-03-07 | 1978-09-22 | Yamanouchi Pharmaceut Co Ltd | Novel guanidine derivative and its preparation |
| US4166860A (en) * | 1977-10-11 | 1979-09-04 | William H. Rorer, Inc. | Imidazole amidinoureas for stimulating H2 -receptors |
| US4304786A (en) * | 1978-09-14 | 1981-12-08 | William H. Rorer, Inc. | Amidinoureas |
| US4225315A (en) * | 1978-11-13 | 1980-09-30 | William H. Rorer, Inc. | Triazinones from amidinoureas |
| DE2853220A1 (de) * | 1978-12-09 | 1980-07-03 | Hoechst Ag | Neue amino-pyrimidin-carbanilide, verfahren zu ihrer herstellung, diese verbindungen enthaltende arzneimittel und ihre verwendung |
| US4241087A (en) * | 1979-04-02 | 1980-12-23 | William H. Rorer, Inc. | Dysmenorrhea treatment |
| US4340609A (en) * | 1980-01-02 | 1982-07-20 | William H. Rorer, Inc. | Amidinourea derivative veterinary compositions for suppression of parasitemia |
| US4486439A (en) * | 1981-08-24 | 1984-12-04 | William H. Rorer, Inc. | Treatment of coccidiosis |
-
1981
- 1981-08-24 JP JP56502922A patent/JPS58501468A/ja active Pending
- 1981-08-24 GB GB08310965A patent/GB2115419B/en not_active Expired
- 1981-08-24 US US06/425,095 patent/US4707478A/en not_active Expired - Fee Related
- 1981-08-24 WO PCT/US1981/001146 patent/WO1983000627A1/en not_active Application Discontinuation
- 1981-08-24 DE DE813152942T patent/DE3152942T1/de not_active Withdrawn
- 1981-08-24 AU AU75394/81A patent/AU543834B2/en not_active Ceased
- 1981-08-24 NL NL8120313A patent/NL8120313A/nl not_active Application Discontinuation
- 1981-08-24 CH CH2394/83A patent/CH656125A5/de not_active IP Right Cessation
- 1981-08-24 EP EP19810902423 patent/EP0086775A4/en not_active Withdrawn
-
1983
- 1983-04-22 SE SE8302283A patent/SE452007B/sv not_active IP Right Cessation
- 1983-04-25 DK DK1815/83A patent/DK181583D0/da not_active Application Discontinuation
- 1983-04-26 CA CA000426738A patent/CA1210394A/en not_active Expired
Also Published As
| Publication number | Publication date |
|---|---|
| GB2115419A (en) | 1983-09-07 |
| SE8302283D0 (sv) | 1983-04-22 |
| DK181583A (da) | 1983-04-25 |
| JPS58501468A (ja) | 1983-09-01 |
| WO1983000627A1 (en) | 1983-03-03 |
| EP0086775A4 (en) | 1984-09-05 |
| GB8310965D0 (en) | 1983-05-25 |
| SE452007B (sv) | 1987-11-09 |
| DK181583D0 (da) | 1983-04-25 |
| AU543834B2 (en) | 1985-05-02 |
| GB2115419B (en) | 1985-10-02 |
| NL8120313A (nl) | 1983-07-01 |
| EP0086775A1 (en) | 1983-08-31 |
| AU7539481A (en) | 1983-03-08 |
| US4707478A (en) | 1987-11-17 |
| CH656125A5 (en) | 1986-06-13 |
| DE3152942T1 (de) | 1983-12-15 |
| CA1210394A (en) | 1986-08-26 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| NUG | Patent has lapsed |
Ref document number: 8302283-0 Effective date: 19890911 Format of ref document f/p: F |