SE8204694L - Alkanoylanilinderivat - Google Patents

Alkanoylanilinderivat

Info

Publication number
SE8204694L
SE8204694L SE8204694A SE8204694A SE8204694L SE 8204694 L SE8204694 L SE 8204694L SE 8204694 A SE8204694 A SE 8204694A SE 8204694 A SE8204694 A SE 8204694A SE 8204694 L SE8204694 L SE 8204694L
Authority
SE
Sweden
Prior art keywords
formula
denotes
compound
acid
trans
Prior art date
Application number
SE8204694A
Other languages
English (en)
Other versions
SE8204694D0 (sv
Inventor
J Szmuszkovicz
Original Assignee
Upjohn Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Upjohn Co filed Critical Upjohn Co
Publication of SE8204694D0 publication Critical patent/SE8204694D0/sv
Publication of SE8204694L publication Critical patent/SE8204694L/sv

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/12—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms
    • C07D295/135—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms with the ring nitrogen atoms and the substituent nitrogen atoms separated by carbocyclic rings or by carbon chains interrupted by carbocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/26—Psychostimulants, e.g. nicotine, cocaine
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C55/00—Saturated compounds having more than one carboxyl group bound to acyclic carbon atoms
    • C07C55/02—Dicarboxylic acids
    • C07C55/06—Oxalic acid
    • C07C55/07—Salts thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C57/00—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms
    • C07C57/02—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms with only carbon-to-carbon double bonds as unsaturation
    • C07C57/13—Dicarboxylic acids
    • C07C57/145—Maleic acid
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C57/00—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms
    • C07C57/02—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms with only carbon-to-carbon double bonds as unsaturation
    • C07C57/13—Dicarboxylic acids
    • C07C57/15—Fumaric acid

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Psychiatry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Pain & Pain Management (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Claims (1)

Patentkrav 1. Ferfarande for framstAllning av en ferening med formeln C1-12-CH.CH-R3 (Mrbetecknar cis- respektive trans-konfiguration mod av- seende pi aminogruppen i 2-attaining, ddr Q betecknar syre eller svavel, dir R betecknar alkyl mod 1-3 kolatomer, cykloalkyl med 3-6 kolatomer, vinyl, etoxi eller metoximetyl, dAr RI betecknar alkyl med 1-3 kolatomer,kNnnetecknat av att R1 NN/ b• i2-CH=CR-R3 f) reaktion mellan foreningen enligt steg e) och ett acylerande model, nAmligen en anhydrid av en karbonsyra 1. ller en syraklorid eller syrabromid under bildning av en N-acylerad produkt med formeln 2. — zR, -"CH2-Cli■Cli-R3 3. vilken ingliende symboler tlAlgare definierats, varefter om si Onskas forenlngen fir reagera med perkarboxylsyra under blldning av en forming dIr p betecknar 1 och/eller upphettas med ett tiolerande Nadel i lAmpligt 18sningsmedel under bildning av en fOrening dar 0 betecknar svavel. 1. en 1,2-cykloheptenoxid med formeln far reagera med en R1-bensylamin under bildning av en trans-2-aminocyklopentanol med formeln cr,OH 2. att trans-2-aminocyklopentanolen fair reagera mad natriumhydrid och darefter med metansulfonylklorid under bildning av ett mesylat med formeln 0-S°2-CH2 N111
1. CH2-0 c) att reaktionsblandningen fran stag b) behandlas mod en anilin med formeln under bildning av en diamin med formeln 114z N, 1 N 'CH2 -(f5) r.,111 NCH2
SE8204694A 1977-03-21 1982-08-13 Alkanoylanilinderivat SE8204694L (sv)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US77959377A 1977-03-21 1977-03-21

Publications (2)

Publication Number Publication Date
SE8204694D0 SE8204694D0 (sv) 1982-08-13
SE8204694L true SE8204694L (sv) 1982-08-13

Family

ID=25116918

Family Applications (3)

Application Number Title Priority Date Filing Date
SE7713440A SE442198B (sv) 1977-03-21 1977-11-28 Forfarande for framstellning av nya n-(2-aminocykloheptyl)-n-alkanoylanilider
SE8204694A SE8204694L (sv) 1977-03-21 1982-08-13 Alkanoylanilinderivat
SE8204695A SE8204695D0 (sv) 1977-03-21 1982-08-13 Alkanoylanilinderivat

Family Applications Before (1)

Application Number Title Priority Date Filing Date
SE7713440A SE442198B (sv) 1977-03-21 1977-11-28 Forfarande for framstellning av nya n-(2-aminocykloheptyl)-n-alkanoylanilider

Family Applications After (1)

Application Number Title Priority Date Filing Date
SE8204695A SE8204695D0 (sv) 1977-03-21 1982-08-13 Alkanoylanilinderivat

Country Status (9)

Country Link
JP (1) JPS53116347A (sv)
AU (1) AU511540B2 (sv)
BE (1) BE861352A (sv)
CH (4) CH636341A5 (sv)
DE (1) DE2749213A1 (sv)
FR (1) FR2384744A1 (sv)
GB (2) GB1557595A (sv)
NL (1) NL7712898A (sv)
SE (3) SE442198B (sv)

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3510492A (en) * 1968-05-13 1970-05-05 Upjohn Co 2-anilino and 2-anilinomethyl cycloalkylamines

Also Published As

Publication number Publication date
DE2749213C2 (sv) 1988-09-08
SE442198B (sv) 1985-12-09
SE8204695L (sv) 1982-08-13
SE8204694D0 (sv) 1982-08-13
NL7712898A (nl) 1978-09-25
JPS53116347A (en) 1978-10-11
BE861352A (fr) 1978-05-30
GB1557594A (en) 1979-12-12
CH636597A5 (en) 1983-06-15
AU3049077A (en) 1979-05-17
CH636604A5 (en) 1983-06-15
DE2749213A1 (de) 1978-10-05
CH637110A5 (en) 1983-07-15
FR2384744B1 (sv) 1980-08-22
SE7713440L (sv) 1978-09-22
GB1557595A (en) 1979-12-12
JPS6146471B2 (sv) 1986-10-14
AU511540B2 (en) 1980-08-21
CH636341A5 (en) 1983-05-31
FR2384744A1 (fr) 1978-10-20
SE8204695D0 (sv) 1982-08-13

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