SE8008189L - COMPOUNDS WITH ANTIALLERGIC AND ANTIULCEROS EFFECTS, SUCH 1-OXO-1H-TIAZOLO (3,2-A) PYRIMIDIN-2-CARBOXAMIDES AND INTERMEDIATES FOR THESE - Google Patents

COMPOUNDS WITH ANTIALLERGIC AND ANTIULCEROS EFFECTS, SUCH 1-OXO-1H-TIAZOLO (3,2-A) PYRIMIDIN-2-CARBOXAMIDES AND INTERMEDIATES FOR THESE

Info

Publication number
SE8008189L
SE8008189L SE8008189A SE8008189A SE8008189L SE 8008189 L SE8008189 L SE 8008189L SE 8008189 A SE8008189 A SE 8008189A SE 8008189 A SE8008189 A SE 8008189A SE 8008189 L SE8008189 L SE 8008189L
Authority
SE
Sweden
Prior art keywords
formula
intermediates
compounds
carbon atoms
antiulceros
Prior art date
Application number
SE8008189A
Other languages
Swedish (sv)
Other versions
SE448732B (en
Inventor
S B Kadin
Original Assignee
Pfizer
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer filed Critical Pfizer
Publication of SE8008189L publication Critical patent/SE8008189L/en
Publication of SE448732B publication Critical patent/SE448732B/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/60—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings condensed with carbocyclic rings or ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/16—Otologicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/10—Antioedematous agents; Diuretics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D277/38—Nitrogen atoms
    • C07D277/40—Unsubstituted amino or imino radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D277/38—Nitrogen atoms
    • C07D277/42—Amino or imino radicals substituted by hydrocarbon or substituted hydrocarbon radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/60—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings condensed with carbocyclic rings or ring systems
    • C07D277/62—Benzothiazoles
    • C07D277/68—Benzothiazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
    • C07D277/82—Nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
    • C07D513/04—Ortho-condensed systems

Abstract

Antiallergy and antiulcer agents having the formula (I), <IMAGE> and their pharmaceutically acceptable salts, wherein R1 and R2 taken separately are each hydrogen or C1-5 alkyl; and R1 and R2 taken together are alkylene of 3 - 9 carbon atoms or phenylalkylene of 9 - 11 carbon atoms, with the proviso that the ring so formed is between 5- and 8-membered; acids of the formula (II), <IMAGE> wherein R1 and R2 are as defined above and R3 is hydrogen, which are useful as intermediates for compounds of the formula (I), but in many instances also possess the same useful biological activity as do formula I compounds; and intermediates of the formula II wherein R1 and R2 are defined as above, and R3 is alkyl of 1 to 4 carbon atoms, carbalkoxy of 2 to 5 carbon atoms, carbophenoxy or carbobenzoxy, are described.
SE8008189A 1979-11-23 1980-11-21 N- (5-TETRAZOLYL) -1-OXO-1H-TIAZOLO / 3,2-A / -PYRIMIDIN-2-CARBOXAMIDES WITH ANTI-ALLERGIC AND ANTIULCEROS EFFECTS AND THE SIMILAR 2-CARBOXYL ACID SE448732B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US9663179A 1979-11-23 1979-11-23

Publications (2)

Publication Number Publication Date
SE8008189L true SE8008189L (en) 1981-05-24
SE448732B SE448732B (en) 1987-03-16

Family

ID=22258306

Family Applications (1)

Application Number Title Priority Date Filing Date
SE8008189A SE448732B (en) 1979-11-23 1980-11-21 N- (5-TETRAZOLYL) -1-OXO-1H-TIAZOLO / 3,2-A / -PYRIMIDIN-2-CARBOXAMIDES WITH ANTI-ALLERGIC AND ANTIULCEROS EFFECTS AND THE SIMILAR 2-CARBOXYL ACID

Country Status (35)

Country Link
JP (1) JPS5687586A (en)
KR (1) KR830004322A (en)
AR (2) AR228859A1 (en)
AT (1) AT380883B (en)
AU (1) AU520995B2 (en)
BE (1) BE886319A (en)
CA (1) CA1143731A (en)
CH (1) CH649299A5 (en)
CS (1) CS241476B2 (en)
DD (1) DD154608A5 (en)
DE (2) DE3043979C2 (en)
DK (1) DK151811C (en)
EG (1) EG14929A (en)
ES (1) ES497066A0 (en)
FI (1) FI67706C (en)
FR (1) FR2470132A1 (en)
GB (1) GB2063862B (en)
GR (1) GR72132B (en)
GT (1) GT198066458A (en)
HU (1) HU179091B (en)
IE (1) IE50404B1 (en)
IL (1) IL61535A (en)
IN (1) IN154926B (en)
IT (1) IT1209373B (en)
LU (1) LU82950A1 (en)
NL (1) NL182565C (en)
NO (1) NO803521L (en)
NZ (1) NZ195596A (en)
PH (1) PH16666A (en)
PL (1) PL132354B1 (en)
PT (1) PT72090B (en)
SE (1) SE448732B (en)
SU (1) SU1042620A3 (en)
YU (1) YU41953B (en)
ZA (1) ZA807293B (en)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8300728D0 (en) * 1983-01-12 1983-02-16 Erba Farmitalia Substituted carboxy-thiazolo / 3 2 - a / pyrimidine derivatives
US4457932A (en) * 1983-07-22 1984-07-03 Bristol-Myers Company Anti-ulcer agents
GB8422916D0 (en) * 1984-09-11 1984-10-17 May & Baker Ltd Compositions of matter
JP2690742B2 (en) * 1987-03-30 1997-12-17 第一製薬株式会社 Heterocyclic amine derivative
ES2087072T3 (en) * 1988-03-28 1996-07-16 Janssen Pharmaceutica Nv AGENTS TO PRESERVE OR RESTORE SKIN HEALTH.
TWI500623B (en) * 2009-10-13 2015-09-21 Torrent Pharmaceuticals Ltd Novel fused thiazolo and oxazolo pyrimidinones

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1331059A (en) * 1971-04-19 1973-09-19 Lilly Industries Ltd Pyrimidotriazinone compounds
US4041163A (en) * 1976-03-29 1977-08-09 Pfizer Inc. N-(5-Tetrazolyl)-4-oxo-4H-pyrimido(2,1-b)benzothiazole-3-carboxamide antiallergy agents
DE2810863A1 (en) * 1978-03-13 1979-09-27 Boehringer Mannheim Gmbh 1-OXO-1H-PYRIMIDO ANGLE CLAMP ON 6.1-B ANGLE CLAMP ON BENZTHIAZOLE DERIVATIVES AND METHOD FOR THE PRODUCTION THEREOF
US4223031A (en) * 1978-05-05 1980-09-16 Mead Johnson & Company Azolopyrimidinones

Also Published As

Publication number Publication date
SE448732B (en) 1987-03-16
CH649299A5 (en) 1985-05-15
CA1143731A (en) 1983-03-29
FR2470132A1 (en) 1981-05-29
IL61535A0 (en) 1980-12-31
JPS617432B2 (en) 1986-03-06
IT8026176A0 (en) 1980-11-21
NO803521L (en) 1981-05-25
AU520995B2 (en) 1982-03-11
NL182565B (en) 1987-11-02
BE886319A (en) 1981-05-25
NL182565C (en) 1988-04-05
EG14929A (en) 1989-01-30
NL8006362A (en) 1981-06-16
DE3043979C2 (en) 1986-08-21
GR72132B (en) 1983-09-19
ZA807293B (en) 1981-12-30
GB2063862A (en) 1981-06-10
FI803628L (en) 1981-05-24
AU6459580A (en) 1981-05-28
IN154926B (en) 1984-12-22
AR228859A1 (en) 1983-04-29
DD154608A5 (en) 1982-04-07
YU295080A (en) 1983-06-30
IE802418L (en) 1981-05-23
LU82950A1 (en) 1981-06-04
CS782080A2 (en) 1985-06-13
DK151811C (en) 1988-06-06
AT380883B (en) 1986-07-25
FI67706C (en) 1985-05-10
PT72090A (en) 1980-12-01
IL61535A (en) 1984-06-29
IT1209373B (en) 1989-07-16
ES8203363A1 (en) 1982-04-01
FR2470132B1 (en) 1983-07-29
DE3043979A1 (en) 1981-09-03
IE50404B1 (en) 1986-04-16
ATA570780A (en) 1985-12-15
PL132354B1 (en) 1985-02-28
SU1042620A3 (en) 1983-09-15
DK413180A (en) 1981-05-24
GB2063862B (en) 1983-06-22
ES497066A0 (en) 1982-04-01
KR830004322A (en) 1983-07-09
AR231296A1 (en) 1984-10-31
YU41953B (en) 1988-02-29
HU179091B (en) 1982-08-28
PT72090B (en) 1981-09-29
DE3050491C2 (en) 1985-10-10
NZ195596A (en) 1984-05-31
PL228008A1 (en) 1981-12-11
PH16666A (en) 1983-12-13
GT198066458A (en) 1982-05-15
JPS5687586A (en) 1981-07-16
DK151811B (en) 1988-01-04
FI67706B (en) 1985-01-31
CS241476B2 (en) 1986-03-13

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