DE68901153D1 - DERIVATIVES OF PURIN, METHOD FOR THEIR PRODUCTION AND PHARMACEUTICAL PREPARATION. - Google Patents
DERIVATIVES OF PURIN, METHOD FOR THEIR PRODUCTION AND PHARMACEUTICAL PREPARATION.Info
- Publication number
- DE68901153D1 DE68901153D1 DE8989850146T DE68901153T DE68901153D1 DE 68901153 D1 DE68901153 D1 DE 68901153D1 DE 8989850146 T DE8989850146 T DE 8989850146T DE 68901153 T DE68901153 T DE 68901153T DE 68901153 D1 DE68901153 D1 DE 68901153D1
- Authority
- DE
- Germany
- Prior art keywords
- hydroxy
- amino
- hydrogen
- compounds
- chem
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
- 238000000034 method Methods 0.000 title abstract 3
- 238000004519 manufacturing process Methods 0.000 title abstract 2
- 239000000825 pharmaceutical preparation Substances 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 4
- 229910052739 hydrogen Inorganic materials 0.000 abstract 4
- 239000001257 hydrogen Substances 0.000 abstract 4
- 125000004435 hydrogen atom Chemical class [H]* 0.000 abstract 4
- 125000004356 hydroxy functional group Chemical group O* 0.000 abstract 3
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 abstract 3
- RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 abstract 2
- -1 hydroxy, mercapto Chemical class 0.000 abstract 2
- 208000030507 AIDS Diseases 0.000 abstract 1
- 125000001309 chloro group Chemical group Cl* 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 125000004185 ester group Chemical group 0.000 abstract 1
- 125000001153 fluoro group Chemical group F* 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 230000009385 viral infection Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D473/00—Heterocyclic compounds containing purine ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/20—Antivirals for DNA viruses
- A61P31/22—Antivirals for DNA viruses for herpes viruses
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/6561—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings
- C07F9/65616—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings containing the ring system having three or more than three double bonds between ring members or between ring members and non-ring members, e.g. purine or analogs
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/6564—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having phosphorus atoms, with or without nitrogen, oxygen, sulfur, selenium or tellurium atoms, as ring hetero atoms
- C07F9/6571—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having phosphorus atoms, with or without nitrogen, oxygen, sulfur, selenium or tellurium atoms, as ring hetero atoms having phosphorus and oxygen atoms as the only ring hetero atoms
- C07F9/657163—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having phosphorus atoms, with or without nitrogen, oxygen, sulfur, selenium or tellurium atoms, as ring hetero atoms having phosphorus and oxygen atoms as the only ring hetero atoms the ring phosphorus atom being bound to at least one carbon atom
- C07F9/657181—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having phosphorus atoms, with or without nitrogen, oxygen, sulfur, selenium or tellurium atoms, as ring hetero atoms having phosphorus and oxygen atoms as the only ring hetero atoms the ring phosphorus atom being bound to at least one carbon atom the ring phosphorus atom and, at least, one ring oxygen atom being part of a (thio)phosphonic acid derivative
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Virology (AREA)
- General Health & Medical Sciences (AREA)
- Molecular Biology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Communicable Diseases (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Oncology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Biochemistry (AREA)
- Engineering & Computer Science (AREA)
- Biotechnology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Saccharide Compounds (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Abstract
Antivirally active compounds of the formula <CHEM> wherein: R<1> is hydrogen, hydroxy, mercapto or amino; R<2> is hydrogen, hydroxy, fluoro, chloro or amino; R<3> and R<4> are independently selected from - @(OM)2, <CHEM> amino, hydroxy or an ether or ester residue thereof, or R<3> together with R<4> is <CHEM> wherein M is hydrogen or a pharmaceutically acceptable counterion; and n is 1 or 2; with the proviso that, when R<2> is amino and R<3> and R<4> are hydroxy, R<1> is not hydroxy and in addition, when n = 1, R<1> is not hydrogen, and pharmaceutically acceptable salts thereof; processes and preparation of said compounds, a pharmaceutical composition comprising said compounds, methods for treatment of virus infections as well as use of compounds of the formula I without the proviso for the manufacture of a medicament for treatment of AIDS.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
SE8801729A SE8801729D0 (en) | 1988-05-06 | 1988-05-06 | PURINE DERIVATIVES FOR USE IN THERAPY |
Publications (1)
Publication Number | Publication Date |
---|---|
DE68901153D1 true DE68901153D1 (en) | 1992-05-14 |
Family
ID=20372263
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE8989850146T Expired - Fee Related DE68901153D1 (en) | 1988-05-06 | 1989-05-05 | DERIVATIVES OF PURIN, METHOD FOR THEIR PRODUCTION AND PHARMACEUTICAL PREPARATION. |
Country Status (18)
Country | Link |
---|---|
EP (1) | EP0343133B1 (en) |
JP (1) | JP2866688B2 (en) |
KR (1) | KR0141913B1 (en) |
AT (1) | ATE74603T1 (en) |
CA (1) | CA1340909C (en) |
DE (1) | DE68901153D1 (en) |
DK (1) | DK174986B1 (en) |
ES (1) | ES2033548T3 (en) |
FI (1) | FI98729C (en) |
GR (1) | GR3004482T3 (en) |
HU (1) | HU207082B (en) |
IE (1) | IE62066B1 (en) |
IL (1) | IL90166A (en) |
MY (1) | MY108541A (en) |
NZ (1) | NZ229002A (en) |
PT (1) | PT90478B (en) |
SE (1) | SE8801729D0 (en) |
WO (1) | WO1989010923A1 (en) |
Families Citing this family (26)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB8904855D0 (en) * | 1989-03-03 | 1989-04-12 | Beecham Group Plc | Pharmaceutical treatment |
US5728575A (en) * | 1990-02-01 | 1998-03-17 | Emory University | Method of resolution of 1,3-oxathiolane nucleoside enantiomers |
US5356886A (en) * | 1990-07-19 | 1994-10-18 | Beecham Group P.L.C. | Antiviral phosphono-alken derivatives of purines |
GB9020932D0 (en) * | 1990-09-26 | 1990-11-07 | Wellcome Found | Heterocyclic compounds |
US5208221A (en) * | 1990-11-29 | 1993-05-04 | Bristol-Myers Squibb Company | Antiviral (phosphonomethoxy) methoxy purine/pyrimidine derivatives |
US5334525A (en) * | 1992-08-28 | 1994-08-02 | Fox Chase Cancer Center | Hepadnavirus polymerase gene product having RNA-dependent DNA priming and reverse transcriptase activities and methods of measuring the activities thereof |
US5360714A (en) * | 1992-08-28 | 1994-11-01 | Fox Chase Cancer Center | Hepadnavirus polymerase gene product having RNA-dependent DNA priming and reverse transcriptase activities and methods of measuring the activities thereof |
US5798340A (en) | 1993-09-17 | 1998-08-25 | Gilead Sciences, Inc. | Nucleotide analogs |
US5656745A (en) * | 1993-09-17 | 1997-08-12 | Gilead Sciences, Inc. | Nucleotide analogs |
JPH09506333A (en) * | 1993-09-17 | 1997-06-24 | ギリアード サイエンシーズ,インコーポレイテッド | Method of administering therapeutic compound |
DE19540798A1 (en) * | 1995-11-02 | 1997-05-07 | Hoechst Ag | Alkylxanthine phosphonates and alkylxanthine phosphine oxides and their use as medicines |
US20030040467A1 (en) | 1998-06-15 | 2003-02-27 | Mary Ann Pelleymounter | Ig/ob fusions and uses thereof. |
US5717095A (en) * | 1995-12-29 | 1998-02-10 | Gilead Sciences, Inc. | Nucleotide analogs |
CA2239020A1 (en) * | 1995-12-29 | 1997-07-10 | Norbert W. Bischofberger | Nucleotide analogs |
US5869493A (en) | 1996-02-16 | 1999-02-09 | Medivir Ab | Acyclic nucleoside derivatives |
US6703394B2 (en) | 1996-02-16 | 2004-03-09 | Medivir Ab | Acyclic nucleoside derivatives |
US6184376B1 (en) | 1997-02-10 | 2001-02-06 | Mediver Ab | Synthesis of acyclic nucleoside derivatives |
CA2277151C (en) * | 1997-02-10 | 2007-04-17 | Medivir Ab | Synthesis of acyclic nucleoside derivatives |
JP2009298785A (en) * | 1997-02-10 | 2009-12-24 | Medivir Ab | Synthesis of acyclic nucleoside derivative |
US6753322B2 (en) | 2000-06-06 | 2004-06-22 | Pfizer Inc | 2-aminocarbonyl-9H-purine derivatives |
JP4397691B2 (en) | 2001-10-30 | 2010-01-13 | コンフォーマ・セラピューティクス・コーポレイション | Purine analogs having HSP90 inhibitory activity |
TWI332507B (en) | 2002-11-19 | 2010-11-01 | Hoffmann La Roche | Antiviral nucleoside derivatives |
US7138401B2 (en) | 2003-09-18 | 2006-11-21 | Conforma Therapeutics Corporation | 2-aminopurine analogs having HSP90-inhibiting activity |
JP2008534609A (en) | 2005-03-30 | 2008-08-28 | コンフォーマ・セラピューティクス・コーポレイション | Alkynylpyrrolopyrimidines and related analogs as HSP90 inhibitors |
EP2326619B1 (en) | 2008-08-01 | 2019-02-27 | Bioxiness Pharmaceuticals, Inc. | Methionine analogs and methods of using same |
CN102250126A (en) * | 2010-05-18 | 2011-11-23 | 北京化工大学 | Dipurine derivative and synthesis thereof |
Family Cites Families (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
KR890001487B1 (en) * | 1982-10-14 | 1989-05-04 | 더 웰컴 파운데이숀 리미티드 | Process for the preparation of purine derivatives |
CS233665B1 (en) * | 1983-01-06 | 1985-03-14 | Antonin Holy | Processing of isomere o-phosphonylmethylderivative of anantiomere racemic vicinal diene |
IL73682A (en) * | 1983-12-20 | 1991-08-16 | Medivir Ab | Antiviral pharmaceutical compositions containing 9-hydroxy aliphatic derivatives of guanine,some new such derivatives and process for their preparation |
SE8406538D0 (en) * | 1984-12-21 | 1984-12-21 | Astra Laekemedel Ab | NOVEL DERIVATIVES OF PURINE |
MY101126A (en) * | 1985-12-13 | 1991-07-31 | Beecham Group Plc | Novel compounds |
-
1988
- 1988-05-06 SE SE8801729A patent/SE8801729D0/en unknown
-
1989
- 1989-05-03 IL IL9016689A patent/IL90166A/en active IP Right Grant
- 1989-05-04 NZ NZ229002A patent/NZ229002A/en unknown
- 1989-05-05 MY MYPI89000618A patent/MY108541A/en unknown
- 1989-05-05 WO PCT/SE1989/000255 patent/WO1989010923A1/en active IP Right Grant
- 1989-05-05 IE IE147289A patent/IE62066B1/en not_active IP Right Cessation
- 1989-05-05 CA CA000598887A patent/CA1340909C/en not_active Expired - Fee Related
- 1989-05-05 DE DE8989850146T patent/DE68901153D1/en not_active Expired - Fee Related
- 1989-05-05 HU HU893004A patent/HU207082B/en not_active IP Right Cessation
- 1989-05-05 AT AT89850146T patent/ATE74603T1/en not_active IP Right Cessation
- 1989-05-05 JP JP1505738A patent/JP2866688B2/en not_active Expired - Fee Related
- 1989-05-05 EP EP89850146A patent/EP0343133B1/en not_active Expired - Lifetime
- 1989-05-05 ES ES198989850146T patent/ES2033548T3/en not_active Expired - Lifetime
- 1989-05-15 PT PT90478A patent/PT90478B/en not_active IP Right Cessation
-
1990
- 1990-01-06 KR KR90700035A patent/KR0141913B1/en not_active IP Right Cessation
- 1990-11-05 DK DK199002649A patent/DK174986B1/en not_active IP Right Cessation
- 1990-11-05 FI FI905475A patent/FI98729C/en active IP Right Grant
-
1992
- 1992-05-05 GR GR920400840T patent/GR3004482T3/el unknown
Also Published As
Publication number | Publication date |
---|---|
JP2866688B2 (en) | 1999-03-08 |
HU893004D0 (en) | 1991-09-30 |
SE8801729D0 (en) | 1988-05-06 |
HU207082B (en) | 1993-03-01 |
DK264990D0 (en) | 1990-11-05 |
EP0343133A1 (en) | 1989-11-23 |
FI98729C (en) | 1997-08-11 |
HUT57767A (en) | 1991-12-30 |
ES2033548T3 (en) | 1993-03-16 |
MY108541A (en) | 1996-10-31 |
AU626300B2 (en) | 1992-07-30 |
DK174986B1 (en) | 2004-04-13 |
NZ229002A (en) | 1997-05-26 |
FI905475A0 (en) | 1990-11-05 |
IE62066B1 (en) | 1994-12-14 |
ATE74603T1 (en) | 1992-04-15 |
EP0343133B1 (en) | 1992-04-08 |
PT90478B (en) | 1994-08-31 |
PT90478A (en) | 1989-11-30 |
IE891472L (en) | 1989-11-06 |
GR3004482T3 (en) | 1993-03-31 |
WO1989010923A1 (en) | 1989-11-16 |
AU3572689A (en) | 1989-11-29 |
IL90166A (en) | 1996-09-12 |
DK264990A (en) | 1990-11-05 |
IL90166A0 (en) | 1989-12-15 |
JPH03504243A (en) | 1991-09-19 |
KR0141913B1 (en) | 1998-06-01 |
FI98729B (en) | 1997-04-30 |
CA1340909C (en) | 2000-02-22 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
8364 | No opposition during term of opposition | ||
8339 | Ceased/non-payment of the annual fee |