KR830004322A - Anti-allergic and anti-ulcer agents 1-oxo-1H-thiazolo [3,2-a] pyrimidine-2-carboxamide and its intermediates - Google Patents

Anti-allergic and anti-ulcer agents 1-oxo-1H-thiazolo [3,2-a] pyrimidine-2-carboxamide and its intermediates Download PDF

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Publication number
KR830004322A
KR830004322A KR1019800004474A KR800004474A KR830004322A KR 830004322 A KR830004322 A KR 830004322A KR 1019800004474 A KR1019800004474 A KR 1019800004474A KR 800004474 A KR800004474 A KR 800004474A KR 830004322 A KR830004322 A KR 830004322A
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KR
South Korea
Prior art keywords
equivalent
formula
compound
thiazolo
allergic
Prior art date
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KR1019800004474A
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Korean (ko)
Inventor
버나드 카딘 솔
Original Assignee
에밀 안토니 아고스티니
화이자 인코포레이티드
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Application filed by 에밀 안토니 아고스티니, 화이자 인코포레이티드 filed Critical 에밀 안토니 아고스티니
Publication of KR830004322A publication Critical patent/KR830004322A/en

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/60—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings condensed with carbocyclic rings or ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/16—Otologicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/10—Antioedematous agents; Diuretics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D277/38—Nitrogen atoms
    • C07D277/40—Unsubstituted amino or imino radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D277/38—Nitrogen atoms
    • C07D277/42—Amino or imino radicals substituted by hydrocarbon or substituted hydrocarbon radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/60—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings condensed with carbocyclic rings or ring systems
    • C07D277/62—Benzothiazoles
    • C07D277/68—Benzothiazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
    • C07D277/82—Nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
    • C07D513/04—Ortho-condensed systems

Abstract

내용 없음No content

Description

항알러지 및 항궤양제 1-옥소-1H-티아졸로[3,2-a]피리미딘Anti-allergic and anti-ulcer agents 1-oxo-1H-thiazolo [3,2-a] pyrimidine

본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음As this is a public information case, the full text was not included.

Claims (1)

구조식(Ⅱ)의 화합물과 5-아미노테트라졸 적어도 1당량에 탈수적-커플링 시약 적어도 1당량을 작용시켜 불활성 유기용매중에서 반응시키거나, 구조식(Ⅱ)의 화합물을 구조식(Ⅲ)의 화합물 약 1당량과 3급 아민 적어도 1당량존재하에 불활성 유기용매중에서 반응시켜 구조식(Ⅳ)의 화합물 용액을 제조한 후 이 용액을 5-아미노테트라졸 약 1당량과 동일한 반응 불활성 유기용매중에서 반응시킴을 특징으로하여 구조식(Ⅰ)의 화합물을 제조하는 방법.At least one equivalent of the compound of formula (II) and at least one equivalent of 5-aminotetrazole is reacted in an inert organic solvent by reacting at least one equivalent of the dehydrating-coupling reagent, or the compound of formula (II) 1 equivalent and tertiary amine were reacted in an inert organic solvent in the presence of at least 1 equivalent to prepare a solution of the compound of formula (IV), and then the solution was reacted in a reaction inert organic solvent equivalent to about 1 equivalent of 5-aminotetrazole. Thereby producing a compound of formula (I). 상기 구조식중In the above structural formula R1과 R2는 함께 탄소수 3내지 9의 알킬렌 또는 탄소수 9내지 11의 페닐 알킬렌이며, 따라서 제조된 환상계는 5-내지 8-원이고R 1 and R 2 together are alkylene having 3 to 9 carbon atoms or phenyl alkylene having 9 to 11 carbon atoms, and thus the cyclic system produced is 5- to 8-membered R1과 R2는 별개로는 각기 수소 또는 탄소수 1내지 5의 알킬이며R 1 and R 2 are each independently hydrogen or alkyl of 1 to 5 carbon atoms R은 알킬, 벤질 또는 페닐이다.R is alkyl, benzyl or phenyl. ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.※ Note: The disclosure is based on the initial application.
KR1019800004474A 1979-11-23 1980-11-22 Anti-allergic and anti-ulcer agents 1-oxo-1H-thiazolo [3,2-a] pyrimidine-2-carboxamide and its intermediates KR830004322A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US9663179A 1979-11-23 1979-11-23
US96631 1979-11-23

Publications (1)

Publication Number Publication Date
KR830004322A true KR830004322A (en) 1983-07-09

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KR1019800004474A KR830004322A (en) 1979-11-23 1980-11-22 Anti-allergic and anti-ulcer agents 1-oxo-1H-thiazolo [3,2-a] pyrimidine-2-carboxamide and its intermediates

Country Status (35)

Country Link
JP (1) JPS5687586A (en)
KR (1) KR830004322A (en)
AR (2) AR228859A1 (en)
AT (1) AT380883B (en)
AU (1) AU520995B2 (en)
BE (1) BE886319A (en)
CA (1) CA1143731A (en)
CH (1) CH649299A5 (en)
CS (1) CS241476B2 (en)
DD (1) DD154608A5 (en)
DE (2) DE3043979C2 (en)
DK (1) DK151811C (en)
EG (1) EG14929A (en)
ES (1) ES497066A0 (en)
FI (1) FI67706C (en)
FR (1) FR2470132A1 (en)
GB (1) GB2063862B (en)
GR (1) GR72132B (en)
GT (1) GT198066458A (en)
HU (1) HU179091B (en)
IE (1) IE50404B1 (en)
IL (1) IL61535A (en)
IN (1) IN154926B (en)
IT (1) IT1209373B (en)
LU (1) LU82950A1 (en)
NL (1) NL182565C (en)
NO (1) NO803521L (en)
NZ (1) NZ195596A (en)
PH (1) PH16666A (en)
PL (1) PL132354B1 (en)
PT (1) PT72090B (en)
SE (1) SE448732B (en)
SU (1) SU1042620A3 (en)
YU (1) YU41953B (en)
ZA (1) ZA807293B (en)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8300728D0 (en) * 1983-01-12 1983-02-16 Erba Farmitalia Substituted carboxy-thiazolo / 3 2 - a / pyrimidine derivatives
US4457932A (en) * 1983-07-22 1984-07-03 Bristol-Myers Company Anti-ulcer agents
GB8422916D0 (en) * 1984-09-11 1984-10-17 May & Baker Ltd Compositions of matter
JP2690742B2 (en) * 1987-03-30 1997-12-17 第一製薬株式会社 Heterocyclic amine derivative
ES2087072T3 (en) * 1988-03-28 1996-07-16 Janssen Pharmaceutica Nv AGENTS TO PRESERVE OR RESTORE SKIN HEALTH.
TWI500623B (en) * 2009-10-13 2015-09-21 Torrent Pharmaceuticals Ltd Novel fused thiazolo and oxazolo pyrimidinones

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1331059A (en) * 1971-04-19 1973-09-19 Lilly Industries Ltd Pyrimidotriazinone compounds
US4041163A (en) * 1976-03-29 1977-08-09 Pfizer Inc. N-(5-Tetrazolyl)-4-oxo-4H-pyrimido(2,1-b)benzothiazole-3-carboxamide antiallergy agents
DE2810863A1 (en) * 1978-03-13 1979-09-27 Boehringer Mannheim Gmbh 1-OXO-1H-PYRIMIDO ANGLE CLAMP ON 6.1-B ANGLE CLAMP ON BENZTHIAZOLE DERIVATIVES AND METHOD FOR THE PRODUCTION THEREOF
US4223031A (en) * 1978-05-05 1980-09-16 Mead Johnson & Company Azolopyrimidinones

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Publication number Publication date
SE448732B (en) 1987-03-16
CH649299A5 (en) 1985-05-15
CA1143731A (en) 1983-03-29
FR2470132A1 (en) 1981-05-29
IL61535A0 (en) 1980-12-31
JPS617432B2 (en) 1986-03-06
IT8026176A0 (en) 1980-11-21
NO803521L (en) 1981-05-25
AU520995B2 (en) 1982-03-11
NL182565B (en) 1987-11-02
BE886319A (en) 1981-05-25
NL182565C (en) 1988-04-05
EG14929A (en) 1989-01-30
NL8006362A (en) 1981-06-16
DE3043979C2 (en) 1986-08-21
GR72132B (en) 1983-09-19
ZA807293B (en) 1981-12-30
GB2063862A (en) 1981-06-10
FI803628L (en) 1981-05-24
AU6459580A (en) 1981-05-28
IN154926B (en) 1984-12-22
AR228859A1 (en) 1983-04-29
DD154608A5 (en) 1982-04-07
YU295080A (en) 1983-06-30
IE802418L (en) 1981-05-23
LU82950A1 (en) 1981-06-04
CS782080A2 (en) 1985-06-13
DK151811C (en) 1988-06-06
AT380883B (en) 1986-07-25
FI67706C (en) 1985-05-10
PT72090A (en) 1980-12-01
IL61535A (en) 1984-06-29
IT1209373B (en) 1989-07-16
ES8203363A1 (en) 1982-04-01
FR2470132B1 (en) 1983-07-29
DE3043979A1 (en) 1981-09-03
IE50404B1 (en) 1986-04-16
ATA570780A (en) 1985-12-15
PL132354B1 (en) 1985-02-28
SU1042620A3 (en) 1983-09-15
DK413180A (en) 1981-05-24
GB2063862B (en) 1983-06-22
ES497066A0 (en) 1982-04-01
AR231296A1 (en) 1984-10-31
YU41953B (en) 1988-02-29
HU179091B (en) 1982-08-28
PT72090B (en) 1981-09-29
DE3050491C2 (en) 1985-10-10
NZ195596A (en) 1984-05-31
PL228008A1 (en) 1981-12-11
PH16666A (en) 1983-12-13
SE8008189L (en) 1981-05-24
GT198066458A (en) 1982-05-15
JPS5687586A (en) 1981-07-16
DK151811B (en) 1988-01-04
FI67706B (en) 1985-01-31
CS241476B2 (en) 1986-03-13

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