SE8004873L - Forfarande for framstellning av oleandomycinderivat - Google Patents

Forfarande for framstellning av oleandomycinderivat

Info

Publication number
SE8004873L
SE8004873L SE8004873A SE8004873A SE8004873L SE 8004873 L SE8004873 L SE 8004873L SE 8004873 A SE8004873 A SE 8004873A SE 8004873 A SE8004873 A SE 8004873A SE 8004873 L SE8004873 L SE 8004873L
Authority
SE
Sweden
Prior art keywords
preparation
procedure
alkanoyl
reed
carbon atoms
Prior art date
Application number
SE8004873A
Other languages
English (en)
Other versions
SE436284B (sv
Inventor
F C Sciavolino
Original Assignee
Pfizer
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US05/709,703 external-priority patent/US4069379A/en
Application filed by Pfizer filed Critical Pfizer
Publication of SE8004873L publication Critical patent/SE8004873L/sv
Publication of SE436284B publication Critical patent/SE436284B/sv

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
    • C07H17/04—Heterocyclic radicals containing only oxygen as ring hetero atoms
    • C07H17/08—Hetero rings containing eight or more ring members, e.g. erythromycins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Communicable Diseases (AREA)
  • Medicinal Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Oncology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biotechnology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

Claims (2)

PATENTXRPN
1. POrfarande for framstallning av en forening, son: her formeln:. 2 N(CH3)2 CH3 och de icke-toxiska syraadditionssalterna darav, van i X hetecknar gruppen R2CC112; R Sr vdte eller alkanoyl reed
2-3 kolatomer; Ri Sr vate eller alkanoyl med 2-3 kolatomer: och R2 5r vdte, tri-(15gre alkyl) -silyl rued 1-6 kolatomer vane alkylgrupp.eller alkanoyl reed 2-3 kolatomer, k anneteckn-t darav, att forening, som har formeln III ___ 0_„_..„.,, 0 OCH3 van i R, Ri och R2 tar oVan angiVen betydelse, bringas att reagera i ett reaktionsinert losningsmedel under kylning Oct i ett isvattenbad med fran 1 till 1,5 mol per mol oleandomycinderivat reed dimetylsulfoxoniummetylid, varefter blandningen f5r anta rumstemperatur under uppratthallande av kontakten mellan de reagerande substanserna tills reaktionen Sr VOsentligen fullstandig och, ndr s5 onskas, framstallning av syraadditicnssaltet. N(CR3)2
SE8004873A 1976-03-03 1980-07-01 Forfarande for framstellning av cyklopropyloleandomyciner och icke-toxiska syraadditionssalter derav SE436284B (sv)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US66346776A 1976-03-03 1976-03-03
US70346476A 1976-07-08 1976-07-08
US05/709,703 US4069379A (en) 1976-07-08 1976-07-29 Semi-synthetic oleandomycins

Publications (2)

Publication Number Publication Date
SE8004873L true SE8004873L (sv) 1980-07-01
SE436284B SE436284B (sv) 1984-11-26

Family

ID=27418084

Family Applications (2)

Application Number Title Priority Date Filing Date
SE7700786A SE436283B (sv) 1976-03-03 1977-01-25 Forfarande for framstellning av halvsyntetiska oleandomycin-derivat och icke-toxiska syraadditionssalter derav
SE8004873A SE436284B (sv) 1976-03-03 1980-07-01 Forfarande for framstellning av cyklopropyloleandomyciner och icke-toxiska syraadditionssalter derav

Family Applications Before (1)

Application Number Title Priority Date Filing Date
SE7700786A SE436283B (sv) 1976-03-03 1977-01-25 Forfarande for framstellning av halvsyntetiska oleandomycin-derivat och icke-toxiska syraadditionssalter derav

Country Status (21)

Country Link
JP (1) JPS52106880A (sv)
AR (1) AR212524A1 (sv)
AT (1) AT347586B (sv)
BG (2) BG27914A4 (sv)
CA (1) CA1069503A (sv)
DD (1) DD129789A5 (sv)
DE (2) DE2660089C2 (sv)
DK (1) DK146778C (sv)
ES (1) ES455805A1 (sv)
FI (1) FI770440A (sv)
FR (1) FR2342989A1 (sv)
GB (1) GB1567390A (sv)
IE (1) IE44509B1 (sv)
IL (1) IL51361A (sv)
LU (1) LU76764A1 (sv)
NL (1) NL170151C (sv)
NZ (1) NZ183235A (sv)
PH (1) PH13171A (sv)
PT (1) PT66157B (sv)
RO (2) RO76882A (sv)
SE (2) SE436283B (sv)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4180654A (en) * 1978-01-03 1979-12-25 Pfizer Inc. 4"-Deoxy-4"-acylamido derivatives of oleandomycin, erythromycin and erythromycin carbonate
US4166901A (en) * 1978-01-03 1979-09-04 Pfizer Inc. 4"-Deoxy-4"-arylglyoxamido- and aroylthioformamido derivatives of oleandomycin and its esters

Also Published As

Publication number Publication date
SE436284B (sv) 1984-11-26
IE44509B1 (en) 1981-12-30
DD129789A5 (de) 1978-02-08
ES455805A1 (es) 1978-04-01
LU76764A1 (sv) 1977-08-19
DK57177A (da) 1977-09-04
DE2654627B2 (de) 1979-11-29
NL7701401A (nl) 1977-09-06
NL170151C (nl) 1982-10-01
RO72560A (ro) 1983-07-07
DK146778B (da) 1984-01-02
DK146778C (da) 1984-06-12
FR2342989B1 (sv) 1980-07-04
PH13171A (en) 1980-01-08
IL51361A0 (en) 1977-03-31
CA1069503A (en) 1980-01-08
JPS52106880A (en) 1977-09-07
RO76882A (ro) 1981-08-17
DE2660089B1 (de) 1980-03-20
AT347586B (de) 1979-01-10
AU2200677A (en) 1978-05-18
DE2660089C2 (de) 1980-11-06
PT66157A (en) 1977-03-01
DE2654627A1 (de) 1977-09-08
ATA62777A (de) 1978-05-15
RO72560B (ro) 1983-06-30
FI770440A (sv) 1977-09-04
AR212524A1 (es) 1978-07-31
GB1567390A (en) 1980-05-14
SE436283B (sv) 1984-11-26
NZ183235A (en) 1978-11-13
BG27914A4 (en) 1980-01-15
NL170151B (nl) 1982-05-03
PT66157B (en) 1978-07-10
FR2342989A1 (fr) 1977-09-30
IL51361A (en) 1979-10-31
JPS552437B2 (sv) 1980-01-19
IE44509L (en) 1977-09-03
DE2654627C3 (de) 1980-07-31
BG27913A3 (en) 1980-01-15
SE7700786L (sv) 1977-10-03

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