SE8004873L - PROCEDURE FOR THE PREPARATION OF OLEANDOMYCIN DERIVATIVES - Google Patents

PROCEDURE FOR THE PREPARATION OF OLEANDOMYCIN DERIVATIVES

Info

Publication number
SE8004873L
SE8004873L SE8004873A SE8004873A SE8004873L SE 8004873 L SE8004873 L SE 8004873L SE 8004873 A SE8004873 A SE 8004873A SE 8004873 A SE8004873 A SE 8004873A SE 8004873 L SE8004873 L SE 8004873L
Authority
SE
Sweden
Prior art keywords
preparation
procedure
alkanoyl
reed
carbon atoms
Prior art date
Application number
SE8004873A
Other languages
Swedish (sv)
Other versions
SE436284B (en
Inventor
F C Sciavolino
Original Assignee
Pfizer
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US05/709,703 external-priority patent/US4069379A/en
Application filed by Pfizer filed Critical Pfizer
Publication of SE8004873L publication Critical patent/SE8004873L/en
Publication of SE436284B publication Critical patent/SE436284B/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
    • C07H17/04—Heterocyclic radicals containing only oxygen as ring hetero atoms
    • C07H17/08—Hetero rings containing eight or more ring members, e.g. erythromycins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Oncology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Communicable Diseases (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

Claims (2)

PATENTXRPNPATENTXRPN 1. POrfarande for framstallning av en forening, son: her formeln:. 2 N(CH3)2 CH3 och de icke-toxiska syraadditionssalterna darav, van i X hetecknar gruppen R2CC112; R Sr vdte eller alkanoyl reed1. Process for the preparation of a compound, son: her formula :. 2 N (CH3) 2 CH3 and the non-toxic acid addition salts thereof, of which X represents the group R2CC12; R Sr vdte or alkanoyl reed 2-3 kolatomer; Ri Sr vate eller alkanoyl med 2-3 kolatomer: och R2 5r vdte, tri-(15gre alkyl) -silyl rued 1-6 kolatomer vane alkylgrupp.eller alkanoyl reed 2-3 kolatomer, k anneteckn-t darav, att forening, som har formeln III ___ 0_„_..„.,, 0 OCH3 van i R, Ri och R2 tar oVan angiVen betydelse, bringas att reagera i ett reaktionsinert losningsmedel under kylning Oct i ett isvattenbad med fran 1 till 1,5 mol per mol oleandomycinderivat reed dimetylsulfoxoniummetylid, varefter blandningen f5r anta rumstemperatur under uppratthallande av kontakten mellan de reagerande substanserna tills reaktionen Sr VOsentligen fullstandig och, ndr s5 onskas, framstallning av syraadditicnssaltet. N(CR3)22-3 carbon atoms; R 1 is hydrogen or alkanoyl having 2 to 3 carbon atoms: has the formula III ___ 0 _ „_ ..„. ,, 0 OCH3 van in R 1, R oleandomycin derivatives reed dimethylsulfoxonium methylide, after which the mixture is allowed to warm to room temperature while maintaining the contact between the reactants until the reaction is substantially complete and, if desired, the preparation of the acid addition salt. N (CR3) 2
SE8004873A 1976-03-03 1980-07-01 PROCEDURE FOR THE PREPARATION OF CYCLOPROPYLOLEANDOMYCINES AND NON-TOXIC ACID ADDITION SALTS THEREOF SE436284B (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US66346776A 1976-03-03 1976-03-03
US70346476A 1976-07-08 1976-07-08
US05/709,703 US4069379A (en) 1976-07-08 1976-07-29 Semi-synthetic oleandomycins

Publications (2)

Publication Number Publication Date
SE8004873L true SE8004873L (en) 1980-07-01
SE436284B SE436284B (en) 1984-11-26

Family

ID=27418084

Family Applications (2)

Application Number Title Priority Date Filing Date
SE7700786A SE436283B (en) 1976-03-03 1977-01-25 PROCEDURE FOR PREPARING SEMI-SYNTHETIC OLEANDOMYCIN DERIVATIVES AND NON-TOXIC ACID ADDITION SALTS THEREOF
SE8004873A SE436284B (en) 1976-03-03 1980-07-01 PROCEDURE FOR THE PREPARATION OF CYCLOPROPYLOLEANDOMYCINES AND NON-TOXIC ACID ADDITION SALTS THEREOF

Family Applications Before (1)

Application Number Title Priority Date Filing Date
SE7700786A SE436283B (en) 1976-03-03 1977-01-25 PROCEDURE FOR PREPARING SEMI-SYNTHETIC OLEANDOMYCIN DERIVATIVES AND NON-TOXIC ACID ADDITION SALTS THEREOF

Country Status (21)

Country Link
JP (1) JPS52106880A (en)
AR (1) AR212524A1 (en)
AT (1) AT347586B (en)
BG (2) BG27913A3 (en)
CA (1) CA1069503A (en)
DD (1) DD129789A5 (en)
DE (2) DE2654627C3 (en)
DK (1) DK146778C (en)
ES (1) ES455805A1 (en)
FI (1) FI770440A (en)
FR (1) FR2342989A1 (en)
GB (1) GB1567390A (en)
IE (1) IE44509B1 (en)
IL (1) IL51361A (en)
LU (1) LU76764A1 (en)
NL (1) NL170151C (en)
NZ (1) NZ183235A (en)
PH (1) PH13171A (en)
PT (1) PT66157B (en)
RO (2) RO72560A (en)
SE (2) SE436283B (en)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4180654A (en) * 1978-01-03 1979-12-25 Pfizer Inc. 4"-Deoxy-4"-acylamido derivatives of oleandomycin, erythromycin and erythromycin carbonate
US4166901A (en) * 1978-01-03 1979-09-04 Pfizer Inc. 4"-Deoxy-4"-arylglyoxamido- and aroylthioformamido derivatives of oleandomycin and its esters

Also Published As

Publication number Publication date
DE2660089C2 (en) 1980-11-06
GB1567390A (en) 1980-05-14
SE436283B (en) 1984-11-26
FI770440A (en) 1977-09-04
PT66157A (en) 1977-03-01
PH13171A (en) 1980-01-08
FR2342989B1 (en) 1980-07-04
LU76764A1 (en) 1977-08-19
ES455805A1 (en) 1978-04-01
JPS52106880A (en) 1977-09-07
RO76882A (en) 1981-08-17
DD129789A5 (en) 1978-02-08
RO72560B (en) 1983-06-30
IE44509L (en) 1977-09-03
NL170151B (en) 1982-05-03
DK146778B (en) 1984-01-02
FR2342989A1 (en) 1977-09-30
DE2654627C3 (en) 1980-07-31
DE2654627A1 (en) 1977-09-08
ATA62777A (en) 1978-05-15
DE2660089B1 (en) 1980-03-20
DK146778C (en) 1984-06-12
BG27914A4 (en) 1980-01-15
RO72560A (en) 1983-07-07
NZ183235A (en) 1978-11-13
DK57177A (en) 1977-09-04
SE436284B (en) 1984-11-26
AT347586B (en) 1979-01-10
PT66157B (en) 1978-07-10
AU2200677A (en) 1978-05-18
DE2654627B2 (en) 1979-11-29
NL170151C (en) 1982-10-01
AR212524A1 (en) 1978-07-31
IL51361A0 (en) 1977-03-31
CA1069503A (en) 1980-01-08
BG27913A3 (en) 1980-01-15
IL51361A (en) 1979-10-31
JPS552437B2 (en) 1980-01-19
NL7701401A (en) 1977-09-06
SE7700786L (en) 1977-10-03
IE44509B1 (en) 1981-12-30

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