RO72560B - Process for preparing oleandomycin derivatives - Google Patents

Process for preparing oleandomycin derivatives

Info

Publication number
RO72560B
RO72560B RO89496A RO8949677A RO72560B RO 72560 B RO72560 B RO 72560B RO 89496 A RO89496 A RO 89496A RO 8949677 A RO8949677 A RO 8949677A RO 72560 B RO72560 B RO 72560B
Authority
RO
Romania
Prior art keywords
preparing
general formula
oleandomycin derivatives
compound
oleandomycin
Prior art date
Application number
RO89496A
Other languages
Romanian (ro)
Other versions
RO72560A (en
Inventor
C. Frank Sciavolino
Original Assignee
Pfizer Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US05/709,703 external-priority patent/US4069379A/en
Application filed by Pfizer Inc. filed Critical Pfizer Inc.
Publication of RO72560B publication Critical patent/RO72560B/en
Publication of RO72560A publication Critical patent/RO72560A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
    • C07H17/04—Heterocyclic radicals containing only oxygen as ring hetero atoms
    • C07H17/08—Hetero rings containing eight or more ring members, e.g. erythromycins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Oncology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Communicable Diseases (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

Abstract

Procedeu pentru prepararea unor derivati de oleandomicina cu formula generala I: (vezi formula) în care simbolul X reprezinta radicalul mai mic C=CH2, R, R1 si R2 reprezinta un atom de hidrogen sau un radical alchil cu 2...3 atomi de carbon, caracterizat prin aceea ca un compus, avînd formula generala II: (vezi formula) în care R, R1 si R2 au semnificatiile sus-mentionate, se aduce în reactie, sub atomsfera de CO2, la temperatura camerei, cu o sare anorganica, care contine ionul unui metal, si anume, Cr la puterea 2+, Ti la 3+ sau V la 2+, într-un solvent inert în conditiile reactiei, de preferinta acetona, alcanoli inferiori, tetrahidrofuran, dupa care, în compusul obtinut poate fi eventual, înlocuit substituentul R2 cu radicali trifluoracetil, sililtrialchil inferior sau se prepara o sare de aditie cu un acid, prin metode cunoscute.Process for the preparation of oleandomycin derivatives of the general formula I wherein X represents the lower C = CH 2, R, R 1 and R 2 represents a hydrogen atom or a 2- or 3-alkyl- carbon, characterized in that a compound having the general formula II wherein R, R 1 and R 2 have the abovementioned meanings is reacted under the CO2 atmosphere at room temperature with an inorganic salt, which contains a metal ion, namely, Cr at 2+, Ti at 3+ or V at 2+, in an inert solvent under the conditions of the reaction, preferably acetone, lower alkanols, tetrahydrofuran, whereupon in the compound obtained optionally replacing the R2 substituent with trifluoroacetyl radicals, lower alkyl silyl, or preparing an acid addition salt by known methods.

RO7789496A 1976-03-03 1977-02-23 PROCEDURE FOR PREPARING OLEANDOMICINE DERIVATIVES RO72560A (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US66346776A 1976-03-03 1976-03-03
US70346476A 1976-07-08 1976-07-08
US05/709,703 US4069379A (en) 1976-07-08 1976-07-29 Semi-synthetic oleandomycins

Publications (2)

Publication Number Publication Date
RO72560B true RO72560B (en) 1983-06-30
RO72560A RO72560A (en) 1983-07-07

Family

ID=27418084

Family Applications (2)

Application Number Title Priority Date Filing Date
RO7789496A RO72560A (en) 1976-03-03 1977-02-23 PROCEDURE FOR PREPARING OLEANDOMICINE DERIVATIVES
RO7797127A RO76882A (en) 1976-03-03 1977-02-23 PROCEDURE FOR PREPARING OLEANDOMICINE DERIVATIVES

Family Applications After (1)

Application Number Title Priority Date Filing Date
RO7797127A RO76882A (en) 1976-03-03 1977-02-23 PROCEDURE FOR PREPARING OLEANDOMICINE DERIVATIVES

Country Status (21)

Country Link
JP (1) JPS52106880A (en)
AR (1) AR212524A1 (en)
AT (1) AT347586B (en)
BG (2) BG27914A4 (en)
CA (1) CA1069503A (en)
DD (1) DD129789A5 (en)
DE (2) DE2660089C2 (en)
DK (1) DK146778C (en)
ES (1) ES455805A1 (en)
FI (1) FI770440A (en)
FR (1) FR2342989A1 (en)
GB (1) GB1567390A (en)
IE (1) IE44509B1 (en)
IL (1) IL51361A (en)
LU (1) LU76764A1 (en)
NL (1) NL170151C (en)
NZ (1) NZ183235A (en)
PH (1) PH13171A (en)
PT (1) PT66157B (en)
RO (2) RO72560A (en)
SE (2) SE436283B (en)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4166901A (en) * 1978-01-03 1979-09-04 Pfizer Inc. 4"-Deoxy-4"-arylglyoxamido- and aroylthioformamido derivatives of oleandomycin and its esters
US4180654A (en) * 1978-01-03 1979-12-25 Pfizer Inc. 4"-Deoxy-4"-acylamido derivatives of oleandomycin, erythromycin and erythromycin carbonate

Also Published As

Publication number Publication date
NZ183235A (en) 1978-11-13
AR212524A1 (en) 1978-07-31
SE8004873L (en) 1980-07-01
FR2342989A1 (en) 1977-09-30
SE436283B (en) 1984-11-26
DK146778B (en) 1984-01-02
ATA62777A (en) 1978-05-15
CA1069503A (en) 1980-01-08
DE2660089B1 (en) 1980-03-20
NL170151B (en) 1982-05-03
FI770440A (en) 1977-09-04
IE44509L (en) 1977-09-03
SE7700786L (en) 1977-10-03
ES455805A1 (en) 1978-04-01
IE44509B1 (en) 1981-12-30
DK146778C (en) 1984-06-12
DE2654627C3 (en) 1980-07-31
FR2342989B1 (en) 1980-07-04
SE436284B (en) 1984-11-26
IL51361A (en) 1979-10-31
DE2660089C2 (en) 1980-11-06
DD129789A5 (en) 1978-02-08
LU76764A1 (en) 1977-08-19
NL7701401A (en) 1977-09-06
RO72560A (en) 1983-07-07
BG27913A3 (en) 1980-01-15
IL51361A0 (en) 1977-03-31
AT347586B (en) 1979-01-10
DK57177A (en) 1977-09-04
PT66157A (en) 1977-03-01
JPS552437B2 (en) 1980-01-19
BG27914A4 (en) 1980-01-15
JPS52106880A (en) 1977-09-07
DE2654627A1 (en) 1977-09-08
PT66157B (en) 1978-07-10
DE2654627B2 (en) 1979-11-29
NL170151C (en) 1982-10-01
PH13171A (en) 1980-01-08
GB1567390A (en) 1980-05-14
AU2200677A (en) 1978-05-18
RO76882A (en) 1981-08-17

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