SE7709482L - METHOD OF PREPARING NEW 0- (3-AMINO-2-HYDROXIPROPYL) -AMIDOXIMI DERIVATIVES - Google Patents

METHOD OF PREPARING NEW 0- (3-AMINO-2-HYDROXIPROPYL) -AMIDOXIMI DERIVATIVES

Info

Publication number
SE7709482L
SE7709482L SE7709482A SE7709482A SE7709482L SE 7709482 L SE7709482 L SE 7709482L SE 7709482 A SE7709482 A SE 7709482A SE 7709482 A SE7709482 A SE 7709482A SE 7709482 L SE7709482 L SE 7709482L
Authority
SE
Sweden
Prior art keywords
formula
amino
reacting
amidoxime
amidoximi
Prior art date
Application number
SE7709482A
Other languages
Swedish (sv)
Other versions
SE435280B (en
Inventor
K Takacs
P Literati
I Kiss
A Simay
M Szentivanyi
S Virag
K Farago
Original Assignee
Chinoin Gyogyszer Es Vegyeszet
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Chinoin Gyogyszer Es Vegyeszet filed Critical Chinoin Gyogyszer Es Vegyeszet
Publication of SE7709482L publication Critical patent/SE7709482L/en
Publication of SE435280B publication Critical patent/SE435280B/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C259/00—Compounds containing carboxyl groups, an oxygen atom of a carboxyl group being replaced by a nitrogen atom, this nitrogen atom being further bound to an oxygen atom and not being part of nitro or nitroso groups
    • C07C259/12—Compounds containing carboxyl groups, an oxygen atom of a carboxyl group being replaced by a nitrogen atom, this nitrogen atom being further bound to an oxygen atom and not being part of nitro or nitroso groups with replacement of the other oxygen atom of the carboxyl group by nitrogen atoms, e.g. N-hydroxyamidines
    • C07C259/14—Compounds containing carboxyl groups, an oxygen atom of a carboxyl group being replaced by a nitrogen atom, this nitrogen atom being further bound to an oxygen atom and not being part of nitro or nitroso groups with replacement of the other oxygen atom of the carboxyl group by nitrogen atoms, e.g. N-hydroxyamidines having carbon atoms of hydroxamidine groups bound to hydrogen atoms or to acyclic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
    • C07D217/02—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with only hydrogen atoms or radicals containing only carbon and hydrogen atoms, directly attached to carbon atoms of the nitrogen-containing ring; Alkylene-bis-isoquinolines
    • C07D217/04—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with only hydrogen atoms or radicals containing only carbon and hydrogen atoms, directly attached to carbon atoms of the nitrogen-containing ring; Alkylene-bis-isoquinolines with hydrocarbon or substituted hydrocarbon radicals attached to the ring nitrogen atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/08—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms
    • C07D295/084—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
    • C07D295/088—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings to an acyclic saturated chain

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Diabetes (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Emergency Medicine (AREA)
  • Endocrinology (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Cardiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pyrrole Compounds (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)
  • Pyridine Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Quinoline Compounds (AREA)

Abstract

The compounds of general formula I, wherein R<1> to R<5>, m and n have the meaning given in Claim 1, are valuable medicaments which are suitable for the treatment of diabetic angiopathy. They are prepared by either reacting an amidoxime of formula II with epichlorohydrin to give an epoxide of formula IV and then reacting the epoxide with an amine of formula III or by directly reacting the amidoxime of formula II with a 3-amino-2-hydroxy-1-halogenopropane of formula Va, wherein X represents halogen, or a 3-amino-1,2-epoxypropane of formula Vb. Compounds of formula I, wherein R<1> denotes hydrogen, are also prepared by reacting an amidoxime of formula II with a 2-phenyl-5-halogenomethyloxazolidine of formula VI, wherein X represents halogen, after which the ring compound obtained, of formula VII, is cleaved hydrolytically. <IMAGE>
SE7709482A 1976-08-27 1977-08-23 SET TO MAKE NEW 0- (3-AMINO-2-HYDROXYPROPYL) -AMIDOXIME DERIVATIVES SE435280B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
HU76CI1682A HU177578B (en) 1976-08-27 1976-08-27 Process for preparing new 0-/3-amino-2-hydroxy-propyl/-amidoxime derivatives

Publications (2)

Publication Number Publication Date
SE7709482L true SE7709482L (en) 1978-02-28
SE435280B SE435280B (en) 1984-09-17

Family

ID=10994625

Family Applications (1)

Application Number Title Priority Date Filing Date
SE7709482A SE435280B (en) 1976-08-27 1977-08-23 SET TO MAKE NEW 0- (3-AMINO-2-HYDROXYPROPYL) -AMIDOXIME DERIVATIVES

Country Status (23)

Country Link
JP (1) JPS5350131A (en)
AT (1) AT355554B (en)
AU (1) AU521432B2 (en)
BE (1) BE858134A (en)
CA (1) CA1077506A (en)
CH (1) CH630344A5 (en)
CS (1) CS204008B2 (en)
DD (1) DD132433A5 (en)
DE (1) DE2738589A1 (en)
DK (1) DK150196C (en)
ES (1) ES462346A1 (en)
FI (1) FI68396C (en)
FR (1) FR2362845A1 (en)
GB (1) GB1582029A (en)
GR (1) GR63623B (en)
HU (1) HU177578B (en)
IL (1) IL52804A (en)
NL (1) NL187478C (en)
NO (1) NO144793C (en)
PL (1) PL107628B1 (en)
SE (1) SE435280B (en)
SU (1) SU730296A3 (en)
YU (2) YU202377A (en)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4849522A (en) * 1983-11-03 1989-07-18 Merrell Dow Pharmaceuticals Novel alkoxyimino ether derivatives of 5-acyl-2(1H)-pyridinones
ZA848428B (en) * 1983-11-03 1985-06-26 Merrell Pharma Inc Novel alkoxyimino ether derivatives of 5-acyl-2(1h)-pyridiones
US5212314A (en) * 1983-11-03 1993-05-18 Merrell Dow Pharmaceuticals Inc. Alkoxyimino ether derivatives of 5-acyl-2(1H)-pyridinones
JPH01169445A (en) * 1987-12-25 1989-07-04 Fuji Photo Film Co Ltd Focal distance switching camera
HU207988B (en) * 1988-10-20 1993-07-28 Biorex Kutato Fejlesztoe Kft Process for producing halogenides of o-/3-amino-2-hydroxy-propyl/hydroximic acid and pharmaceutical compositions containing them as active components
HUT54347A (en) * 1989-01-10 1991-02-28 Chinoin Gyogyszer Es Vegyeszet Improved process for producing amidoximes
HU222994B1 (en) * 1995-11-02 2004-01-28 BIOREX Kutató és Fejlesztő Rt. Hydroxylamine derivatives and use thereof in the preparation of a pharmaceutical compositions for enhancing of molecular chaperon production of cells
HUT78139A (en) * 1995-12-22 2000-11-28 BIOREX Kutató és Fejlesztő Rt. Composition for reducing skin state aging
ATE272625T1 (en) 1998-05-11 2004-08-15 Takeda Chemical Industries Ltd OXYIMINOALKANEOUS ACID DERIVATIVES WITH HYPOGLYCEMIC AND HYPOLIPIDEMIC EFFECTS
AU5296799A (en) * 1998-08-03 2000-02-28 N-Gene Kutato Kft. Pharmaceutical compositions against autoimmune diseases
KR20040089102A (en) 2002-01-11 2004-10-20 비오렉스 쿠타토 에쉬 훼레스테 에르테 Carboxamidine derivatives and their use in the treatment of vascular diseases
HUP0303584A3 (en) 2003-10-30 2009-12-28 Cytrx Corp Use of a hydroximic acid halide derivative in the treatment of neurodegenerative diseases
IL303026A (en) 2020-11-19 2023-07-01 Zevra Denmark As Processes for preparing arimoclomol citrate and intermediates thereof

Also Published As

Publication number Publication date
AU2825477A (en) 1979-03-01
JPS6216942B2 (en) 1987-04-15
JPS5350131A (en) 1978-05-08
DK150196C (en) 1987-07-06
CS204008B2 (en) 1981-03-31
PL107628B1 (en) 1980-02-29
DK150196B (en) 1987-01-05
HU177578B (en) 1981-11-28
FI772551A (en) 1978-02-28
CH630344A5 (en) 1982-06-15
GB1582029A (en) 1980-12-31
FI68396B (en) 1985-05-31
SU730296A3 (en) 1980-04-25
ATA605477A (en) 1979-08-15
YU237782A (en) 1983-12-31
DD132433A5 (en) 1978-09-27
FR2362845A1 (en) 1978-03-24
IL52804A0 (en) 1977-10-31
NO772958L (en) 1978-02-28
NL187478C (en) 1991-10-16
IL52804A (en) 1981-06-29
DK379777A (en) 1978-02-28
YU202377A (en) 1983-12-31
NO144793B (en) 1981-08-03
NO144793C (en) 1981-11-11
BE858134A (en) 1977-12-16
SE435280B (en) 1984-09-17
CA1077506A (en) 1980-05-13
NL7709276A (en) 1978-03-01
FR2362845B1 (en) 1981-01-09
FI68396C (en) 1985-09-10
ES462346A1 (en) 1978-06-16
AU521432B2 (en) 1982-04-01
DE2738589A1 (en) 1978-03-02
AT355554B (en) 1980-03-10
GR63623B (en) 1979-11-27

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