DK379777A - O- (3-AMINO-2-HYDROXYPROPYL) -AMIDOXIMI DERIVATIVES THEIR PREPARATION AND USE - Google Patents

O- (3-AMINO-2-HYDROXYPROPYL) -AMIDOXIMI DERIVATIVES THEIR PREPARATION AND USE

Info

Publication number
DK379777A
DK379777A DK379777A DK379777A DK379777A DK 379777 A DK379777 A DK 379777A DK 379777 A DK379777 A DK 379777A DK 379777 A DK379777 A DK 379777A DK 379777 A DK379777 A DK 379777A
Authority
DK
Denmark
Prior art keywords
amidoximi
hydroxypropyl
derivatives
amino
preparation
Prior art date
Application number
DK379777A
Other languages
Danish (da)
Other versions
DK150196C (en
DK150196B (en
Inventor
K Takacs
P L Nagy
I Kiss
A Simay
M Szentivanyi
S Virag
K Farago
Original Assignee
Chinoin Gyogyszer Es Vegyeszet
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Chinoin Gyogyszer Es Vegyeszet filed Critical Chinoin Gyogyszer Es Vegyeszet
Publication of DK379777A publication Critical patent/DK379777A/en
Publication of DK150196B publication Critical patent/DK150196B/en
Application granted granted Critical
Publication of DK150196C publication Critical patent/DK150196C/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C259/00—Compounds containing carboxyl groups, an oxygen atom of a carboxyl group being replaced by a nitrogen atom, this nitrogen atom being further bound to an oxygen atom and not being part of nitro or nitroso groups
    • C07C259/12—Compounds containing carboxyl groups, an oxygen atom of a carboxyl group being replaced by a nitrogen atom, this nitrogen atom being further bound to an oxygen atom and not being part of nitro or nitroso groups with replacement of the other oxygen atom of the carboxyl group by nitrogen atoms, e.g. N-hydroxyamidines
    • C07C259/14—Compounds containing carboxyl groups, an oxygen atom of a carboxyl group being replaced by a nitrogen atom, this nitrogen atom being further bound to an oxygen atom and not being part of nitro or nitroso groups with replacement of the other oxygen atom of the carboxyl group by nitrogen atoms, e.g. N-hydroxyamidines having carbon atoms of hydroxamidine groups bound to hydrogen atoms or to acyclic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
    • C07D217/02—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with only hydrogen atoms or radicals containing only carbon and hydrogen atoms, directly attached to carbon atoms of the nitrogen-containing ring; Alkylene-bis-isoquinolines
    • C07D217/04—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with only hydrogen atoms or radicals containing only carbon and hydrogen atoms, directly attached to carbon atoms of the nitrogen-containing ring; Alkylene-bis-isoquinolines with hydrocarbon or substituted hydrocarbon radicals attached to the ring nitrogen atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/08—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms
    • C07D295/084—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
    • C07D295/088—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings to an acyclic saturated chain

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Diabetes (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Obesity (AREA)
  • Endocrinology (AREA)
  • Emergency Medicine (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hematology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pyrrole Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Pyridine Compounds (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)
  • Quinoline Compounds (AREA)
DK379777A 1976-08-27 1977-08-26 METHOD OF ANALOGUE FOR THE PREPARATION OF 0- (3-AMINO-2-HYDROXYPROPYL) AMIDOXIME DERIVATIVES OR PHARMACEUTICAL ACCEPTABLE SALTS THEREOF DK150196C (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
HU76CI1682A HU177578B (en) 1976-08-27 1976-08-27 Process for preparing new 0-/3-amino-2-hydroxy-propyl/-amidoxime derivatives
HUCI001682 1976-08-27

Publications (3)

Publication Number Publication Date
DK379777A true DK379777A (en) 1978-02-28
DK150196B DK150196B (en) 1987-01-05
DK150196C DK150196C (en) 1987-07-06

Family

ID=10994625

Family Applications (1)

Application Number Title Priority Date Filing Date
DK379777A DK150196C (en) 1976-08-27 1977-08-26 METHOD OF ANALOGUE FOR THE PREPARATION OF 0- (3-AMINO-2-HYDROXYPROPYL) AMIDOXIME DERIVATIVES OR PHARMACEUTICAL ACCEPTABLE SALTS THEREOF

Country Status (23)

Country Link
JP (1) JPS5350131A (en)
AT (1) AT355554B (en)
AU (1) AU521432B2 (en)
BE (1) BE858134A (en)
CA (1) CA1077506A (en)
CH (1) CH630344A5 (en)
CS (1) CS204008B2 (en)
DD (1) DD132433A5 (en)
DE (1) DE2738589A1 (en)
DK (1) DK150196C (en)
ES (1) ES462346A1 (en)
FI (1) FI68396C (en)
FR (1) FR2362845A1 (en)
GB (1) GB1582029A (en)
GR (1) GR63623B (en)
HU (1) HU177578B (en)
IL (1) IL52804A (en)
NL (1) NL187478C (en)
NO (1) NO144793C (en)
PL (1) PL107628B1 (en)
SE (1) SE435280B (en)
SU (1) SU730296A3 (en)
YU (2) YU202377A (en)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5212314A (en) * 1983-11-03 1993-05-18 Merrell Dow Pharmaceuticals Inc. Alkoxyimino ether derivatives of 5-acyl-2(1H)-pyridinones
ZA848428B (en) * 1983-11-03 1985-06-26 Merrell Pharma Inc Novel alkoxyimino ether derivatives of 5-acyl-2(1h)-pyridiones
US4849522A (en) * 1983-11-03 1989-07-18 Merrell Dow Pharmaceuticals Novel alkoxyimino ether derivatives of 5-acyl-2(1H)-pyridinones
JPH01169445A (en) * 1987-12-25 1989-07-04 Fuji Photo Film Co Ltd Focal distance switching camera
HU207988B (en) * 1988-10-20 1993-07-28 Biorex Kutato Fejlesztoe Kft Process for producing halogenides of o-/3-amino-2-hydroxy-propyl/hydroximic acid and pharmaceutical compositions containing them as active components
HUT54347A (en) * 1989-01-10 1991-02-28 Chinoin Gyogyszer Es Vegyeszet Improved process for producing amidoximes
HU222994B1 (en) 1995-11-02 2004-01-28 BIOREX Kutató és Fejlesztő Rt. Hydroxylamine derivatives and use thereof in the preparation of a pharmaceutical compositions for enhancing of molecular chaperon production of cells
HUT78139A (en) * 1995-12-22 2000-11-28 BIOREX Kutató és Fejlesztő Rt. Composition for reducing skin state aging
KR100388120B1 (en) 1998-05-11 2003-06-18 다케다 야쿠힌 고교 가부시키가이샤 Oxyiminoalkanoic acid derivatives with hypoglycemic and hypolipidemic activity
AU5296799A (en) * 1998-08-03 2000-02-28 N-Gene Kutato Kft. Pharmaceutical compositions against autoimmune diseases
NZ533795A (en) 2002-01-11 2006-03-31 Biorex Kutato Fejlesztoe Kft Carboxamidine derivatives and their use in the treatment of vascular diseases
HUP0303584A3 (en) 2003-10-30 2009-12-28 Cytrx Corp Use of a hydroximic acid halide derivative in the treatment of neurodegenerative diseases
EP4247792A1 (en) 2020-11-19 2023-09-27 Zevra Denmark A/S Processes for preparing arimoclomol citrate and intermediates thereof

Also Published As

Publication number Publication date
NO772958L (en) 1978-02-28
ES462346A1 (en) 1978-06-16
DK150196C (en) 1987-07-06
GR63623B (en) 1979-11-27
BE858134A (en) 1977-12-16
NL187478C (en) 1991-10-16
IL52804A (en) 1981-06-29
FR2362845A1 (en) 1978-03-24
SU730296A3 (en) 1980-04-25
FI68396C (en) 1985-09-10
DK150196B (en) 1987-01-05
FI772551A (en) 1978-02-28
YU202377A (en) 1983-12-31
HU177578B (en) 1981-11-28
SE7709482L (en) 1978-02-28
JPS5350131A (en) 1978-05-08
YU237782A (en) 1983-12-31
NO144793C (en) 1981-11-11
AU521432B2 (en) 1982-04-01
AT355554B (en) 1980-03-10
NL7709276A (en) 1978-03-01
ATA605477A (en) 1979-08-15
IL52804A0 (en) 1977-10-31
SE435280B (en) 1984-09-17
CH630344A5 (en) 1982-06-15
DE2738589A1 (en) 1978-03-02
CS204008B2 (en) 1981-03-31
PL107628B1 (en) 1980-02-29
DD132433A5 (en) 1978-09-27
AU2825477A (en) 1979-03-01
GB1582029A (en) 1980-12-31
FI68396B (en) 1985-05-31
NO144793B (en) 1981-08-03
CA1077506A (en) 1980-05-13
JPS6216942B2 (en) 1987-04-15
FR2362845B1 (en) 1981-01-09

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Legal Events

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PBP Patent lapsed