SE7706245L - PROCEDURE FOR PRODUCTION OF PROSTACYCLIN DERIVATIVES - Google Patents
PROCEDURE FOR PRODUCTION OF PROSTACYCLIN DERIVATIVESInfo
- Publication number
- SE7706245L SE7706245L SE7706245A SE7706245A SE7706245L SE 7706245 L SE7706245 L SE 7706245L SE 7706245 A SE7706245 A SE 7706245A SE 7706245 A SE7706245 A SE 7706245A SE 7706245 L SE7706245 L SE 7706245L
- Authority
- SE
- Sweden
- Prior art keywords
- compound
- procedure
- production
- compounds
- formula
- Prior art date
Links
- KAQKFAOMNZTLHT-VVUHWYTRSA-N epoprostenol Chemical class O1C(=CCCCC(O)=O)C[C@@H]2[C@@H](/C=C/[C@@H](O)CCCCC)[C@H](O)C[C@@H]21 KAQKFAOMNZTLHT-VVUHWYTRSA-N 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 4
- RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 abstract 2
- 239000007795 chemical reaction product Substances 0.000 abstract 2
- RJADQDXZYFCVHV-JQMWNLLFSA-N 5-[(2s,4r,5r,6ar)-5-hydroxy-4-[(e,3s)-3-hydroxyoct-1-enyl]-3,3a,4,5,6,6a-hexahydro-2h-cyclopenta[b]furan-2-yl]pentanoic acid Chemical class O1[C@@H](CCCCC(O)=O)CC2[C@@H](/C=C/[C@@H](O)CCCCC)[C@H](O)C[C@H]21 RJADQDXZYFCVHV-JQMWNLLFSA-N 0.000 abstract 1
- 230000015572 biosynthetic process Effects 0.000 abstract 1
- 230000002140 halogenating effect Effects 0.000 abstract 1
- QSHDDOUJBYECFT-UHFFFAOYSA-N mercury Chemical compound [Hg] QSHDDOUJBYECFT-UHFFFAOYSA-N 0.000 abstract 1
- 229910052753 mercury Inorganic materials 0.000 abstract 1
- 229940100892 mercury compound Drugs 0.000 abstract 1
- 150000002731 mercury compounds Chemical class 0.000 abstract 1
- 229940094443 oxytocics prostaglandins Drugs 0.000 abstract 1
- 230000000144 pharmacologic effect Effects 0.000 abstract 1
- 150000003180 prostaglandins Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D307/93—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems condensed with a ring other than six-membered
- C07D307/935—Not further condensed cyclopenta [b] furans or hydrogenated cyclopenta [b] furans
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C405/00—Compounds containing a five-membered ring having two side-chains in ortho position to each other, and having oxygen atoms directly attached to the ring in ortho position to one of the side-chains, one side-chain containing, not directly attached to the ring, a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, and the other side-chain having oxygen atoms attached in gamma-position to the ring, e.g. prostaglandins ; Analogues or derivatives thereof
- C07C405/0008—Analogues having the carboxyl group in the side-chains replaced by other functional groups
- C07C405/0041—Analogues having the carboxyl group in the side-chains replaced by other functional groups containing nitrogen
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D307/93—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems condensed with a ring other than six-membered
- C07D307/935—Not further condensed cyclopenta [b] furans or hydrogenated cyclopenta [b] furans
- C07D307/937—Not further condensed cyclopenta [b] furans or hydrogenated cyclopenta [b] furans with hydrocarbon or substituted hydrocarbon radicals directly attached in position 2, e.g. prostacyclins
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F3/00—Compounds containing elements of Groups 2 or 12 of the Periodic Table
- C07F3/10—Mercury compounds
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Pharmacology & Pharmacy (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Furan Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
Analogues of 5,6-dihydroprostacyclin of the formula <IMAGE> in which the substituents are defined in claim 1, are prepared. These compounds are obtained by halogenating and cyclising a compound of the formula <IMAGE> and subsequently reductively dehalogenating the reaction product, with the formation of the desired ether, or by converting the said compound LXII into a corresponding mercury compound and then subjecting the reaction product to the removal of mercury by reduction. The compounds which are obtained may be used for the same pharmacological purposes as the known prostaglandins.
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US69139976A | 1976-06-01 | 1976-06-01 | |
| US69140076A | 1976-06-01 | 1976-06-01 | |
| US78814677A | 1977-04-19 | 1977-04-19 | |
| US78814777A | 1977-04-19 | 1977-04-19 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| SE7706245L true SE7706245L (en) | 1977-12-16 |
| SE436744B SE436744B (en) | 1985-01-21 |
Family
ID=27505431
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SE7706245A SE436744B (en) | 1976-06-01 | 1977-05-27 | PROCEDURE FOR THE PREPARATION OF PROSTACYCLINE DERIVATIVES |
| SE7811142A SE432101B (en) | 1976-06-01 | 1978-10-26 | PROSTACYCLINE DERIVATIVES FOR USE TO REGULATE THE REPRODUCTION CYCLE OF MENSTRUCTING DOGS |
| SE8201649A SE8201649L (en) | 1976-06-01 | 1982-03-16 | PROCEDURE FOR THE PREPARATION OF PROSTACYCLINE DERIVATIVES |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SE7811142A SE432101B (en) | 1976-06-01 | 1978-10-26 | PROSTACYCLINE DERIVATIVES FOR USE TO REGULATE THE REPRODUCTION CYCLE OF MENSTRUCTING DOGS |
| SE8201649A SE8201649L (en) | 1976-06-01 | 1982-03-16 | PROCEDURE FOR THE PREPARATION OF PROSTACYCLINE DERIVATIVES |
Country Status (13)
| Country | Link |
|---|---|
| JP (1) | JPS5936912B2 (en) |
| AU (1) | AU508891B2 (en) |
| BE (1) | BE855224A (en) |
| CA (1) | CA1196632A (en) |
| CH (1) | CH640847A5 (en) |
| DE (1) | DE2724555A1 (en) |
| FR (1) | FR2353543B1 (en) |
| GB (1) | GB1554048A (en) |
| IE (1) | IE45604B1 (en) |
| IL (1) | IL52099A (en) |
| MX (1) | MX4813E (en) |
| NL (1) | NL7705991A (en) |
| SE (3) | SE436744B (en) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IL51189A (en) * | 1976-02-04 | 1985-08-30 | Upjohn Co | Prostaglandin analogs |
| FI71138C (en) | 1976-12-31 | 1986-11-24 | Erba Farmitalia | FOERFARANDE FOER FRAMSTAELLNING AV TERAPEUTISKT ACTIVE BISYCLISKA PROSTAGLANDINER |
| AU524786B2 (en) * | 1977-03-07 | 1982-10-07 | The Upjohn Company | Prostacyclins |
| DE2743283A1 (en) * | 1977-09-27 | 1979-04-05 | Hoechst Ag | NEW PROSTACYCLIN ANALOG |
| DE2811950A1 (en) * | 1978-03-18 | 1979-12-13 | Hoechst Ag | NEW PROSTACYCLIN ANALOGS |
| US4237060A (en) | 1979-03-23 | 1980-12-02 | Hoffmann-La Roche Inc. | Prostacyclin analogs |
| CN1377263A (en) * | 1999-08-05 | 2002-10-30 | 帝人株式会社 | Neuropathy improves containing nitrogenous compounds as the active ingredient |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IT1079025B (en) * | 1976-05-11 | 1985-05-08 | Wellcome Found | IMPROVEMENT IN THE PREPARATION OF ETERI |
-
1977
- 1977-04-10 MX MX77100668U patent/MX4813E/en unknown
- 1977-05-11 AU AU25086/77A patent/AU508891B2/en not_active Ceased
- 1977-05-16 IL IL52099A patent/IL52099A/en unknown
- 1977-05-20 GB GB21363/77A patent/GB1554048A/en not_active Expired
- 1977-05-25 CA CA000279106A patent/CA1196632A/en not_active Expired
- 1977-05-27 SE SE7706245A patent/SE436744B/en not_active IP Right Cessation
- 1977-05-27 CH CH660877A patent/CH640847A5/en not_active IP Right Cessation
- 1977-05-31 FR FR7716615A patent/FR2353543B1/en not_active Expired
- 1977-05-31 DE DE19772724555 patent/DE2724555A1/en not_active Withdrawn
- 1977-05-31 BE BE178059A patent/BE855224A/en not_active IP Right Cessation
- 1977-06-01 IE IE1133/77A patent/IE45604B1/en unknown
- 1977-06-01 NL NL7705991A patent/NL7705991A/en not_active Application Discontinuation
- 1977-06-01 JP JP52063395A patent/JPS5936912B2/en not_active Expired
-
1978
- 1978-10-26 SE SE7811142A patent/SE432101B/en unknown
-
1982
- 1982-03-16 SE SE8201649A patent/SE8201649L/en not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| CA1196632A (en) | 1985-11-12 |
| SE8201649L (en) | 1982-03-16 |
| FR2353543B1 (en) | 1986-02-21 |
| IL52099A (en) | 1985-03-31 |
| SE436744B (en) | 1985-01-21 |
| AU508891B2 (en) | 1980-04-03 |
| IE45604B1 (en) | 1982-10-06 |
| DE2724555A1 (en) | 1977-12-15 |
| JPS52156854A (en) | 1977-12-27 |
| JPS5936912B2 (en) | 1984-09-06 |
| SE7811142L (en) | 1978-11-28 |
| FR2353543A1 (en) | 1977-12-30 |
| BE855224A (en) | 1977-11-30 |
| AU2508677A (en) | 1978-11-16 |
| IL52099A0 (en) | 1977-07-31 |
| CH640847A5 (en) | 1984-01-31 |
| GB1554048A (en) | 1979-10-17 |
| SE432101B (en) | 1984-03-19 |
| MX4813E (en) | 1982-10-19 |
| IE45604L (en) | 1977-12-01 |
| NL7705991A (en) | 1977-12-05 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| NUG | Patent has lapsed |
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