GB1525372A - 4-deacetoxyvincristine - Google Patents

4-deacetoxyvincristine

Info

Publication number
GB1525372A
GB1525372A GB7677/77A GB767777A GB1525372A GB 1525372 A GB1525372 A GB 1525372A GB 7677/77 A GB7677/77 A GB 7677/77A GB 767777 A GB767777 A GB 767777A GB 1525372 A GB1525372 A GB 1525372A
Authority
GB
United Kingdom
Prior art keywords
compound
deacetoxyvincristine
acid addition
addition salts
deacetoxyvinblastine
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB7677/77A
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Richter Gedeon Vegyeszeti Gyar Nyrt
Original Assignee
Richter Gedeon Vegyeszeti Gyar RT
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Richter Gedeon Vegyeszeti Gyar RT filed Critical Richter Gedeon Vegyeszeti Gyar RT
Publication of GB1525372A publication Critical patent/GB1525372A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
    • C07D519/04—Dimeric indole alkaloids, e.g. vincaleucoblastine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

Abstract

4-Deacetoxyvincristine and acid addition salts of this compound are obtained by subjecting 4-deacetoxyvinblastine to oxydative formylation and converting the resulting compound where appropriate into its acid addition salts. This compound which can be prepared according to the invention has, for example, excellent cytostatic properties and is less toxic than vincristine, which has similar actions.
GB7677/77A 1976-02-24 1977-02-23 4-deacetoxyvincristine Expired GB1525372A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
HU76RI00000586A HU172183B (en) 1976-02-24 1976-02-24 Process for producing 4-deacetoxy-vinchristine and acid additional salts

Publications (1)

Publication Number Publication Date
GB1525372A true GB1525372A (en) 1978-09-20

Family

ID=11000995

Family Applications (1)

Application Number Title Priority Date Filing Date
GB7677/77A Expired GB1525372A (en) 1976-02-24 1977-02-23 4-deacetoxyvincristine

Country Status (15)

Country Link
JP (1) JPS52102300A (en)
AT (1) AT353429B (en)
AU (1) AU506508B2 (en)
BE (1) BE851697A (en)
CA (1) CA1094551A (en)
CH (1) CH627185A5 (en)
DE (1) DE2706366A1 (en)
DK (1) DK142815B (en)
FR (1) FR2342295A1 (en)
GB (1) GB1525372A (en)
HU (1) HU172183B (en)
IL (1) IL51486A (en)
NL (1) NL7701948A (en)
SE (1) SE430694B (en)
SU (1) SU673174A3 (en)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN112521408A (en) * 2020-12-16 2021-03-19 广州白云山汉方现代药业有限公司 Bisindole alkaloid compound and preparation method and application thereof
CN114933604A (en) * 2021-12-10 2022-08-23 广州白云山汉方现代药业有限公司 Vincristine chiral compound impurity and preparation method and application thereof

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5891011A (en) * 1981-11-25 1983-05-30 Toshiba Ceramics Co Ltd Manufacture of silicon nitride powder with high alpha-phase content

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN112521408A (en) * 2020-12-16 2021-03-19 广州白云山汉方现代药业有限公司 Bisindole alkaloid compound and preparation method and application thereof
CN114933604A (en) * 2021-12-10 2022-08-23 广州白云山汉方现代药业有限公司 Vincristine chiral compound impurity and preparation method and application thereof

Also Published As

Publication number Publication date
DK142815C (en) 1981-08-24
BE851697A (en) 1977-06-16
IL51486A (en) 1979-10-31
FR2342295B1 (en) 1980-09-05
SE7701377L (en) 1977-08-25
AU2217377A (en) 1978-08-17
SU673174A3 (en) 1979-07-05
FR2342295A1 (en) 1977-09-23
DK78777A (en) 1977-08-25
DE2706366A1 (en) 1977-08-25
HU172183B (en) 1978-06-28
CA1094551A (en) 1981-01-27
AU506508B2 (en) 1980-01-10
AT353429B (en) 1979-11-12
IL51486A0 (en) 1977-04-29
CH627185A5 (en) 1981-12-31
JPS52102300A (en) 1977-08-27
NL7701948A (en) 1977-08-26
ATA84177A (en) 1979-04-15
DK142815B (en) 1981-02-02
SE430694B (en) 1983-12-05

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Legal Events

Date Code Title Description
PS Patent sealed [section 19, patents act 1949]
PCNP Patent ceased through non-payment of renewal fee