SE7701377L - METHOD OF PREPARING 4-DESACETOXIVINE CHRISTINE AND ACID ADDITIONAL SALTS THEREOF - Google Patents

METHOD OF PREPARING 4-DESACETOXIVINE CHRISTINE AND ACID ADDITIONAL SALTS THEREOF

Info

Publication number
SE7701377L
SE7701377L SE7701377A SE7701377A SE7701377L SE 7701377 L SE7701377 L SE 7701377L SE 7701377 A SE7701377 A SE 7701377A SE 7701377 A SE7701377 A SE 7701377A SE 7701377 L SE7701377 L SE 7701377L
Authority
SE
Sweden
Prior art keywords
desacetoxivine
christine
preparing
additional salts
acid additional
Prior art date
Application number
SE7701377A
Other languages
Swedish (sv)
Other versions
SE430694B (en
Inventor
K Jovanovics
L Dancsi
S Eckhardt
C Lorincz
J Sugar
Z Relle
K Szasz
J Tamas
A Szollosy
Original Assignee
Richter Gedeon Vegyeszet
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Richter Gedeon Vegyeszet filed Critical Richter Gedeon Vegyeszet
Publication of SE7701377L publication Critical patent/SE7701377L/en
Publication of SE430694B publication Critical patent/SE430694B/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
    • C07D519/04—Dimeric indole alkaloids, e.g. vincaleucoblastine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

Abstract

4-Deacetoxyvincristine and acid addition salts of this compound are obtained by subjecting 4-deacetoxyvinblastine to oxydative formylation and converting the resulting compound where appropriate into its acid addition salts. This compound which can be prepared according to the invention has, for example, excellent cytostatic properties and is less toxic than vincristine, which has similar actions.
SE7701377A 1976-02-24 1977-02-08 SET TO MAKE 4-DESACETOXIVINKRISTIN SE430694B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
HU76RI00000586A HU172183B (en) 1976-02-24 1976-02-24 Process for producing 4-deacetoxy-vinchristine and acid additional salts

Publications (2)

Publication Number Publication Date
SE7701377L true SE7701377L (en) 1977-08-25
SE430694B SE430694B (en) 1983-12-05

Family

ID=11000995

Family Applications (1)

Application Number Title Priority Date Filing Date
SE7701377A SE430694B (en) 1976-02-24 1977-02-08 SET TO MAKE 4-DESACETOXIVINKRISTIN

Country Status (15)

Country Link
JP (1) JPS52102300A (en)
AT (1) AT353429B (en)
AU (1) AU506508B2 (en)
BE (1) BE851697A (en)
CA (1) CA1094551A (en)
CH (1) CH627185A5 (en)
DE (1) DE2706366A1 (en)
DK (1) DK142815B (en)
FR (1) FR2342295A1 (en)
GB (1) GB1525372A (en)
HU (1) HU172183B (en)
IL (1) IL51486A (en)
NL (1) NL7701948A (en)
SE (1) SE430694B (en)
SU (1) SU673174A3 (en)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5891011A (en) * 1981-11-25 1983-05-30 Toshiba Ceramics Co Ltd Manufacture of silicon nitride powder with high alpha-phase content
CN112521408B (en) * 2020-12-16 2022-05-17 广州白云山汉方现代药业有限公司 Bisindole alkaloid compound and preparation method and application thereof
CN114933604A (en) * 2021-12-10 2022-08-23 广州白云山汉方现代药业有限公司 Vincristine chiral compound impurity and preparation method and application thereof

Also Published As

Publication number Publication date
SU673174A3 (en) 1979-07-05
CH627185A5 (en) 1981-12-31
DE2706366A1 (en) 1977-08-25
BE851697A (en) 1977-06-16
GB1525372A (en) 1978-09-20
JPS52102300A (en) 1977-08-27
SE430694B (en) 1983-12-05
AU2217377A (en) 1978-08-17
FR2342295A1 (en) 1977-09-23
HU172183B (en) 1978-06-28
NL7701948A (en) 1977-08-26
AT353429B (en) 1979-11-12
IL51486A0 (en) 1977-04-29
ATA84177A (en) 1979-04-15
CA1094551A (en) 1981-01-27
IL51486A (en) 1979-10-31
DK142815B (en) 1981-02-02
AU506508B2 (en) 1980-01-10
DK142815C (en) 1981-08-24
DK78777A (en) 1977-08-25
FR2342295B1 (en) 1980-09-05

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