SE7701377L - METHOD OF PREPARING 4-DESACETOXIVINE CHRISTINE AND ACID ADDITIONAL SALTS THEREOF - Google Patents
METHOD OF PREPARING 4-DESACETOXIVINE CHRISTINE AND ACID ADDITIONAL SALTS THEREOFInfo
- Publication number
- SE7701377L SE7701377L SE7701377A SE7701377A SE7701377L SE 7701377 L SE7701377 L SE 7701377L SE 7701377 A SE7701377 A SE 7701377A SE 7701377 A SE7701377 A SE 7701377A SE 7701377 L SE7701377 L SE 7701377L
- Authority
- SE
- Sweden
- Prior art keywords
- desacetoxivine
- christine
- preparing
- additional salts
- acid additional
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
- C07D519/04—Dimeric indole alkaloids, e.g. vincaleucoblastine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Abstract
4-Deacetoxyvincristine and acid addition salts of this compound are obtained by subjecting 4-deacetoxyvinblastine to oxydative formylation and converting the resulting compound where appropriate into its acid addition salts. This compound which can be prepared according to the invention has, for example, excellent cytostatic properties and is less toxic than vincristine, which has similar actions.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
HU76RI00000586A HU172183B (en) | 1976-02-24 | 1976-02-24 | Process for producing 4-deacetoxy-vinchristine and acid additional salts |
Publications (2)
Publication Number | Publication Date |
---|---|
SE7701377L true SE7701377L (en) | 1977-08-25 |
SE430694B SE430694B (en) | 1983-12-05 |
Family
ID=11000995
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
SE7701377A SE430694B (en) | 1976-02-24 | 1977-02-08 | SET TO MAKE 4-DESACETOXIVINKRISTIN |
Country Status (15)
Country | Link |
---|---|
JP (1) | JPS52102300A (en) |
AT (1) | AT353429B (en) |
AU (1) | AU506508B2 (en) |
BE (1) | BE851697A (en) |
CA (1) | CA1094551A (en) |
CH (1) | CH627185A5 (en) |
DE (1) | DE2706366A1 (en) |
DK (1) | DK142815B (en) |
FR (1) | FR2342295A1 (en) |
GB (1) | GB1525372A (en) |
HU (1) | HU172183B (en) |
IL (1) | IL51486A (en) |
NL (1) | NL7701948A (en) |
SE (1) | SE430694B (en) |
SU (1) | SU673174A3 (en) |
Families Citing this family (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS5891011A (en) * | 1981-11-25 | 1983-05-30 | Toshiba Ceramics Co Ltd | Manufacture of silicon nitride powder with high alpha-phase content |
CN112521408B (en) * | 2020-12-16 | 2022-05-17 | 广州白云山汉方现代药业有限公司 | Bisindole alkaloid compound and preparation method and application thereof |
CN114933604A (en) * | 2021-12-10 | 2022-08-23 | 广州白云山汉方现代药业有限公司 | Vincristine chiral compound impurity and preparation method and application thereof |
-
1976
- 1976-02-24 HU HU76RI00000586A patent/HU172183B/en unknown
-
1977
- 1977-02-08 SE SE7701377A patent/SE430694B/en not_active IP Right Cessation
- 1977-02-09 AT AT84177A patent/AT353429B/en not_active IP Right Cessation
- 1977-02-10 AU AU22173/77A patent/AU506508B2/en not_active Expired
- 1977-02-10 CH CH162477A patent/CH627185A5/en not_active IP Right Cessation
- 1977-02-15 DE DE19772706366 patent/DE2706366A1/en not_active Withdrawn
- 1977-02-17 IL IL51486A patent/IL51486A/en unknown
- 1977-02-22 BE BE175146A patent/BE851697A/en not_active IP Right Cessation
- 1977-02-22 FR FR7705059A patent/FR2342295A1/en active Granted
- 1977-02-22 SU SU772453504A patent/SU673174A3/en active
- 1977-02-23 CA CA272,431A patent/CA1094551A/en not_active Expired
- 1977-02-23 DK DK78777AA patent/DK142815B/en not_active IP Right Cessation
- 1977-02-23 GB GB7677/77A patent/GB1525372A/en not_active Expired
- 1977-02-23 JP JP1824577A patent/JPS52102300A/en active Pending
- 1977-02-23 NL NL7701948A patent/NL7701948A/en not_active Application Discontinuation
Also Published As
Publication number | Publication date |
---|---|
SU673174A3 (en) | 1979-07-05 |
CH627185A5 (en) | 1981-12-31 |
DE2706366A1 (en) | 1977-08-25 |
BE851697A (en) | 1977-06-16 |
GB1525372A (en) | 1978-09-20 |
JPS52102300A (en) | 1977-08-27 |
SE430694B (en) | 1983-12-05 |
AU2217377A (en) | 1978-08-17 |
FR2342295A1 (en) | 1977-09-23 |
HU172183B (en) | 1978-06-28 |
NL7701948A (en) | 1977-08-26 |
AT353429B (en) | 1979-11-12 |
IL51486A0 (en) | 1977-04-29 |
ATA84177A (en) | 1979-04-15 |
CA1094551A (en) | 1981-01-27 |
IL51486A (en) | 1979-10-31 |
DK142815B (en) | 1981-02-02 |
AU506508B2 (en) | 1980-01-10 |
DK142815C (en) | 1981-08-24 |
DK78777A (en) | 1977-08-25 |
FR2342295B1 (en) | 1980-09-05 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
SE443981B (en) | ANALOGY PROCEDURE FOR PREPARING SYN-ISOMERS OF 3.7 DISUBSTITUTED 3-CEFEM-4-CARBOXYLIC ACID COMPOUNDS | |
SE7710698L (en) | PROCEDURE FOR THE PREPARATION OF PSEUDOTRISACARIDES | |
BG32851A3 (en) | Method for obtaining of 3, 4, 5, 6- tetrahydro- 2 h- 1- benzoxycin | |
BG29722A3 (en) | Method for obtaining of 2, 5- disubstituated pyrimidin- 4- on | |
SE7408486L (en) | METHOD OF PREPARING POPERAZINYL-KINOXALIN COMPOUND | |
SE7504762L (en) | PROCEDURE FOR THE PREPARATION OF PYRIMIDINTRIOXIDES. | |
BG32855A3 (en) | METHOD FOR OBTAINING 1-OXADETHIACEPHALOSPORINS | |
SE7514554L (en) | ANTISEPTIC AND DISINFECTING COMPOSITIONS | |
BG28049A3 (en) | Method of obtaining of 2- bromine- 6- fluor- n- 2- imdazolidinilidene- benzamine and its additional salts with acid | |
BG33289A3 (en) | Method for obtaining of 8, 8- disubstituated- 6- methylergolin | |
SE7701377L (en) | METHOD OF PREPARING 4-DESACETOXIVINE CHRISTINE AND ACID ADDITIONAL SALTS THEREOF | |
ES492537A0 (en) | PROCEDURE FOR THE OBTAINING OF PSEUDO-TRISACARIDES | |
SU474135A3 (en) | Method for preparing 4-chloro-2,5-dimethoxyaniline | |
BG33435A3 (en) | Method for obtaining of 6- methyl- 8- (substituated) methylergoline | |
BG33436A3 (en) | Method for obtaining of 4- dezacetyl- vinblastine- 3- spiro- 5"- oxazolidin- 2", 4"- dion | |
BG31796A3 (en) | Method for obtaining of disubstituated phenol ethers of 3- amino- 2- hydrox- propane | |
IT1209137B (en) | PROCEDURE FOR THE PRODUCTION OF PHENOXYALKENE DERIVATIVES. | |
BG28062A3 (en) | Method of obtaining of 6a,10a, cishexahydrodibenzopyranones | |
BG33280A3 (en) | Method for obtaining of (2, 2- dimethyl- 1, 2- hydrohinolin- 4- il)- methylsulphon acid and its salts | |
SE8205383D0 (en) | 1-ACYL-2-IMIDAZOLINE AND PROCEDURE FOR ITS PREPARATION | |
BG30918A3 (en) | Method for obtaining of substituated 5h- dibenz ( b, f )- azerine | |
ES501979A0 (en) | PROCEDURE FOR PREPARING AN AMOXICILLIN SODICACON N-METHYL-2-METHYL-PIRROLIDONE SOLVATE | |
SE8101733L (en) | HERBICIDA 2-HALOACETAMIDES | |
BG36496A3 (en) | Method for preparing substituted 2, 3- alkylene- bis- (oxy) benzamines | |
SE7613545L (en) | METHOD OF PREPARING DIFLUOROMETHYL-1,2,2-TRIFLNORETHYLETHER |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
NUG | Patent has lapsed |
Ref document number: 7701377-9 Effective date: 19880125 Format of ref document f/p: F |